RU2015143108A - Мышь с общей легкой цепью - Google Patents
Мышь с общей легкой цепью Download PDFInfo
- Publication number
- RU2015143108A RU2015143108A RU2015143108A RU2015143108A RU2015143108A RU 2015143108 A RU2015143108 A RU 2015143108A RU 2015143108 A RU2015143108 A RU 2015143108A RU 2015143108 A RU2015143108 A RU 2015143108A RU 2015143108 A RU2015143108 A RU 2015143108A
- Authority
- RU
- Russia
- Prior art keywords
- human
- gene
- gene segments
- mouse
- heavy chain
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 claims 142
- 238000000034 method Methods 0.000 claims 50
- 241000699666 Mus <mouse, genus> Species 0.000 claims 47
- 210000004602 germ cell Anatomy 0.000 claims 32
- 210000003719 b-lymphocyte Anatomy 0.000 claims 28
- 230000008707 rearrangement Effects 0.000 claims 16
- 101150008942 J gene Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 101150098072 20 gene Proteins 0.000 claims 4
- 101150086149 39 gene Proteins 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 4
- 102000025171 antigen binding proteins Human genes 0.000 claims 4
- 108091000831 antigen binding proteins Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000002955 isolation Methods 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Image Processing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,310 US20130185821A1 (en) | 2010-02-08 | 2013-03-13 | Common Light Chain Mouse |
| US13/798,310 | 2013-03-13 | ||
| PCT/US2014/025982 WO2014160179A1 (fr) | 2013-03-13 | 2014-03-13 | Souris à chaine légère classique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015143108A true RU2015143108A (ru) | 2017-04-20 |
Family
ID=50555217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015143108A RU2015143108A (ru) | 2013-03-13 | 2014-03-13 | Мышь с общей легкой цепью |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2970437A1 (fr) |
| JP (1) | JP2016519568A (fr) |
| KR (1) | KR20150126863A (fr) |
| CN (1) | CN105189545A (fr) |
| AU (1) | AU2014244079A1 (fr) |
| CA (1) | CA2903696A1 (fr) |
| HK (1) | HK1218550A1 (fr) |
| IL (1) | IL240562A0 (fr) |
| MX (1) | MX2015012540A (fr) |
| NL (4) | NL2012424C2 (fr) |
| RU (1) | RU2015143108A (fr) |
| SG (1) | SG11201506294TA (fr) |
| WO (1) | WO2014160179A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| RS55315B2 (sr) | 2010-02-08 | 2020-08-31 | Regeneron Pharma | Miš sa zajedničkim lakim lancem |
| PT2739740T (pt) | 2011-08-05 | 2020-01-09 | Regeneron Pharma | Cadeia leve universal humanizada de murganhos |
| KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| JP2018508224A (ja) | 2015-03-19 | 2018-03-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗原を結合する軽鎖可変領域を選択する非ヒト動物 |
| CA3011359A1 (fr) | 2016-01-13 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Rongeurs presentant une region de diversite de chaine lourde modifiee |
| GB201710984D0 (en) | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
| SG11202012084WA (en) | 2018-06-14 | 2021-01-28 | Regeneron Pharma | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
| AU2020226865A1 (en) | 2019-02-22 | 2021-07-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| WO2020247623A1 (fr) * | 2019-06-05 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Animaux non humains ayant un répertoire de chaînes légères lambda limité exprimé à partir du locus kappa et leurs utilisations |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| TW202229328A (zh) | 2020-09-11 | 2022-08-01 | 美商再生元醫藥公司 | 抗原特異性抗體之鑑定及產生 |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| CA3197426A1 (fr) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Procedes d'obtention d'anticorps qui se lient a des proteines transmembranaires et cellules qui les produisent |
