RU2011116181A - Составы и способы лечения заболеваний и нарушений, связанных с передачей сигналов цитокинами - Google Patents

Составы и способы лечения заболеваний и нарушений, связанных с передачей сигналов цитокинами Download PDF

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RU2011116181A
RU2011116181A RU2011116181/10A RU2011116181A RU2011116181A RU 2011116181 A RU2011116181 A RU 2011116181A RU 2011116181/10 A RU2011116181/10 A RU 2011116181/10A RU 2011116181 A RU2011116181 A RU 2011116181A RU 2011116181 A RU2011116181 A RU 2011116181A
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antibody
hybridoma
antagonist
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Ивонне ЧЭНЬ (US)
Ивонне ЧЭНЬ
Анан ЧУНТАРАПАИ (US)
Анан ЧУНТАРАПАИ
Димитрий ДАНИЛЕНКО (US)
Димитрий ДАНИЛЕНКО
Вэньцзюнь ОУЯН (US)
Вэньцзюнь ОУЯН
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Сьюзан СА
Патрисия ВАЛДЕЗ (US)
Патрисия ВАЛДЕЗ
Цзяньфенг У (US)
Цзяньфенг У
Ян ЧЖЕН (US)
Ян ЧЖЕН
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Дженентек, Инк. (Us)
Дженентек, Инк.
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Abstract

1. Применение антагониста IL-22 для приготовления фармацевтической композиции, содержащей эффективное количество антагониста IL-22, для ослабления нарушения, характеризующегося воспалением кожи. ! 2. Применение по п.1, где воспаление кожи вызвано IL-23. ! 3. Применение по п.1, где нарушение дополнительно характеризуется гиперпролиферацией кератиноцитов. ! 4. Применение по п.3, где гиперпролиферация вызвана IL-23. ! 5. Применение по п.4, где гиперпролиферация включает эпидермальный акантоз. ! 6. Применение по п.5, где эпидермальный акантоз вызван IL-23. ! 7. Применение по любому из пп.2, 4 и 6, где индукция IL-23 характеризуется стимуляцией IL-23-опосредованного пути передачи сигнала. ! 8. Применение по любому из пп.2, 4 и 6, где индукция IL-23 характеризуется стимуляцией функции ThIL-17 клетки, опосредованной IL-23. ! 9. Применение по любому из пп.1-6, где нарушение характеризуется симптомами псориаза. !10. Применение по любому из пп.1-6, где нарушение представляет собой псориаз. ! 11. Применение по п.1, где антагонист IL-22 представляет собой антитело, которое специфически связывается с IL-22. ! 12. Применение по п.11, где антитело представляет собой ! (a) антитело, продуцируемое гибридомой, выбранной из группы, состоящей из гибридомы 3F11.3 (№ доступа ATCC PTA-7312), гибридомы 11H4.4 (№ доступа ATCC PTA-7315) и гибридомы 8E11.9 (№ доступа ATCC PTA-7319); ! (b) аффинно-зрелую форму антитела из (a); ! (c) антигенсвязывающий фрагмент антитела из (a) или (b); или ! (d) гуманизированную форму антитела из (a), (b) или (c). ! 13. Применение по п.1, где антагонист IL-22 представляет собой антитело, которое специфически связывается с IL-22. ! 14. Применение по п.13, где антитело представляет собой ! (a) антитело, продуцируемое гибридом�

Claims (17)

1. Применение антагониста IL-22 для приготовления фармацевтической композиции, содержащей эффективное количество антагониста IL-22, для ослабления нарушения, характеризующегося воспалением кожи.
2. Применение по п.1, где воспаление кожи вызвано IL-23.
3. Применение по п.1, где нарушение дополнительно характеризуется гиперпролиферацией кератиноцитов.
4. Применение по п.3, где гиперпролиферация вызвана IL-23.
5. Применение по п.4, где гиперпролиферация включает эпидермальный акантоз.
6. Применение по п.5, где эпидермальный акантоз вызван IL-23.
7. Применение по любому из пп.2, 4 и 6, где индукция IL-23 характеризуется стимуляцией IL-23-опосредованного пути передачи сигнала.
8. Применение по любому из пп.2, 4 и 6, где индукция IL-23 характеризуется стимуляцией функции ThIL-17 клетки, опосредованной IL-23.
9. Применение по любому из пп.1-6, где нарушение характеризуется симптомами псориаза.
10. Применение по любому из пп.1-6, где нарушение представляет собой псориаз.
11. Применение по п.1, где антагонист IL-22 представляет собой антитело, которое специфически связывается с IL-22.
12. Применение по п.11, где антитело представляет собой
(a) антитело, продуцируемое гибридомой, выбранной из группы, состоящей из гибридомы 3F11.3 (№ доступа ATCC PTA-7312), гибридомы 11H4.4 (№ доступа ATCC PTA-7315) и гибридомы 8E11.9 (№ доступа ATCC PTA-7319);
(b) аффинно-зрелую форму антитела из (a);
(c) антигенсвязывающий фрагмент антитела из (a) или (b); или
(d) гуманизированную форму антитела из (a), (b) или (c).
13. Применение по п.1, где антагонист IL-22 представляет собой антитело, которое специфически связывается с IL-22.
14. Применение по п.13, где антитело представляет собой
(a) антитело, продуцируемое гибридомой, выбранной из группы, состоящей из гибридомы 7Е9 (№ доступа ATCC PTA-7313), гибридомы 8А12 (№ доступа ATCC PTA-7318) и гибридомы 8Н11 (№ доступа ATCC PTA-7317);
(b) аффинно-зрелую форму антитела из (a);
(c) антигенсвязывающий фрагмент антитела из (a) или (b); или
(d) гуманизированную форму антитела из (a), (b) или (c).
15. Применение по п.1, где антагонист IL-22 представляет собой IL-22BP.
16. Применение антагониста IL-22, выбранного из антитела, которое специфически связывается с IL20Ra; антитела, которое специфически связывается с IL20Rb; и антитела, которое специфически связывается с IL20R, для приготовления фармацевтической композиции для введения с фармацевтической композицией, определенной в п.1.
17. Применение по п.16, где антагонист IL-22 представляет собой антитело, которое специфически связывается с IL-22R.
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