IN2014DN09097A - - Google Patents

Info

Publication number
IN2014DN09097A
IN2014DN09097A IN9097DEN2014A IN2014DN09097A IN 2014DN09097 A IN2014DN09097 A IN 2014DN09097A IN 9097DEN2014 A IN9097DEN2014 A IN 9097DEN2014A IN 2014DN09097 A IN2014DN09097 A IN 2014DN09097A
Authority
IN
India
Prior art keywords
antibodies
crystallization
methods
disclosure relates
culture supernatant
Prior art date
Application number
Inventor
Dariusch Hekmat
Bernhard Helk
Henk Konrad Schulz
Benjamin Smejkal
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2014DN09097A publication Critical patent/IN2014DN09097A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This disclosure relates to methods for crystallization of antibodies from cell free culture supernatant.
IN9097DEN2014 2012-05-11 2013-05-10 IN2014DN09097A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261645855P 2012-05-11 2012-05-11
PCT/EP2013/059696 WO2013167720A1 (en) 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies

Publications (1)

Publication Number Publication Date
IN2014DN09097A true IN2014DN09097A (en) 2015-05-22

Family

ID=48326319

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9097DEN2014 IN2014DN09097A (en) 2012-05-11 2013-05-10

Country Status (14)

Country Link
US (2) US20150133642A1 (en)
EP (1) EP2846830A1 (en)
JP (1) JP2015517306A (en)
KR (1) KR20150016503A (en)
CN (1) CN104284676B (en)
AU (1) AU2013258006B2 (en)
BR (1) BR112014027994A2 (en)
CA (1) CA2872145A1 (en)
IL (1) IL235483A0 (en)
IN (1) IN2014DN09097A (en)
MX (1) MX2014013754A (en)
RU (1) RU2014150071A (en)
SG (1) SG11201406664SA (en)
WO (1) WO2013167720A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3015542A1 (en) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modular system and method for continuous, germ reduced production and/or processing of a product
JP7222891B2 (en) * 2016-12-23 2023-02-15 アーラ フーズ エエムビエ Production of novel beta-lactoglobulin preparations and related methods, uses and foods
EP3596101B1 (en) * 2017-03-14 2022-01-05 Amgen Inc. Methods directed to crystalline biomolecules
PL3813549T3 (en) 2018-06-27 2026-03-09 Arla Foods Amba Ph neutral beta-lactoglobulin beverage preparation
JP7467438B2 (en) 2018-10-18 2024-04-15 メルク・シャープ・アンド・ドーム・エルエルシー Anti-RSV antibody formulations and methods of use thereof
CN113015748B (en) 2018-10-31 2025-12-12 默沙东有限责任公司 Anti-human PD-1 antibody crystals and their usage
IT202100004496A1 (en) 2021-02-25 2022-08-25 Univ Della Calabria RECOVERY OF BIOLOGICAL DRUGS OR THEIR FRAGMENTS FROM IMPURE SOLUTIONS BY CRYSTALLIZATION OR PRECIPITATION WITH MEMBRANE
CN116949036B (en) * 2023-09-11 2023-12-15 成都斯马特科技有限公司 Kit for rapidly extracting nucleic acid from ascites and extraction method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4731793B2 (en) * 2000-12-28 2011-07-27 アルセア テクノロジーズ インコーポレイテッド Crystals of whole antibodies or fragments thereof, and methods for making and using the crystals
DE60237841D1 (en) * 2001-11-13 2010-11-11 Genentech Inc Compositions based on APO2 ligand / TRAIL and their use
US7087719B2 (en) * 2002-11-19 2006-08-08 Gtc Biotherapeutics, Inc. Method for the crystallization of human serum albumin
EP2235056A1 (en) * 2007-12-21 2010-10-06 Genentech, Inc. Crystallization of anti-cd20 antibodies
CN101320006B (en) * 2008-07-17 2010-12-01 西北工业大学 Screening method for protein crystallization conditions

Also Published As

Publication number Publication date
EP2846830A1 (en) 2015-03-18
CN104284676A (en) 2015-01-14
AU2013258006A1 (en) 2014-11-06
AU2013258006B2 (en) 2016-04-28
CN104284676B (en) 2018-11-27
JP2015517306A (en) 2015-06-22
MX2014013754A (en) 2015-02-12
WO2013167720A1 (en) 2013-11-14
KR20150016503A (en) 2015-02-12
BR112014027994A2 (en) 2017-06-27
US20170198028A1 (en) 2017-07-13
CA2872145A1 (en) 2013-11-14
IL235483A0 (en) 2014-12-31
SG11201406664SA (en) 2014-11-27
US20150133642A1 (en) 2015-05-14
RU2014150071A (en) 2016-07-10

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