IL240562A0 - Common light chain mouse - Google Patents
Common light chain mouseInfo
- Publication number
- IL240562A0 IL240562A0 IL240562A IL24056215A IL240562A0 IL 240562 A0 IL240562 A0 IL 240562A0 IL 240562 A IL240562 A IL 240562A IL 24056215 A IL24056215 A IL 24056215A IL 240562 A0 IL240562 A0 IL 240562A0
- Authority
- IL
- Israel
- Prior art keywords
- light chain
- common light
- chain mouse
- mouse
- common
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/798,310 US20130185821A1 (en) | 2010-02-08 | 2013-03-13 | Common Light Chain Mouse |
PCT/US2014/025982 WO2014160179A1 (en) | 2013-03-13 | 2014-03-13 | Common light chain mouse |
Publications (1)
Publication Number | Publication Date |
---|---|
IL240562A0 true IL240562A0 (en) | 2015-09-24 |
Family
ID=50555217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL240562A IL240562A0 (en) | 2013-03-13 | 2015-08-13 | Common light chain mouse |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2970437A1 (en) |
JP (1) | JP2016519568A (en) |
KR (1) | KR20150126863A (en) |
CN (1) | CN105189545A (en) |
AU (1) | AU2014244079A1 (en) |
CA (1) | CA2903696A1 (en) |
HK (1) | HK1218550A1 (en) |
IL (1) | IL240562A0 (en) |
MX (1) | MX2015012540A (en) |
NL (4) | NL2012424C2 (en) |
RU (1) | RU2015143108A (en) |
SG (1) | SG11201506294TA (en) |
WO (1) | WO2014160179A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
ES2603559T5 (en) | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Mouse common light chain |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
ES2872081T3 (en) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Humanized Universal Light Chain Mice |
JP6636498B2 (en) | 2014-03-21 | 2020-01-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
JP2018508224A (en) | 2015-03-19 | 2018-03-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Non-human animals that select light chain variable regions that bind antigen |
CN114128676A (en) | 2016-01-13 | 2022-03-04 | 瑞泽恩制药公司 | Non-human animals having immunoglobulin heavy chain variable regions comprising engineered diversity clusters and uses thereof |
GB201710984D0 (en) | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
WO2019241692A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
MX2021009855A (en) | 2019-02-22 | 2021-09-10 | Regeneron Pharma | Rodents having genetically modified sodium channels and methods of use thereof. |
MX2021014893A (en) * | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof. |
KR20210095781A (en) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety |
JP2023540808A (en) | 2020-09-11 | 2023-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Identification and production of antigen-specific antibodies |
CN116848254A (en) | 2020-12-16 | 2023-10-03 | 瑞泽恩制药公司 | Mice expressing humanized Fc alpha receptors |
CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
TW202241934A (en) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | Nucleic acids encoding anchor modified antibodies and uses thereof |
GB202107372D0 (en) | 2021-05-24 | 2021-07-07 | Petmedix Ltd | Animal models and therapeutics molecules |
GB202209247D0 (en) | 2022-06-23 | 2022-08-10 | Petmedix Ltd | Animal models and therapeutic molecules |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
WO2004009618A2 (en) * | 2002-07-18 | 2004-01-29 | Crucell Holland B.V. | Recombinant production of mixtures of antibodies |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
ATE537190T1 (en) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | HIGH AFFINE ANTIBODIES AGAINST THE HUMAN IL-6 RECEPTOR |
KR102010827B1 (en) | 2009-06-26 | 2019-08-14 | 리제너론 파마슈티칼스 인코포레이티드 | Readily isolated bispecific antibodies with native immunoglobulin format |
US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
ES2603559T5 (en) * | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Mouse common light chain |
US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
JP2015509380A (en) * | 2012-03-06 | 2015-03-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Common light chain mice |
KR20150023535A (en) * | 2012-06-05 | 2015-03-05 | 리제너론 파마슈티칼스 인코포레이티드 | Methods for making fully human bispecific antibodies using a common light chain |
-
2014
- 2014-03-13 WO PCT/US2014/025982 patent/WO2014160179A1/en active Application Filing
- 2014-03-13 AU AU2014244079A patent/AU2014244079A1/en not_active Abandoned
- 2014-03-13 EP EP14722432.3A patent/EP2970437A1/en not_active Withdrawn
- 2014-03-13 JP JP2016502014A patent/JP2016519568A/en active Pending
- 2014-03-13 MX MX2015012540A patent/MX2015012540A/en unknown
- 2014-03-13 RU RU2015143108A patent/RU2015143108A/en not_active Application Discontinuation
- 2014-03-13 SG SG11201506294TA patent/SG11201506294TA/en unknown
- 2014-03-13 KR KR1020157025655A patent/KR20150126863A/en not_active Application Discontinuation
- 2014-03-13 CA CA2903696A patent/CA2903696A1/en not_active Abandoned
- 2014-03-13 NL NL2012424A patent/NL2012424C2/en active
- 2014-03-13 CN CN201480013861.1A patent/CN105189545A/en active Pending
- 2014-11-21 NL NL2013851A patent/NL2013851C2/en active
-
2015
- 2015-05-07 NL NL2014775A patent/NL2014775B1/en active
- 2015-08-13 IL IL240562A patent/IL240562A0/en unknown
- 2015-10-12 NL NL2015603A patent/NL2015603B1/en active
-
2016
- 2016-06-06 HK HK16106452.0A patent/HK1218550A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20150126863A (en) | 2015-11-13 |
WO2014160179A4 (en) | 2014-11-20 |
NL2014775A (en) | 2015-06-09 |
NL2013851A (en) | 2015-01-12 |
SG11201506294TA (en) | 2015-09-29 |
NL2014775B1 (en) | 2016-03-16 |
JP2016519568A (en) | 2016-07-07 |
NL2015603B1 (en) | 2016-09-23 |
NL2012424C2 (en) | 2014-12-08 |
MX2015012540A (en) | 2016-04-19 |
NL2012424A (en) | 2014-09-16 |
HK1218550A1 (en) | 2017-02-24 |
CA2903696A1 (en) | 2014-10-02 |
WO2014160179A1 (en) | 2014-10-02 |
RU2015143108A (en) | 2017-04-20 |
NL2015603A (en) | 2016-03-16 |
EP2970437A1 (en) | 2016-01-20 |
NL2013851C2 (en) | 2015-06-08 |
CN105189545A (en) | 2015-12-23 |
AU2014244079A1 (en) | 2015-09-24 |
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