RU2011142618A - Замещенные спироамидные соединения - Google Patents

Info

Publication number

RU2011142618A

RU2011142618A RU2011142618/04A RU2011142618A RU2011142618A RU 2011142618 A RU2011142618 A RU 2011142618A RU 2011142618/04 A RU2011142618/04 A RU 2011142618/04A RU 2011142618 A RU2011142618 A RU 2011142618A RU 2011142618 A RU2011142618 A RU 2011142618A

Authority

RU

Russia

Prior art keywords

carbonyl

dihydro

diazaspiro

inden

ind

Prior art date

2009-03-25

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• 150000001875 compounds Chemical class 0.000 title claims abstract 19
• 125000003118 aryl group Chemical group 0.000 claims abstract 105
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract 81
• 125000001424 substituent group Chemical group 0.000 claims abstract 48
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract 39
• 229910052731 fluorine Inorganic materials 0.000 claims abstract 30
• 229910052801 chlorine Inorganic materials 0.000 claims abstract 29
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract 21
• 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 17
• 229910052794 bromium Inorganic materials 0.000 claims abstract 11
• 125000005842 heteroatom Chemical group 0.000 claims abstract 10
• 229910052740 iodine Inorganic materials 0.000 claims abstract 10
• 229910052717 sulfur Inorganic materials 0.000 claims abstract 10
• 229910052760 oxygen Inorganic materials 0.000 claims abstract 8
• 229920006395 saturated elastomer Polymers 0.000 claims abstract 5
• 125000002993 cycloalkylene group Chemical group 0.000 claims abstract 2
• -1 NR 50 Inorganic materials 0.000 claims 201
• 150000001408 amides Chemical class 0.000 claims 160
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 72
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 61
• 125000000217 alkyl group Chemical group 0.000 claims 59
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 52
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 30
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 29
• 239000000460 chlorine Substances 0.000 claims 28
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 27
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 27
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 27
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 27
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 27
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 27
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 25
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 25
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 25
• 229910052799 carbon Inorganic materials 0.000 claims 23
• 150000003254 radicals Chemical class 0.000 claims 23
• 125000000623 heterocyclic group Chemical group 0.000 claims 19
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
• 125000003541 2-chlorobenzoyl group Chemical group ClC1=C(C(=O)*)C=CC=C1 0.000 claims 17
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 15
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 14
• 125000002947 alkylene group Chemical group 0.000 claims 12
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 10
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 8
• 229940092714 benzenesulfonic acid Drugs 0.000 claims 8
• 125000004076 pyridyl group Chemical group 0.000 claims 8
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 6
• 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 6
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 6
• SVSARCCKBMZNMR-UHFFFAOYSA-N [1-[2-[methyl-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethyl]amino]ethyl]pyridin-4-ylidene]methyl-oxoazanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1CCN(C)CCN1C=CC(=C[NH+]=O)C=C1 SVSARCCKBMZNMR-UHFFFAOYSA-N 0.000 claims 6
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 6
• QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 claims 6
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 4
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 4
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
• DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 4
• NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 4
• 229940098779 methanesulfonic acid Drugs 0.000 claims 4
• 125000001624 naphthyl group Chemical group 0.000 claims 4
• 125000001544 thienyl group Chemical group 0.000 claims 4
• 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims 3
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 3
• 208000002193 Pain Diseases 0.000 claims 3
• 125000004450 alkenylene group Chemical group 0.000 claims 3
• 125000006317 cyclopropyl amino group Chemical group 0.000 claims 3
• 125000002541 furyl group Chemical group 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• MGHNDJJPPOAIHK-UHFFFAOYSA-N 1H-inden-1-yl Chemical group C1=CC=C2[CH]C=CC2=C1 MGHNDJJPPOAIHK-UHFFFAOYSA-N 0.000 claims 2
• JXRNFFDLFRJVHT-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 JXRNFFDLFRJVHT-UHFFFAOYSA-N 0.000 claims 2
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 2
• WJZIPMQUKSTHLV-UHFFFAOYSA-N 2-ethyldecanoic acid Chemical compound CCCCCCCCC(CC)C(O)=O WJZIPMQUKSTHLV-UHFFFAOYSA-N 0.000 claims 2
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
• 150000001204 N-oxides Chemical class 0.000 claims 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 150000007513 acids Chemical class 0.000 claims 2
• 125000004419 alkynylene group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
• DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 2
• 229940080818 propionamide Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• XQTMJXDTVIYKOO-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]urea Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 XQTMJXDTVIYKOO-UHFFFAOYSA-N 0.000 claims 1
• XKEVFQIKHPMUIE-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]urea Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 XKEVFQIKHPMUIE-UHFFFAOYSA-N 0.000 claims 1
