RU2009139259A - Соединения на основе лизина - Google Patents
Соединения на основе лизина Download PDFInfo
- Publication number
- RU2009139259A RU2009139259A RU2009139259/04A RU2009139259A RU2009139259A RU 2009139259 A RU2009139259 A RU 2009139259A RU 2009139259/04 A RU2009139259/04 A RU 2009139259/04A RU 2009139259 A RU2009139259 A RU 2009139259A RU 2009139259 A RU2009139259 A RU 2009139259A
- Authority
- RU
- Russia
- Prior art keywords
- group
- compound according
- compound
- carbon atoms
- group containing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 2
- 101150065749 Churc1 gene Proteins 0.000 claims 2
- 102100038239 Protein Churchill Human genes 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- -1 methylenedioxy group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CAPCT/CA2004/001440 | 2004-08-02 | ||
| PCT/CA2004/001440 WO2006012725A1 (en) | 2004-08-02 | 2004-08-02 | Lysine based compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007107798/04A Division RU2379312C2 (ru) | 2004-08-02 | 2004-08-02 | Соединения на основе лизина, фармацевтическая композиция, содержащая эти соединения, применение указанных соединений для лечения или профилактики вич инфекции |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009139259A true RU2009139259A (ru) | 2011-04-27 |
Family
ID=35786842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009139259/04A RU2009139259A (ru) | 2004-08-02 | 2009-10-23 | Соединения на основе лизина |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP2165709B1 (enExample) |
| JP (1) | JP4579970B2 (enExample) |
| CN (1) | CN1942436B (enExample) |
| AT (1) | ATE417823T1 (enExample) |
| AU (2) | AU2004322123B2 (enExample) |
| BR (1) | BRPI0418651A (enExample) |
| CA (1) | CA2560071C (enExample) |
| DE (1) | DE602004018548D1 (enExample) |
| ES (2) | ES2319996T3 (enExample) |
| IL (1) | IL180958A0 (enExample) |
| MX (1) | MX2007001278A (enExample) |
| NO (1) | NO20071152L (enExample) |
| RU (1) | RU2009139259A (enExample) |
| WO (1) | WO2006012725A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| EP2165709B1 (en) | 2004-08-02 | 2016-03-16 | Ambrilia Biopharma Inc. | Pharmaceutical compositions comprising a lysine based compound and an HIV antiviral or antiretroviral agent |
| WO2007062526A1 (en) | 2005-11-30 | 2007-06-07 | Ambrilia Biopharma Inc. | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
| AU2007287353A1 (en) * | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| ES2628730T3 (es) | 2006-09-21 | 2017-08-03 | Taimed Biologics, Inc. | Inhibidores de proteasa |
| WO2009148600A2 (en) * | 2008-06-06 | 2009-12-10 | Concert Pharmaceuticals, Inc. | Deuterated lysine-based compounds |
| CA2762582A1 (en) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
| US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
| US9187415B2 (en) | 2010-10-29 | 2015-11-17 | Merck Canada Inc. | Sulfonamides as HIV protease inhibitors |
| US9133157B2 (en) | 2011-10-26 | 2015-09-15 | Merck Canada Inc. | HIV protease inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| WO2001076531A2 (en) * | 2000-04-07 | 2001-10-18 | University Of Maryland, Baltimore | Bile acid containing prodrugs with enhanced bioavailability |
| US6617310B2 (en) * | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
| CA2418479C (en) * | 2000-08-18 | 2007-12-18 | The Board Of Trustees Of The University Of Illinois | Prodrugs of betulinic acid derivatives for the treatment of cancer |
| US6506786B2 (en) * | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| US6632816B1 (en) * | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
| EP2165709B1 (en) | 2004-08-02 | 2016-03-16 | Ambrilia Biopharma Inc. | Pharmaceutical compositions comprising a lysine based compound and an HIV antiviral or antiretroviral agent |
