SG11201601182QA - Method for the clarification of high density crude cell culture harvest - Google Patents

Method for the clarification of high density crude cell culture harvest

Info

Publication number
SG11201601182QA
SG11201601182QA SG11201601182QA SG11201601182QA SG11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA
Authority
SG
Singapore
Prior art keywords
clarification
cell culture
high density
crude cell
culture harvest
Prior art date
Application number
SG11201601182QA
Inventor
Villiers Ann-Marie De
Charles M H Hensgens
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of SG11201601182QA publication Critical patent/SG11201601182QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02Separating microorganisms from their culture media

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201601182QA 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest SG11201601182QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13186692 2013-09-30
PCT/EP2014/070786 WO2015044418A1 (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Publications (1)

Publication Number Publication Date
SG11201601182QA true SG11201601182QA (en) 2016-04-28

Family

ID=49261472

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201808061WA SG10201808061WA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest
SG11201601182QA SG11201601182QA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201808061WA SG10201808061WA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Country Status (11)

Country Link
US (1) US10421986B2 (en)
EP (1) EP3052613A1 (en)
JP (1) JP6683604B2 (en)
KR (1) KR102245547B1 (en)
CN (1) CN105579572B (en)
AU (1) AU2014326706A1 (en)
BR (1) BR112016006063A2 (en)
CA (1) CA2924042C (en)
EA (1) EA201690684A1 (en)
SG (2) SG10201808061WA (en)
WO (1) WO2015044418A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201690684A1 (en) 2013-09-30 2016-09-30 Круселл Холланд Б.В. METHOD OF LIGHTING UP ADULT CELLULAR MASS OF UNCLEANED CULTURE OF CELLS WITH HIGH CELL DENSITY
CN106474466B (en) * 2016-12-07 2018-04-13 申联生物医药(上海)股份有限公司 A kind of preparation method of aftosa vaccine
AU2020329234A1 (en) * 2019-08-13 2022-03-24 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633565T3 (en) 1995-06-15 2013-01-17 Crucell Holland B.V. PACKAGING SYSTEMS FOR HUMAN, HUMAN ADENOVIRES, FOR USE IN GENE THERAPY
EA008670B1 (en) 2003-05-09 2007-06-29 Круселл Холланд Б.В. Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom
SI1720972T1 (en) 2004-03-05 2014-06-30 Dsm Ip Assets B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
CN101490239A (en) * 2006-07-14 2009-07-22 帝斯曼知识产权资产管理有限公司 Improved process for the culturing of cells
HUE032608T2 (en) 2006-07-14 2017-10-30 Patheon Holdings I B V Improved process for the culturing of cells
JP5778389B2 (en) * 2007-10-26 2015-09-16 旭化成ケミカルズ株式会社 Protein purification method
EP2268807A2 (en) 2008-04-21 2011-01-05 Novo Nordisk A/S Hyperglycosylated human coagulation factor ix
JP5496901B2 (en) * 2008-09-26 2014-05-21 旭化成ケミカルズ株式会社 Use of porous hollow fiber membranes to produce clarified biopharmaceutical cultures
KR20110085980A (en) 2008-10-17 2011-07-27 퍼시비아 엘엘씨 Clarification process at higher cell density
KR101805938B1 (en) 2009-10-15 2018-01-10 얀센 백신스 앤드 프리벤션 비.브이. Process for adenovirus purification from high cell density cultures
HUE035508T2 (en) * 2009-11-17 2018-05-02 Squibb & Sons Llc Methods for enhanced protein production
CA2787656A1 (en) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
JP6282467B2 (en) * 2010-10-05 2018-02-21 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー Method for producing a protein
US9603356B2 (en) * 2011-10-24 2017-03-28 Kaneka Corporation Method for producing cell concentrate
EA201690684A1 (en) 2013-09-30 2016-09-30 Круселл Холланд Б.В. METHOD OF LIGHTING UP ADULT CELLULAR MASS OF UNCLEANED CULTURE OF CELLS WITH HIGH CELL DENSITY

Also Published As

Publication number Publication date
CN105579572A (en) 2016-05-11
BR112016006063A2 (en) 2017-08-01
AU2014326706A1 (en) 2016-03-10
CN105579572B (en) 2018-08-10
CA2924042A1 (en) 2015-04-02
CA2924042C (en) 2023-04-18
JP6683604B2 (en) 2020-04-22
JP2016531558A (en) 2016-10-13
KR20160060058A (en) 2016-05-27
SG10201808061WA (en) 2018-10-30
US10421986B2 (en) 2019-09-24
EP3052613A1 (en) 2016-08-10
US20160222429A1 (en) 2016-08-04
EA201690684A1 (en) 2016-09-30
WO2015044418A1 (en) 2015-04-02
KR102245547B1 (en) 2021-04-28

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