RU2010123781A - Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли - Google Patents
Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли Download PDFInfo
- Publication number
- RU2010123781A RU2010123781A RU2010123781/04A RU2010123781A RU2010123781A RU 2010123781 A RU2010123781 A RU 2010123781A RU 2010123781/04 A RU2010123781/04 A RU 2010123781/04A RU 2010123781 A RU2010123781 A RU 2010123781A RU 2010123781 A RU2010123781 A RU 2010123781A
- Authority
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- Russia
- Prior art keywords
- pain
- aliphatic group
- compound according
- compound
- acute
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 33
- 102000004310 Ion Channels Human genes 0.000 title abstract 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 2
- 125000001931 aliphatic group Chemical group 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 10
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- 230000001154 acute effect Effects 0.000 claims 7
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- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
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- MKLARCZMDNIPPA-UHFFFAOYSA-N benzenesulfonamide;pyrrolidin-2-one Chemical class O=C1CCCN1.NS(=O)(=O)C1=CC=CC=C1 MKLARCZMDNIPPA-UHFFFAOYSA-N 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
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- 0 CC(CCCN(C1)C(CCN2c(cc3)ccc3S(NC3CCCCCCCCC3)(=O)=O)*2=O)C1c1cc(*)c(*)c(*)c1 Chemical compound CC(CCCN(C1)C(CCN2c(cc3)ccc3S(NC3CCCCCCCCC3)(=O)=O)*2=O)C1c1cc(*)c(*)c(*)c1 0.000 description 2
- RWQAGKGHFCSUJO-SFTDATJTSA-N O=C([C@H](CC1)N2C[C@@H](c3cc(Cl)cc(Cl)c3)OCC2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N2C[C@@H](c3cc(Cl)cc(Cl)c3)OCC2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O RWQAGKGHFCSUJO-SFTDATJTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98748507P | 2007-11-13 | 2007-11-13 | |
| US60/987,485 | 2007-11-13 | ||
| US8814108P | 2008-08-12 | 2008-08-12 | |
| US61/088,141 | 2008-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010123781A true RU2010123781A (ru) | 2011-12-20 |
Family
ID=40380263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010123781/04A RU2010123781A (ru) | 2007-11-13 | 2008-11-12 | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7994166B2 (enExample) |
| EP (1) | EP2231655B1 (enExample) |
| JP (1) | JP2011503112A (enExample) |
| KR (1) | KR20100098396A (enExample) |
| CN (1) | CN102036985A (enExample) |
| AT (1) | ATE522526T1 (enExample) |
| AU (1) | AU2008321137A1 (enExample) |
| CA (1) | CA2705336A1 (enExample) |
| IL (1) | IL205697A0 (enExample) |
| MX (1) | MX2010005309A (enExample) |
| NZ (1) | NZ585332A (enExample) |
| RU (1) | RU2010123781A (enExample) |
| WO (1) | WO2009064747A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080021030A (ko) * | 2005-05-16 | 2008-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| WO2007030618A2 (en) * | 2005-09-09 | 2007-03-15 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of voltage gated ion channels |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ581309A (en) | 2007-05-25 | 2012-02-24 | Vertex Pharma | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| AU2008321137A1 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| AU2008321142A1 (en) * | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| CN102099356A (zh) * | 2008-07-01 | 2011-06-15 | 沃泰克斯药物股份有限公司 | 用作离子通道调节剂的杂环衍生物 |
| MX2014008591A (es) * | 2012-01-16 | 2014-08-22 | Vertex Pharma | Piperidinamidas piranoespirociclicas como moduladores de canales de iones. |
| CA2885417A1 (en) | 2012-10-12 | 2014-04-17 | F. Hoffmann-La Roche Ag | Substituted phenylcarbamate compounds |
| EP2909170A1 (en) | 2012-10-16 | 2015-08-26 | F. Hoffmann-La Roche AG | Substituted carbamate compounds and their use as transient receptor potential (trp) channel antagonists |
