KR20150016503A - 모노클로날 항체의 정제를 위한 결정화 방법 - Google Patents

모노클로날 항체의 정제를 위한 결정화 방법 Download PDF

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Publication number
KR20150016503A
KR20150016503A KR1020147031286A KR20147031286A KR20150016503A KR 20150016503 A KR20150016503 A KR 20150016503A KR 1020147031286 A KR1020147031286 A KR 1020147031286A KR 20147031286 A KR20147031286 A KR 20147031286A KR 20150016503 A KR20150016503 A KR 20150016503A
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KR
South Korea
Prior art keywords
crystallization
tris
mab01
buffer
crystals
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Ceased
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KR1020147031286A
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English (en)
Korean (ko)
Inventor
다리우쉬 헤크마트
베른하르트 헬크
헨크 콘라트 슐츠
벤자민 스메칼
Original Assignee
노파르티스 아게
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Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20150016503A publication Critical patent/KR20150016503A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020147031286A 2012-05-11 2013-05-10 모노클로날 항체의 정제를 위한 결정화 방법 Ceased KR20150016503A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645855P 2012-05-11 2012-05-11
US61/645,855 2012-05-11
PCT/EP2013/059696 WO2013167720A1 (en) 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies

Publications (1)

Publication Number Publication Date
KR20150016503A true KR20150016503A (ko) 2015-02-12

Family

ID=48326319

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147031286A Ceased KR20150016503A (ko) 2012-05-11 2013-05-10 모노클로날 항체의 정제를 위한 결정화 방법

Country Status (14)

Country Link
US (2) US20150133642A1 (enExample)
EP (1) EP2846830A1 (enExample)
JP (1) JP2015517306A (enExample)
KR (1) KR20150016503A (enExample)
CN (1) CN104284676B (enExample)
AU (1) AU2013258006B2 (enExample)
BR (1) BR112014027994A2 (enExample)
CA (1) CA2872145A1 (enExample)
IL (1) IL235483A0 (enExample)
IN (1) IN2014DN09097A (enExample)
MX (1) MX2014013754A (enExample)
RU (1) RU2014150071A (enExample)
SG (1) SG11201406664SA (enExample)
WO (1) WO2013167720A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
JP7222891B2 (ja) * 2016-12-23 2023-02-15 アーラ フーズ エエムビエ 新規のベータ－ラクトグロブリン調製物の製造ならびに関連する方法、使用および食品
EP3596101B1 (en) * 2017-03-14 2022-01-05 Amgen Inc. Methods directed to crystalline biomolecules
PL3813549T3 (pl) 2018-06-27 2026-03-09 Arla Foods Amba Preparat napoju z beta-laktoglobuliną o obojętnym ph
JP7467438B2 (ja) 2018-10-18 2024-04-15 メルク・シャープ・アンド・ドーム・エルエルシー 抗ｒｓｖ抗体の製剤及びその使用方法
CN113015748B (zh) 2018-10-31 2025-12-12 默沙东有限责任公司 抗人pd-1抗体晶体及其使用方法
IT202100004496A1 (it) 2021-02-25 2022-08-25 Univ Della Calabria Recupero di farmaci biologici o loro frammenti da soluzioni impure mediante cristallizzazione o precipitazione con membrane
CN116949036B (zh) * 2023-09-11 2023-12-15 成都斯马特科技有限公司 一种快速从腹水中提取核酸的试剂盒及提取方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4731793B2 (ja) * 2000-12-28 2011-07-27 アルセア テクノロジーズ インコーポレイテッド 抗体全体またはそのフラグメントの結晶、ならびにこの結晶を作製および使用するための方法
DE60237841D1 (de) * 2001-11-13 2010-11-11 Genentech Inc Zusammensetzungen basierend auf APO2-Ligand/ TRAIL und ihre Verwendung
US7087719B2 (en) * 2002-11-19 2006-08-08 Gtc Biotherapeutics, Inc. Method for the crystallization of human serum albumin
EP2235056A1 (en) * 2007-12-21 2010-10-06 Genentech, Inc. Crystallization of anti-cd20 antibodies
CN101320006B (zh) * 2008-07-17 2010-12-01 西北工业大学 蛋白质结晶条件的筛选方法

Also Published As

Publication number Publication date
EP2846830A1 (en) 2015-03-18
CN104284676A (zh) 2015-01-14
AU2013258006A1 (en) 2014-11-06
IN2014DN09097A (enExample) 2015-05-22
AU2013258006B2 (en) 2016-04-28
CN104284676B (zh) 2018-11-27
JP2015517306A (ja) 2015-06-22
MX2014013754A (es) 2015-02-12
WO2013167720A1 (en) 2013-11-14
BR112014027994A2 (pt) 2017-06-27
US20170198028A1 (en) 2017-07-13
CA2872145A1 (en) 2013-11-14
IL235483A0 (en) 2014-12-31
SG11201406664SA (en) 2014-11-27
US20150133642A1 (en) 2015-05-14
RU2014150071A (ru) 2016-07-10

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