• CGRWXCIZPBWBGU-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 CGRWXCIZPBWBGU-UHFFFAOYSA-N 0.000 claims 1
• QPFSIMKLUGWYIE-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 QPFSIMKLUGWYIE-UHFFFAOYSA-N 0.000 claims 1
• YCKMHEZFMGEQSN-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 YCKMHEZFMGEQSN-UHFFFAOYSA-N 0.000 claims 1
• OMSITMXPMRYKTF-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)NC=4C=C(Cl)C(Cl)=CC=4)CCC3=CC=2)CC1 OMSITMXPMRYKTF-UHFFFAOYSA-N 0.000 claims 1
• XDVQCZBGRJPEAM-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]urea Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)NCC1=CC=CC=C1Cl XDVQCZBGRJPEAM-UHFFFAOYSA-N 0.000 claims 1
• IINUGUBUKSLPRA-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]urea Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)NCC1=CC=CC=C1Cl IINUGUBUKSLPRA-UHFFFAOYSA-N 0.000 claims 1
• FEDOMGVBKNJYFR-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound ClC1=CC=CC=C1CNC(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 FEDOMGVBKNJYFR-UHFFFAOYSA-N 0.000 claims 1
• VSFAVKHLAWAUGT-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound ClC1=CC=CC=C1CNC(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VSFAVKHLAWAUGT-UHFFFAOYSA-N 0.000 claims 1
• GOBAHCSVRSVQBZ-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound ClC1=CC=CC=C1CNC(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 GOBAHCSVRSVQBZ-UHFFFAOYSA-N 0.000 claims 1
• NJURBIOQEULIDP-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)NCC=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 NJURBIOQEULIDP-UHFFFAOYSA-N 0.000 claims 1
• JBUSVVXOVQFRGR-HHHXNRCGSA-N 2,3-dichloro-n-[(1r)-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)N[C@H]2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1Cl JBUSVVXOVQFRGR-HHHXNRCGSA-N 0.000 claims 1
• UFRNUZNUSDBQKY-UHFFFAOYSA-N 2,3-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=CC(Cl)=C1Cl UFRNUZNUSDBQKY-UHFFFAOYSA-N 0.000 claims 1
• RZGRIWKIKVIOSN-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-(2-methylpropyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(C)C)CCC21CCN(C(=O)C=1C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=1)CC2 RZGRIWKIKVIOSN-UHFFFAOYSA-N 0.000 claims 1
• KUKHBRGXFBZGJS-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 KUKHBRGXFBZGJS-UHFFFAOYSA-N 0.000 claims 1
• FYUGUVMPTDFDRT-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[(2-chloro-6-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 FYUGUVMPTDFDRT-UHFFFAOYSA-N 0.000 claims 1
• HGTDDDPZXRGBAF-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[3-(3-fluorophenyl)propyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(CCCN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)=C1 HGTDDDPZXRGBAF-UHFFFAOYSA-N 0.000 claims 1
• UKRXNYWVXUTXFA-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[3-(4-fluorophenyl)propyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(F)=CC=C1CCCN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 UKRXNYWVXUTXFA-UHFFFAOYSA-N 0.000 claims 1
• WAFHISSSDYTPDQ-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 WAFHISSSDYTPDQ-UHFFFAOYSA-N 0.000 claims 1
• ZATFKHAXJBZUPZ-UHFFFAOYSA-N 2,3-dichloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC(Cl)=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 ZATFKHAXJBZUPZ-UHFFFAOYSA-N 0.000 claims 1
• IXRMWWXEUHNRSI-UHFFFAOYSA-N 2,4-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=C(Cl)C=C1Cl IXRMWWXEUHNRSI-UHFFFAOYSA-N 0.000 claims 1
• MHMLFEUFSQUMLU-UHFFFAOYSA-N 2,4-dichloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]benzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=CC=C(Cl)C=C1Cl MHMLFEUFSQUMLU-UHFFFAOYSA-N 0.000 claims 1
• FJWRRUKEKROSGX-UHFFFAOYSA-N 2,4-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC(Cl)=CC=4)Cl)CCC3=CC=2)CC1 FJWRRUKEKROSGX-UHFFFAOYSA-N 0.000 claims 1
• DGJPVLYVGLPGOE-UHFFFAOYSA-N 2,4-dichloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 DGJPVLYVGLPGOE-UHFFFAOYSA-N 0.000 claims 1
• 125000006334 2,4-difluoro benzoyl group Chemical group [H]C1=C([H])C(C(*)=O)=C(F)C([H])=C1F 0.000 claims 1
• IHYMCHARCGAOSI-UHFFFAOYSA-N 2,5-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC(Cl)=CC=C1Cl IHYMCHARCGAOSI-UHFFFAOYSA-N 0.000 claims 1
• PHHXFOUEHWNYMC-UHFFFAOYSA-N 2,5-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)Cl)CCC3=CC=2)CC1 PHHXFOUEHWNYMC-UHFFFAOYSA-N 0.000 claims 1
• ZYQLBNQYEPRDRI-UHFFFAOYSA-N 2,5-dichloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C(Cl)=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 ZYQLBNQYEPRDRI-UHFFFAOYSA-N 0.000 claims 1
• AQECLZNFHUAYSB-HHHXNRCGSA-N 2,6-dichloro-n-[(1r)-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 AQECLZNFHUAYSB-HHHXNRCGSA-N 0.000 claims 1
• UTUBQBSESYQKGZ-UHFFFAOYSA-N 2,6-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=C(Cl)C=CC=C1Cl UTUBQBSESYQKGZ-UHFFFAOYSA-N 0.000 claims 1
• INYYSVFZEKVHDG-UHFFFAOYSA-N 2,6-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4Cl)Cl)CCC3=CC=2)CC1 INYYSVFZEKVHDG-UHFFFAOYSA-N 0.000 claims 1
• VYTFJKKPPVMEJS-UHFFFAOYSA-N 2,6-dichloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 VYTFJKKPPVMEJS-UHFFFAOYSA-N 0.000 claims 1
• NPPIMWCAFJMXRN-UHFFFAOYSA-N 2,6-difluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC=1C=CC=C(F)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 NPPIMWCAFJMXRN-UHFFFAOYSA-N 0.000 claims 1
• QTUQLYUCVGINBE-UHFFFAOYSA-N 2,6-dimethyl-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=CC(C)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 QTUQLYUCVGINBE-UHFFFAOYSA-N 0.000 claims 1
• BOLIUIKTVTYLRP-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)C(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 BOLIUIKTVTYLRP-UHFFFAOYSA-N 0.000 claims 1
• YPNRQAQXVGRPQG-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 YPNRQAQXVGRPQG-UHFFFAOYSA-N 0.000 claims 1
