CA2903696A1 - Souris a chaine legere classique - Google Patents
Souris a chaine legere classique Download PDFInfo
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- CA2903696A1 CA2903696A1 CA2903696A CA2903696A CA2903696A1 CA 2903696 A1 CA2903696 A1 CA 2903696A1 CA 2903696 A CA2903696 A CA 2903696A CA 2903696 A CA2903696 A CA 2903696A CA 2903696 A1 CA2903696 A1 CA 2903696A1
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- human
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- gene
- kappa
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Image Processing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,310 | 2013-03-13 | ||
| US13/798,310 US20130185821A1 (en) | 2010-02-08 | 2013-03-13 | Common Light Chain Mouse |
| PCT/US2014/025982 WO2014160179A1 (fr) | 2013-03-13 | 2014-03-13 | Souris à chaine légère classique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2903696A1 true CA2903696A1 (fr) | 2014-10-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2903696A Abandoned CA2903696A1 (fr) | 2013-03-13 | 2014-03-13 | Souris a chaine legere classique |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2970437A1 (fr) |
| JP (1) | JP2016519568A (fr) |
| KR (1) | KR20150126863A (fr) |
| CN (1) | CN105189545A (fr) |
| AU (1) | AU2014244079A1 (fr) |
| CA (1) | CA2903696A1 (fr) |
| HK (1) | HK1218550A1 (fr) |
| IL (1) | IL240562A0 (fr) |
| MX (1) | MX2015012540A (fr) |
| NL (4) | NL2012424C2 (fr) |
| RU (1) | RU2015143108A (fr) |
| SG (1) | SG11201506294TA (fr) |
| WO (1) | WO2014160179A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| PT2505654T (pt) | 2010-02-08 | 2016-11-18 | Regeneron Pharma | Rato de cadeia leve comum |
| EP3865581A1 (fr) | 2011-08-05 | 2021-08-18 | Regeneron Pharmaceuticals, Inc. | Souris à chaîne légère universelle humanisée |
| EP3119194B1 (fr) | 2014-03-21 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Animaux non humains qui produisent des protéines de liaison monodomaine |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR20230006929A (ko) | 2016-01-13 | 2023-01-11 | 리제너론 파마슈티칼스 인코포레이티드 | 조작된 중쇄 다양성 영역을 갖는 설치류 |
| GB201710984D0 (en) | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
| US20190380316A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
| JP2022520819A (ja) | 2019-02-22 | 2022-04-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法 |
| MX2021014893A (es) * | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos. |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| US20220195014A1 (en) | 2020-12-23 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| MX2023007583A (es) | 2020-12-23 | 2023-07-07 | Regeneron Pharma | Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen. |
| GB202107372D0 (en) | 2021-05-24 | 2021-07-07 | Petmedix Ltd | Animal models and therapeutics molecules |
| GB202209247D0 (en) | 2022-06-23 | 2022-08-10 | Petmedix Ltd | Animal models and therapeutic molecules |
| GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| PT2314629E (pt) * | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2005007696A2 (fr) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Locus d'immunoglobuline humanises |
| PT1802193E (pt) | 2004-10-19 | 2014-06-23 | Regeneron Pharma | Método para gerar um murganho homozigótico para uma modificação genética |
| CN102585002A (zh) | 2006-06-02 | 2012-07-18 | 瑞泽恩制药公司 | 人il-6受体的高亲和力抗体 |
| EP2445936A1 (fr) | 2009-06-26 | 2012-05-02 | Regeneron Pharmaceuticals, Inc. | Anticorps bispécifiques facilement isolés avec un format d'immunoglobuline native |
| PT2505654T (pt) * | 2010-02-08 | 2016-11-18 | Regeneron Pharma | Rato de cadeia leve comum |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| NZ630637A (en) * | 2012-03-06 | 2016-09-30 | Regeneron Pharma | Common light chain mouse |
| WO2013184761A1 (fr) * | 2012-06-05 | 2013-12-12 | Regeneron Pharmaceuticals, Inc. | Procédés pour préparer des anticorps bispécifiques entièrement humains en utilisant une chaîne légère commune |
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2014
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- 2014-03-13 CA CA2903696A patent/CA2903696A1/fr not_active Abandoned
- 2014-03-13 MX MX2015012540A patent/MX2015012540A/es unknown
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- 2014-03-13 SG SG11201506294TA patent/SG11201506294TA/en unknown
- 2014-03-13 JP JP2016502014A patent/JP2016519568A/ja active Pending
- 2014-03-13 KR KR1020157025655A patent/KR20150126863A/ko not_active Application Discontinuation
- 2014-03-13 EP EP14722432.3A patent/EP2970437A1/fr not_active Withdrawn
- 2014-03-13 WO PCT/US2014/025982 patent/WO2014160179A1/fr active Application Filing
- 2014-03-13 RU RU2015143108A patent/RU2015143108A/ru not_active Application Discontinuation
- 2014-03-13 CN CN201480013861.1A patent/CN105189545A/zh active Pending
- 2014-11-21 NL NL2013851A patent/NL2013851C2/en active
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2015
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- 2015-08-13 IL IL240562A patent/IL240562A0/en unknown
- 2015-10-12 NL NL2015603A patent/NL2015603B1/en active
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2016
- 2016-06-06 HK HK16106452.0A patent/HK1218550A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL2013851A (en) | 2015-01-12 |
| JP2016519568A (ja) | 2016-07-07 |
| MX2015012540A (es) | 2016-04-19 |
| NL2012424A (en) | 2014-09-16 |
| EP2970437A1 (fr) | 2016-01-20 |
| NL2012424C2 (en) | 2014-12-08 |
| HK1218550A1 (zh) | 2017-02-24 |
| NL2015603A (en) | 2016-03-16 |
| WO2014160179A1 (fr) | 2014-10-02 |
| NL2015603B1 (en) | 2016-09-23 |
| CN105189545A (zh) | 2015-12-23 |
| WO2014160179A4 (fr) | 2014-11-20 |
| NL2014775A (en) | 2015-06-09 |
| AU2014244079A1 (en) | 2015-09-24 |
| KR20150126863A (ko) | 2015-11-13 |
| SG11201506294TA (en) | 2015-09-29 |
| NL2013851C2 (en) | 2015-06-08 |
| NL2014775B1 (en) | 2016-03-16 |
| IL240562A0 (en) | 2015-09-24 |
| RU2015143108A (ru) | 2017-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20200313 |