| US9187506B2 (en) * | 2014-01-09 | 2015-11-17 | Bristol-Myers Squibb Company | (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| EP3541373B1 (en) * | 2016-11-17 | 2023-11-01 | Merck Sharp & Dohme LLC | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| CN110446708B (zh) | 2017-07-21 | 2022-12-02 | 安塔比奥公司 | 化学化合物 |
| CN113008999B (zh) * | 2019-12-19 | 2024-08-23 | 重庆药友制药有限责任公司 | 一种分离测定氟比洛芬酯中2种基因毒性杂质的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| EP1631558A1 (en) * | 2003-05-21 | 2006-03-08 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| TW200524888A (en) | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| JP2007261945A (ja) * | 2004-04-07 | 2007-10-11 | Taisho Pharmaceut Co Ltd | チアゾール誘導体 |
| US7786137B2 (en) | 2005-05-10 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| KR20080021030A (ko) | 2005-05-16 | 2008-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| WO2006127329A1 (en) | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Quinoline derivatives useful as modulators of ion channels |
| WO2006133459A1 (en) | 2005-06-09 | 2006-12-14 | Vertex Pharmaceuticals Incorporated | Indane derivatives as modulators of ion channels |
| WO2007030618A2 (en) | 2005-09-09 | 2007-03-15 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of voltage gated ion channels |
| ES2383090T3 (es) | 2005-10-12 | 2012-06-18 | Vertex Pharmaceuticals, Inc. | Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje |
| EP1948597A1 (en) | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) * | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| WO2007075896A2 (en) * | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Heterocyclic cytokine inhibitors |
| NZ581309A (en) | 2007-05-25 | 2012-02-24 | Vertex Pharma | Ion channel modulators and methods of use |
| US7994174B2 (en) | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| AU2008321142A1 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| AU2008321137A1 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| CN102099356A (zh) | 2008-07-01 | 2011-06-15 | 沃泰克斯药物股份有限公司 | 用作离子通道调节剂的杂环衍生物 |
-
2008
- 2008-11-12 AU AU2008321137A patent/AU2008321137A1/en not_active Abandoned
- 2008-11-12 KR KR1020107012968A patent/KR20100098396A/ko not_active Withdrawn
- 2008-11-12 EP EP08850039A patent/EP2231655B1/en not_active Not-in-force
- 2008-11-12 CN CN2008801225096A patent/CN102036985A/zh active Pending
- 2008-11-12 MX MX2010005309A patent/MX2010005309A/es active IP Right Grant
- 2008-11-12 AT AT08850039T patent/ATE522526T1/de active
- 2008-11-12 JP JP2010533335A patent/JP2011503112A/ja not_active Withdrawn
- 2008-11-12 CA CA2705336A patent/CA2705336A1/en not_active Abandoned
- 2008-11-12 NZ NZ585332A patent/NZ585332A/en not_active IP Right Cessation
- 2008-11-12 WO PCT/US2008/083165 patent/WO2009064747A2/en not_active Ceased
- 2008-11-12 RU RU2010123781/04A patent/RU2010123781A/ru not_active Application Discontinuation
- 2008-11-12 US US12/269,108 patent/US7994166B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 IL IL205697A patent/IL205697A0/en unknown
-
2011
- 2011-07-08 US US13/178,877 patent/US20120010416A1/en not_active Abandoned
-
2013
- 2013-08-15 US US13/967,732 patent/US8841282B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102036985A (zh) | 2011-04-27 |
| US8841282B2 (en) | 2014-09-23 |
| US20120010416A1 (en) | 2012-01-12 |
| IL205697A0 (en) | 2010-11-30 |
| KR20100098396A (ko) | 2010-09-06 |
| AU2008321137A1 (en) | 2009-05-22 |
| JP2011503112A (ja) | 2011-01-27 |
| CA2705336A1 (en) | 2009-05-22 |
| WO2009064747A3 (en) | 2010-08-19 |
| US20130338119A1 (en) | 2013-12-19 |
| WO2009064747A2 (en) | 2009-05-22 |
| EP2231655B1 (en) | 2011-08-31 |
| NZ585332A (en) | 2012-05-25 |
| EP2231655A2 (en) | 2010-09-29 |
| US20090131440A1 (en) | 2009-05-21 |
| ATE522526T1 (de) | 2011-09-15 |
| MX2010005309A (es) | 2010-06-25 |
| US7994166B2 (en) | 2011-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20121022 |