• XHBHWVVZYSLVTC-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 XHBHWVVZYSLVTC-UHFFFAOYSA-N 0.000 claims 1
• YLYXNNOQCNWWKP-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C(C=4C=CC=CC=4)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 YLYXNNOQCNWWKP-UHFFFAOYSA-N 0.000 claims 1
• MKZVERAHTZFQJA-MUUNZHRXSA-N 2-(2-chlorophenyl)-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1CC(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 MKZVERAHTZFQJA-MUUNZHRXSA-N 0.000 claims 1
• GZCIXCFEOMKPFD-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]acetamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)CC1=CC=CC=C1Cl GZCIXCFEOMKPFD-UHFFFAOYSA-N 0.000 claims 1
• UXMUGZHLZCRQEM-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]-2-phenylacetamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C(C=1C(=CC=CC=1)Cl)C1=CC=CC=C1 UXMUGZHLZCRQEM-UHFFFAOYSA-N 0.000 claims 1
• KGBJFCTZKVOSTH-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]acetamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)CC1=CC=CC=C1Cl KGBJFCTZKVOSTH-UHFFFAOYSA-N 0.000 claims 1
• XRXVJWJEWAHNRG-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1CC(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 XRXVJWJEWAHNRG-UHFFFAOYSA-N 0.000 claims 1
• MKZVERAHTZFQJA-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1CC(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 MKZVERAHTZFQJA-UHFFFAOYSA-N 0.000 claims 1
• DOLSRRDEAFOMAN-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1CC(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 DOLSRRDEAFOMAN-UHFFFAOYSA-N 0.000 claims 1
• VBOSWEIEPITXGH-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)CC=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VBOSWEIEPITXGH-UHFFFAOYSA-N 0.000 claims 1
• QTJCUQCLLYFWDS-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-methyl-2-phenyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound C=1C=CC=CC=1C(C=1C(=CC=CC=1)Cl)C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QTJCUQCLLYFWDS-UHFFFAOYSA-N 0.000 claims 1
• RXFYPGGGHJQXHK-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound C=1C=CC=C(Cl)C=1CC(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 RXFYPGGGHJQXHK-UHFFFAOYSA-N 0.000 claims 1
• DWBXEAHGBRIOSE-MUUNZHRXSA-N 2-(2-fluorophenyl)-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound FC1=CC=CC=C1CC(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 DWBXEAHGBRIOSE-MUUNZHRXSA-N 0.000 claims 1
• NNQKEIBIYKXWNO-GDLZYMKVSA-N 2-(2-methylphenyl)-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound CC1=CC=CC=C1CC(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 NNQKEIBIYKXWNO-GDLZYMKVSA-N 0.000 claims 1
• WAGJBQBHXXFGGJ-UHFFFAOYSA-N 2-(trifluoromethyl)-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)C(F)(F)F)CCC3=CC=2)CC1 WAGJBQBHXXFGGJ-UHFFFAOYSA-N 0.000 claims 1
• PDMBJHLIRJAKRD-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(F)=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 PDMBJHLIRJAKRD-UHFFFAOYSA-N 0.000 claims 1
• JZUDCDJHCXEFKA-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(F)=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 JZUDCDJHCXEFKA-UHFFFAOYSA-N 0.000 claims 1
• IDTRLZPBTFUJGW-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C(F)=C(F)C=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 IDTRLZPBTFUJGW-UHFFFAOYSA-N 0.000 claims 1
• IRUJAQDSTCJDIK-UHFFFAOYSA-N 2-chloro-4-fluoro-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 IRUJAQDSTCJDIK-UHFFFAOYSA-N 0.000 claims 1
• GWKGYURCZUQFET-UHFFFAOYSA-N 2-chloro-4-fluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 GWKGYURCZUQFET-UHFFFAOYSA-N 0.000 claims 1
• WWPIXDAQNABCEC-UHFFFAOYSA-N 2-chloro-4-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C(F)C=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 WWPIXDAQNABCEC-UHFFFAOYSA-N 0.000 claims 1
• UOWXPSDJDNYUEW-UHFFFAOYSA-N 2-chloro-4-methoxy-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 UOWXPSDJDNYUEW-UHFFFAOYSA-N 0.000 claims 1
• DNXJSHYDCNVIDB-UHFFFAOYSA-N 2-chloro-4-methoxy-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 DNXJSHYDCNVIDB-UHFFFAOYSA-N 0.000 claims 1
• VPFPTTCPUXIGOK-UHFFFAOYSA-N 2-chloro-4-methoxy-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)N(C)C1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VPFPTTCPUXIGOK-UHFFFAOYSA-N 0.000 claims 1
• XGUNRLRQDYHMJF-UHFFFAOYSA-N 2-chloro-5-fluoro-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1 XGUNRLRQDYHMJF-UHFFFAOYSA-N 0.000 claims 1
• CJMPKYIZQKNWSW-UHFFFAOYSA-N 2-chloro-5-fluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CC(=CC=2)C(F)(F)F)=C1 CJMPKYIZQKNWSW-UHFFFAOYSA-N 0.000 claims 1
• QZHPFZDZAVBJPP-UHFFFAOYSA-N 2-chloro-5-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C(F)=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QZHPFZDZAVBJPP-UHFFFAOYSA-N 0.000 claims 1
• PDKICULSLPZGRX-UHFFFAOYSA-N 2-chloro-6-fluoro-3-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=C(F)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1Cl PDKICULSLPZGRX-UHFFFAOYSA-N 0.000 claims 1
• PJQVBDKAXJBGIL-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 PJQVBDKAXJBGIL-UHFFFAOYSA-N 0.000 claims 1
• KDDUEAYZNUJICJ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(3-fluoro-4-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KDDUEAYZNUJICJ-UHFFFAOYSA-N 0.000 claims 1
• DZDYWJQVGPKMJI-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 DZDYWJQVGPKMJI-UHFFFAOYSA-N 0.000 claims 1
• AAKRMMPTHDNATC-MUUNZHRXSA-N 2-chloro-n-[(1r)-4-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C(C=CC=C2C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=C2CC1 AAKRMMPTHDNATC-MUUNZHRXSA-N 0.000 claims 1
• GXTOEUZKSZCCOM-MUUNZHRXSA-N 2-chloro-n-[(1r)-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2CC1 GXTOEUZKSZCCOM-MUUNZHRXSA-N 0.000 claims 1