| US20240317849A1 (en) | 2020-12-23 | 2024-09-26 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| GB202107372D0 (en) | 2021-05-24 | 2021-07-07 | Petmedix Ltd | Animal models and therapeutics molecules |
| GB202209247D0 (en) | 2022-06-23 | 2022-08-10 | Petmedix Ltd | Animal models and therapeutic molecules |
| GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| SI1523496T1 (sl) * | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP2007537704A (ja) * | 2003-07-15 | 2007-12-27 | セラピューティック ヒューマン ポリクローナルズ， インコーポレイテッド | ヒト化免疫グロブリン遺伝子座 |
| PL1802193T3 (pl) | 2004-10-19 | 2014-09-30 | Regeneron Pharma | Sposób wytwarzania myszy homozygotycznej pod względem modyfikacji genetycznej |
| MY159787A (en) | 2006-06-02 | 2017-01-31 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| KR101747103B1 (ko) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
| RS55315B2 (sr) * | 2010-02-08 | 2020-08-31 | Regeneron Pharma | Miš sa zajedničkim lakim lancem |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| KR20140136462A (ko) * | 2012-03-06 | 2014-11-28 | 리제너론 파마슈티칼스 인코포레이티드 | 공통 경쇄 마우스 |
| WO2013184761A1 (fr) * | 2012-06-05 | 2013-12-12 | Regeneron Pharmaceuticals, Inc. | Procédés pour préparer des anticorps bispécifiques entièrement humains en utilisant une chaîne légère commune |
-
2014
- 2014-03-13 RU RU2015143108A patent/RU2015143108A/ru not_active Application Discontinuation
- 2014-03-13 KR KR1020157025655A patent/KR20150126863A/ko not_active Application Discontinuation
- 2014-03-13 JP JP2016502014A patent/JP2016519568A/ja active Pending
- 2014-03-13 CA CA2903696A patent/CA2903696A1/fr not_active Abandoned
- 2014-03-13 NL NL2012424A patent/NL2012424C2/en active
- 2014-03-13 AU AU2014244079A patent/AU2014244079A1/en not_active Abandoned
- 2014-03-13 EP EP14722432.3A patent/EP2970437A1/fr not_active Withdrawn
- 2014-03-13 WO PCT/US2014/025982 patent/WO2014160179A1/fr active Application Filing
- 2014-03-13 CN CN201480013861.1A patent/CN105189545A/zh active Pending
- 2014-03-13 SG SG11201506294TA patent/SG11201506294TA/en unknown
- 2014-03-13 MX MX2015012540A patent/MX2015012540A/es unknown
- 2014-11-21 NL NL2013851A patent/NL2013851C2/en active
-
2015
- 2015-05-07 NL NL2014775A patent/NL2014775B1/en active
- 2015-08-13 IL IL240562A patent/IL240562A0/en unknown
- 2015-10-12 NL NL2015603A patent/NL2015603B1/en active
-
2016
- 2016-06-06 HK HK16106452.0A patent/HK1218550A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL2012424C2 (en) | 2014-12-08 |
| NL2015603B1 (en) | 2016-09-23 |
| IL240562A0 (en) | 2015-09-24 |
| NL2013851C2 (en) | 2015-06-08 |
| EP2970437A1 (fr) | 2016-01-20 |
| CN105189545A (zh) | 2015-12-23 |
| NL2015603A (en) | 2016-03-16 |
| NL2014775B1 (en) | 2016-03-16 |
| JP2016519568A (ja) | 2016-07-07 |
| SG11201506294TA (en) | 2015-09-29 |
| WO2014160179A1 (fr) | 2014-10-02 |
| MX2015012540A (es) | 2016-04-19 |
| WO2014160179A4 (fr) | 2014-11-20 |
| HK1218550A1 (zh) | 2017-02-24 |
| KR20150126863A (ko) | 2015-11-13 |
| NL2014775A (en) | 2015-06-09 |
| CA2903696A1 (fr) | 2014-10-02 |
| NL2013851A (en) | 2015-01-12 |
| NL2012424A (en) | 2014-09-16 |
| AU2014244079A1 (en) | 2015-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20170314 |