RU2010123781A - Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли - Google Patents
Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли Download PDFInfo
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- RU2010123781A RU2010123781A RU2010123781/04A RU2010123781A RU2010123781A RU 2010123781 A RU2010123781 A RU 2010123781A RU 2010123781/04 A RU2010123781/04 A RU 2010123781/04A RU 2010123781 A RU2010123781 A RU 2010123781A RU 2010123781 A RU2010123781 A RU 2010123781A
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- Prior art keywords
- pain
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- 150000001875 compounds Chemical class 0.000 title claims abstract 33
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98748507P | 2007-11-13 | 2007-11-13 | |
| US60/987,485 | 2007-11-13 | ||
| US8814108P | 2008-08-12 | 2008-08-12 | |
| US61/088,141 | 2008-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010123781A true RU2010123781A (ru) | 2011-12-20 |
Family
ID=40380263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010123781/04A RU2010123781A (ru) | 2007-11-13 | 2008-11-12 | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7994166B2 (OSRAM) |
| EP (1) | EP2231655B1 (OSRAM) |
| JP (1) | JP2011503112A (OSRAM) |
| KR (1) | KR20100098396A (OSRAM) |
| CN (1) | CN102036985A (OSRAM) |
| AT (1) | ATE522526T1 (OSRAM) |
| AU (1) | AU2008321137A1 (OSRAM) |
| CA (1) | CA2705336A1 (OSRAM) |
| IL (1) | IL205697A0 (OSRAM) |
| MX (1) | MX2010005309A (OSRAM) |
| NZ (1) | NZ585332A (OSRAM) |
| RU (1) | RU2010123781A (OSRAM) |
| WO (1) | WO2009064747A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| CN101218226A (zh) * | 2005-05-16 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
| RU2008113836A (ru) * | 2005-09-09 | 2009-10-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные в качестве модуляторов потенциалозависимых ионных каналов |
| WO2007050522A1 (en) * | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| US8193194B2 (en) | 2007-05-25 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| ES2377172T3 (es) * | 2007-11-13 | 2012-03-23 | Vertex Pharmaceuticals Incorporated | Derivados heterocíclicos como moduladores de canales iónicos |
| RU2010123781A (ru) | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
| KR20110025855A (ko) * | 2008-07-01 | 2011-03-11 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 헤테로사이클릭 유도체 |
| JP6215230B2 (ja) * | 2012-01-16 | 2017-10-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド |
| KR20150065177A (ko) | 2012-10-12 | 2015-06-12 | 에프. 호프만-라 로슈 아게 | 치환된 페닐카르바메이트 화합물 |
| WO2014060341A1 (en) | 2012-10-16 | 2014-04-24 | F. Hoffmann-La Roche Ag | Substituted carbamate compounds and their use as transient receptor potential (trp) channel antagonists |
| US9187506B2 (en) * | 2014-01-09 | 2015-11-17 | Bristol-Myers Squibb Company | (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| EP3541373B1 (en) | 2016-11-17 | 2023-11-01 | Merck Sharp & Dohme LLC | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| SG11202000217QA (en) | 2017-07-21 | 2020-02-27 | Antabio Sas | Chemical compounds |
| CN113008999B (zh) * | 2019-12-19 | 2024-08-23 | 重庆药友制药有限责任公司 | 一种分离测定氟比洛芬酯中2种基因毒性杂质的方法 |
Family Cites Families (21)
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|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| AU2004240885A1 (en) * | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20060073930A (ko) | 2003-08-08 | 2006-06-29 | 버텍스 파마슈티칼스 인코포레이티드 | 통증 치료시 나트륨 또는 칼슘 채널 차단제로서 유용한헤테로아릴아미노설포닐페닐 유도체 |
| JP2007261945A (ja) * | 2004-04-07 | 2007-10-11 | Taisho Pharmaceut Co Ltd | チアゾール誘導体 |
| JP2008540539A (ja) | 2005-05-10 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャンネルの調節因子としての二環系誘導体 |
| CN101218226A (zh) * | 2005-05-16 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
| JP5112297B2 (ja) | 2005-05-20 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なキノリン誘導体 |
| KR20080019693A (ko) * | 2005-06-09 | 2008-03-04 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 인단 유도체 |
| RU2008113836A (ru) | 2005-09-09 | 2009-10-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные в качестве модуляторов потенциалозависимых ионных каналов |
| CA2624831A1 (en) * | 2005-10-12 | 2007-04-26 | Vertex Pharmaceuticals Incorporated | Biphenyl derivatives as modulators of voltage gated ion channels |
| WO2007050522A1 (en) | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| CA2633653A1 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| WO2007075896A2 (en) * | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Heterocyclic cytokine inhibitors |
| US8193194B2 (en) | 2007-05-25 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| ES2377172T3 (es) * | 2007-11-13 | 2012-03-23 | Vertex Pharmaceuticals Incorporated | Derivados heterocíclicos como moduladores de canales iónicos |
| RU2010123781A (ru) | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
| KR20110025855A (ko) | 2008-07-01 | 2011-03-11 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 헤테로사이클릭 유도체 |
-
2008
- 2008-11-12 RU RU2010123781/04A patent/RU2010123781A/ru not_active Application Discontinuation
- 2008-11-12 EP EP08850039A patent/EP2231655B1/en not_active Not-in-force
- 2008-11-12 CA CA2705336A patent/CA2705336A1/en not_active Abandoned
- 2008-11-12 AU AU2008321137A patent/AU2008321137A1/en not_active Abandoned
- 2008-11-12 MX MX2010005309A patent/MX2010005309A/es active IP Right Grant
- 2008-11-12 CN CN2008801225096A patent/CN102036985A/zh active Pending
- 2008-11-12 US US12/269,108 patent/US7994166B2/en not_active Expired - Fee Related
- 2008-11-12 JP JP2010533335A patent/JP2011503112A/ja not_active Withdrawn
- 2008-11-12 AT AT08850039T patent/ATE522526T1/de active
- 2008-11-12 WO PCT/US2008/083165 patent/WO2009064747A2/en not_active Ceased
- 2008-11-12 NZ NZ585332A patent/NZ585332A/en not_active IP Right Cessation
- 2008-11-12 KR KR1020107012968A patent/KR20100098396A/ko not_active Withdrawn
-
2010
- 2010-05-11 IL IL205697A patent/IL205697A0/en unknown
-
2011
- 2011-07-08 US US13/178,877 patent/US20120010416A1/en not_active Abandoned
-
2013
- 2013-08-15 US US13/967,732 patent/US8841282B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102036985A (zh) | 2011-04-27 |
| WO2009064747A3 (en) | 2010-08-19 |
| MX2010005309A (es) | 2010-06-25 |
| ATE522526T1 (de) | 2011-09-15 |
| US8841282B2 (en) | 2014-09-23 |
| IL205697A0 (en) | 2010-11-30 |
| NZ585332A (en) | 2012-05-25 |
| US20120010416A1 (en) | 2012-01-12 |
| JP2011503112A (ja) | 2011-01-27 |
| AU2008321137A1 (en) | 2009-05-22 |
| CA2705336A1 (en) | 2009-05-22 |
| US20130338119A1 (en) | 2013-12-19 |
| EP2231655A2 (en) | 2010-09-29 |
| US20090131440A1 (en) | 2009-05-21 |
| EP2231655B1 (en) | 2011-08-31 |
| WO2009064747A2 (en) | 2009-05-22 |
| US7994166B2 (en) | 2011-08-09 |
| KR20100098396A (ko) | 2010-09-06 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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