• AGPGFEUAWMXQHD-MUUNZHRXSA-N 2-chloro-n-[(1r)-5-fluoro-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N([C@@H]1CCC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)F)C(=O)C1=CC=CC=C1Cl AGPGFEUAWMXQHD-MUUNZHRXSA-N 0.000 claims 1
• MRFXKHMDRDCBRF-GDLZYMKVSA-N 2-chloro-n-[(1r)-5-methyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N([C@@H]1CCC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)C)C(=O)C1=CC=CC=C1Cl MRFXKHMDRDCBRF-GDLZYMKVSA-N 0.000 claims 1
• ZXKKNOYWSCYMGF-MUUNZHRXSA-N 2-chloro-n-[(1r)-6-(9-pyridin-4-yl-2,9-diazaspiro[5.5]undecane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CCN(CC4)C=4C=CN=CC=4)CCC3)=CC=C2CC1 ZXKKNOYWSCYMGF-MUUNZHRXSA-N 0.000 claims 1
• FPKVIWCZTZRDEO-HHHXNRCGSA-N 2-chloro-n-[(1r)-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 FPKVIWCZTZRDEO-HHHXNRCGSA-N 0.000 claims 1
• SEERBTDVQSXSHJ-GDLZYMKVSA-N 2-chloro-n-[(1r)-6-[9-(1-methylpiperidin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCC1N1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 SEERBTDVQSXSHJ-GDLZYMKVSA-N 0.000 claims 1
• XHUZWUPKYJFEJD-GDLZYMKVSA-N 2-chloro-n-[(1r)-6-[9-(4-methylpiperazine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCN1C(=O)C1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 XHUZWUPKYJFEJD-GDLZYMKVSA-N 0.000 claims 1
• ZUOCFTPUNLKYBV-SSEXGKCCSA-N 2-chloro-n-[(1r)-6-[9-[(1-methylpiperidin-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCC1CN1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 ZUOCFTPUNLKYBV-SSEXGKCCSA-N 0.000 claims 1
• LBZGBKJRJUGNRO-GDLZYMKVSA-N 2-chloro-n-[(1r)-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CCC1 LBZGBKJRJUGNRO-GDLZYMKVSA-N 0.000 claims 1
• AAKRMMPTHDNATC-NDEPHWFRSA-N 2-chloro-n-[(1s)-4-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@@H]1C(C=CC=C2C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=C2CC1 AAKRMMPTHDNATC-NDEPHWFRSA-N 0.000 claims 1
• GXTOEUZKSZCCOM-NDEPHWFRSA-N 2-chloro-n-[(1s)-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@@H]1C2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2CC1 GXTOEUZKSZCCOM-NDEPHWFRSA-N 0.000 claims 1
• LBZGBKJRJUGNRO-LJAQVGFWSA-N 2-chloro-n-[(1s)-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CCC1 LBZGBKJRJUGNRO-LJAQVGFWSA-N 0.000 claims 1
• SXGGFPSUDUPVDM-MHZLTWQESA-N 2-chloro-n-[(1s)-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@@H]1C2=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=CC=C2CC1 SXGGFPSUDUPVDM-MHZLTWQESA-N 0.000 claims 1
• NCPGDYYPSVWHPP-HHHXNRCGSA-N 2-chloro-n-[(4r)-7-fluoro-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-3,4-dihydro-2h-chromen-4-yl]benzamide Chemical compound N([C@@H]1CCOC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)F)C(=O)C1=CC=CC=C1Cl NCPGDYYPSVWHPP-HHHXNRCGSA-N 0.000 claims 1
• UKRCOVZIZYNUPW-HHHXNRCGSA-N 2-chloro-n-[(4r)-8-fluoro-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-3,4-dihydro-2h-chromen-4-yl]benzamide Chemical compound N([C@H]1C=2C=C(C=C(C=2OCC1)F)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)C(=O)C1=CC=CC=C1Cl UKRCOVZIZYNUPW-HHHXNRCGSA-N 0.000 claims 1
• BGUJZWSLSRYXRQ-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-3-(trifluoromethyl)benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=CC(C(F)(F)F)=C1Cl BGUJZWSLSRYXRQ-UHFFFAOYSA-N 0.000 claims 1
• RUNIECZEUMRRLE-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-4,5-difluorobenzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC(F)=C(F)C=C1Cl RUNIECZEUMRRLE-UHFFFAOYSA-N 0.000 claims 1
• LQIGDBYGAXPEAQ-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-4-fluorobenzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=C(F)C=C1Cl LQIGDBYGAXPEAQ-UHFFFAOYSA-N 0.000 claims 1
• VDOTYBDTOJLAKU-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC(C(F)(F)F)=CC=C1Cl VDOTYBDTOJLAKU-UHFFFAOYSA-N 0.000 claims 1
• VPFOUWAHFRPXNT-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-5-fluorobenzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC(F)=CC=C1Cl VPFOUWAHFRPXNT-UHFFFAOYSA-N 0.000 claims 1
• LYYLJPWNOFPPGB-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=C(Cl)C=CC=C1C(F)(F)F LYYLJPWNOFPPGB-UHFFFAOYSA-N 0.000 claims 1
• VIHOAUCYKHHMQT-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]-6-fluoro-3-methylbenzamide Chemical compound CC1=CC=C(F)C(C(=O)NC2C(CC3=CC=C(C=C32)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)(C)C)=C1Cl VIHOAUCYKHHMQT-UHFFFAOYSA-N 0.000 claims 1
• GFUCDKWHZUANAQ-UHFFFAOYSA-N 2-chloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=CC=C1Cl GFUCDKWHZUANAQ-UHFFFAOYSA-N 0.000 claims 1
• JHZSLZHJKGUPRM-UHFFFAOYSA-N 2-chloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]-4-fluorobenzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=CC=C(F)C=C1Cl JHZSLZHJKGUPRM-UHFFFAOYSA-N 0.000 claims 1
• QLBLHOWSQRZFJH-UHFFFAOYSA-N 2-chloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]-5-fluorobenzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=CC(F)=CC=C1Cl QLBLHOWSQRZFJH-UHFFFAOYSA-N 0.000 claims 1
• KNVOSSFNQYBBSW-UHFFFAOYSA-N 2-chloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]-6-fluoro-3-methylbenzamide Chemical compound CC1=CC=C(F)C(C(=O)NC2C3=CC(=CC=C3C(C)(C)C2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1Cl KNVOSSFNQYBBSW-UHFFFAOYSA-N 0.000 claims 1
• VZIRGRKIIJGTKD-UHFFFAOYSA-N 2-chloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]-6-fluorobenzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=C(F)C=CC=C1Cl VZIRGRKIIJGTKD-UHFFFAOYSA-N 0.000 claims 1
• VLXJWFABQNTKMU-UHFFFAOYSA-N 2-chloro-n-[6-[2-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecan-3-yl]-2-oxoethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)CC=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VLXJWFABQNTKMU-UHFFFAOYSA-N 0.000 claims 1
• VHFBCTUKBUREJE-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-8-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 VHFBCTUKBUREJE-UHFFFAOYSA-N 0.000 claims 1
