AU2012245301B2 - Method of drug delivery for PTH, PTHrP and related peptides - Google Patents

Method of drug delivery for PTH, PTHrP and related peptides Download PDF

Info

Publication number
AU2012245301B2
AU2012245301B2 AU2012245301A AU2012245301A AU2012245301B2 AU 2012245301 B2 AU2012245301 B2 AU 2012245301B2 AU 2012245301 A AU2012245301 A AU 2012245301A AU 2012245301 A AU2012245301 A AU 2012245301A AU 2012245301 B2 AU2012245301 B2 AU 2012245301B2
Authority
AU
Australia
Prior art keywords
aib
glu
lys
hpthrp
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012245301A
Other languages
English (en)
Other versions
AU2012245301A1 (en
Inventor
Amy S. Determan
Kris J. Hansen
Gary Hattersley
Ying Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Radius Health Inc
Original Assignee
3M Innovative Properties Co
Radius Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co, Radius Health Inc filed Critical 3M Innovative Properties Co
Publication of AU2012245301A1 publication Critical patent/AU2012245301A1/en
Application granted granted Critical
Publication of AU2012245301B2 publication Critical patent/AU2012245301B2/en
Priority to AU2016216584A priority Critical patent/AU2016216584A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AU2012245301A 2011-04-22 2012-04-20 Method of drug delivery for PTH, PTHrP and related peptides Ceased AU2012245301B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016216584A AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161478466P 2011-04-22 2011-04-22
US61/478,466 2011-04-22
US201161578120P 2011-12-20 2011-12-20
US61/578,120 2011-12-20
PCT/US2012/034510 WO2012145665A2 (en) 2011-04-22 2012-04-20 Method of drug delivery for pth, pthrp and related peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016216584A Division AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Publications (2)

Publication Number Publication Date
AU2012245301A1 AU2012245301A1 (en) 2013-12-12
AU2012245301B2 true AU2012245301B2 (en) 2016-05-19

Family

ID=47042187

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012245301A Ceased AU2012245301B2 (en) 2011-04-22 2012-04-20 Method of drug delivery for PTH, PTHrP and related peptides
AU2016216584A Abandoned AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016216584A Abandoned AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Country Status (14)

Country Link
US (6) US20130006217A1 (enExample)
EP (2) EP2699252B1 (enExample)
JP (2) JP6033280B2 (enExample)
KR (1) KR20140047043A (enExample)
CN (1) CN103917242A (enExample)
AU (2) AU2012245301B2 (enExample)
BR (1) BR112013027153A2 (enExample)
CA (1) CA2833571A1 (enExample)
ES (1) ES2648864T3 (enExample)
IL (1) IL228942A0 (enExample)
MX (1) MX2013012349A (enExample)
RU (1) RU2013151314A (enExample)
SG (1) SG194570A1 (enExample)
WO (1) WO2012145665A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2568806T3 (pl) 2010-05-12 2017-03-31 Radius Health, Inc. Schematy lecznicze
US20130158482A1 (en) * 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
AU2012345777B2 (en) * 2011-11-30 2016-05-12 Kindeva Drug Delivery L.P. Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
JPWO2014034882A1 (ja) * 2012-08-30 2016-08-08 株式会社 メドレックス 薬剤組成物が塗布されたマイクロニードルアレイ
ES2939940T3 (es) 2014-03-28 2023-04-28 Univ Duke Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos
EP4137147A3 (en) * 2015-03-03 2023-04-05 Radius Health, Inc. Uses of abaloparatide in reducing fracture risk
MX384605B (es) 2015-04-29 2025-03-14 Radius Pharmaceuticals Inc Combinación de palbociclib y rad1901 para usarse en el tratamiento de cáncer de mama en un sujeto con cáncer positivo a receptor de estrógeno.
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
DK3359129T3 (da) 2015-10-09 2022-05-09 Kindeva Drug Delivery Lp Zinksammensætninger til belagte mikronåleanordninger
HRP20211127T1 (hr) * 2015-10-09 2021-10-15 Radius Health, Inc. Formulacije analoga pthrp, njihovi transdermalni flasteri, i njihova uporaba
ES2904891T3 (es) * 2016-04-18 2022-04-06 Radius Health Inc Formulaciones de abaloparatida, parche transdérmico de la misma y usos de la misma
WO2017223115A1 (en) 2016-06-22 2017-12-28 Radius Health, Inc. Ar+ breast cancer treatment methods
IL266977B2 (en) * 2016-11-30 2024-01-01 Purdue Research Foundation Fracture-targeted bone regeneration using thyroid hormone receptor stimulation
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
EP3796941A4 (en) 2018-05-30 2022-12-28 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
US12441745B2 (en) 2019-02-12 2025-10-14 Radius Pharmaceuticals, Inc. Processes and compounds
WO2021149012A1 (en) 2020-01-24 2021-07-29 Radius Health, Inc. Methods of stimulating bone growth with abalopartide and denosumab
WO2021221973A1 (en) 2020-04-28 2021-11-04 Ticona Llc Microneedle assembly
EP4142693A1 (en) * 2020-05-01 2023-03-08 Emergex USA Corporation Transdermal drug delivery devices having psilocybin, lysergic acid diethylamide or 3,4-methylenedioxymethamphetamine coated microprotrusions
JP2024502334A (ja) * 2021-01-05 2024-01-18 ラジウス ヘルス，インコーポレイテッド アバロパラチドを用いた長骨骨折の治療
US12029562B2 (en) 2021-04-14 2024-07-09 Satio, Inc. Dermal patch system
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921750B2 (en) * 1995-07-13 2005-07-26 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
WO2008063279A2 (en) * 2006-10-03 2008-05-29 Radius Health, Inc. A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof
US20090117158A1 (en) * 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
WO2009137093A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Method of subcutaneous drug delivery of pthrp analogs

