CA3011359A1 - Rongeurs presentant une region de diversite de chaine lourde modifiee - Google Patents
Rongeurs presentant une region de diversite de chaine lourde modifiee Download PDFInfo
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- CA3011359A1 CA3011359A1 CA3011359A CA3011359A CA3011359A1 CA 3011359 A1 CA3011359 A1 CA 3011359A1 CA 3011359 A CA3011359 A CA 3011359A CA 3011359 A CA3011359 A CA 3011359A CA 3011359 A1 CA3011359 A1 CA 3011359A1
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- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- C—CHEMISTRY; METALLURGY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract
La présente invention concerne des animaux non humains et des procédés et des compositions de préparation et d'utilisation de ceux-ci, lesdits animaux non humains présentant un génome comprenant une grappe de diversité modifiée ou recombinée dans une région variable de chaîne lourde d'immunoglobuline, ladite grappe de diversité modifiée ou recombinée comprenant une insertion d'une ou plusieurs séquences codantes d'un polypeptide d'intérêt qui n'est pas l'immunoglobuline. Les animaux non humains décrits dans la présente description expriment des anticorps caractérisés par des régions déterminant la complémentarité (CDR), en particulier, des CDR3 présentant une diversité qui dirige la liaison à des antigènes particuliers. L'invention concerne également des procédés de production d'anticorps à partir d'animaux non humains, lesdits anticorps contenant des régions variables humaines et des régions constantes murines.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201662278127P | 2016-01-13 | 2016-01-13 | |
US62/278,127 | 2016-01-13 | ||
PCT/US2017/013247 WO2017123804A1 (fr) | 2016-01-13 | 2017-01-12 | Rongeurs présentant une région de diversité de chaîne lourde modifiée |
Publications (1)
Publication Number | Publication Date |
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CA3011359A1 true CA3011359A1 (fr) | 2017-07-20 |
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ID=58010373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA3011359A Pending CA3011359A1 (fr) | 2016-01-13 | 2017-01-12 | Rongeurs presentant une region de diversite de chaine lourde modifiee |
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US (2) | US20190037816A1 (fr) |
EP (2) | EP4257599A3 (fr) |
JP (3) | JP6979955B2 (fr) |
KR (2) | KR102482103B1 (fr) |
CN (2) | CN114128676A (fr) |
AU (2) | AU2017206785C1 (fr) |
BR (1) | BR112018014250A2 (fr) |
CA (1) | CA3011359A1 (fr) |
IL (2) | IL302725A (fr) |
MX (1) | MX2018008701A (fr) |
RU (1) | RU2763320C2 (fr) |
SG (2) | SG10201914034WA (fr) |
WO (1) | WO2017123804A1 (fr) |
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US20200131540A1 (en) * | 2017-04-20 | 2020-04-30 | Ramof at Tel-Aviv University Ltd. | Recombination activating gene (rag) induced v(d)j gene targeting |
AU2021259958A1 (en) * | 2020-04-21 | 2022-11-17 | Tempus Ai, Inc. | TCR/BCR profiling |
MX2020012914A (es) * | 2020-11-27 | 2022-05-30 | Centro De Investig Cientifica Y De Educacion Superior De Ensenada Baja California Cicese | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
WO2003084477A2 (fr) * | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Corps mimetiques de cdr de mammifere, compositions, procedes et utilisations |
AU2004261980A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody CDR polypeptide sequences with restricted diversity |
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2017
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- 2017-01-12 US US16/074,042 patent/US20190037816A1/en not_active Abandoned
- 2017-01-12 CN CN202111210808.9A patent/CN114128676A/zh active Pending
- 2017-01-12 EP EP23169890.3A patent/EP4257599A3/fr active Pending
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- 2017-01-12 EP EP17704340.3A patent/EP3402326A1/fr not_active Withdrawn
- 2017-01-12 BR BR112018014250-6A patent/BR112018014250A2/pt not_active IP Right Cessation
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KR102482103B1 (ko) | 2022-12-28 |
EP4257599A2 (fr) | 2023-10-11 |
MX2018008701A (es) | 2019-06-06 |
SG11201805973WA (en) | 2018-08-30 |
CN114128676A (zh) | 2022-03-04 |
RU2763320C2 (ru) | 2021-12-28 |
AU2017206785C1 (en) | 2023-09-07 |
IL260526A (fr) | 2018-08-30 |
JP2021101738A (ja) | 2021-07-15 |
KR20230006929A (ko) | 2023-01-11 |
BR112018014250A2 (pt) | 2018-12-18 |
RU2018129169A (ru) | 2020-02-13 |
CN108777951B (zh) | 2021-11-05 |
EP3402326A1 (fr) | 2018-11-21 |
EP4257599A3 (fr) | 2024-01-17 |
US20190037816A1 (en) | 2019-02-07 |
IL302725A (en) | 2023-07-01 |
US20220174920A1 (en) | 2022-06-09 |
WO2017123804A1 (fr) | 2017-07-20 |
CN108777951A (zh) | 2018-11-09 |
JP2019501660A (ja) | 2019-01-24 |
AU2023201372A1 (en) | 2023-04-06 |
JP6979955B2 (ja) | 2021-12-15 |
AU2017206785B2 (en) | 2023-03-16 |
WO2017123804A9 (fr) | 2017-08-17 |
JP2023024619A (ja) | 2023-02-16 |
IL260526B1 (en) | 2023-06-01 |
RU2018129169A3 (fr) | 2020-05-25 |
AU2017206785A1 (en) | 2018-08-02 |
SG10201914034WA (en) | 2020-03-30 |
KR20180108652A (ko) | 2018-10-04 |
IL260526B2 (en) | 2023-10-01 |
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