RU2013151314A - СПОСОБ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ РТН, РТНrР И РОДСТВЕННЫХ ПЕПТИДОВ - Google Patents
СПОСОБ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ РТН, РТНrР И РОДСТВЕННЫХ ПЕПТИДОВ Download PDFInfo
- Publication number
- RU2013151314A RU2013151314A RU2013151314/15A RU2013151314A RU2013151314A RU 2013151314 A RU2013151314 A RU 2013151314A RU 2013151314/15 A RU2013151314/15 A RU 2013151314/15A RU 2013151314 A RU2013151314 A RU 2013151314A RU 2013151314 A RU2013151314 A RU 2013151314A
- Authority
- RU
- Russia
- Prior art keywords
- microprotrusion
- array
- microprotrusions
- hpthrp
- aib
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 239000003814 drug Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000011248 coating agent Substances 0.000 claims abstract 6
- 238000000576 coating method Methods 0.000 claims abstract 6
- 239000002552 dosage form Substances 0.000 claims abstract 5
- 229920000106 Liquid crystal polymer Polymers 0.000 claims abstract 3
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 claims abstract 3
- 229920000515 polycarbonate Polymers 0.000 claims abstract 3
- 239000004417 polycarbonate Substances 0.000 claims abstract 3
- 229920000642 polymer Polymers 0.000 claims abstract 3
- 239000000463 material Substances 0.000 claims abstract 2
- 239000000758 substrate Substances 0.000 claims abstract 2
- 238000013271 transdermal drug delivery Methods 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 4
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010049088 Osteopenia Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 238000005452 bending Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478466P | 2011-04-22 | 2011-04-22 | |
| US61/478,466 | 2011-04-22 | ||
| US201161578120P | 2011-12-20 | 2011-12-20 | |
| US61/578,120 | 2011-12-20 | ||
| PCT/US2012/034510 WO2012145665A2 (en) | 2011-04-22 | 2012-04-20 | Method of drug delivery for pth, pthrp and related peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013151314A true RU2013151314A (ru) | 2015-05-27 |
Family
ID=47042187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013151314/15A RU2013151314A (ru) | 2011-04-22 | 2012-04-20 | СПОСОБ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ РТН, РТНrР И РОДСТВЕННЫХ ПЕПТИДОВ |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US20130006217A1 (enExample) |
| EP (2) | EP2699252B1 (enExample) |
| JP (2) | JP6033280B2 (enExample) |
| KR (1) | KR20140047043A (enExample) |
| CN (1) | CN103917242A (enExample) |
| AU (2) | AU2012245301B2 (enExample) |
| BR (1) | BR112013027153A2 (enExample) |
| CA (1) | CA2833571A1 (enExample) |
| ES (1) | ES2648864T3 (enExample) |
| IL (1) | IL228942A0 (enExample) |
| MX (1) | MX2013012349A (enExample) |
| RU (1) | RU2013151314A (enExample) |
| SG (1) | SG194570A1 (enExample) |
| WO (1) | WO2012145665A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2568806T1 (sl) | 2010-05-12 | 2016-09-30 | Radius Health, Inc. | Režimi zdravljenja |
| US20130158482A1 (en) * | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| AU2011312490B2 (en) | 2010-09-28 | 2015-06-25 | Radius Pharmaceuticals, Inc. | Selective androgen receptor modulators |
| ES2565805T3 (es) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Sistemas e interfaces para el muestreo de sangre |
| AU2012345768B2 (en) * | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| KR20150052092A (ko) * | 2012-08-30 | 2015-05-13 | 테이진 가부시키가이샤 | 약제 조성물이 도포된 마이크로 니들 어레이 |
