RU2014121489A - Соединения бензоксазолинона с селективной активностью в отношении потенциалзависимых натриевых каналов - Google Patents
Соединения бензоксазолинона с селективной активностью в отношении потенциалзависимых натриевых каналов Download PDFInfo
- Publication number
- RU2014121489A RU2014121489A RU2014121489/04A RU2014121489A RU2014121489A RU 2014121489 A RU2014121489 A RU 2014121489A RU 2014121489/04 A RU2014121489/04 A RU 2014121489/04A RU 2014121489 A RU2014121489 A RU 2014121489A RU 2014121489 A RU2014121489 A RU 2014121489A
- Authority
- RU
- Russia
- Prior art keywords
- oxo
- sulfonamide
- dihydro
- benzoxazole
- thiadiazol
- Prior art date
Links
- 0 C[C@]1[C@@](*)(C2C*)C2(*2)[C@]22[C@@]1(*)*2 Chemical compound C[C@]1[C@@](*)(C2C*)C2(*2)[C@]22[C@@]1(*)*2 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552885P | 2011-10-28 | 2011-10-28 | |
| US61/552,885 | 2011-10-28 | ||
| PCT/US2012/062207 WO2013063459A1 (en) | 2011-10-28 | 2012-10-26 | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014121489A true RU2014121489A (ru) | 2015-12-10 |
Family
ID=48168585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121489/04A RU2014121489A (ru) | 2011-10-28 | 2012-10-26 | Соединения бензоксазолинона с селективной активностью в отношении потенциалзависимых натриевых каналов |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9273040B2 (https=) |
| EP (1) | EP2770995B1 (https=) |
| JP (1) | JP2014532660A (https=) |
| KR (1) | KR20140095067A (https=) |
| CN (1) | CN103889419A (https=) |
| AU (1) | AU2012328561A1 (https=) |
| BR (1) | BR112014010197A2 (https=) |
| CA (1) | CA2852796A1 (https=) |
| IN (1) | IN2014CN02959A (https=) |
| MX (1) | MX2014005068A (https=) |
| RU (1) | RU2014121489A (https=) |
| WO (1) | WO2013063459A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
| KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
| RU2015143906A (ru) | 2013-03-14 | 2017-04-18 | Дженентек, Инк. | Замещенные триазолопиридины и способы их применения |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| WO2015078374A1 (en) | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| MA39778A (fr) | 2014-03-29 | 2017-02-08 | Lupin Ltd | Composés sulfonamides comme modulateurs des canaux sodiques potentiel-dépendants |
| JP2017525677A (ja) | 2014-07-07 | 2017-09-07 | ジェネンテック， インコーポレイテッド | 治療用化合物及びその使用方法 |
| HK1248687B (en) * | 2015-03-02 | 2020-01-10 | Amgen Inc. | Bicyclic ketone sulfonamide compounds |
| HK1252567A1 (zh) | 2015-05-22 | 2019-05-31 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
| JP2018526371A (ja) | 2015-08-27 | 2018-09-13 | ジェネンテック， インコーポレイテッド | 治療化合物及びその使用方法 |
| CA2999769A1 (en) | 2015-09-28 | 2017-04-06 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| AU2016370554B2 (en) | 2015-12-18 | 2018-11-29 | Merck Sharp & Dohme Corp. | Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3436432B1 (en) | 2016-03-30 | 2021-01-27 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| PL3458449T3 (pl) | 2016-05-20 | 2025-06-23 | Xenon Pharmaceuticals Inc. | Związki benzenosulfonamidowe i ich zastosowanie jako środki terapeutyczne |
| PE20190980A1 (es) | 2016-10-17 | 2019-07-09 | Genentech Inc | Compuestos terapeuticos y metodos para utilizarlos |
| CN110325531B (zh) | 2016-12-09 | 2022-05-27 | 泽农医药公司 | 苯磺酰胺及其作为治疗剂的用途 |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック， インコーポレイテッド | ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体 |
| WO2018205948A1 (en) * | 2017-05-11 | 2018-11-15 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| US10947251B2 (en) | 2018-03-30 | 2021-03-16 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| US11512072B2 (en) | 2018-04-19 | 2022-11-29 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using azetidines |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| US10745392B2 (en) | 2018-06-13 | 2020-08-18 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| KR20210054510A (ko) | 2018-08-31 | 2021-05-13 | 제논 파마슈티칼스 인크. | 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도 |