• YNOJONCCTBHQKK-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decan-2-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 YNOJONCCTBHQKK-UHFFFAOYSA-N 0.000 claims 1
• WQLIPDVWVNLSFN-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecan-3-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CCC4(CC3)CCN(CC4)C=3C=NC=CC=3)=CC=C2CC1 WQLIPDVWVNLSFN-UHFFFAOYSA-N 0.000 claims 1
• VUSAGLORJLKSBW-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VUSAGLORJLKSBW-UHFFFAOYSA-N 0.000 claims 1
• LJDAADTUTYXAHN-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-chloro-4-fluorobenzoyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 LJDAADTUTYXAHN-UHFFFAOYSA-N 0.000 claims 1
• HUPIJMWLKNJYFK-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-chloro-4-fluorobenzoyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C(=O)C1=CC=C(F)C=C1Cl HUPIJMWLKNJYFK-UHFFFAOYSA-N 0.000 claims 1
• XDSKXASNKGANRR-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-cyanophenyl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC2)S(=O)(=O)C=1C(=CC=CC=1)C#N)C1CC1 XDSKXASNKGANRR-UHFFFAOYSA-N 0.000 claims 1
• CLZRBRHMAXYHIQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1CN(CC(CC)CC)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 CLZRBRHMAXYHIQ-UHFFFAOYSA-N 0.000 claims 1
• XFXFROPUEVEUER-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound C1CN(CC(CC)CC)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 XFXFROPUEVEUER-UHFFFAOYSA-N 0.000 claims 1
• KUKTZVVJNMNNJF-UHFFFAOYSA-N 2-chloro-n-[6-[8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC21CCN(C(=O)CC(C)(C)C)CC2 KUKTZVVJNMNNJF-UHFFFAOYSA-N 0.000 claims 1
• PSXAJQOXXULQPO-UHFFFAOYSA-N 2-chloro-n-[6-[8-(3-cyano-4-fluorophenyl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound C1=C(C#N)C(F)=CC=C1S(=O)(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 PSXAJQOXXULQPO-UHFFFAOYSA-N 0.000 claims 1
• BEJBXZPNVQNTES-UHFFFAOYSA-N 2-chloro-n-[6-[8-(5-chlorothiophen-2-yl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound S1C(Cl)=CC=C1S(=O)(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 BEJBXZPNVQNTES-UHFFFAOYSA-N 0.000 claims 1
• KEUHWFAJNGFKDV-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1,5-dimethylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KEUHWFAJNGFKDV-UHFFFAOYSA-N 0.000 claims 1
• LPLZCUHLCVZIEJ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1,5-dimethylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 LPLZCUHLCVZIEJ-UHFFFAOYSA-N 0.000 claims 1
• KTZNXQZHJVMBKR-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KTZNXQZHJVMBKR-UHFFFAOYSA-N 0.000 claims 1
• ACDDPIVNTMDUSF-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 ACDDPIVNTMDUSF-UHFFFAOYSA-N 0.000 claims 1
• RWHVRYUAMGSFGP-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=C(F)C=C1F RWHVRYUAMGSFGP-UHFFFAOYSA-N 0.000 claims 1
• QVQCNUPWSYFDHT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,5-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC(F)=CC=C1F QVQCNUPWSYFDHT-UHFFFAOYSA-N 0.000 claims 1
• PANMOFCMHZNNPA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-4-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 PANMOFCMHZNNPA-UHFFFAOYSA-N 0.000 claims 1
• BQGAVWGRGQHJHX-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-4-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC(F)=CC=3)Cl)CC4)=CC=C2CC1 BQGAVWGRGQHJHX-UHFFFAOYSA-N 0.000 claims 1
• VWDAXPDBMNNVJI-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-4-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VWDAXPDBMNNVJI-UHFFFAOYSA-N 0.000 claims 1
• GBBFXQVSXDBQDQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3F)Cl)CC4)=CC=C2CC1 GBBFXQVSXDBQDQ-UHFFFAOYSA-N 0.000 claims 1
• ADEZONDXQIIKRJ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 ADEZONDXQIIKRJ-UHFFFAOYSA-N 0.000 claims 1
• QNHPDRQPJQRXAT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=C(F)C=CC=C1Cl QNHPDRQPJQRXAT-UHFFFAOYSA-N 0.000 claims 1
• RTWDRMSGIIPXLX-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3)C#N)CC4)=CC=C2CC1 RTWDRMSGIIPXLX-UHFFFAOYSA-N 0.000 claims 1
• KXKUNRPLBQLRPM-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3)C#N)CC4)=CC=C2CC1 KXKUNRPLBQLRPM-UHFFFAOYSA-N 0.000 claims 1
• JIZFIBVKKVVFEX-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC=1C(=CC=CC=1)C#N)CC2)C1CC1 JIZFIBVKKVVFEX-UHFFFAOYSA-N 0.000 claims 1
• WWEFPTACAFJRIW-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC=C1C#N WWEFPTACAFJRIW-UHFFFAOYSA-N 0.000 claims 1
• KQJVRCKSINJNOF-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=C(F)C(F)=C1 KQJVRCKSINJNOF-UHFFFAOYSA-N 0.000 claims 1
• KNVDMXGAAQUZLV-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KNVDMXGAAQUZLV-UHFFFAOYSA-N 0.000 claims 1
• ODPIRKHWVWIIQD-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 ODPIRKHWVWIIQD-UHFFFAOYSA-N 0.000 claims 1
• WJWCOZQCKZJPJG-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C(C=CC=3)C#N)CC4)=CC=C2CC1 WJWCOZQCKZJPJG-UHFFFAOYSA-N 0.000 claims 1
• CBGVXPRVGVDYIA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC=1C=C(C=CC=1)C#N)CC2)C1CC1 CBGVXPRVGVDYIA-UHFFFAOYSA-N 0.000 claims 1
• QHJGEEGCFLCCQC-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC(C#N)=C1 QHJGEEGCFLCCQC-UHFFFAOYSA-N 0.000 claims 1
• DUQNZIVUFRHCOQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-fluoro-4-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 DUQNZIVUFRHCOQ-UHFFFAOYSA-N 0.000 claims 1
• MTZKLHFMOOEUFU-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=CC(=CC=3)C#N)CC4)=CC=C2CC1 MTZKLHFMOOEUFU-UHFFFAOYSA-N 0.000 claims 1
• CPWUJFCGFLRLCK-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=CC(=CC=3)C#N)CC4)=CC=C2CC1 CPWUJFCGFLRLCK-UHFFFAOYSA-N 0.000 claims 1
• WYDPAWFWDSOUGA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC=1C=CC(=CC=1)C#N)CC2)C1CC1 WYDPAWFWDSOUGA-UHFFFAOYSA-N 0.000 claims 1
• DOMBAZHMTAIQOK-UHFFFAOYSA-N 2-chloro-n-[6-[8-[2-(4-chlorophenyl)acetyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C(=O)CC1=CC=C(Cl)C=C1 DOMBAZHMTAIQOK-UHFFFAOYSA-N 0.000 claims 1
• IOLWJRFYRRCGMW-UHFFFAOYSA-N 2-chloro-n-[6-[8-[3-(3-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CCCC=3C=C(F)C=CC=3)CC4)=CC=C2CC1 IOLWJRFYRRCGMW-UHFFFAOYSA-N 0.000 claims 1
• DLLOIXLKIGHPGC-UHFFFAOYSA-N 2-chloro-n-[6-[8-[3-(4-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CCCC=3C=CC(F)=CC=3)CC4)=CC=C2CC1 DLLOIXLKIGHPGC-UHFFFAOYSA-N 0.000 claims 1
• RTLAZLHBTAENEZ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 RTLAZLHBTAENEZ-UHFFFAOYSA-N 0.000 claims 1
• FLNUZFWIIPJIHP-UHFFFAOYSA-N 2-chloro-n-[6-[9-(3,3-difluoroazetidin-1-yl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1C(F)(F)CN1C1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 FLNUZFWIIPJIHP-UHFFFAOYSA-N 0.000 claims 1
• ODAHQYHZLOVGKX-UHFFFAOYSA-N 2-chloro-n-[6-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=C(F)C=C1 ODAHQYHZLOVGKX-UHFFFAOYSA-N 0.000 claims 1
• BJLRFRSLVZRWRO-UHFFFAOYSA-N 2-chloro-n-[6-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2N(C)C(=O)C1=CC=CC=C1Cl BJLRFRSLVZRWRO-UHFFFAOYSA-N 0.000 claims 1
• FCGGQGOMROPUMK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1,5-dimethylpyrazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 FCGGQGOMROPUMK-UHFFFAOYSA-N 0.000 claims 1
• JAGHSAKFVXVVJI-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 JAGHSAKFVXVVJI-UHFFFAOYSA-N 0.000 claims 1
• BYBUWYPHJWQYSO-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 BYBUWYPHJWQYSO-UHFFFAOYSA-N 0.000 claims 1
• GQTHCBWZALGEPU-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 GQTHCBWZALGEPU-UHFFFAOYSA-N 0.000 claims 1
• NUVJQNGVWOWWJU-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,5-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)=C1 NUVJQNGVWOWWJU-UHFFFAOYSA-N 0.000 claims 1
• PAERKRVDZKMNAN-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,5-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)=C1 PAERKRVDZKMNAN-UHFFFAOYSA-N 0.000 claims 1
• HRVMUJORPYLNRX-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,5-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)=C1 HRVMUJORPYLNRX-UHFFFAOYSA-N 0.000 claims 1
• FRGJXBJGOVEPDR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,6-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 FRGJXBJGOVEPDR-UHFFFAOYSA-N 0.000 claims 1
• DATXJXZLAOVDCE-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,6-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 DATXJXZLAOVDCE-UHFFFAOYSA-N 0.000 claims 1
• GYYFXYAYXMRTQU-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 GYYFXYAYXMRTQU-UHFFFAOYSA-N 0.000 claims 1
• XGRKAMXLAMWUKH-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 XGRKAMXLAMWUKH-UHFFFAOYSA-N 0.000 claims 1
• VHNJBTSDADSQOQ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VHNJBTSDADSQOQ-UHFFFAOYSA-N 0.000 claims 1
• SEZSEJULXJMNLZ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-6-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 SEZSEJULXJMNLZ-UHFFFAOYSA-N 0.000 claims 1
• LTWSNNOUQSETQK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-6-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 LTWSNNOUQSETQK-UHFFFAOYSA-N 0.000 claims 1
• UEGLCMGUZYDKBK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)C#N)CC3)CC2)=C1 UEGLCMGUZYDKBK-UHFFFAOYSA-N 0.000 claims 1
• VUAZYJCKTSDMKD-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C(=CC=CC=5)C#N)CC4)CC3)=CC=C2CC1 VUAZYJCKTSDMKD-UHFFFAOYSA-N 0.000 claims 1
• YCLDEUWZSLJLPT-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C(=CC=CC=5)C#N)CC4)CC3)=CC=C2CC1 YCLDEUWZSLJLPT-UHFFFAOYSA-N 0.000 claims 1
• QOPBTPQOIRIKOP-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 QOPBTPQOIRIKOP-UHFFFAOYSA-N 0.000 claims 1
• SIXPLPIAJCPBGG-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 SIXPLPIAJCPBGG-UHFFFAOYSA-N 0.000 claims 1
• UUWGGRMORPJQBR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 UUWGGRMORPJQBR-UHFFFAOYSA-N 0.000 claims 1
• ZAJSKFDYZRSXJM-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 ZAJSKFDYZRSXJM-UHFFFAOYSA-N 0.000 claims 1
• JOICRRJODWSPJB-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 JOICRRJODWSPJB-UHFFFAOYSA-N 0.000 claims 1
• JSBMCJPDWDVKKO-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 JSBMCJPDWDVKKO-UHFFFAOYSA-N 0.000 claims 1
• UTSSEJMBPZWBRW-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=C(C=CC=4)C#N)CC3)CC2)=C1 UTSSEJMBPZWBRW-UHFFFAOYSA-N 0.000 claims 1
• XQFPVUJEPZAOJJ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C(C=CC=5)C#N)CC4)CC3)=CC=C2CC1 XQFPVUJEPZAOJJ-UHFFFAOYSA-N 0.000 claims 1
• XMAPLXPDEAIVOC-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C(C=CC=5)C#N)CC4)CC3)=CC=C2CC1 XMAPLXPDEAIVOC-UHFFFAOYSA-N 0.000 claims 1
• CRTPYUFARRTOQR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-fluoro-4-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 CRTPYUFARRTOQR-UHFFFAOYSA-N 0.000 claims 1
• HOJHLNAVOVSPAF-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(4-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=CC(=CC=4)C#N)CC3)CC2)=C1 HOJHLNAVOVSPAF-UHFFFAOYSA-N 0.000 claims 1
• UNEKRRJXVMSNDR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(4-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CC(=CC=5)C#N)CC4)CC3)=CC=C2CC1 UNEKRRJXVMSNDR-UHFFFAOYSA-N 0.000 claims 1
• FATBDKBGLYCPTD-UHFFFAOYSA-N 2-chloro-n-[6-[9-[3-(3-fluorophenyl)propyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(CCCN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)=C1 FATBDKBGLYCPTD-UHFFFAOYSA-N 0.000 claims 1
• ABHPDHSUYFQICL-UHFFFAOYSA-N 2-chloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 ABHPDHSUYFQICL-UHFFFAOYSA-N 0.000 claims 1
• ZXAINXFWYXBFHS-UHFFFAOYSA-N 2-chloro-n-[[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 ZXAINXFWYXBFHS-UHFFFAOYSA-N 0.000 claims 1
• MFTZTSCFMOBJHD-UHFFFAOYSA-N 2-chloro-n-[[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 MFTZTSCFMOBJHD-UHFFFAOYSA-N 0.000 claims 1
