MX2020012914A - Proteina andamio para la generacion de proteinas quimericas de union a antigeno. - Google Patents
Proteina andamio para la generacion de proteinas quimericas de union a antigeno.Info
- Publication number
- MX2020012914A MX2020012914A MX2020012914A MX2020012914A MX2020012914A MX 2020012914 A MX2020012914 A MX 2020012914A MX 2020012914 A MX2020012914 A MX 2020012914A MX 2020012914 A MX2020012914 A MX 2020012914A MX 2020012914 A MX2020012914 A MX 2020012914A
- Authority
- MX
- Mexico
- Prior art keywords
- scaffold protein
- binding proteins
- chimeric antigen
- generating chimeric
- conotoxin
- Prior art date
Links
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 title abstract 2
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 title abstract 2
- 101710204410 Scaffold protein Proteins 0.000 title abstract 2
- 102000025171 antigen binding proteins Human genes 0.000 title 1
- 108091000831 antigen binding proteins Proteins 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108050003126 conotoxin Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
- C07K16/205—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Una proteína de andamio de SEQ ID NO: 1 derivada de una conotoxina, que no presenta residuos de aminoácidos asociados a la actividad tóxica de la conotoxina, y que puede ser usada para la generación de proteínas quiméricas de entre 19 a 47 aminoácidos, insertándole entre sus aminoácidos 11 y 12, fragmentos de un CDR3 de un vNAR con afinidad por un antígeno específico.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2020012914A MX2020012914A (es) | 2020-11-27 | 2020-11-27 | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
EP21898766.7A EP4253399A1 (en) | 2020-11-27 | 2021-11-19 | Scaffolding protein for generating antigen-binding chimeral proteins |
US18/253,971 US20230374072A1 (en) | 2020-11-27 | 2021-11-19 | Scaffolding protein for generating antigen-binding chimeral proteins |
PCT/MX2021/050077 WO2022114946A1 (es) | 2020-11-27 | 2021-11-19 | Proteína andamio para la generación de proteínas quiméricas de unión a antígeno |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2020012914A MX2020012914A (es) | 2020-11-27 | 2020-11-27 | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020012914A true MX2020012914A (es) | 2022-05-30 |
Family
ID=81754659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020012914A MX2020012914A (es) | 2020-11-27 | 2020-11-27 | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
Country Status (4)
Country | Link |
---|---|
US (1) | US20230374072A1 (es) |
EP (1) | EP4253399A1 (es) |
MX (1) | MX2020012914A (es) |
WO (1) | WO2022114946A1 (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2638173T3 (da) * | 2010-11-08 | 2019-09-30 | Univ Leland Stanford Junior | Fusionsproteiner omfattende et manipuleret knottin-peptid og anvendelser deraf |
RU2763320C2 (ru) * | 2016-01-13 | 2021-12-28 | Регенерон Фармасьютикалз, Инк. | Грызуны, имеющие сконструированный участок разнообразия тяжелой цепи |
-
2020
- 2020-11-27 MX MX2020012914A patent/MX2020012914A/es unknown
-
2021
- 2021-11-19 WO PCT/MX2021/050077 patent/WO2022114946A1/es unknown
- 2021-11-19 US US18/253,971 patent/US20230374072A1/en active Pending
- 2021-11-19 EP EP21898766.7A patent/EP4253399A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230374072A1 (en) | 2023-11-23 |
EP4253399A1 (en) | 2023-10-04 |
WO2022114946A1 (es) | 2022-06-02 |
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