| MA53488A (fr) | 2018-08-31 | 2021-12-08 | Xenon Pharmaceuticals Inc | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| EP1144387A1 (en) | 1998-12-04 | 2001-10-17 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| NZ551453A (en) | 2001-04-18 | 2008-02-29 | Euro Celtique Sa | Nociceptin analogs for the treatment of pain |
| WO2003062224A1 (en) | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| NZ593074A (en) | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| CA2693588C (en) * | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
| US20110190347A1 (en) | 2008-08-21 | 2011-08-04 | Richter Gedeon Nyrt. | Methods for treating neuropathic pain |
| HUE025013T2 (hu) | 2009-01-12 | 2016-04-28 | Pfizer Ltd | Szulfonamid-származékok |
| WO2010129596A1 (en) * | 2009-05-04 | 2010-11-11 | Agios Pharmaceuticals, Inc. | Pmk2 modulators for use in the treatment of cancer |
-
2012
- 2012-10-26 JP JP2014539066A patent/JP2014532660A/ja active Pending
- 2012-10-26 KR KR1020147013911A patent/KR20140095067A/ko not_active Withdrawn
- 2012-10-26 MX MX2014005068A patent/MX2014005068A/es not_active Application Discontinuation
- 2012-10-26 AU AU2012328561A patent/AU2012328561A1/en not_active Abandoned
- 2012-10-26 EP EP12843015.4A patent/EP2770995B1/en not_active Not-in-force
- 2012-10-26 BR BR112014010197A patent/BR112014010197A2/pt not_active IP Right Cessation
- 2012-10-26 RU RU2014121489/04A patent/RU2014121489A/ru not_active Application Discontinuation
- 2012-10-26 CA CA2852796A patent/CA2852796A1/en not_active Abandoned
- 2012-10-26 CN CN201280052937.2A patent/CN103889419A/zh active Pending
- 2012-10-26 WO PCT/US2012/062207 patent/WO2013063459A1/en not_active Ceased
- 2012-10-26 IN IN2959CHN2014 patent/IN2014CN02959A/en unknown
- 2012-10-26 US US14/353,488 patent/US9273040B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014CN02959A (https=) | 2015-07-03 |
| JP2014532660A (ja) | 2014-12-08 |
| EP2770995A1 (en) | 2014-09-03 |
| AU2012328561A8 (en) | 2014-05-01 |
| BR112014010197A2 (pt) | 2017-04-18 |
| EP2770995B1 (en) | 2019-01-02 |
| WO2013063459A1 (en) | 2013-05-02 |
| US9273040B2 (en) | 2016-03-01 |
| CN103889419A (zh) | 2014-06-25 |
| AU2012328561A1 (en) | 2014-04-17 |
| EP2770995A4 (en) | 2015-06-03 |
| KR20140095067A (ko) | 2014-07-31 |
| CA2852796A1 (en) | 2013-05-02 |
| US20140303143A1 (en) | 2014-10-09 |
| MX2014005068A (es) | 2014-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014121489A (ru) | Соединения бензоксазолинона с селективной активностью в отношении потенциалзависимых натриевых каналов | |
| JP2014532660A5 (https=) | ||
| RU2292346C2 (ru) | Гетероциклические мускариновые агонисты и композиции, их применение и способы лечения | |
| JP6080227B2 (ja) | ロイコトリエン生成を阻害するためのベンゾジオキサン | |
| WO2017068412A1 (en) | Benzolactam compounds as protein kinase inhibitors | |
| JP2015535251A (ja) | 電位作動型ナトリウムチャネルにおいて選択的活性を有するベンゾオキサゾリノン化合物 | |
| JP6482545B2 (ja) | シクロペンチルベンズアミド誘導体及びそれらの精神障害及び認知障害の治療への使用 | |
| JP2019104734A (ja) | 治療活性化合物及びその使用 | |
| JP2014532619A5 (https=) | ||
| EP2582698A1 (en) | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use | |
| CN1403453A (zh) | 用于治疗、特别是治疗良性前列腺增生的喹啉和喹唑啉化合物 | |
| CN104487435A (zh) | 用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合 | |
| JP6917379B2 (ja) | ８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 | |
| US11976067B2 (en) | APOL1 inhibitors and methods of use | |
| ES2391107T3 (es) | Compuestos que tienen actividad en el receptor M1 y sus usos en medicina | |
| RU2229476C2 (ru) | Производные фталазина и терапевтические средства для эректильной дисфункции | |
| EP2486009A1 (en) | 2h-pyrrol-5-amine derivatives as alpha adrenergic receptor modulators | |
| CN116332937A (zh) | 二肽基肽酶ⅰ抑制剂及其用途 | |
| US20240158412A1 (en) | Ubiquitin-specific protease 7 (usp7) inhibitors and uses thereof | |
| ES2602308T3 (es) | Compuestos novedosos | |
| TW202511261A (zh) | 使用ａｐｏｌ１抑制劑之方法 | |
| CN118946349A (zh) | Apol1抑制剂及使用方法 | |
| ES2356843T3 (es) | Derivados de triazol como moduladores de los receptores d3 de dopamina. | |
| RU2779018C1 (ru) | Бензолактамы в качестве ингибиторов протеинкиназ | |
| TW202604519A (zh) | Ｃｄｋ４抑制劑㖠啶化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170418 |