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
PT1037686E (pt) * 1997-12-11 2005-10-31 Alza Corp Aparelho para potenciar o fluxo de agente transdermico
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
GB9930882D0 (en) * 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
JP2007535337A (ja) * 2003-10-28 2007-12-06 アルザ・コーポレーシヨン 被覆された微小突起による治療用ペプチドおよびタンパクのポリマー接合体の送達
US7097631B2 (en) 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
CA2546280A1 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
MXPA06013168A (es) 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP2009522288A (ja) * 2005-12-28 2009-06-11 アルザ コーポレイション 安定な治療剤形
WO2007106597A2 (en) * 2006-03-15 2007-09-20 Alza Corporation Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
CA2649388A1 (en) * 2006-04-20 2007-11-01 Velocys, Inc. Process for treating and/or forming a non-newtonian fluid using microchannel process technology
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
ES2473620T3 (es) * 2007-02-06 2014-07-07 Hisamitsu Pharmaceutical Co., Inc. Dispositivo de microagujas para el diagnóstico de una alergia
EP2205169B1 (en) * 2007-09-28 2016-11-16 The Queen's University of Belfast Delivery device and method
EP2052736A1 (en) * 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
RU2561057C2 (ru) * 2008-11-04 2015-08-20 Аска Фармасьютикал Ко., Лтд. Водная композиция, содержащая фолликулостимулирующий гормон
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921750B2 (en) * 1995-07-13 2005-07-26 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
WO2008063279A2 (en) * 2006-10-03 2008-05-29 Radius Health, Inc. A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof
US20090117158A1 (en) * 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
WO2009137093A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Method of subcutaneous drug delivery of pthrp analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DADDONA, P.E. et al.Pharm. Res. 2011, vol. 28 pages 159-165 *

Also Published As

Publication number Publication date
NZ618003A (en) 2016-05-27
CA2833571A1 (en) 2012-10-26
EP2699252B1 (en) 2017-10-25
RU2013151314A (ru) 2015-05-27
WO2012145665A2 (en) 2012-10-26
SG194570A1 (en) 2013-12-30
ES2648864T3 (es) 2018-01-08
JP2017036323A (ja) 2017-02-16
JP2014517825A (ja) 2014-07-24
AU2016216584A1 (en) 2016-09-01
EP3332799A1 (en) 2018-06-13
US20130006217A1 (en) 2013-01-03
BR112013027153A2 (pt) 2016-11-29
JP6033280B2 (ja) 2016-11-30
EP2699252A2 (en) 2014-02-26
WO2012145665A3 (en) 2014-04-24
EP2699252A4 (en) 2015-05-27
US20190290738A1 (en) 2019-09-26
US20210052705A1 (en) 2021-02-25
IL228942A0 (en) 2013-12-31
US20140046292A1 (en) 2014-02-13
CN103917242A (zh) 2014-07-09
MX2013012349A (es) 2014-07-09
US20170189493A1 (en) 2017-07-06
KR20140047043A (ko) 2014-04-21
US20140046293A1 (en) 2014-02-13

Similar Documents

Publication Publication Date Title
US20210052705A1 (en) METHOD OF DRUG DELIVERY FOR PTH, PTHrP AND RELATED PEPTIDES
AU2012245301A1 (en) Method of drug delivery for PTH, PTHrP and related peptides
US12377044B2 (en) Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US20230277444A1 (en) FORMULATIONS OF PTHrP ANALOGUES, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
Weinstein Glucocorticoid‐induced bone disease
Henriksen et al. Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2
JP6867379B2 (ja) ＰＴＨｒＰ類似体の製剤、その経皮パッチ、およびその使用
JP2557779B2 (ja) ２成分型骨粗鬆症用薬剤
JP2019511558A (ja) アバロパラチドの製剤、その経皮パッチ、およびその使用
CN116831978A (zh) 用于口服的活性剂的制剂
JP2018508530A (ja) 骨折リスクの低減におけるＰＴＨｒＰアナログの使用
Tang et al. Thermosensitive drug delivery system of salmon calcitonin: in vitro release, in vivo absorption, bioactivity and therapeutic efficacies
HK1192138A (en) Method of drug delivery for pth, pthrp and related peptides
HK1192138B (en) Method of drug delivery for pth, pthrp and related peptides
NZ618003B2 (en) Method of drug delivery for pth, pthrp and related peptides
JPS63243033A (ja) 経鼻投与組成物
Standard et al. PrTEVA-TERIPARATIDE INJECTION
WO2019102310A1 (en) Vip formulation for management of inflammatory conditions
Tucker Novel Insulin Cuts Hypoglycemia, Weight Gain

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired