RU2014141984A - Способы и композиции для лечения воспаления - Google Patents
Способы и композиции для лечения воспаления Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title claims 5
- 206010061218 Inflammation Diseases 0.000 title claims 3
- 230000004054 inflammatory process Effects 0.000 title claims 3
- 239000002105 nanoparticle Substances 0.000 claims abstract 51
- 239000000427 antigen Substances 0.000 claims abstract 14
- 102000036639 antigens Human genes 0.000 claims abstract 14
- 108091007433 antigens Proteins 0.000 claims abstract 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 9
- 241000606125 Bacteroides Species 0.000 claims abstract 8
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract 8
- 102000004169 proteins and genes Human genes 0.000 claims abstract 6
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 244000005700 microbiome Species 0.000 claims abstract 4
- 230000002496 gastric effect Effects 0.000 claims abstract 3
- 241000186000 Bifidobacterium Species 0.000 claims abstract 2
- 241000193403 Clostridium Species 0.000 claims abstract 2
- 241000186394 Eubacterium Species 0.000 claims abstract 2
- 241000605909 Fusobacterium Species 0.000 claims abstract 2
- 108010061711 Gliadin Proteins 0.000 claims abstract 2
- 102100034343 Integrase Human genes 0.000 claims abstract 2
- 108010061833 Integrases Proteins 0.000 claims abstract 2
- 229920000057 Mannan Polymers 0.000 claims abstract 2
- 108010058846 Ovalbumin Proteins 0.000 claims abstract 2
- 241000206591 Peptococcus Species 0.000 claims abstract 2
- 241000191992 Peptostreptococcus Species 0.000 claims abstract 2
- 241000192031 Ruminococcus Species 0.000 claims abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 239000002502 liposome Substances 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 229940092253 ovalbumin Drugs 0.000 claims abstract 2
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 230000031990 negative regulation of inflammatory response Effects 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 230000009285 allergic inflammation Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Abstract
1. Наночастица, содержащая комплекс антиген-ГКГС, где а) комплекс содержит белок ГКГС, находящийся в комплексе с антигеном, полученным из микроорганизма желудочно-кишечного тракта, или с ЖКТ-ассоциированным антигеном;.b) диаметр наночастицы выбран из группы: приблизительно от 1 нм приблизительно до 100 нм; приблизительно от 5 нм приблизительно до 50 нм или приблизительно от 5 приблизительно до 15 нмc) соотношение комплексов антиген-ГКГС и наночастиц составляет приблизительно от 10:1 приблизительно до 1000:1d) комплекс антиген-ГКГС связан с наночастицей при помощи ковалентной или нековалентной связи.2. Наночастица по п. 1, где комплекс антиген-ГКГС ковалентно связан с наночастицей посредством линкера размером менее 5 кДа.3. Наночастица по п. 1, где антиген получен из микроорганизма, выбранного из группы, состоящей из: Bacteroides Clostridium, Fusobacterium, Eubacterium, Ruminococcus, Peptococcus, Peptostreptococcus или Bifidobacterium, или представляет собой ЖКТ-ассоциированный антиген, полученный из белка, выбранного из группы, состоящей из: овальбумина, маннана дрожжей или глиадина.4. Наночастица по п. 1, где антиген получен из Bacteroides или из белка Bacteroides.5. Наночастица по п. 1, где антиген получен из интегразы Bacteroides.6. Наночастица по п. 1, где антиген содержит пептид, последовательность которого идентична по меньшей мере на 80% пептидной последовательности, выбранной из группы SEQ ID Nos. 1, 4, 5, 6, 7 или 8.7. Наночастица по п. 1, где наночастица является биосовместимой или биоабсорбируемой.8. Наночастица по п. 1, где ГКГС включает ГКГС класса I или ГКГС класса II.9. Наночастица по п. 1, где наночастица не является липосомой.10. Композиция, содержащая наночастицу по любому из пп. 1-9 и носитель.11. Способ изготовления или получения наночастицы по любому из пп. 1-9, включающий образование комплекса между комплексом антиген-ГКГС и наночастиц
Claims (25)
1. Наночастица, содержащая комплекс антиген-ГКГС, где а) комплекс содержит белок ГКГС, находящийся в комплексе с антигеном, полученным из микроорганизма желудочно-кишечного тракта, или с ЖКТ-ассоциированным антигеном;.
b) диаметр наночастицы выбран из группы: приблизительно от 1 нм приблизительно до 100 нм; приблизительно от 5 нм приблизительно до 50 нм или приблизительно от 5 приблизительно до 15 нм
c) соотношение комплексов антиген-ГКГС и наночастиц составляет приблизительно от 10:1 приблизительно до 1000:1
d) комплекс антиген-ГКГС связан с наночастицей при помощи ковалентной или нековалентной связи.
2. Наночастица по п. 1, где комплекс антиген-ГКГС ковалентно связан с наночастицей посредством линкера размером менее 5 кДа.
3. Наночастица по п. 1, где антиген получен из микроорганизма, выбранного из группы, состоящей из: Bacteroides Clostridium, Fusobacterium, Eubacterium, Ruminococcus, Peptococcus, Peptostreptococcus или Bifidobacterium, или представляет собой ЖКТ-ассоциированный антиген, полученный из белка, выбранного из группы, состоящей из: овальбумина, маннана дрожжей или глиадина.
4. Наночастица по п. 1, где антиген получен из Bacteroides или из белка Bacteroides.
5. Наночастица по п. 1, где антиген получен из интегразы Bacteroides.
6. Наночастица по п. 1, где антиген содержит пептид, последовательность которого идентична по меньшей мере на 80% пептидной последовательности, выбранной из группы SEQ ID Nos. 1, 4, 5, 6, 7 или 8.