| PT3122426T (pt) | 2014-03-28 | 2023-02-28 | Univ Duke | Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio |
| EP4137147A3 (en) * | 2015-03-03 | 2023-04-05 | Radius Health, Inc. | Uses of abaloparatide in reducing fracture risk |
| EP3288383A4 (en) | 2015-04-29 | 2019-01-23 | Radius Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
| SI3359241T1 (sl) * | 2015-10-09 | 2021-11-30 | Radius Health, Inc. | Formulacije PTHRP-analogov, transdermalni obliži le-teh in uporabe le-teh |
| US10695289B2 (en) | 2015-10-09 | 2020-06-30 | 3M Innovative Properties Company | Zinc compositions for coated microneedle arrays |
| AU2017253674B2 (en) * | 2016-04-18 | 2021-07-29 | Kindeva Drug Delivery L.P. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| HRP20220619T1 (hr) | 2016-06-22 | 2023-02-03 | Ellipses Pharma Ltd | Postupci za liječenje ar+ raka dojke |
| CA3045458A1 (en) * | 2016-11-30 | 2018-06-07 | Purdue Research Foundation | Fracture targeted bone regeneration through parathyroid hormone receptor stimulation |
| ES2981967T3 (es) | 2017-01-05 | 2024-10-14 | Radius Pharmaceuticals Inc | Formas polimórficas de RAD1901-2HCl |
| US9968767B1 (en) | 2017-10-10 | 2018-05-15 | King Saud University | Combination microarray patch for drug delivery and electrochemotherapy device |
| EP3796941A4 (en) | 2018-05-30 | 2022-12-28 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| JP7473486B2 (ja) | 2018-07-04 | 2024-04-23 | ラジウス ファーマシューティカルズ，インコーポレイテッド | Ｒａｄ１９０１－２ｈｃｌの多形形態 |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
| WO2021149012A1 (en) | 2020-01-24 | 2021-07-29 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
| CN115734798A (zh) | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
| IL297669A (en) * | 2020-05-01 | 2022-12-01 | Emergex Usa Corp | Transdermal drug delivery devices having psilocybin, lysergic acid diethylamide or 3,4-methylenedioxymethamphetamine coated microprotrusions |
| AU2022205801A1 (en) * | 2021-01-05 | 2023-07-13 | Radius Health, Inc. | Treatment of long bone fractures with abaloparatide |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544949B1 (en) * | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
| US5969095A (en) | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
| WO1999029365A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| DE69806963T2 (de) * | 1997-12-11 | 2002-11-21 | Alza Corp., Mountain View | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
| US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| AU2004287059A1 (en) * | 2003-10-28 | 2005-05-19 | Alza Corporation | Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections |
| WO2005044333A2 (en) | 2003-10-31 | 2005-05-19 | Alza Corporation | Self-actuating applicator for microprojection array |
| CN100548228C (zh) * | 2003-11-13 | 2009-10-14 | 阿尔扎公司 | 用于透皮递送的组合物和装置 |
| EP1744683B1 (en) | 2004-05-13 | 2016-03-16 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| US8632801B2 (en) * | 2005-12-28 | 2014-01-21 | Alza Corporation | Stable therapeutic formulations |
| JP2009530307A (ja) * | 2006-03-15 | 2009-08-27 | アルザ コーポレイション | 骨減少症を予防し、または治療するための副甲状腺ホルモン薬の経皮送達のための装置、並びに方法 |
| WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| CN101472676B (zh) * | 2006-04-20 | 2013-09-11 | 万罗赛斯公司 | 利用微通道工艺技术处理和/或形成一种非牛顿流体的方法 |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| JP5375611B2 (ja) * | 2006-10-03 | 2013-12-25 | ラジウス ヘルス，インコーポレイテッド | 骨同化作用を有するタンパク質のための薬物送達方法 |
