RU2011151287A - АНТИ Notch-1 АНТИТЕЛА - Google Patents

АНТИ Notch-1 АНТИТЕЛА Download PDF

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Publication number
RU2011151287A
RU2011151287A RU2011151287/10A RU2011151287A RU2011151287A RU 2011151287 A RU2011151287 A RU 2011151287A RU 2011151287/10 A RU2011151287/10 A RU 2011151287/10A RU 2011151287 A RU2011151287 A RU 2011151287A RU 2011151287 A RU2011151287 A RU 2011151287A
Authority
RU
Russia
Prior art keywords
antibody
antigen binding
binding portion
epitope
seq
Prior art date
Application number
RU2011151287/10A
Other languages
English (en)
Russian (ru)
Inventor
Зденек ХОСТОМСКИ
Канг ЛИ
Джон Эндрю ЛИППИНКОТ
Квингхай ПЭНГ
Донна Марие СТОУН
Пинг ВЕЙ
Original Assignee
Пфайзер Инк.
Ринат Нейросаенз Корпорэйшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2011151287(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Инк., Ринат Нейросаенз Корпорэйшн filed Critical Пфайзер Инк.
Publication of RU2011151287A publication Critical patent/RU2011151287A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2011151287/10A 2009-06-18 2010-06-16 АНТИ Notch-1 АНТИТЕЛА RU2011151287A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18
US61/218,193 2009-06-18
PCT/IB2010/052711 WO2010146550A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Publications (1)

Publication Number Publication Date
RU2011151287A true RU2011151287A (ru) 2013-07-27

Family

ID=42575817

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011151287/10A RU2011151287A (ru) 2009-06-18 2010-06-16 АНТИ Notch-1 АНТИТЕЛА

Country Status (18)

Country Link
US (1) US9090690B2 (OSRAM)
EP (2) EP2443151A1 (OSRAM)
JP (2) JP6059985B2 (OSRAM)
KR (1) KR101570898B1 (OSRAM)
CN (1) CN102686610A (OSRAM)
AU (1) AU2010261364B2 (OSRAM)
BR (1) BRPI1011805A2 (OSRAM)
CA (1) CA2765989C (OSRAM)
CO (1) CO6480924A2 (OSRAM)
IL (1) IL217066A0 (OSRAM)
MX (1) MX337468B (OSRAM)
NZ (1) NZ597611A (OSRAM)
PE (1) PE20121494A1 (OSRAM)
PH (1) PH12011502609B1 (OSRAM)
RU (1) RU2011151287A (OSRAM)
SG (1) SG176731A1 (OSRAM)
WO (1) WO2010146550A1 (OSRAM)
ZA (1) ZA201109282B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120080A1 (es) * 2008-10-01 2012-02-17 Genentech Inc Anticuerpos anti-notch2 y metodos de uso
WO2010146550A1 (en) * 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
RU2012117619A (ru) * 2009-09-30 2013-11-10 Дженентек, Инк. ЛЕЧЕНИЕ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ, УСТОЙЧИВЫХ К ДЕЙСТВИЮ АНТАГОНИСТА Notch1, С ПОМОЩЬЮ АНТАГОНИСТА Notch3
WO2012080926A2 (en) * 2010-12-15 2012-06-21 Wyeth Llc Anti-notch1 antibodies
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
BR112015010436A2 (pt) 2012-11-07 2017-08-22 Pfizer Anticorpos anti-notch3 e conjugados anticorpo-fármaco
WO2015134627A1 (en) * 2014-03-07 2015-09-11 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with notch1 antibodies
MX2017000363A (es) 2014-07-11 2017-04-27 Genentech Inc Inhibicion de la via de notch.
US11026996B2 (en) * 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
JP2019535250A (ja) * 2016-10-29 2019-12-12 ジェネンテック， インコーポレイテッド 抗ｍｉｃ抗体及び使用方法
WO2020045646A1 (ja) 2018-08-31 2020-03-05 Ｂｌｏｏｍ Ｔｅｃｈｎｏｌｏｇｙ 株式会社 終末糖化産物に対する抗体およびその使用
WO2024053742A1 (ja) 2022-09-09 2024-03-14 国立大学法人 東京医科歯科大学 コロナウイルス感染症の治療薬

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Also Published As

Publication number Publication date
PE20121494A1 (es) 2012-11-01
BRPI1011805A2 (pt) 2016-10-11
US9090690B2 (en) 2015-07-28
PH12011502609A1 (en) 2012-11-12
CA2765989C (en) 2016-11-29
US20120093813A1 (en) 2012-04-19
EP3431501A1 (en) 2019-01-23
AU2010261364B2 (en) 2015-05-07
JP2012530487A (ja) 2012-12-06
MX337468B (es) 2016-03-02
NZ597611A (en) 2014-03-28
KR101570898B1 (ko) 2015-11-23
CO6480924A2 (es) 2012-07-16
CA2765989A1 (en) 2010-12-23
WO2010146550A1 (en) 2010-12-23
JP6059985B2 (ja) 2017-01-11
SG176731A1 (en) 2012-01-30
AU2010261364A1 (en) 2012-01-19
CN102686610A (zh) 2012-09-19
KR20120071379A (ko) 2012-07-02
IL217066A0 (en) 2012-02-29
EP2443151A1 (en) 2012-04-25
PH12011502609B1 (en) 2018-11-07
MX2011013717A (es) 2012-05-29
ZA201109282B (en) 2012-08-29
JP2016121162A (ja) 2016-07-07

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