• WOIBDCRRJNNSJF-UHFFFAOYSA-N 2-chloro-n-[[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=NC=CC=3)=CC=C2CC1 WOIBDCRRJNNSJF-UHFFFAOYSA-N 0.000 claims 1
• VIUDPGHGFCAROI-UHFFFAOYSA-N 2-chloro-n-[[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VIUDPGHGFCAROI-UHFFFAOYSA-N 0.000 claims 1
• LBROVVAYRCXODG-UHFFFAOYSA-N 2-chloro-n-[[6-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(CNC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 LBROVVAYRCXODG-UHFFFAOYSA-N 0.000 claims 1
• ORVOQJGSJBPWHL-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=NC=CC=1)C1CC1 ORVOQJGSJBPWHL-UHFFFAOYSA-N 0.000 claims 1
• XLCOYKFBIRPQSL-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)C1CC1 XLCOYKFBIRPQSL-UHFFFAOYSA-N 0.000 claims 1
• KJHSEOWSVMJJNY-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 KJHSEOWSVMJJNY-UHFFFAOYSA-N 0.000 claims 1
• NPLFFXBHHNJXCT-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=CN=C1 NPLFFXBHHNJXCT-UHFFFAOYSA-N 0.000 claims 1
• PJFOBQCOIVSQIE-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3-(trifluoromethyl)benzamide Chemical compound C=1C=CC(C(F)(F)F)=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 PJFOBQCOIVSQIE-UHFFFAOYSA-N 0.000 claims 1
• UMPOMJAEFXEXCP-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C=1C(C(F)(F)F)=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 UMPOMJAEFXEXCP-UHFFFAOYSA-N 0.000 claims 1
• NRJFMMPTJBKXFH-UHFFFAOYSA-N 2-cyano-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)C#N)CCC3=CC=2)CC1 NRJFMMPTJBKXFH-UHFFFAOYSA-N 0.000 claims 1
• YRCGAHTZOXPQPR-UHFFFAOYSA-N 2-ethylnonanoic acid Chemical compound CCCCCCCC(CC)C(O)=O YRCGAHTZOXPQPR-UHFFFAOYSA-N 0.000 claims 1
• SWNFABIJBOPMJG-UHFFFAOYSA-N 2-fluoro-4-methoxy-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(OC)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 SWNFABIJBOPMJG-UHFFFAOYSA-N 0.000 claims 1
• PUDXGTOKVBILET-UHFFFAOYSA-N 2-fluoro-4-methoxy-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(OC)=CC=C1C(=O)N(C)C1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 PUDXGTOKVBILET-UHFFFAOYSA-N 0.000 claims 1
• WDMKRRYHTODLOW-UHFFFAOYSA-N 2-fluoro-4-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(C)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 WDMKRRYHTODLOW-UHFFFAOYSA-N 0.000 claims 1
• PTZYGFAAQDFFTO-UHFFFAOYSA-N 2-fluoro-n,4-dimethyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C(C)C=C(F)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 PTZYGFAAQDFFTO-UHFFFAOYSA-N 0.000 claims 1
• HDUIRNQJBSTSBH-MUUNZHRXSA-N 2-fluoro-n-[(1r)-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 HDUIRNQJBSTSBH-MUUNZHRXSA-N 0.000 claims 1
• NICNFMXFNUKDEC-UHFFFAOYSA-N 2-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC=C(F)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 NICNFMXFNUKDEC-UHFFFAOYSA-N 0.000 claims 1
• PPVBINGORIGGEN-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-1-methyl-1-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C=1C=C(Cl)C(Cl)=CC=1NC(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 PPVBINGORIGGEN-UHFFFAOYSA-N 0.000 claims 1
• SHCUCTXWNGSJIV-UHFFFAOYSA-N 3-[(2-chlorophenyl)methyl]-1-methyl-1-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C=1C=CC=C(Cl)C=1CNC(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 SHCUCTXWNGSJIV-UHFFFAOYSA-N 0.000 claims 1
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
• NOEBFEGJYCVMHG-UHFFFAOYSA-N 4-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-2-(trifluoromethyl)benzamide Chemical compound C=1C=C(F)C=C(C(F)(F)F)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 NOEBFEGJYCVMHG-UHFFFAOYSA-N 0.000 claims 1
• HLNSCLFULSQCMG-UHFFFAOYSA-N 4-methoxy-2,6-dimethyl-n-[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=NC=CC=3)=CC=C2CC1 HLNSCLFULSQCMG-UHFFFAOYSA-N 0.000 claims 1
• CFDIULVJOMYZCL-UHFFFAOYSA-N 4-methoxy-2,6-dimethyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 CFDIULVJOMYZCL-UHFFFAOYSA-N 0.000 claims 1
• RICPSVJQYOZWMM-UHFFFAOYSA-N 4-methoxy-2,6-dimethyl-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 RICPSVJQYOZWMM-UHFFFAOYSA-N 0.000 claims 1
• STTDEQQYJJTWMW-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)N(C)C1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 STTDEQQYJJTWMW-UHFFFAOYSA-N 0.000 claims 1
• SLGQOOSQAUFBQI-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(2-methylpropyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(C)C)CCC21CCN(C(=O)C=1C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=1)CC2 SLGQOOSQAUFBQI-UHFFFAOYSA-N 0.000 claims 1
• GMLPSGAVFJOTJQ-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-[(3-fluoro-4-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 GMLPSGAVFJOTJQ-UHFFFAOYSA-N 0.000 claims 1
• KURHRRVQHZKKSA-UHFFFAOYSA-N 5-chloro-n-[6-[8-[(2,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 KURHRRVQHZKKSA-UHFFFAOYSA-N 0.000 claims 1
• VOYBGKJJDFCBCT-UHFFFAOYSA-N 5-chloro-n-[6-[8-[(3,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 VOYBGKJJDFCBCT-UHFFFAOYSA-N 0.000 claims 1
• NEJUTFTVDIYQJW-UHFFFAOYSA-N 5-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C(C=CC=3)C#N)CC4)=CC=C2CC1 NEJUTFTVDIYQJW-UHFFFAOYSA-N 0.000 claims 1
• VGMUCXVGKOMFBE-UHFFFAOYSA-N 5-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=CC(=CC=3)C#N)CC4)=CC=C2CC1 VGMUCXVGKOMFBE-UHFFFAOYSA-N 0.000 claims 1
• PGIMKCGSJSKGLO-UHFFFAOYSA-N 5-chloro-n-[6-[9-[(2,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 PGIMKCGSJSKGLO-UHFFFAOYSA-N 0.000 claims 1
• HFUFBBKBZBGQFX-UHFFFAOYSA-N 5-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 HFUFBBKBZBGQFX-UHFFFAOYSA-N 0.000 claims 1
• YWSHPUWFJPPOEL-UHFFFAOYSA-N 5-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C(C=CC=5)C#N)CC4)CC3)=CC=C2CC1 YWSHPUWFJPPOEL-UHFFFAOYSA-N 0.000 claims 1
• OCDZZXHEOTYVBE-UHFFFAOYSA-N 5-chloro-n-[6-[9-[(4-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CC(=CC=5)C#N)CC4)CC3)=CC=C2CC1 OCDZZXHEOTYVBE-UHFFFAOYSA-N 0.000 claims 1
