MX2011010068A - Compuestos de espiro-amida sustituida. - Google Patents

Info

Publication number

MX2011010068A

MX2011010068A MX2011010068A MX2011010068A MX2011010068A MX 2011010068 A MX2011010068 A MX 2011010068A MX 2011010068 A MX2011010068 A MX 2011010068A MX 2011010068 A MX2011010068 A MX 2011010068A MX 2011010068 A MX2011010068 A MX 2011010068A

Authority

MX

Mexico

Prior art keywords

dihydro

diazaspiro

carbonyl

inden

ind

Prior art date

2009-03-25

Links

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• 150000001875 compounds Chemical class 0.000 claims abstract description 149
• 239000003814 drug Substances 0.000 claims abstract description 22
• 238000002360 preparation method Methods 0.000 claims abstract description 20
• -1 C2-6-alkylene Chemical group 0.000 claims description 1037
• 150000001408 amides Chemical class 0.000 claims description 214
• 125000003118 aryl group Chemical group 0.000 claims description 205
• 125000001072 heteroaryl group Chemical group 0.000 claims description 161
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 145
• 125000001424 substituent group Chemical group 0.000 claims description 120
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 113
• 150000003254 radicals Chemical class 0.000 claims description 87
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 81
• 239000000203 mixture Substances 0.000 claims description 80
• 229910052731 fluorine Inorganic materials 0.000 claims description 73
• 229910052801 chlorine Inorganic materials 0.000 claims description 72
• 239000002253 acid Substances 0.000 claims description 68
• 229940092714 benzenesulfonic acid Drugs 0.000 claims description 64
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 64
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 63
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 62
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 62
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 61
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 60
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 59
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 58
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 57
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 54
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 52
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 52
• 125000000623 heterocyclic group Chemical group 0.000 claims description 50
• 125000003541 2-chlorobenzoyl group Chemical group ClC1=C(C(=O)*)C=CC=C1 0.000 claims description 46
• 229910052757 nitrogen Inorganic materials 0.000 claims description 43
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 41
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 41
• 125000004076 pyridyl group Chemical group 0.000 claims description 40
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 40
• 229910052739 hydrogen Inorganic materials 0.000 claims description 39
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 33
• 125000001544 thienyl group Chemical group 0.000 claims description 32
• 229910052794 bromium Inorganic materials 0.000 claims description 30
• 229910052740 iodine Inorganic materials 0.000 claims description 26
• 208000002193 Pain Diseases 0.000 claims description 25
• AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Substances CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 25
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 23
• 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims description 20
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 20
• 125000005842 heteroatom Chemical group 0.000 claims description 20
• 229940098779 methanesulfonic acid Drugs 0.000 claims description 20
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 20
• 125000001624 naphthyl group Chemical group 0.000 claims description 19
• 229920006395 saturated elastomer Polymers 0.000 claims description 19
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims description 18
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 18
• 229910052717 sulfur Inorganic materials 0.000 claims description 18
• 125000002541 furyl group Chemical group 0.000 claims description 15
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 14
• 206010061218 Inflammation Diseases 0.000 claims description 13
• 125000004432 carbon atom Chemical group C* 0.000 claims description 13
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
• 150000007513 acids Chemical class 0.000 claims description 12
• 230000004054 inflammatory process Effects 0.000 claims description 12
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 10
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
• 239000004202 carbamide Substances 0.000 claims description 10
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 9
• 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims description 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
• 150000003839 salts Chemical class 0.000 claims description 9
• YRCGAHTZOXPQPR-UHFFFAOYSA-N 2-ethylnonanoic acid Chemical compound CCCCCCCC(CC)C(O)=O YRCGAHTZOXPQPR-UHFFFAOYSA-N 0.000 claims description 8
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 8
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 8
• 125000000217 alkyl group Chemical group 0.000 claims description 8
• 201000010099 disease Diseases 0.000 claims description 8
• 229940080818 propionamide Drugs 0.000 claims description 8
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 7
• 125000004450 alkenylene group Chemical group 0.000 claims description 7
• 125000002947 alkylene group Chemical group 0.000 claims description 7
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 7
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 6
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 6
• 125000004419 alkynylene group Chemical group 0.000 claims description 6
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
• 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims description 5
• 125000006334 2,4-difluoro benzoyl group Chemical group [H]C1=C([H])C(C(*)=O)=C(F)C([H])=C1F 0.000 claims description 5
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims description 5
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 5
• 208000000094 Chronic Pain Diseases 0.000 claims description 5
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
• 125000005872 benzooxazolyl group Chemical group 0.000 claims description 5
• 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims description 5
• 229910052799 carbon Inorganic materials 0.000 claims description 5
• 125000004988 dibenzothienyl group Chemical group C1(=CC=CC=2SC3=C(C21)C=CC=C3)* 0.000 claims description 5
• 125000001041 indolyl group Chemical group 0.000 claims description 5
• 229910052760 oxygen Inorganic materials 0.000 claims description 5
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 5
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 5
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
• 150000001204 N-oxides Chemical class 0.000 claims description 4
• 101150020251 NR13 gene Proteins 0.000 claims description 4
• 208000008589 Obesity Diseases 0.000 claims description 4
• 206010040070 Septic Shock Diseases 0.000 claims description 4
• KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical compound C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 claims description 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
• SYGWYBOJXOGMRU-UHFFFAOYSA-N chembl233051 Chemical compound C1=CC=C2C3=CC(C(N(CCN(C)C)C4=O)=O)=C5C4=CC=CC5=C3SC2=C1 SYGWYBOJXOGMRU-UHFFFAOYSA-N 0.000 claims description 4
• 235000020824 obesity Nutrition 0.000 claims description 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 4
