BR112013027153A2 - método de aplicação de fármaco para pth, pthrp e peptídeos relacionados - Google Patents
método de aplicação de fármaco para pth, pthrp e peptídeos relacionadosInfo
- Publication number
- BR112013027153A2 BR112013027153A2 BR112013027153A BR112013027153A BR112013027153A2 BR 112013027153 A2 BR112013027153 A2 BR 112013027153A2 BR 112013027153 A BR112013027153 A BR 112013027153A BR 112013027153 A BR112013027153 A BR 112013027153A BR 112013027153 A2 BR112013027153 A2 BR 112013027153A2
- Authority
- BR
- Brazil
- Prior art keywords
- pthrp
- pth
- related peptides
- drug application
- application method
- Prior art date
Links
- 101150071808 PTHLH gene Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
abstract of the disclosure the present invention provides compositions, devices, methods and processes related to the intradermal delivery of pthrp and pthrp analogues, particularly [glu22,25, leu23,28,31, aib29, lys26,30]hpthrp(1-34)nh2 . tradução do resumo resumo patente de invenção: "método de aplicação de fármaco para pth, pthrp e peptídeos relacionados". a presente invenção provê composições, dispositivos, métodos e processos relacionados à aplicação intradermal de pthrp e análogos de pthrp, particularmente [glu22,25, leu23,28,31, aib29, lys26,30]hpthrp(1-34)nh2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161478466P | 2011-04-22 | 2011-04-22 | |
US201161578120P | 2011-12-20 | 2011-12-20 | |
PCT/US2012/034510 WO2012145665A2 (en) | 2011-04-22 | 2012-04-20 | Method of drug delivery for pth, pthrp and related peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013027153A2 true BR112013027153A2 (pt) | 2016-11-29 |
Family
ID=47042187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027153A BR112013027153A2 (pt) | 2011-04-22 | 2012-04-20 | método de aplicação de fármaco para pth, pthrp e peptídeos relacionados |
Country Status (14)
Country | Link |
---|---|
US (6) | US20130006217A1 (pt) |
EP (2) | EP3332799A1 (pt) |
JP (2) | JP6033280B2 (pt) |
KR (1) | KR20140047043A (pt) |
CN (1) | CN103917242A (pt) |
AU (2) | AU2012245301B2 (pt) |
BR (1) | BR112013027153A2 (pt) |
CA (1) | CA2833571A1 (pt) |
ES (1) | ES2648864T3 (pt) |
IL (1) | IL228942A0 (pt) |
MX (1) | MX2013012349A (pt) |
RU (1) | RU2013151314A (pt) |
SG (1) | SG194570A1 (pt) |
WO (1) | WO2012145665A2 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2568806B1 (en) | 2010-05-12 | 2016-05-11 | Radius Health, Inc. | Therapeutic regimens |
US20130158482A1 (en) * | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
BR112014013151B1 (pt) * | 2011-11-30 | 2022-02-08 | 3M Innovative Properties Company | Dispositivo médico compreendendo microagulhas incluindo um agente terapêutico peptídeo e um aminoácido, métodos para produzir o dispositivo e método para estabilizar um agente terapêutico peptídeo |
IN2015DN01454A (pt) * | 2012-08-30 | 2015-07-03 | Teijin Ltd | |
WO2016141250A1 (en) * | 2015-03-03 | 2016-09-09 | Radius Health, Inc. | USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK |
CA2984357A1 (en) | 2015-04-29 | 2016-11-03 | Radius Pharmaceuticals, Inc. | Methods for treating cancer |
CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
EP3359241B1 (en) * | 2015-10-09 | 2021-04-14 | Radius Health, Inc. | Formulations of pthrp analogues, transdermal patches thereof, and uses thereof |
EP4049651A1 (en) | 2015-10-09 | 2022-08-31 | Kindeva Drug Delivery L.P. | Zinc compositions for coated microneedle arrays |
JP6920341B2 (ja) | 2016-04-18 | 2021-08-18 | ラジウス ヘルス,インコーポレイテッド | アバロパラチドの製剤、その経皮パッチ、およびその使用 |
US20170368036A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
JP2020500871A (ja) * | 2016-11-30 | 2020-01-16 | パーデュー リサーチ ファウンデーション | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
KR102322802B1 (ko) | 2017-01-05 | 2021-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
US9968767B1 (en) | 2017-10-10 | 2018-05-15 | King Saud University | Combination microarray patch for drug delivery and electrochemotherapy device |
AU2019297421A1 (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD 1901-2HCL |
EP4110371A1 (en) | 2020-01-24 | 2023-01-04 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
CN115484930A (zh) * | 2020-05-01 | 2022-12-16 | 埃默杰克斯美国有限公司 | 具有赛洛西宾、麦角酸二乙酰胺或3,4-亚甲二氧基甲基苯丙胺涂覆的微突起的经皮药物递送装置 |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544949B1 (en) * | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
US5969095A (en) | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
DE69831268T2 (de) * | 1997-12-11 | 2006-03-09 | Alza Corp., Palo Alto | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
BRPI0415967A (pt) * | 2003-10-28 | 2007-01-23 | Alza Corp | aplicação de conjugados de polìmero de peptìdeos e proteìnas terapêuticos através de microprojeções revestidas |
CA2543641A1 (en) * | 2003-10-31 | 2005-05-19 | Alza Corporation | Self-actuating applicator for microprojection array |
AU2004292954A1 (en) * | 2003-11-13 | 2005-06-09 | Alza Corporation | Composition and apparatus for transdermal delivery |
WO2005112984A2 (en) | 2004-05-13 | 2005-12-01 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
EP1981547B1 (en) * | 2005-12-28 | 2015-09-30 | Alza Corporation | Stable therapeutic formulations |
CA2680690A1 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
CN101472676B (zh) * | 2006-04-20 | 2013-09-11 | 万罗赛斯公司 | 利用微通道工艺技术处理和/或形成一种非牛顿流体的方法 |
WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
EP2073789B8 (en) * | 2006-10-03 | 2022-09-14 | Radius Health, Inc. | A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof |
US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
US20100030100A1 (en) * | 2007-02-06 | 2010-02-04 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle Device For Diagnosis Of Allergy |
WO2009040548A1 (en) * | 2007-09-28 | 2009-04-02 | The Queen's University Of Belfast | Delivery device and method |
WO2009054988A1 (en) * | 2007-10-23 | 2009-04-30 | Alza Corporation | Transdermal sustained release drug delivery |
EP2052736A1 (en) * | 2007-10-26 | 2009-04-29 | Nycomed Danmark ApS | Parathyroid hormone formulations und uses thereof |
MX2011004453A (es) * | 2008-11-04 | 2011-08-12 | Aska Pharm Co Ltd | Composicion acuosa que contiene hormona foliculo estimulante. |
US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
-
2012
- 2012-04-20 BR BR112013027153A patent/BR112013027153A2/pt not_active IP Right Cessation
- 2012-04-20 KR KR1020137031111A patent/KR20140047043A/ko not_active Application Discontinuation
- 2012-04-20 ES ES12773751.8T patent/ES2648864T3/es active Active
- 2012-04-20 CA CA2833571A patent/CA2833571A1/en not_active Abandoned
- 2012-04-20 JP JP2014506585A patent/JP6033280B2/ja active Active
- 2012-04-20 MX MX2013012349A patent/MX2013012349A/es not_active Application Discontinuation
- 2012-04-20 RU RU2013151314/15A patent/RU2013151314A/ru unknown
- 2012-04-20 SG SG2013078324A patent/SG194570A1/en unknown
- 2012-04-20 WO PCT/US2012/034510 patent/WO2012145665A2/en active Application Filing
- 2012-04-20 AU AU2012245301A patent/AU2012245301B2/en not_active Ceased
- 2012-04-20 CN CN201280030749.XA patent/CN103917242A/zh active Pending
- 2012-04-20 EP EP17190659.7A patent/EP3332799A1/en not_active Withdrawn
- 2012-04-20 US US13/452,412 patent/US20130006217A1/en not_active Abandoned
- 2012-04-20 EP EP12773751.8A patent/EP2699252B1/en active Active
-
2013
- 2013-03-08 US US13/791,360 patent/US20140046293A1/en not_active Abandoned