• HXQAULIBGVQAIK-UHFFFAOYSA-N 5-chloro-n-[6-[9-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-2-fluorobenzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)F)CCC3=CC=2)CC1 HXQAULIBGVQAIK-UHFFFAOYSA-N 0.000 claims 1
• BAUAZBRRFSTEDT-UHFFFAOYSA-N 5-chloro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-2-(trifluoromethyl)benzamide Chemical compound C=1C(Cl)=CC=C(C(F)(F)F)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 BAUAZBRRFSTEDT-UHFFFAOYSA-N 0.000 claims 1
• MHFSLYNJRFQZAL-HHHXNRCGSA-N 5-methyl-2-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-1h-pyrrolo[1,2-c]imidazol-3-one Chemical compound C([C@H](C1=C2)N3CC4=CC=C(N4C3=O)C)CC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 MHFSLYNJRFQZAL-HHHXNRCGSA-N 0.000 claims 1
• MHHHAUCGPISNKL-HHHXNRCGSA-N 7-chloro-2-[(1r)-4-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@H]1N2CC=3C=CC=C(C=3C2=O)Cl)CC2=C1C=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 MHHHAUCGPISNKL-HHHXNRCGSA-N 0.000 claims 1
• BPPXYCRRJRZBPC-MUUNZHRXSA-N 7-chloro-2-[(1r)-4-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@H]1N2CC=3C=CC=C(C=3C2=O)Cl)CC2=C1C=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 BPPXYCRRJRZBPC-MUUNZHRXSA-N 0.000 claims 1
• DFTMYKYPZBZBIY-HHHXNRCGSA-N 7-chloro-2-[(1r)-5-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@H](C1=CC=2)N3CC=4C=CC=C(C=4C3=O)Cl)CC1=CC=2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 DFTMYKYPZBZBIY-HHHXNRCGSA-N 0.000 claims 1
• QEUPGTDRJUIOOK-MUUNZHRXSA-N 7-chloro-2-[(1r)-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@H](C1=CC=2)N3CC=4C=CC=C(C=4C3=O)Cl)CC1=CC=2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QEUPGTDRJUIOOK-MUUNZHRXSA-N 0.000 claims 1
• CCALLNUGHMNCNK-HHHXNRCGSA-N 7-chloro-2-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@H](C1=C2)N3CC=4C=CC=C(C=4C3=O)Cl)CC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 CCALLNUGHMNCNK-HHHXNRCGSA-N 0.000 claims 1
• HMXGEOYRGPPHJN-MUUNZHRXSA-N 7-chloro-2-[(1r)-7-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-3h-isoindol-1-one Chemical compound C([C@H](C1=C2)N3CC=4C=CC=C(C=4C3=O)Cl)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 HMXGEOYRGPPHJN-MUUNZHRXSA-N 0.000 claims 1
• VLNXYAYPDQGLGX-GDLZYMKVSA-N 7-chloro-2-[(1r)-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-3h-isoindol-1-one Chemical compound C([C@H](C1=C2)N3CC=4C=CC=C(C=4C3=O)Cl)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 VLNXYAYPDQGLGX-GDLZYMKVSA-N 0.000 claims 1
• MHHHAUCGPISNKL-MHZLTWQESA-N 7-chloro-2-[(1s)-4-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@@H]1N2CC=3C=CC=C(C=3C2=O)Cl)CC2=C1C=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 MHHHAUCGPISNKL-MHZLTWQESA-N 0.000 claims 1
• DFTMYKYPZBZBIY-MHZLTWQESA-N 7-chloro-2-[(1s)-5-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@@H](C1=CC=2)N3CC=4C=CC=C(C=4C3=O)Cl)CC1=CC=2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 DFTMYKYPZBZBIY-MHZLTWQESA-N 0.000 claims 1
• QEUPGTDRJUIOOK-NDEPHWFRSA-N 7-chloro-2-[(1s)-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound C([C@@H](C1=CC=2)N3CC=4C=CC=C(C=4C3=O)Cl)CC1=CC=2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QEUPGTDRJUIOOK-NDEPHWFRSA-N 0.000 claims 1
• HMXGEOYRGPPHJN-NDEPHWFRSA-N 7-chloro-2-[(1s)-7-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-3h-isoindol-1-one Chemical compound C([C@@H](C1=C2)N3CC=4C=CC=C(C=4C3=O)Cl)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 HMXGEOYRGPPHJN-NDEPHWFRSA-N 0.000 claims 1
• ZGYUAKNWHZOFQY-UHFFFAOYSA-N 7-chloro-2-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-isoindol-1-one Chemical compound O=C1C=2C(Cl)=CC=CC=2CN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 ZGYUAKNWHZOFQY-UHFFFAOYSA-N 0.000 claims 1
• WALMLISKSUSLNV-UHFFFAOYSA-N 8-chloro-2-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound O=C1C2=C(Cl)C=CN2CCN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(C1)CCN1C1=CC=NC=C1 WALMLISKSUSLNV-UHFFFAOYSA-N 0.000 claims 1
• YPLOAIXRRAGXOF-UHFFFAOYSA-N 8-chloro-2-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound O=C1C2=C(Cl)C=CN2CCN1C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 YPLOAIXRRAGXOF-UHFFFAOYSA-N 0.000 claims 1
• ATJFVLNFNAZGHD-UHFFFAOYSA-N 8-chloro-2-[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound O=C1C2=C(Cl)C=CN2CCN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=CN=C1 ATJFVLNFNAZGHD-UHFFFAOYSA-N 0.000 claims 1
• QOGLKOAKUPSFNI-UHFFFAOYSA-N 8-chloro-2-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound O=C1C2=C(Cl)C=CN2CCN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QOGLKOAKUPSFNI-UHFFFAOYSA-N 0.000 claims 1
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• IQQVJXPBSXPGFY-UHFFFAOYSA-N 8-chloro-2-[6-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(N4C(C5=C(Cl)C=CN5CC4)=O)CCC3=CC=2)CC1 IQQVJXPBSXPGFY-UHFFFAOYSA-N 0.000 claims 1
• XCJDURYUBHGDGG-UHFFFAOYSA-N 8-chloro-2-[6-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-4-methyl-3h-pyrrolo[3,4-b]indol-1-one Chemical compound O=C1C=2C3=C(Cl)C=CC=C3N(C)C=2CN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=C(F)C=C1 XCJDURYUBHGDGG-UHFFFAOYSA-N 0.000 claims 1
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• VGTDEFDDXNSXBW-UHFFFAOYSA-N 8-chloro-4-methyl-2-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-pyrrolo[3,4-b]indol-1-one Chemical compound O=C1C=2C3=C(Cl)C=CC=C3N(C)C=2CN1C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 VGTDEFDDXNSXBW-UHFFFAOYSA-N 0.000 claims 1
• FLFCUYPMCWZUQF-UHFFFAOYSA-N 8-chloro-4-methyl-2-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-3h-pyrrolo[3,4-b]indol-1-one Chemical compound O=C1C=2C3=C(Cl)C=CC=C3N(C)C=2CN1C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 FLFCUYPMCWZUQF-UHFFFAOYSA-N 0.000 claims 1
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