• 230000036303 septic shock Effects 0.000 claims description 4
• 208000011580 syndromic disease Diseases 0.000 claims description 4
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 3
• WJZIPMQUKSTHLV-UHFFFAOYSA-N 2-ethyldecanoic acid Chemical compound CCCCCCCCC(CC)C(O)=O WJZIPMQUKSTHLV-UHFFFAOYSA-N 0.000 claims description 3
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 3
• 208000012902 Nervous system disease Diseases 0.000 claims description 3
• 208000025966 Neurological disease Diseases 0.000 claims description 3
• 208000025747 Rheumatic disease Diseases 0.000 claims description 3
• 208000005298 acute pain Diseases 0.000 claims description 3
• 230000033115 angiogenesis Effects 0.000 claims description 3
• 150000001721 carbon Chemical group 0.000 claims description 3
• 125000005509 dibenzothiophenyl group Chemical group 0.000 claims description 3
• 239000003112 inhibitor Substances 0.000 claims description 3
• 230000004770 neurodegeneration Effects 0.000 claims description 3
• 239000011664 nicotinic acid Substances 0.000 claims description 3
• 230000010410 reperfusion Effects 0.000 claims description 3
• VVHQVXXPZDALDV-BOXHHOBZSA-N (3s)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione;hydrochloride Chemical compound Cl.O=C1N([C@@H]2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 VVHQVXXPZDALDV-BOXHHOBZSA-N 0.000 claims description 2
• VSFAVKHLAWAUGT-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound ClC1=CC=CC=C1CNC(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VSFAVKHLAWAUGT-UHFFFAOYSA-N 0.000 claims description 2
• GOBAHCSVRSVQBZ-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound ClC1=CC=CC=C1CNC(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 GOBAHCSVRSVQBZ-UHFFFAOYSA-N 0.000 claims description 2
• NJURBIOQEULIDP-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)NCC=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 NJURBIOQEULIDP-UHFFFAOYSA-N 0.000 claims description 2
• QMOZODQZPSZNMF-UHFFFAOYSA-N 2,3-dichloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]benzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=CC=CC(Cl)=C1Cl QMOZODQZPSZNMF-UHFFFAOYSA-N 0.000 claims description 2
• IAJOTLDOEGRGKY-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(CC)CC)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 IAJOTLDOEGRGKY-UHFFFAOYSA-N 0.000 claims description 2
• NKSNRUHHXXVQSM-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-(2-methylpropyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(C)C)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 NKSNRUHHXXVQSM-UHFFFAOYSA-N 0.000 claims description 2
• BLQKRUUDAIAEJO-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-(2-phenylethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CCC=2C=CC=CC=2)CC3)=C1Cl BLQKRUUDAIAEJO-UHFFFAOYSA-N 0.000 claims description 2
• SOZSXCOZSXDXKJ-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 SOZSXCOZSXDXKJ-UHFFFAOYSA-N 0.000 claims description 2
• BCYDPZHDMRRZJW-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 BCYDPZHDMRRZJW-UHFFFAOYSA-N 0.000 claims description 2
• XRXLFGRGRMEANH-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC=2C(=CC=CC=2)C#N)CC3)=C1Cl XRXLFGRGRMEANH-UHFFFAOYSA-N 0.000 claims description 2
• ZJYJUYAJAFZXBI-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 ZJYJUYAJAFZXBI-UHFFFAOYSA-N 0.000 claims description 2
• KSZIBYRWJUHRMK-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[3-(3-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(CCCN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=C(Cl)C=CC=5)Cl)CCC4=CC=3)CC2)=C1 KSZIBYRWJUHRMK-UHFFFAOYSA-N 0.000 claims description 2
• QNZFYXPYMIYGNW-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[3-(4-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(F)=CC=C1CCCN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 QNZFYXPYMIYGNW-UHFFFAOYSA-N 0.000 claims description 2
• JCDYEOMCNCQRDF-UHFFFAOYSA-N 2,3-dichloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 JCDYEOMCNCQRDF-UHFFFAOYSA-N 0.000 claims description 2
• NJIMXMIVJTVADL-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-(2-phenylethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CCC=4C=CC=CC=4)CC3)CC2)=C1Cl NJIMXMIVJTVADL-UHFFFAOYSA-N 0.000 claims description 2
• NFUZCNTVMBHJSA-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-(quinolin-6-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=C5C=CC=NC5=CC=4)CC3)CC2)=C1Cl NFUZCNTVMBHJSA-UHFFFAOYSA-N 0.000 claims description 2
• SQBUIEIKWZJGDE-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-(quinoxalin-6-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=C5N=CC=NC5=CC=4)CC3)CC2)=C1Cl SQBUIEIKWZJGDE-UHFFFAOYSA-N 0.000 claims description 2
• JLOIXIVYRJZNQK-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 JLOIXIVYRJZNQK-UHFFFAOYSA-N 0.000 claims description 2
• TZIOBNXASVALAL-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[(1-methylbenzotriazol-5-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C2N(C)N=NC2=CC=1CN(CC1)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC=CC(Cl)=C1Cl TZIOBNXASVALAL-UHFFFAOYSA-N 0.000 claims description 2
• KUKHBRGXFBZGJS-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 KUKHBRGXFBZGJS-UHFFFAOYSA-N 0.000 claims description 2
• WAFHISSSDYTPDQ-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 WAFHISSSDYTPDQ-UHFFFAOYSA-N 0.000 claims description 2
• ITSCTKXEWXXCSF-UHFFFAOYSA-N 2,3-dichloro-n-[6-[9-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=C(Cl)C=CC=4)Cl)CCC3=CC=2)CC1 ITSCTKXEWXXCSF-UHFFFAOYSA-N 0.000 claims description 2
• IXRMWWXEUHNRSI-UHFFFAOYSA-N 2,4-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC=C(Cl)C=C1Cl IXRMWWXEUHNRSI-UHFFFAOYSA-N 0.000 claims description 2
• IHYMCHARCGAOSI-UHFFFAOYSA-N 2,5-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=CC(Cl)=CC=C1Cl IHYMCHARCGAOSI-UHFFFAOYSA-N 0.000 claims description 2
• KXBRCTWYVHQOSN-UHFFFAOYSA-N 2,5-dichloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]benzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=CC(Cl)=CC=C1Cl KXBRCTWYVHQOSN-UHFFFAOYSA-N 0.000 claims description 2
• PHHXFOUEHWNYMC-UHFFFAOYSA-N 2,5-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(Cl)C=4)Cl)CCC3=CC=2)CC1 PHHXFOUEHWNYMC-UHFFFAOYSA-N 0.000 claims description 2
• UTUBQBSESYQKGZ-UHFFFAOYSA-N 2,6-dichloro-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]benzamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)C1=C(Cl)C=CC=C1Cl UTUBQBSESYQKGZ-UHFFFAOYSA-N 0.000 claims description 2
• KWGOOJJWBMEVJP-UHFFFAOYSA-N 2,6-dichloro-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]benzamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)C1=C(Cl)C=CC=C1Cl KWGOOJJWBMEVJP-UHFFFAOYSA-N 0.000 claims description 2
• INYYSVFZEKVHDG-UHFFFAOYSA-N 2,6-dichloro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4Cl)Cl)CCC3=CC=2)CC1 INYYSVFZEKVHDG-UHFFFAOYSA-N 0.000 claims description 2
• RKIYPFGUGZEZMY-UHFFFAOYSA-N 2,6-difluoro-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 RKIYPFGUGZEZMY-UHFFFAOYSA-N 0.000 claims description 2
• BOLIUIKTVTYLRP-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)C(=O)NC1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 BOLIUIKTVTYLRP-UHFFFAOYSA-N 0.000 claims description 2
• XHBHWVVZYSLVTC-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-phenyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 XHBHWVVZYSLVTC-UHFFFAOYSA-N 0.000 claims description 2
• ZNWALNWJWFYBKQ-OLVCOQPYSA-N 2-(2-chlorophenyl)-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]propanamide Chemical compound C([C@H](C1=C2)NC(=O)C(C)C=3C(=CC=CC=3)Cl)CC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 ZNWALNWJWFYBKQ-OLVCOQPYSA-N 0.000 claims description 2
• GZCIXCFEOMKPFD-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydroinden-1-yl]acetamide Chemical compound CC1(C)CC2=CC=C(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)C=C2C1NC(=O)CC1=CC=CC=C1Cl GZCIXCFEOMKPFD-UHFFFAOYSA-N 0.000 claims description 2
• KGBJFCTZKVOSTH-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[3,3-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2-dihydroinden-1-yl]acetamide Chemical compound C12=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2C(C)(C)CC1NC(=O)CC1=CC=CC=C1Cl KGBJFCTZKVOSTH-UHFFFAOYSA-N 0.000 claims description 2
• VBOSWEIEPITXGH-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)CC=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VBOSWEIEPITXGH-UHFFFAOYSA-N 0.000 claims description 2
• NNQKEIBIYKXWNO-GDLZYMKVSA-N 2-(2-methylphenyl)-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]acetamide Chemical compound CC1=CC=CC=C1CC(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 NNQKEIBIYKXWNO-GDLZYMKVSA-N 0.000 claims description 2
• WAGJBQBHXXFGGJ-UHFFFAOYSA-N 2-(trifluoromethyl)-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)C(F)(F)F)CCC3=CC=2)CC1 WAGJBQBHXXFGGJ-UHFFFAOYSA-N 0.000 claims description 2
• VYLRPJZWWLARBU-AREMUKBSSA-N 2-chloro-3-fluoro-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(C(=O)N[C@H]2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1Cl VYLRPJZWWLARBU-AREMUKBSSA-N 0.000 claims description 2
• JZUDCDJHCXEFKA-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(F)=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 JZUDCDJHCXEFKA-UHFFFAOYSA-N 0.000 claims description 2
• GWKGYURCZUQFET-UHFFFAOYSA-N 2-chloro-4-fluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 GWKGYURCZUQFET-UHFFFAOYSA-N 0.000 claims description 2
• WWPIXDAQNABCEC-UHFFFAOYSA-N 2-chloro-4-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C(F)C=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 WWPIXDAQNABCEC-UHFFFAOYSA-N 0.000 claims description 2
• FIKXECFDJTXDJM-MUUNZHRXSA-N 2-chloro-4-methoxy-n-[(1r)-6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 FIKXECFDJTXDJM-MUUNZHRXSA-N 0.000 claims description 2
• SBYUEZRHPDXQKE-MUUNZHRXSA-N 2-chloro-4-methoxy-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 SBYUEZRHPDXQKE-MUUNZHRXSA-N 0.000 claims description 2
• VPFPTTCPUXIGOK-UHFFFAOYSA-N 2-chloro-4-methoxy-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(OC)=CC=C1C(=O)N(C)C1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VPFPTTCPUXIGOK-UHFFFAOYSA-N 0.000 claims description 2
• LTLRVNXJLRHEPY-UHFFFAOYSA-N 2-chloro-5-(trifluoromethyl)-n-[6-[8-[(1,3,5-trimethylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NN(C)C(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 LTLRVNXJLRHEPY-UHFFFAOYSA-N 0.000 claims description 2
• IFXJGNAIJCLHTD-HHHXNRCGSA-N 2-chloro-5-fluoro-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C(C(=O)N[C@H]2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1 IFXJGNAIJCLHTD-HHHXNRCGSA-N 0.000 claims description 2
• QZHPFZDZAVBJPP-UHFFFAOYSA-N 2-chloro-5-fluoro-n-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C(F)=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 QZHPFZDZAVBJPP-UHFFFAOYSA-N 0.000 claims description 2
• SWXGDWMDGNXVGQ-UHFFFAOYSA-N 2-chloro-6-fluoro-3-methyl-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=C(F)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CN(CC3)C=3C=CN=CC=3)CC2)=C1Cl SWXGDWMDGNXVGQ-UHFFFAOYSA-N 0.000 claims description 2
• PDKICULSLPZGRX-UHFFFAOYSA-N 2-chloro-6-fluoro-3-methyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=C(F)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CC2)CCN(CC3)C=2C=CN=CC=2)=C1Cl PDKICULSLPZGRX-UHFFFAOYSA-N 0.000 claims description 2
• VILSHCHACZSPQC-AREMUKBSSA-N 2-chloro-6-fluoro-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VILSHCHACZSPQC-AREMUKBSSA-N 0.000 claims description 2
• ZXKUIMPCGZGIRS-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[8-(2-methylpropyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(C)C)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 ZXKUIMPCGZGIRS-UHFFFAOYSA-N 0.000 claims description 2
• QLTGCEZEBLBRJE-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[8-(quinolin-6-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C5C=CC=NC5=CC=3)CC4)=CC=C2CC1 QLTGCEZEBLBRJE-UHFFFAOYSA-N 0.000 claims description 2
• BFZJNTFGGWFFPX-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[8-(quinoxalin-6-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C5N=CC=NC5=CC=3)CC4)=CC=C2CC1 BFZJNTFGGWFFPX-UHFFFAOYSA-N 0.000 claims description 2
• YFNSCRFTOYYART-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[8-[(1-methylbenzotriazol-5-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C2N(C)N=NC2=CC=1CN(CC1)CCC1(C1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=C(F)C=CC=C1Cl YFNSCRFTOYYART-UHFFFAOYSA-N 0.000 claims description 2
• ISNMQOMXFUNJTQ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[8-[3-(3-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(CCCN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5F)Cl)CCC4=CC=3)CC2)=C1 ISNMQOMXFUNJTQ-UHFFFAOYSA-N 0.000 claims description 2
• NCIABZICMLOSCZ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-(1h-pyrrol-2-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5NC=CC=5)CC4)CC3)=CC=C2CC1 NCIABZICMLOSCZ-UHFFFAOYSA-N 0.000 claims description 2
• ZZGALJULZXBLIX-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-(pyridin-2-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=CC=CC=5)CC4)CC3)=CC=C2CC1 ZZGALJULZXBLIX-UHFFFAOYSA-N 0.000 claims description 2
• FCQLTTSHTSOKLQ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-(pyridin-3-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=NC=CC=5)CC4)CC3)=CC=C2CC1 FCQLTTSHTSOKLQ-UHFFFAOYSA-N 0.000 claims description 2
• WUBUFOFRXQQSQX-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CC1 WUBUFOFRXQQSQX-UHFFFAOYSA-N 0.000 claims description 2
• KMONJVRKTHGTEI-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-(thiadiazol-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=NSC=5)CC4)CC3)=CC=C2CC1 KMONJVRKTHGTEI-UHFFFAOYSA-N 0.000 claims description 2
• JCWPZQGQWINAFQ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(1-methylpyrrol-2-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CN1C=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 JCWPZQGQWINAFQ-UHFFFAOYSA-N 0.000 claims description 2
• PJQVBDKAXJBGIL-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 PJQVBDKAXJBGIL-UHFFFAOYSA-N 0.000 claims description 2
• YMVDJVODEKAOLM-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(3-methylimidazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CN1C=NC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 YMVDJVODEKAOLM-UHFFFAOYSA-N 0.000 claims description 2
• DZDYWJQVGPKMJI-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[4-(trifluoromethyl)phenyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CC(=CC=3)C(F)(F)F)=CC=C2CC1 DZDYWJQVGPKMJI-UHFFFAOYSA-N 0.000 claims description 2
• GNHUVWXBRRTPJH-UHFFFAOYSA-N 2-chloro-6-methyl-n-[6-[8-(2-methylpropyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(C)C)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 GNHUVWXBRRTPJH-UHFFFAOYSA-N 0.000 claims description 2
• NAKYAAPASASNKM-UHFFFAOYSA-N 2-chloro-6-methyl-n-[6-[8-(quinolin-6-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C5C=CC=NC5=CC=3)CC4)=CC=C2CC1 NAKYAAPASASNKM-UHFFFAOYSA-N 0.000 claims description 2
• QQGVRNZWUBFOCZ-UHFFFAOYSA-N 2-chloro-6-methyl-n-[6-[8-(quinoxalin-6-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C5N=CC=NC5=CC=3)CC4)=CC=C2CC1 QQGVRNZWUBFOCZ-UHFFFAOYSA-N 0.000 claims description 2
• GUSQFVHNRHSYPI-UHFFFAOYSA-N 2-chloro-6-methyl-n-[6-[8-[(1-methylbenzotriazol-5-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C5N=NN(C)C5=CC=3)CC4)=CC=C2CC1 GUSQFVHNRHSYPI-UHFFFAOYSA-N 0.000 claims description 2
• GBQKLTQALCDBRK-UHFFFAOYSA-N 2-chloro-6-methyl-n-[6-[8-[(2-methyl-1h-imidazol-5-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1C(C)=NC(CN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5C)Cl)CCC4=CC=3)CC2)=C1 GBQKLTQALCDBRK-UHFFFAOYSA-N 0.000 claims description 2
• AGPGFEUAWMXQHD-MUUNZHRXSA-N 2-chloro-n-[(1r)-5-fluoro-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N([C@@H]1CCC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)F)C(=O)C1=CC=CC=C1Cl AGPGFEUAWMXQHD-MUUNZHRXSA-N 0.000 claims description 2
• LWHOMDKGGGDQRE-MUUNZHRXSA-N 2-chloro-n-[(1r)-5-methyl-6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N([C@@H]1CCC=2C=C(C(=CC=21)C(=O)N1CCC2(CN(CC2)C=2C=CN=CC=2)CC1)C)C(=O)C1=CC=CC=C1Cl LWHOMDKGGGDQRE-MUUNZHRXSA-N 0.000 claims description 2
• MRFXKHMDRDCBRF-GDLZYMKVSA-N 2-chloro-n-[(1r)-5-methyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N([C@@H]1CCC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)C)C(=O)C1=CC=CC=C1Cl MRFXKHMDRDCBRF-GDLZYMKVSA-N 0.000 claims description 2
• YKHSLCIQANQMPE-AREMUKBSSA-N 2-chloro-n-[(1r)-6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CN(CC4)C=4C=CN=CC=4)CC3)=CC=C2CC1 YKHSLCIQANQMPE-AREMUKBSSA-N 0.000 claims description 2
• DDSFPQRRNQKZLD-KWKRFBHOSA-N 2-chloro-n-[(1r)-6-(8-pyridin-3-yl-2-azaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCC(CC4)C=3C=NC=CC=3)=CC=C2CC1 DDSFPQRRNQKZLD-KWKRFBHOSA-N 0.000 claims description 2
• OLDVXEXPFDBOQD-AREMUKBSSA-N 2-chloro-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 OLDVXEXPFDBOQD-AREMUKBSSA-N 0.000 claims description 2
• FPKVIWCZTZRDEO-HHHXNRCGSA-N 2-chloro-n-[(1r)-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(Cl)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 FPKVIWCZTZRDEO-HHHXNRCGSA-N 0.000 claims description 2
• SODQGKJIQOOMSW-MUUNZHRXSA-N 2-chloro-n-[(1r)-6-[8-(2-methylpyridin-4-yl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NC(C)=CC(N2CCC3(CN(CC3)C(=O)C=3C=C4[C@H](NC(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1 SODQGKJIQOOMSW-MUUNZHRXSA-N 0.000 claims description 2
• UBHNCVHDQRKRRT-HHHXNRCGSA-N 2-chloro-n-[(1r)-6-[8-(2-pyrrolidin-1-ylacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C(=O)CN3CCCC3)=CC=C2CC1 UBHNCVHDQRKRRT-HHHXNRCGSA-N 0.000 claims description 2
• SEERBTDVQSXSHJ-GDLZYMKVSA-N 2-chloro-n-[(1r)-6-[9-(1-methylpiperidin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCC1N1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 SEERBTDVQSXSHJ-GDLZYMKVSA-N 0.000 claims description 2
• XHUZWUPKYJFEJD-GDLZYMKVSA-N 2-chloro-n-[(1r)-6-[9-(4-methylpiperazine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCN1C(=O)C1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 XHUZWUPKYJFEJD-GDLZYMKVSA-N 0.000 claims description 2
• ZUOCFTPUNLKYBV-SSEXGKCCSA-N 2-chloro-n-[(1r)-6-[9-[(1-methylpiperidin-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C)CCC1CN1CCC2(CCN(CC2)C(=O)C=2C=C3[C@H](NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 ZUOCFTPUNLKYBV-SSEXGKCCSA-N 0.000 claims description 2
• RFTQUWZOCGJIIL-MUUNZHRXSA-N 2-chloro-n-[(1r)-6-fluoro-7-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound N([C@@H]1CCCC=2C=C(C(=CC=21)C(=O)N1CCC2(CN(CC2)C=2C=CN=CC=2)CC1)F)C(=O)C1=CC=CC=C1Cl RFTQUWZOCGJIIL-MUUNZHRXSA-N 0.000 claims description 2
• HJYANGXEUGJLAT-GDLZYMKVSA-N 2-chloro-n-[(1r)-6-fluoro-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound N([C@@H]1CCCC=2C=C(C(=CC=21)C(=O)N1CCC2(CC1)CCN(CC2)C=1C=CN=CC=1)F)C(=O)C1=CC=CC=C1Cl HJYANGXEUGJLAT-GDLZYMKVSA-N 0.000 claims description 2
• SAWODAKNIXOXJB-ZZTVPSNHSA-N 2-chloro-n-[(1r)-7-(2-pyridin-4-yl-2,7-diazaspiro[4.5]decane-7-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CN(CC4)C=4C=CN=CC=4)CCC3)=CC=C2CCC1 SAWODAKNIXOXJB-ZZTVPSNHSA-N 0.000 claims description 2
• JILLIZVUACPPFN-MUUNZHRXSA-N 2-chloro-n-[(1r)-7-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CCC1 JILLIZVUACPPFN-MUUNZHRXSA-N 0.000 claims description 2
• DTRZSKRRYJQKFQ-ZZTVPSNHSA-N 2-chloro-n-[(1r)-7-(9-pyridin-4-yl-2,9-diazaspiro[4.5]decane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CN(CCC4)C=3C=CN=CC=3)=CC=C2CCC1 DTRZSKRRYJQKFQ-ZZTVPSNHSA-N 0.000 claims description 2
• AAONUHUNIGKDAY-UHFFFAOYSA-N 2-chloro-n-[3-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=NC=CC=3)=CC=C2CCCC1 AAONUHUNIGKDAY-UHFFFAOYSA-N 0.000 claims description 2
• WHBWEBMIYVWWLZ-UHFFFAOYSA-N 2-chloro-n-[3-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]benzamide Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCCCC3=CC=2)CC1 WHBWEBMIYVWWLZ-UHFFFAOYSA-N 0.000 claims description 2
• DTRZKZUVGZQJFW-UHFFFAOYSA-N 2-chloro-n-[3-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]benzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCCCC2NC(=O)C1=CC=CC=C1Cl DTRZKZUVGZQJFW-UHFFFAOYSA-N 0.000 claims description 2
• KYRUJVZPZHYHJJ-UHFFFAOYSA-N 2-chloro-n-[3-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CCCC1 KYRUJVZPZHYHJJ-UHFFFAOYSA-N 0.000 claims description 2
• IDVIKGYVQXHAPT-UHFFFAOYSA-N 2-chloro-n-[6-(9-pyridin-4-yloxy-3-azaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCC(CC4)OC=4C=CN=CC=4)CC3)=CC=C2CC1 IDVIKGYVQXHAPT-UHFFFAOYSA-N 0.000 claims description 2
• IDGSBBKEGFWETD-UHFFFAOYSA-N 2-chloro-n-[6-[2-[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]decan-2-yl]-2-oxoethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(CC(CC)CC)CCC11CN(C(=O)CC=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 IDGSBBKEGFWETD-UHFFFAOYSA-N 0.000 claims description 2
• VLXJWFABQNTKMU-UHFFFAOYSA-N 2-chloro-n-[6-[2-[9-(4-fluorophenyl)-3,9-diazaspiro[5.5]undecan-3-yl]-2-oxoethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(F)=CC=C1N1CCC2(CCN(CC2)C(=O)CC=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VLXJWFABQNTKMU-UHFFFAOYSA-N 0.000 claims description 2
• NJILFOWSLOIXNR-UHFFFAOYSA-N 2-chloro-n-[6-[2-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecan-3-yl]-2-oxoethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)CC(C=C12)=CC=C1CCC2NC(=O)C1=CC=CC=C1Cl NJILFOWSLOIXNR-UHFFFAOYSA-N 0.000 claims description 2
• YNOJONCCTBHQKK-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decan-2-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 YNOJONCCTBHQKK-UHFFFAOYSA-N 0.000 claims description 2
• VUSAGLORJLKSBW-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 VUSAGLORJLKSBW-UHFFFAOYSA-N 0.000 claims description 2
• ORTGNMFGIGMLMZ-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-[8-(quinolin-6-ylmethyl)-2,8-diazaspiro[4.5]decan-2-yl]ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CC4(CC3)CCN(CC=3C=C5C=CC=NC5=CC=3)CC4)=CC=C2CC1 ORTGNMFGIGMLMZ-UHFFFAOYSA-N 0.000 claims description 2
• JXLOKGJYLNLJJS-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-[8-(quinoxalin-6-ylmethyl)-2,8-diazaspiro[4.5]decan-2-yl]ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CC4(CC3)CCN(CC=3C=C5N=CC=NC5=CC=3)CC4)=CC=C2CC1 JXLOKGJYLNLJJS-UHFFFAOYSA-N 0.000 claims description 2
• VCUYERQRBKGPPW-UHFFFAOYSA-N 2-chloro-n-[6-[2-oxo-2-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecan-3-yl]ethyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(CC(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CC1 VCUYERQRBKGPPW-UHFFFAOYSA-N 0.000 claims description 2
• ISUVTIUAAJAIKR-UHFFFAOYSA-N 2-chloro-n-[6-[3-(1-methylindol-4-yl)sulfonyl-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC=C2N(C)C=CC2=C1S(=O)(=O)N(CC1)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC=CC=C1Cl ISUVTIUAAJAIKR-UHFFFAOYSA-N 0.000 claims description 2
• IXRNVVZSIFPUAE-UHFFFAOYSA-N 2-chloro-n-[6-[3-(2,4-difluorophenyl)sulfonyl-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(F)=CC=C1S(=O)(=O)N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 IXRNVVZSIFPUAE-UHFFFAOYSA-N 0.000 claims description 2
• YQSUZMLQZHKYTK-UHFFFAOYSA-N 2-chloro-n-[6-[3-(2-chloro-4-fluorobenzoyl)-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 YQSUZMLQZHKYTK-UHFFFAOYSA-N 0.000 claims description 2
• PLFCXTLCEGNXEW-UHFFFAOYSA-N 2-chloro-n-[6-[3-(2-methylsulfanylpyridine-3-carbonyl)-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CSC1=NC=CC=C1C(=O)N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 PLFCXTLCEGNXEW-UHFFFAOYSA-N 0.000 claims description 2
• AZXMWVYLKVVIAP-UHFFFAOYSA-N 2-chloro-n-[6-[3-(3-cyano-4-fluorophenyl)sulfonyl-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(C#N)C(F)=CC=C1S(=O)(=O)N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 AZXMWVYLKVVIAP-UHFFFAOYSA-N 0.000 claims description 2
• JENNSQVZSMYTMH-UHFFFAOYSA-N 2-chloro-n-[6-[3-(5-chlorothiophen-2-yl)sulfonyl-3,9-diazaspiro[5.5]undecane-9-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound S1C(Cl)=CC=C1S(=O)(=O)N1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 JENNSQVZSMYTMH-UHFFFAOYSA-N 0.000 claims description 2
• FTYHSWHXRBSUTP-UHFFFAOYSA-N 2-chloro-n-[6-[8-(1-oxidopyridin-1-ium-4-yl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C[N+]([O-])=CC=C1N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 FTYHSWHXRBSUTP-UHFFFAOYSA-N 0.000 claims description 2
• IDXLCKLPYTWFQO-UHFFFAOYSA-N 2-chloro-n-[6-[8-(1h-imidazol-5-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC=2N=CNC=2)CC3)=C1 IDXLCKLPYTWFQO-UHFFFAOYSA-N 0.000 claims description 2
• UWBILZQVAYQGEQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-chloro-4-fluorobenzoyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1C(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 UWBILZQVAYQGEQ-UHFFFAOYSA-N 0.000 claims description 2
• XFXFROPUEVEUER-UHFFFAOYSA-N 2-chloro-n-[6-[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound C1CN(CC(CC)CC)CCC11CN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 XFXFROPUEVEUER-UHFFFAOYSA-N 0.000 claims description 2
• PSXAJQOXXULQPO-UHFFFAOYSA-N 2-chloro-n-[6-[8-(3-cyano-4-fluorophenyl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound C1=C(C#N)C(F)=CC=C1S(=O)(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 PSXAJQOXXULQPO-UHFFFAOYSA-N 0.000 claims description 2
• BEJBXZPNVQNTES-UHFFFAOYSA-N 2-chloro-n-[6-[8-(5-chlorothiophen-2-yl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound S1C(Cl)=CC=C1S(=O)(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 BEJBXZPNVQNTES-UHFFFAOYSA-N 0.000 claims description 2
• NHIYZCSMNHPDLJ-UHFFFAOYSA-N 2-chloro-n-[6-[8-(cyclopropanecarbonyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC2)C(=O)C1CC1)C1CC1 NHIYZCSMNHPDLJ-UHFFFAOYSA-N 0.000 claims description 2
• QISLRDQMXKGXMK-UHFFFAOYSA-N 2-chloro-n-[6-[8-(cyclopropanecarbonyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C(=O)C1CC1 QISLRDQMXKGXMK-UHFFFAOYSA-N 0.000 claims description 2
• QMXOWUAUCRLZFA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1,3,5-trimethylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NN(C)C(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 QMXOWUAUCRLZFA-UHFFFAOYSA-N 0.000 claims description 2
• KEUHWFAJNGFKDV-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1,5-dimethylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KEUHWFAJNGFKDV-UHFFFAOYSA-N 0.000 claims description 2
• KTZNXQZHJVMBKR-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KTZNXQZHJVMBKR-UHFFFAOYSA-N 0.000 claims description 2
• ACDDPIVNTMDUSF-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 ACDDPIVNTMDUSF-UHFFFAOYSA-N 0.000 claims description 2
• KAQKTRNDGKJDJA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-ethyl-3-methylpyrazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NN(CC)C=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 KAQKTRNDGKJDJA-UHFFFAOYSA-N 0.000 claims description 2
• SEYQZOPGPVGLBR-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(1-methylbenzotriazol-5-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C=1C=C2N(C)N=NC2=CC=1CN(CC1)CCC1(C1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC(C(F)(F)F)=CC=C1Cl SEYQZOPGPVGLBR-UHFFFAOYSA-N 0.000 claims description 2
• BLAPQUBFVSDZRZ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 BLAPQUBFVSDZRZ-UHFFFAOYSA-N 0.000 claims description 2
• RWHVRYUAMGSFGP-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=C(F)C=C1F RWHVRYUAMGSFGP-UHFFFAOYSA-N 0.000 claims description 2
• QVQCNUPWSYFDHT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,5-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC(F)=CC=C1F QVQCNUPWSYFDHT-UHFFFAOYSA-N 0.000 claims description 2
• CMAJLBYPGHFYNK-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,5-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1 CMAJLBYPGHFYNK-UHFFFAOYSA-N 0.000 claims description 2
• GNVVRPJGCIIFGR-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2,6-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 GNVVRPJGCIIFGR-UHFFFAOYSA-N 0.000 claims description 2
• QNHPDRQPJQRXAT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=C(F)C=CC=C1Cl QNHPDRQPJQRXAT-UHFFFAOYSA-N 0.000 claims description 2
• WSMQQZQPZJWDJL-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-chloro-6-fluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 WSMQQZQPZJWDJL-UHFFFAOYSA-N 0.000 claims description 2
• MFTKPYJJRXVHBP-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC=2C(=CC=CC=2)C#N)CC3)=C1 MFTKPYJJRXVHBP-UHFFFAOYSA-N 0.000 claims description 2
• RTWDRMSGIIPXLX-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3)C#N)CC4)=CC=C2CC1 RTWDRMSGIIPXLX-UHFFFAOYSA-N 0.000 claims description 2
• KXKUNRPLBQLRPM-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3)C#N)CC4)=CC=C2CC1 KXKUNRPLBQLRPM-UHFFFAOYSA-N 0.000 claims description 2
• JIZFIBVKKVVFEX-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC=1C(=CC=CC=1)C#N)CC2)C1CC1 JIZFIBVKKVVFEX-UHFFFAOYSA-N 0.000 claims description 2
• WWEFPTACAFJRIW-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC=C1C#N WWEFPTACAFJRIW-UHFFFAOYSA-N 0.000 claims description 2
• DRNUFAYPLODLDD-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C(=CC=CC=3)C#N)CC4)=CC=C2CC1 DRNUFAYPLODLDD-UHFFFAOYSA-N 0.000 claims description 2
• RIBJDBWWVZQCQZ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-fluoro-6-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 RIBJDBWWVZQCQZ-UHFFFAOYSA-N 0.000 claims description 2
• BQIOOPBSRUSAIT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(2-methyl-1h-imidazol-5-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1C(C)=NC(CN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1 BQIOOPBSRUSAIT-UHFFFAOYSA-N 0.000 claims description 2
• PIKSYGFMRVLXNS-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,4-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 PIKSYGFMRVLXNS-UHFFFAOYSA-N 0.000 claims description 2
• NYCBRXLIQNRVRW-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 NYCBRXLIQNRVRW-UHFFFAOYSA-N 0.000 claims description 2
• KNVDMXGAAQUZLV-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KNVDMXGAAQUZLV-UHFFFAOYSA-N 0.000 claims description 2
• ODPIRKHWVWIIQD-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 ODPIRKHWVWIIQD-UHFFFAOYSA-N 0.000 claims description 2
• KNLXTMBYPCQELD-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 KNLXTMBYPCQELD-UHFFFAOYSA-N 0.000 claims description 2
• UMEDUUTYQJQICI-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CC3(CC2)CCN(CC=2C=C(C=CC=2)C#N)CC3)=C1 UMEDUUTYQJQICI-UHFFFAOYSA-N 0.000 claims description 2
• WJWCOZQCKZJPJG-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=C(C=CC=3)C#N)CC4)=CC=C2CC1 WJWCOZQCKZJPJG-UHFFFAOYSA-N 0.000 claims description 2
• QHJGEEGCFLCCQC-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC(C#N)=C1 QHJGEEGCFLCCQC-UHFFFAOYSA-N 0.000 claims description 2
• XDZATKCFFRBAAN-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-fluoro-4-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 XDZATKCFFRBAAN-UHFFFAOYSA-N 0.000 claims description 2
• DUQNZIVUFRHCOQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-fluoro-4-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 DUQNZIVUFRHCOQ-UHFFFAOYSA-N 0.000 claims description 2
• PKNRNKIIFMBQDW-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(3-fluoro-4-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 PKNRNKIIFMBQDW-UHFFFAOYSA-N 0.000 claims description 2
• CPWUJFCGFLRLCK-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=CC(=CC=3)C#N)CC4)=CC=C2CC1 CPWUJFCGFLRLCK-UHFFFAOYSA-N 0.000 claims description 2
• WYDPAWFWDSOUGA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-cyclopropylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CC2(CC1)CCN(CC=1C=CC(=CC=1)C#N)CC2)C1CC1 WYDPAWFWDSOUGA-UHFFFAOYSA-N 0.000 claims description 2
• BBLVKJXCSPBIED-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(4-cyanophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3C=CC(=CC=3)C#N)CC4)=CC=C2CC1 BBLVKJXCSPBIED-UHFFFAOYSA-N 0.000 claims description 2
• QDGYKHXFPRGSHQ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[(5-methyl-1h-imidazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1=CNC(CN2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1C QDGYKHXFPRGSHQ-UHFFFAOYSA-N 0.000 claims description 2
• DOMBAZHMTAIQOK-UHFFFAOYSA-N 2-chloro-n-[6-[8-[2-(4-chlorophenyl)acetyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C(=O)CC1=CC=C(Cl)C=C1 DOMBAZHMTAIQOK-UHFFFAOYSA-N 0.000 claims description 2
• FXMNQCFYTOVWHH-UHFFFAOYSA-N 2-chloro-n-[6-[8-[2-(4-chlorophenyl)acetyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(Cl)=CC=C1CC(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 FXMNQCFYTOVWHH-UHFFFAOYSA-N 0.000 claims description 2
• GAWVVTACODHCOY-UHFFFAOYSA-N 2-chloro-n-[6-[8-[2-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NC(C(F)(F)F)=CC(N2CCC3(CN(CC3)C(=O)C=3C=C4C(NC(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1 GAWVVTACODHCOY-UHFFFAOYSA-N 0.000 claims description 2
• QEKBDEZQJMTMAM-UHFFFAOYSA-N 2-chloro-n-[6-[8-[3-(4-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=CC(F)=CC=C1CCCN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 QEKBDEZQJMTMAM-UHFFFAOYSA-N 0.000 claims description 2
• DLLOIXLKIGHPGC-UHFFFAOYSA-N 2-chloro-n-[6-[8-[3-(4-fluorophenyl)propyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound CC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CCCC=3C=CC(F)=CC=3)CC4)=CC=C2CC1 DLLOIXLKIGHPGC-UHFFFAOYSA-N 0.000 claims description 2
• QTNQHQXKZCQIQU-UHFFFAOYSA-N 2-chloro-n-[6-[8-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 QTNQHQXKZCQIQU-UHFFFAOYSA-N 0.000 claims description 2
• VTFFNQKRJXSEMG-UHFFFAOYSA-N 2-chloro-n-[6-[8-[5-(trifluoromethyl)pyridin-2-yl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1=CC(C(F)(F)F)=CC=C1N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VTFFNQKRJXSEMG-UHFFFAOYSA-N 0.000 claims description 2
• DMOUFMQWGQIXQA-UHFFFAOYSA-N 2-chloro-n-[6-[8-[5-(trifluoromethyl)pyrimidin-2-yl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1=CC(C(F)(F)F)=CN=C1N1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 DMOUFMQWGQIXQA-UHFFFAOYSA-N 0.000 claims description 2
• RNAUKHYNJPWTBL-UHFFFAOYSA-N 2-chloro-n-[6-[8-[8-(trifluoromethyl)quinolin-4-yl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=CN=C2C(C(F)(F)F)=CC=CC2=C1N(CC1)CCC1(C1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC=CC=C1Cl RNAUKHYNJPWTBL-UHFFFAOYSA-N 0.000 claims description 2
• MXSDOXPVLNONHS-UHFFFAOYSA-N 2-chloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 MXSDOXPVLNONHS-UHFFFAOYSA-N 0.000 claims description 2
• RTLAZLHBTAENEZ-UHFFFAOYSA-N 2-chloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 RTLAZLHBTAENEZ-UHFFFAOYSA-N 0.000 claims description 2
• BSLHFTUTFKYYBE-UHFFFAOYSA-N 2-chloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-methylbenzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4C)Cl)CCC3=CC=2)CC1 BSLHFTUTFKYYBE-UHFFFAOYSA-N 0.000 claims description 2
• KLWMMZQKFKDTFT-UHFFFAOYSA-N 2-chloro-n-[6-[8-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 KLWMMZQKFKDTFT-UHFFFAOYSA-N 0.000 claims description 2
• UXVYQBPXEKQQCP-UHFFFAOYSA-N 2-chloro-n-[6-[9-(1h-imidazol-5-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4N=CNC=4)CC3)CC2)=C1 UXVYQBPXEKQQCP-UHFFFAOYSA-N 0.000 claims description 2
• AGAOUSRCIYEXJV-UHFFFAOYSA-N 2-chloro-n-[6-[9-(1h-imidazol-5-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=CNC=5)CC4)CC3)=CC=C2CC1 AGAOUSRCIYEXJV-UHFFFAOYSA-N 0.000 claims description 2
• ONOJUAMPPFGUQZ-UHFFFAOYSA-N 2-chloro-n-[6-[9-(1h-pyrrol-2-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4NC=CC=4)CC3)CC2)=C1 ONOJUAMPPFGUQZ-UHFFFAOYSA-N 0.000 claims description 2
• CSKLCBNEXJPQME-UHFFFAOYSA-N 2-chloro-n-[6-[9-(1h-pyrrol-2-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5NC=CC=5)CC4)CC3)=CC=C2CC1 CSKLCBNEXJPQME-UHFFFAOYSA-N 0.000 claims description 2
• CXOLDKOYFWOFIU-UHFFFAOYSA-N 2-chloro-n-[6-[9-(2-imidazol-1-ylethoxy)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCC(CC4)OCCN4C=NC=C4)CC3)=CC=C2CC1 CXOLDKOYFWOFIU-UHFFFAOYSA-N 0.000 claims description 2
• XFYVESGXVMEJGL-UHFFFAOYSA-N 2-chloro-n-[6-[9-(2-phenylethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CCC=4C=CC=CC=4)CC3)CC2)=C1 XFYVESGXVMEJGL-UHFFFAOYSA-N 0.000 claims description 2
• FLNUZFWIIPJIHP-UHFFFAOYSA-N 2-chloro-n-[6-[9-(3,3-difluoroazetidin-1-yl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1C(F)(F)CN1C1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 FLNUZFWIIPJIHP-UHFFFAOYSA-N 0.000 claims description 2
• KYERXPLCPXAXCT-UHFFFAOYSA-N 2-chloro-n-[6-[9-(cyclopropanecarbonyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC4)C(=O)C4CC4)CC3)=CC=C2CC1 KYERXPLCPXAXCT-UHFFFAOYSA-N 0.000 claims description 2
• BJLRFRSLVZRWRO-UHFFFAOYSA-N 2-chloro-n-[6-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-n-methylbenzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2N(C)C(=O)C1=CC=CC=C1Cl BJLRFRSLVZRWRO-UHFFFAOYSA-N 0.000 claims description 2
• LGYZMKPITPZMEY-UHFFFAOYSA-N 2-chloro-n-[6-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC=CC=C1Cl LGYZMKPITPZMEY-UHFFFAOYSA-N 0.000 claims description 2
• FWOGKERFEFZMFG-UHFFFAOYSA-N 2-chloro-n-[6-[9-(thiadiazol-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4N=NSC=4)CC3)CC2)=C1 FWOGKERFEFZMFG-UHFFFAOYSA-N 0.000 claims description 2
• GEOMISPXWCBBBP-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1,5-dimethylpyrazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 GEOMISPXWCBBBP-UHFFFAOYSA-N 0.000 claims description 2
• FCGGQGOMROPUMK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1,5-dimethylpyrazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 FCGGQGOMROPUMK-UHFFFAOYSA-N 0.000 claims description 2
• YSYOAPQOJCPYGR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1,5-dimethylpyrazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=NN(C)C(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 YSYOAPQOJCPYGR-UHFFFAOYSA-N 0.000 claims description 2
• QSODMUPBRNGNET-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1-methylbenzotriazol-5-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C=1C=C2N(C)N=NC2=CC=1CN(CC1)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2NC(=O)C1=CC(C(F)(F)F)=CC=C1Cl QSODMUPBRNGNET-UHFFFAOYSA-N 0.000 claims description 2
• JNTKWQBYEZLIDP-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1-methylpyrrol-2-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound CN1C=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 JNTKWQBYEZLIDP-UHFFFAOYSA-N 0.000 claims description 2
• BWADYVXYSDNLJK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(1-methylpyrrol-2-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CN1C=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 BWADYVXYSDNLJK-UHFFFAOYSA-N 0.000 claims description 2
• JAGHSAKFVXVVJI-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 JAGHSAKFVXVVJI-UHFFFAOYSA-N 0.000 claims description 2
• PAERKRVDZKMNAN-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,5-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)=C1 PAERKRVDZKMNAN-UHFFFAOYSA-N 0.000 claims description 2
• HRVMUJORPYLNRX-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,5-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)=C1 HRVMUJORPYLNRX-UHFFFAOYSA-N 0.000 claims description 2
• IRDQPFRXQBGAEK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,6-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 IRDQPFRXQBGAEK-UHFFFAOYSA-N 0.000 claims description 2
• FRGJXBJGOVEPDR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,6-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 FRGJXBJGOVEPDR-UHFFFAOYSA-N 0.000 claims description 2
• DATXJXZLAOVDCE-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2,6-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 DATXJXZLAOVDCE-UHFFFAOYSA-N 0.000 claims description 2
• GYYFXYAYXMRTQU-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 GYYFXYAYXMRTQU-UHFFFAOYSA-N 0.000 claims description 2
• VHNJBTSDADSQOQ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-4-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VHNJBTSDADSQOQ-UHFFFAOYSA-N 0.000 claims description 2
• SEZSEJULXJMNLZ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-6-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 SEZSEJULXJMNLZ-UHFFFAOYSA-N 0.000 claims description 2
• LTWSNNOUQSETQK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-chloro-6-fluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(Cl)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 LTWSNNOUQSETQK-UHFFFAOYSA-N 0.000 claims description 2
• UEGLCMGUZYDKBK-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)C#N)CC3)CC2)=C1 UEGLCMGUZYDKBK-UHFFFAOYSA-N 0.000 claims description 2
• VUAZYJCKTSDMKD-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C(=CC=CC=5)C#N)CC4)CC3)=CC=C2CC1 VUAZYJCKTSDMKD-UHFFFAOYSA-N 0.000 claims description 2
• YCLDEUWZSLJLPT-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C(=CC=CC=5)C#N)CC4)CC3)=CC=C2CC1 YCLDEUWZSLJLPT-UHFFFAOYSA-N 0.000 claims description 2
• QOPBTPQOIRIKOP-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 QOPBTPQOIRIKOP-UHFFFAOYSA-N 0.000 claims description 2
• SIXPLPIAJCPBGG-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-fluoro-6-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 SIXPLPIAJCPBGG-UHFFFAOYSA-N 0.000 claims description 2
• ZEEABJWQOPSQRX-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-methyl-1h-imidazol-5-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound N1C(C)=NC(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)=C1 ZEEABJWQOPSQRX-UHFFFAOYSA-N 0.000 claims description 2
• UDAMQPWTNMUZGB-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(2-methyl-1h-imidazol-5-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound N1C(C)=NC(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)=C1 UDAMQPWTNMUZGB-UHFFFAOYSA-N 0.000 claims description 2
• UUWGGRMORPJQBR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 UUWGGRMORPJQBR-UHFFFAOYSA-N 0.000 claims description 2
• JOICRRJODWSPJB-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,4-difluorophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(F)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 JOICRRJODWSPJB-UHFFFAOYSA-N 0.000 claims description 2
• MUUWBNHXLNFOHY-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 MUUWBNHXLNFOHY-UHFFFAOYSA-N 0.000 claims description 2
• JSBMCJPDWDVKKO-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound CC1=NOC(C)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 JSBMCJPDWDVKKO-UHFFFAOYSA-N 0.000 claims description 2
• UTSSEJMBPZWBRW-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=C(C=CC=4)C#N)CC3)CC2)=C1 UTSSEJMBPZWBRW-UHFFFAOYSA-N 0.000 claims description 2
• XQFPVUJEPZAOJJ-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-6-fluorobenzamide Chemical compound FC1=CC=CC(Cl)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C(C=CC=5)C#N)CC4)CC3)=CC=C2CC1 XQFPVUJEPZAOJJ-UHFFFAOYSA-N 0.000 claims description 2
• XMAPLXPDEAIVOC-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C(C=CC=5)C#N)CC4)CC3)=CC=C2CC1 XMAPLXPDEAIVOC-UHFFFAOYSA-N 0.000 claims description 2
• ALDMLYHFOJUZDL-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(3-methylimidazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CN1C=NC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 ALDMLYHFOJUZDL-UHFFFAOYSA-N 0.000 claims description 2
• HOJHLNAVOVSPAF-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(4-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(C(=O)NC2C3=CC(=CC=C3CC2)C(=O)N2CCC3(CCN(CC=4C=CC(=CC=4)C#N)CC3)CC2)=C1 HOJHLNAVOVSPAF-UHFFFAOYSA-N 0.000 claims description 2
• UNEKRRJXVMSNDR-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(4-cyanophenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CC(=CC=5)C#N)CC4)CC3)=CC=C2CC1 UNEKRRJXVMSNDR-UHFFFAOYSA-N 0.000 claims description 2
• QPYUCDFBSPNRAL-UHFFFAOYSA-N 2-chloro-n-[6-[9-[(5-methyl-1h-imidazol-4-yl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound N1=CNC(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)=C1C QPYUCDFBSPNRAL-UHFFFAOYSA-N 0.000 claims description 2
• DVGJWDPMXUBMSU-UHFFFAOYSA-N 2-chloro-n-[6-[9-[[2-(dimethylamino)pyrimidin-5-yl]methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1=NC(N(C)C)=NC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=C(C=4)C(F)(F)F)Cl)CCC3=CC=2)CC1 DVGJWDPMXUBMSU-UHFFFAOYSA-N 0.000 claims description 2
• MFTZTSCFMOBJHD-UHFFFAOYSA-N 2-chloro-n-[[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 MFTZTSCFMOBJHD-UHFFFAOYSA-N 0.000 claims description 2
• WOIBDCRRJNNSJF-UHFFFAOYSA-N 2-chloro-n-[[6-(9-pyridin-3-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=NC=CC=3)=CC=C2CC1 WOIBDCRRJNNSJF-UHFFFAOYSA-N 0.000 claims description 2
• LZAUNINLGXNSSA-UHFFFAOYSA-N 2-chloro-n-[[6-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2CNC(=O)C1=CC=CC=C1Cl LZAUNINLGXNSSA-UHFFFAOYSA-N 0.000 claims description 2
• AINHXWAFTKQTPX-UHFFFAOYSA-N 2-chloro-n-[[6-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]methyl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CC1 AINHXWAFTKQTPX-UHFFFAOYSA-N 0.000 claims description 2
• JLXDIBBAOXADRL-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-(1-methylindol-5-yl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=C2N(C)C=CC2=CC=1S(=O)(=O)N(CC1)CCC1(C1)CCN1C(=O)C(C=C12)=CC=C1CCC2N(C(=O)C=1C(=CC=CC=1)Cl)C1CC1 JLXDIBBAOXADRL-UHFFFAOYSA-N 0.000 claims description 2
• VOLOPFBOZLAFAB-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-(2,4-difluorophenyl)sulfonyl-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(F)=CC=C1S(=O)(=O)N1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 VOLOPFBOZLAFAB-UHFFFAOYSA-N 0.000 claims description 2
• YZTDHRZFVVZYNS-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(C(=O)CC(C)(C)C)CCC11CN(C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 YZTDHRZFVVZYNS-UHFFFAOYSA-N 0.000 claims description 2
• OLILGAKUBLKYGC-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-[(2,5-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(F)C(CN2CCC3(CN(CC3)C(=O)C=3C=C4C(N(C5CC5)C(=O)C=5C(=CC=CC=5)Cl)CCC4=CC=3)CC2)=C1 OLILGAKUBLKYGC-UHFFFAOYSA-N 0.000 claims description 2
• YXYBPHAXQIYCQP-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-[(2,6-difluorophenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=CC(F)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 YXYBPHAXQIYCQP-UHFFFAOYSA-N 0.000 claims description 2
• RTFGGVDWYAFLMC-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-[(2-fluoro-6-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound COC1=CC=CC(F)=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 RTFGGVDWYAFLMC-UHFFFAOYSA-N 0.000 claims description 2
• BRWZBMQEYBVOKQ-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-[(3-fluoro-4-methoxyphenyl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 BRWZBMQEYBVOKQ-UHFFFAOYSA-N 0.000 claims description 2
• QXEBEPNBFCVMDB-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[8-[(3-methylimidazol-4-yl)methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CN1C=NC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C(N(C4CC4)C(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 QXEBEPNBFCVMDB-UHFFFAOYSA-N 0.000 claims description 2
• UASKIPLSKAIJLM-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[9-(dimethylamino)-9-(4-fluorophenyl)-3-azaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CC(N(C)C)(C=2C=CC(F)=CC=2)CCC1(CC1)CCN1C(=O)C(C=C12)=CC=C1CCC2N(C(=O)C=1C(=CC=CC=1)Cl)C1CC1 UASKIPLSKAIJLM-UHFFFAOYSA-N 0.000 claims description 2
• GLUDEHIBXPFKBL-UHFFFAOYSA-N 2-chloro-n-cyclopropyl-n-[6-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N(C1C2=CC(=CC=C2CC1)C(=O)N1CCC2(CCN(CC=3C=CN=CC=3)CC2)CC1)C1CC1 GLUDEHIBXPFKBL-UHFFFAOYSA-N 0.000 claims description 2
• HCUSMOPSKKEZDC-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(2-pyridin-4-yl-2,8-diazaspiro[4.5]decane-8-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(C1)CCN1C1=CC=NC=C1 HCUSMOPSKKEZDC-UHFFFAOYSA-N 0.000 claims description 2
• ABFRCLHBJCWJOG-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(C1)CCC1(CC1)CCN1C1=CC=NC=C1 ABFRCLHBJCWJOG-UHFFFAOYSA-N 0.000 claims description 2
• UBPKPBJPPCLCPY-UHFFFAOYSA-N 2-chloro-n-methyl-n-[6-[8-(quinoxalin-6-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CC2=CC=C(C(=O)N3CC4(CC3)CCN(CC=3C=C5N=CC=NC5=CC=3)CC4)C=C2C1N(C)C(=O)C1=CC=CC=C1Cl UBPKPBJPPCLCPY-UHFFFAOYSA-N 0.000 claims description 2
• GSXAPVVCYORKTL-MUUNZHRXSA-N 2-fluoro-4-methoxy-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC(OC)=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 GSXAPVVCYORKTL-MUUNZHRXSA-N 0.000 claims description 2
• MYZDRBMSJHZOKM-AREMUKBSSA-N 2-fluoro-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]-6-(trifluoromethyl)benzamide Chemical compound FC1=CC=CC(C(F)(F)F)=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 MYZDRBMSJHZOKM-AREMUKBSSA-N 0.000 claims description 2
• 125000004011 3 membered carbocyclic group Chemical group 0.000 claims description 2
• SHCUCTXWNGSJIV-UHFFFAOYSA-N 3-[(2-chlorophenyl)methyl]-1-methyl-1-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]urea Chemical compound C=1C=CC=C(Cl)C=1CNC(=O)N(C)C(C1=C2)CCC1=CC=C2C(=O)N(CC1)CCC1(CC1)CCN1C1=CC=NC=C1 SHCUCTXWNGSJIV-UHFFFAOYSA-N 0.000 claims description 2
• 125000001845 4 membered carbocyclic group Chemical group 0.000 claims description 2
• VOENDUZAQWUFLG-UHFFFAOYSA-N 4-methoxy-2,6-dimethyl-n-[6-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CC1 VOENDUZAQWUFLG-UHFFFAOYSA-N 0.000 claims description 2
• HTOHCSFBBNBKIF-GDLZYMKVSA-N 4-methoxy-2-methyl-n-[(1r)-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 HTOHCSFBBNBKIF-GDLZYMKVSA-N 0.000 claims description 2
• STTDEQQYJJTWMW-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound CC1=CC(OC)=CC(C)=C1C(=O)N(C)C1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CC1 STTDEQQYJJTWMW-UHFFFAOYSA-N 0.000 claims description 2
• 125000001054 5 membered carbocyclic group Chemical group 0.000 claims description 2
• DWHJRMYGRMPIIC-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[8-(1h-pyrrol-2-ylmethyl)-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCN(CC=3NC=CC=3)CC4)=CC=C2CC1 DWHJRMYGRMPIIC-UHFFFAOYSA-N 0.000 claims description 2
• NBCMDPSMZQOMFJ-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(1h-imidazol-5-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=CNC=5)CC4)CC3)=CC=C2CC1 NBCMDPSMZQOMFJ-UHFFFAOYSA-N 0.000 claims description 2
• XFJQLTJFOBKYDG-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(pyridin-2-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=CC=CC=5)CC4)CC3)=CC=C2CC1 XFJQLTJFOBKYDG-UHFFFAOYSA-N 0.000 claims description 2
• FDOUADNVOGQBFO-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(pyridin-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=CN=CC=5)CC4)CC3)=CC=C2CC1 FDOUADNVOGQBFO-UHFFFAOYSA-N 0.000 claims description 2
• OVBSIXKGGYZINS-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(quinolin-6-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C6C=CC=NC6=CC=5)CC4)CC3)=CC=C2CC1 OVBSIXKGGYZINS-UHFFFAOYSA-N 0.000 claims description 2
• GHGZHQZYEUODBQ-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(quinoxalin-6-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5C=C6N=CC=NC6=CC=5)CC4)CC3)=CC=C2CC1 GHGZHQZYEUODBQ-UHFFFAOYSA-N 0.000 claims description 2
• WUVVQNRNDLCWGI-UHFFFAOYSA-N 5-chloro-2-fluoro-n-[6-[9-(thiadiazol-4-ylmethyl)-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound FC1=CC=C(Cl)C=C1C(=O)NC1C2=CC(C(=O)N3CCC4(CCN(CC=5N=NSC=5)CC4)CC3)=CC=C2CC1 WUVVQNRNDLCWGI-UHFFFAOYSA-N 0.000 claims description 2
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• KDDUEAYZNUJICJ-UHFFFAOYSA-N 2-chloro-6-fluoro-n-[6-[9-[(3-fluoro-4-methoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1=C(F)C(OC)=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4F)Cl)CCC3=CC=2)CC1 KDDUEAYZNUJICJ-UHFFFAOYSA-N 0.000 claims 1
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• CPEHUUXOEHGQPZ-RUZDIDTESA-N 2-chloro-n-[(1r)-6-(spiro[1h-furo[3,4-c]pyridine-3,4'-piperidine]-1'-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)C3=CN=CC=C3CO4)=CC=C2CC1 CPEHUUXOEHGQPZ-RUZDIDTESA-N 0.000 claims 1
• UYGFTQVWPIHHRZ-HHHXNRCGSA-N 2-chloro-n-[(1r)-7-(7-pyridin-4-yl-2,7-diazaspiro[3.5]nonane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(C3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CCC1 UYGFTQVWPIHHRZ-HHHXNRCGSA-N 0.000 claims 1
• ZDUBJLQSVKJNCK-UYEDPJPISA-N 2-chloro-n-[(1r)-7-(8-pyridin-4-yl-2,8-diazaspiro[5.5]undecane-2-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CC4(CN(CCC4)C=4C=CN=CC=4)CCC3)=CC=C2CCC1 ZDUBJLQSVKJNCK-UYEDPJPISA-N 0.000 claims 1
• LBZGBKJRJUGNRO-GDLZYMKVSA-N 2-chloro-n-[(1r)-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)N[C@H]1C2=CC(C(=O)N3CCC4(CC3)CCN(CC4)C=3C=CN=CC=3)=CC=C2CCC1 LBZGBKJRJUGNRO-GDLZYMKVSA-N 0.000 claims 1
• NWTFLUOVUJLUHQ-UHFFFAOYSA-N 2-chloro-n-[6-(3-propan-2-ylsulfonyl-3,9-diazaspiro[5.5]undecane-9-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound C1CN(S(=O)(=O)C(C)C)CCC11CCN(C(=O)C=2C=C3C(NC(=O)C=4C(=CC=CC=4)Cl)CCC3=CC=2)CC1 NWTFLUOVUJLUHQ-UHFFFAOYSA-N 0.000 claims 1
• LYMPTALDKDKHHJ-UHFFFAOYSA-N 2-chloro-n-[6-(8-pyridin-4-yl-2-azaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1h-inden-1-yl]benzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C2=CC(C(=O)N3CC4(CC3)CCC(CC4)C=3C=CN=CC=3)=CC=C2CC1 LYMPTALDKDKHHJ-UHFFFAOYSA-N 0.000 claims 1
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