- 2013-03-08 US US13/791,170 patent/US20140046292A1/en not_active Abandoned
- 2013-10-17 IL IL228942A patent/IL228942A0/en unknown
-
2016
- 2016-08-16 AU AU2016216584A patent/AU2016216584A1/en not_active Abandoned
- 2016-10-25 JP JP2016208896A patent/JP2017036323A/ja active Pending
- 2016-11-14 US US15/351,317 patent/US20170189493A1/en not_active Abandoned
-
2019
- 2019-02-19 US US16/279,770 patent/US20190290738A1/en not_active Abandoned
-
2020
- 2020-08-31 US US17/008,603 patent/US20210052705A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20190290738A1 (en) | 2019-09-26 |
AU2016216584A1 (en) | 2016-09-01 |
WO2012145665A2 (en) | 2012-10-26 |
NZ618003A (en) | 2016-05-27 |
US20210052705A1 (en) | 2021-02-25 |
JP2017036323A (ja) | 2017-02-16 |
US20140046292A1 (en) | 2014-02-13 |
SG194570A1 (en) | 2013-12-30 |
US20130006217A1 (en) | 2013-01-03 |
AU2012245301B2 (en) | 2016-05-19 |
MX2013012349A (es) | 2014-07-09 |
EP2699252A2 (en) | 2014-02-26 |
EP2699252A4 (en) | 2015-05-27 |
ES2648864T3 (es) | 2018-01-08 |
RU2013151314A (ru) | 2015-05-27 |
KR20140047043A (ko) | 2014-04-21 |
US20140046293A1 (en) | 2014-02-13 |
EP2699252B1 (en) | 2017-10-25 |
WO2012145665A3 (en) | 2014-04-24 |
JP2014517825A (ja) | 2014-07-24 |
EP3332799A1 (en) | 2018-06-13 |
CN103917242A (zh) | 2014-07-09 |
CA2833571A1 (en) | 2012-10-26 |
JP6033280B2 (ja) | 2016-11-30 |
IL228942A0 (en) | 2013-12-31 |
US20170189493A1 (en) | 2017-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013027153A2 (pt) | método de aplicação de fármaco para pth, pthrp e peptídeos relacionados | |
IL254879B (en) | History of dolastatin associated with unnatural amino acids and pharmaceutical preparations containing them | |
CL2013003145A1 (es) | Formulación farmacéutica que comprende mezcla de anticuerpo anti-alfa4beta7, un antioxidante o quelante y al menos un aminoácido libre. | |
BR112014030714A2 (pt) | composto de lipídeo ionizável , composições , carreador de fármaco , formulação farmacêutica e método de entrega de um fármaco | |
CY1116987T1 (el) | Συμπυκνωμενα ιμιδαζολυλιμιδαζολια ως αντιϊικες ενωσεις | |
MX355446B (es) | Tratamiento de rinitis. | |
UA109949C2 (uk) | Композиція і лікарський засіб, які містять ідуронат-2-сульфатазу, і спосіб їх отримання | |
MY161773A (en) | Amylin analogues and pharmaceutical compositions thereof | |
TN2013000275A1 (en) | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd) | |
IL229260A0 (en) | Preparations, methods and systems for respiratory administration of two or more active agents | |
BR112015016930A2 (pt) | formulações farmacêuticas estabilizadas de análogos de insulina e/ou derivados de insulina | |
SV2017005515A (es) | Formulaciones de polvo nasal para el tratamiento de la hipoglicemia | |
BR112015008297A2 (pt) | antagonistas de mglu2/3 para o tratamento de distúrbios autistas | |
EA201490756A1 (ru) | Разагилина цитрамид | |
BR112014008552A2 (pt) | r(+)-n-metil-propargilaminoindano | |
BR112013019513A2 (pt) | métodos para o tratamento de úlceras diabéticas do pé | |
BR112014015084A2 (pt) | chocolate aerado | |
MX348831B (es) | Administración parenteral de tapentadol. | |
EP2552462A4 (en) | CCN3 PEPTIDES AND ANALOGS THEREOF FOR THERAPEUTIC USE | |
GT201400042A (es) | Compuesto de benzotiazolona | |
BR112015005738A2 (pt) | formulações orais de angiotensina | |
BR112014009760A8 (pt) | análogos de ácido siálico | |
CY1119984T1 (el) | Σταθεροποιημενη αμορφη μορφη αγομελατινης, μια μεθοδος για την παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν | |
PE20160847A1 (es) | Nuevo compuesto para el tratamiento de hipoglicemia severa | |
PE20160848A1 (es) | Nuevo compuesto para el tratamiento de hipoglicemia severa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2510 DE 12/02/2019. |