RU2014150071A - Способы кристаллизации для очистки моноклональных антител - Google Patents
Способы кристаллизации для очистки моноклональных антител Download PDFInfo
- Publication number
- RU2014150071A RU2014150071A RU2014150071A RU2014150071A RU2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A
- Authority
- RU
- Russia
- Prior art keywords
- buffer
- paragraphs
- composition
- supernatant
- ionic strength
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Botany (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645855P | 2012-05-11 | 2012-05-11 | |
| US61/645,855 | 2012-05-11 | ||
| PCT/EP2013/059696 WO2013167720A1 (en) | 2012-05-11 | 2013-05-10 | Crystallization methods for purification of monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014150071A true RU2014150071A (ru) | 2016-07-10 |
Family
ID=48326319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014150071A RU2014150071A (ru) | 2012-05-11 | 2013-05-10 | Способы кристаллизации для очистки моноклональных антител |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20150133642A1 (enExample) |
| EP (1) | EP2846830A1 (enExample) |
| JP (1) | JP2015517306A (enExample) |
| KR (1) | KR20150016503A (enExample) |
| CN (1) | CN104284676B (enExample) |
| AU (1) | AU2013258006B2 (enExample) |
| BR (1) | BR112014027994A2 (enExample) |
| CA (1) | CA2872145A1 (enExample) |
| IL (1) | IL235483A0 (enExample) |
| IN (1) | IN2014DN09097A (enExample) |
| MX (1) | MX2014013754A (enExample) |
| RU (1) | RU2014150071A (enExample) |
| SG (1) | SG11201406664SA (enExample) |
| WO (1) | WO2013167720A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3015542A1 (de) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
| JP7222891B2 (ja) * | 2016-12-23 | 2023-02-15 | アーラ フーズ エエムビエ | 新規のベータ－ラクトグロブリン調製物の製造ならびに関連する方法、使用および食品 |
| EP3596101B1 (en) * | 2017-03-14 | 2022-01-05 | Amgen Inc. | Methods directed to crystalline biomolecules |
| PL3813549T3 (pl) | 2018-06-27 | 2026-03-09 | Arla Foods Amba | Preparat napoju z beta-laktoglobuliną o obojętnym ph |
| JP7467438B2 (ja) | 2018-10-18 | 2024-04-15 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｒｓｖ抗体の製剤及びその使用方法 |
| CN113015748B (zh) | 2018-10-31 | 2025-12-12 | 默沙东有限责任公司 | 抗人pd-1抗体晶体及其使用方法 |
| IT202100004496A1 (it) | 2021-02-25 | 2022-08-25 | Univ Della Calabria | Recupero di farmaci biologici o loro frammenti da soluzioni impure mediante cristallizzazione o precipitazione con membrane |
| CN116949036B (zh) * | 2023-09-11 | 2023-12-15 | 成都斯马特科技有限公司 | 一种快速从腹水中提取核酸的试剂盒及提取方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4731793B2 (ja) * | 2000-12-28 | 2011-07-27 | アルセア テクノロジーズ インコーポレイテッド | 抗体全体またはそのフラグメントの結晶、ならびにこの結晶を作製および使用するための方法 |
| DE60237841D1 (de) * | 2001-11-13 | 2010-11-11 | Genentech Inc | Zusammensetzungen basierend auf APO2-Ligand/ TRAIL und ihre Verwendung |
| US7087719B2 (en) * | 2002-11-19 | 2006-08-08 | Gtc Biotherapeutics, Inc. | Method for the crystallization of human serum albumin |
| EP2235056A1 (en) * | 2007-12-21 | 2010-10-06 | Genentech, Inc. | Crystallization of anti-cd20 antibodies |
| CN101320006B (zh) * | 2008-07-17 | 2010-12-01 | 西北工业大学 | 蛋白质结晶条件的筛选方法 |
-
2013
- 2013-05-10 EP EP13721353.4A patent/EP2846830A1/en not_active Withdrawn
- 2013-05-10 KR KR1020147031286A patent/KR20150016503A/ko not_active Ceased
- 2013-05-10 CA CA2872145A patent/CA2872145A1/en not_active Abandoned
- 2013-05-10 SG SG11201406664SA patent/SG11201406664SA/en unknown
- 2013-05-10 BR BR112014027994A patent/BR112014027994A2/pt not_active Application Discontinuation
- 2013-05-10 RU RU2014150071A patent/RU2014150071A/ru not_active Application Discontinuation
- 2013-05-10 IN IN9097DEN2014 patent/IN2014DN09097A/en unknown
- 2013-05-10 CN CN201380024777.5A patent/CN104284676B/zh not_active Expired - Fee Related
- 2013-05-10 WO PCT/EP2013/059696 patent/WO2013167720A1/en not_active Ceased
- 2013-05-10 AU AU2013258006A patent/AU2013258006B2/en not_active Ceased
- 2013-05-10 MX MX2014013754A patent/MX2014013754A/es unknown
- 2013-05-10 US US14/400,179 patent/US20150133642A1/en not_active Abandoned
- 2013-05-10 JP JP2015510828A patent/JP2015517306A/ja active Pending
-
2014
- 2014-11-03 IL IL235483A patent/IL235483A0/en unknown
-
2017
- 2017-02-10 US US15/429,514 patent/US20170198028A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2846830A1 (en) | 2015-03-18 |
| CN104284676A (zh) | 2015-01-14 |
| AU2013258006A1 (en) | 2014-11-06 |
| IN2014DN09097A (enExample) | 2015-05-22 |
| AU2013258006B2 (en) | 2016-04-28 |
| CN104284676B (zh) | 2018-11-27 |
| JP2015517306A (ja) | 2015-06-22 |
| MX2014013754A (es) | 2015-02-12 |
| WO2013167720A1 (en) | 2013-11-14 |
| KR20150016503A (ko) | 2015-02-12 |
| BR112014027994A2 (pt) | 2017-06-27 |
| US20170198028A1 (en) | 2017-07-13 |
| CA2872145A1 (en) | 2013-11-14 |
| IL235483A0 (en) | 2014-12-31 |
| SG11201406664SA (en) | 2014-11-27 |
| US20150133642A1 (en) | 2015-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190403 |