7. Наночастица по п. 1, где наночастица является биосовместимой или биоабсорбируемой.
8. Наночастица по п. 1, где ГКГС включает ГКГС класса I или ГКГС класса II.
9. Наночастица по п. 1, где наночастица не является липосомой.
10. Композиция, содержащая наночастицу по любому из пп. 1-9 и носитель.
11. Способ изготовления или получения наночастицы по любому из пп. 1-9, включающий образование комплекса между комплексом антиген-ГКГС и наночастицей.
12. Выделенный или очищенный полипептид, содержащий аминокислотную последовательность, выбранную из группы SEQ ID Nos. 1, 4, 5, 6, 7 или 8, или полипептид, последовательность которого идентична по меньшей мере на 80% последовательности SEQ ID Nos. 1, 4, 5, 6, 7 или 8, или полипептид, кодируемый полинуклеотидом, гибридизующимся в условиях от умеренной до высокой жесткости с полинуклеотидом, кодирующим последовательность SEQ ID Nos. 1, 4, 5, 6, 7 или 8 или последовательность, идентичную по меньшей мере на 80% последовательности SEQ ID Nos. 1, 4, 5, 6, 7 или 8, или комплементарным ему полинуклеотидом.
13. Выделенный и очищенный полинуклеотид, кодирующий полипептид по п. 12 или его эквивалент, или полнуклеотид, гибридизующийся в жестких условиях с полинуклеотидом, его эквивалентом или комплементарным ему полинуклеотидом, где жесткие условия включают инкубацию при температурах приблизительно от 25°С приблизительно до 37°С, концентрацию буфера для гибридизации приблизительно от 6х SSC приблизительно до 10х SSC, концентрацию формамида приблизительно от 0% приблизительно до 25% и отмывочного раствора приблизительно от 4х SSC приблизительно до 8х SSC.
14. Композиция, содержащая: а) полипептид по п. 12 или полинуклеотид по п. 13 и b) носитель.
15. Наночастица по любому из пп. 1-9 для применения в способе индукции противовоспалительного ответа в клетке или ткани, включающий приведение клетки или ткани в контакт с наночастицами в эффективном количестве.
16. Наночастица по любому из пп. 1-9 для применения в способе лечения воспаления у нуждающегося в этом пациента, включающий введение пациенту комплекса наночастиц в эффективном количестве.
17. Наночастица по любому из пп. 1-9 для применения в способе аккумуляции противовоспалительных Т клеток и/или противовоспалительных клеток в желудочно-кишечном тракте нуждающегося в этом пациента, включающий введение пациенту наночастиц в эффективном количестве.
18. Наночастица по п. 16 или 17, где пациент страдает желудочно-кишечным заболеванием, выбранным из группы, состоящей из: воспалительного заболевания кишечника, колита, болезни Крона, аллергического воспаления желудочно-кишечного тракта или целиакии.
19. Наночастица по п. 15, где клетка или ткань представляет собой клетку или ткань желудочно-кишечного тракта.
20. Наночастица по п. 17, где Т клетка представляет собой CD4+ Т клетку или CD8+ Т клетку.
21. Наночастица по п. 17, где Т клетка секретирует IL-10 или TGFβ.
22. Наночастица по п. 15 или 19, где противовоспалительный ответ индуцируют в желудочно-кишечном тракте.
23. Наночастица по п. 16, где осуществляют лечение воспаления желудочно-кишечного тракта.
24. Наночастица по любому из пп. 1-9 для применения в способе переноса цитотоксических Т-лимфоцитов, направленных против эпитопов бактерий кишечника, у нуждающегося в этом пациента, включающий введение пациенту комплексов антиген-ГКГС-наночастица в эффективном количестве.
25. Наночастица по п. 24, где цитотоксические Т-лимфоциты распознают эпитоп бактерий кишечника с низкой авидностью.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615743P | 2012-03-26 | 2012-03-26 | |
| US61/615,743 | 2012-03-26 | ||
| PCT/IB2013/052352 WO2013144811A2 (en) | 2012-03-26 | 2013-03-25 | Methods and compositions for treating inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014141984A true RU2014141984A (ru) | 2016-05-20 |
| RU2689563C2 RU2689563C2 (ru) | 2019-05-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014141984A RU2689563C2 (ru) | 2012-03-26 | 2013-03-25 | Композиция антиген-гкгс-наночастиц для индуцирования противовоспалительного ответа в кишечнике и способ ее получения |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10988516B2 (ru) |
| EP (2) | EP3590531A1 (ru) |
| JP (3) | JP6199955B2 (ru) |
| CN (2) | CN110354278B (ru) |
| AU (2) | AU2013202911A1 (ru) |
| CA (1) | CA2868551C (ru) |
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| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
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| JP2017500285A (ja) | 2013-11-04 | 2017-01-05 | ユーティーアイ リミテッド パートナーシップ | 持続的免疫療法のための方法および組成物 |
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| US20160346382A1 (en) * | 2015-05-27 | 2016-12-01 | Northwestern University | Carbohydrate-modified particles and particulate formulations for modulating an immune response |
| JP6752231B2 (ja) | 2015-06-01 | 2020-09-09 | カリフォルニア インスティテュート オブ テクノロジー | 抗原を用いて特異的集団に関してｔ細胞をスクリーニングするための組成物および方法 |
| AU2018374569A1 (en) * | 2017-11-29 | 2020-06-18 | Uti Limited Partnership | Methods of treating autoimmune disease |
| BE1026147B1 (nl) * | 2018-03-29 | 2019-10-28 | Farm@Nutrition Besloten Vennootschap Met Beperkte Aansprakelijkheid | Samenstelling voor een voedingsadditief voor dieren en werkwijze om het additief toe te dienen. |
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