| US20100030100A1 (en) * | 2007-02-06 | 2010-02-04 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle Device For Diagnosis Of Allergy |
| JP5559054B2 (ja) * | 2007-09-28 | 2014-07-23 | ザ クイーンズ ユニヴァーシティ オブ ベルファスト | 送達装置および方法 |
| US20090117158A1 (en) * | 2007-10-23 | 2009-05-07 | Mahmoud Ameri | Transdermal sustained release drug delivery |
| EP2052736A1 (en) * | 2007-10-26 | 2009-04-29 | Nycomed Danmark ApS | Parathyroid hormone formulations und uses thereof |
| US8329649B2 (en) * | 2008-11-04 | 2012-12-11 | Aska Pharmaceutical Co., Ltd. | Aqueous composition containing follicle-stimulating hormone and histidine |
| US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
-
2012
- 2012-04-20 US US13/452,412 patent/US20130006217A1/en not_active Abandoned
- 2012-04-20 EP EP12773751.8A patent/EP2699252B1/en active Active
- 2012-04-20 ES ES12773751.8T patent/ES2648864T3/es active Active
- 2012-04-20 CN CN201280030749.XA patent/CN103917242A/zh active Pending
- 2012-04-20 MX MX2013012349A patent/MX2013012349A/es not_active Application Discontinuation
- 2012-04-20 RU RU2013151314/15A patent/RU2013151314A/ru unknown
- 2012-04-20 BR BR112013027153A patent/BR112013027153A2/pt not_active IP Right Cessation
- 2012-04-20 EP EP17190659.7A patent/EP3332799A1/en not_active Withdrawn
- 2012-04-20 KR KR1020137031111A patent/KR20140047043A/ko not_active Withdrawn
- 2012-04-20 SG SG2013078324A patent/SG194570A1/en unknown
- 2012-04-20 CA CA2833571A patent/CA2833571A1/en not_active Abandoned
- 2012-04-20 AU AU2012245301A patent/AU2012245301B2/en not_active Ceased
- 2012-04-20 WO PCT/US2012/034510 patent/WO2012145665A2/en not_active Ceased
- 2012-04-20 JP JP2014506585A patent/JP6033280B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-08 US US13/791,360 patent/US20140046293A1/en not_active Abandoned
- 2013-03-08 US US13/791,170 patent/US20140046292A1/en not_active Abandoned
- 2013-10-17 IL IL228942A patent/IL228942A0/en unknown
-
2016
- 2016-08-16 AU AU2016216584A patent/AU2016216584A1/en not_active Abandoned
- 2016-10-25 JP JP2016208896A patent/JP2017036323A/ja active Pending
- 2016-11-14 US US15/351,317 patent/US20170189493A1/en not_active Abandoned
-
2019
- 2019-02-19 US US16/279,770 patent/US20190290738A1/en not_active Abandoned
-
2020
- 2020-08-31 US US17/008,603 patent/US20210052705A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20210052705A1 (en) | 2021-02-25 |
| EP2699252A4 (en) | 2015-05-27 |
| US20140046292A1 (en) | 2014-02-13 |
| JP2017036323A (ja) | 2017-02-16 |
| BR112013027153A2 (pt) | 2016-11-29 |
| JP2014517825A (ja) | 2014-07-24 |
| AU2016216584A1 (en) | 2016-09-01 |
| IL228942A0 (en) | 2013-12-31 |
| ES2648864T3 (es) | 2018-01-08 |
| MX2013012349A (es) | 2014-07-09 |
| US20130006217A1 (en) | 2013-01-03 |
| US20140046293A1 (en) | 2014-02-13 |
| WO2012145665A3 (en) | 2014-04-24 |
| KR20140047043A (ko) | 2014-04-21 |
| AU2012245301B2 (en) | 2016-05-19 |
| JP6033280B2 (ja) | 2016-11-30 |
| EP2699252A2 (en) | 2014-02-26 |
| US20190290738A1 (en) | 2019-09-26 |
| US20170189493A1 (en) | 2017-07-06 |
| WO2012145665A2 (en) | 2012-10-26 |
| EP3332799A1 (en) | 2018-06-13 |
| SG194570A1 (en) | 2013-12-30 |
| EP2699252B1 (en) | 2017-10-25 |
| CN103917242A (zh) | 2014-07-09 |
| CA2833571A1 (en) | 2012-10-26 |
| NZ618003A (en) | 2016-05-27 |
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