-
2004
- 2004-08-02 EP EP08021798.7A patent/EP2165709B1/en not_active Expired - Lifetime
- 2004-08-02 AU AU2004322123A patent/AU2004322123B2/en not_active Ceased
- 2004-08-02 ES ES04761606T patent/ES2319996T3/es not_active Expired - Lifetime
- 2004-08-02 JP JP2007501073A patent/JP4579970B2/ja not_active Expired - Fee Related
- 2004-08-02 DE DE602004018548T patent/DE602004018548D1/de not_active Expired - Lifetime
- 2004-08-02 CA CA2560071A patent/CA2560071C/en not_active Expired - Fee Related
- 2004-08-02 MX MX2007001278A patent/MX2007001278A/es active IP Right Grant
- 2004-08-02 AT AT04761606T patent/ATE417823T1/de not_active IP Right Cessation
- 2004-08-02 EP EP04761606A patent/EP1773763B1/en not_active Expired - Lifetime
- 2004-08-02 WO PCT/CA2004/001440 patent/WO2006012725A1/en not_active Ceased
- 2004-08-02 CN CN2004800427980A patent/CN1942436B/zh not_active Expired - Fee Related
- 2004-08-02 BR BRPI0418651-6A patent/BRPI0418651A/pt not_active IP Right Cessation
- 2004-08-02 ES ES08021798.7T patent/ES2575871T3/es not_active Expired - Lifetime
-
2007
- 2007-01-25 IL IL180958A patent/IL180958A0/en unknown
- 2007-03-01 NO NO20071152A patent/NO20071152L/no not_active Application Discontinuation
-
2009
- 2009-10-23 RU RU2009139259/04A patent/RU2009139259A/ru not_active Application Discontinuation
- 2009-10-28 AU AU2009230800A patent/AU2009230800A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004018548D1 (de) | 2009-01-29 |
| EP2165709A2 (en) | 2010-03-24 |
| NO20071152L (no) | 2007-03-01 |
| EP2165709B1 (en) | 2016-03-16 |
| HK1105406A1 (en) | 2008-02-15 |
| AU2009230800A1 (en) | 2009-11-19 |
| JP2007525527A (ja) | 2007-09-06 |
| CN1942436A (zh) | 2007-04-04 |
| CA2560071A1 (en) | 2006-02-09 |
| EP1773763B1 (en) | 2008-12-17 |
| ATE417823T1 (de) | 2009-01-15 |
| MX2007001278A (es) | 2007-09-14 |
| EP1773763A1 (en) | 2007-04-18 |
| ES2319996T3 (es) | 2009-05-18 |
| AU2004322123B2 (en) | 2009-08-13 |
| ES2575871T3 (es) | 2016-07-01 |
| AU2004322123A1 (en) | 2006-02-09 |
| JP4579970B2 (ja) | 2010-11-10 |
| BRPI0418651A (pt) | 2007-05-29 |
| CN1942436B (zh) | 2011-03-23 |
| EP2165709A3 (en) | 2010-06-23 |
| EP1773763A4 (en) | 2007-08-08 |
| IL180958A0 (en) | 2007-07-04 |
| CA2560071C (en) | 2012-09-25 |
| WO2006012725A1 (en) | 2006-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO2022019I1 (no) | Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC | |
| RU2350605C2 (ru) | Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ | |
| ES2102478T3 (es) | Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen. | |
| RU2008152087A (ru) | Макроциклические оксимильные ингибиторы протеазы гепатита | |
| RU2000127105A (ru) | Соединения с активностью в отношении мускариновых рецепторов | |
| BR9916790A (pt) | Uso de um composto, composto, processo para amanufatura do mesmo, composição farmacêtica, e,método para produzir um efeito de dano vascularem um animal de sangue quente | |
| EA200100983A1 (ru) | Производные 13-метилэритромицина | |
| EA200001146A1 (ru) | Производные изотиазола, применимые в качестве противораковых агентов | |
| RU98102128A (ru) | Производные бензо[g]хинолина | |
| RU2006101987A (ru) | Трициклические производные или их фармацевтически приемлемые соли, способы их получения и содержащие их фармацевтические композиции | |
| DE68901153D1 (de) | Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung. | |
| RU2001124604A (ru) | Лекарственное средство для лечения гипертензии | |
| EA200400140A1 (ru) | Пероральные противодиабетические агенты | |
| RU2014122866A (ru) | Пропеноатные производные бетулина | |
| RU2004126700A (ru) | Синтез эктеинасцидинов, встречающихся в природе, и родственных соединений | |
| RU2000115947A (ru) | Производные бифениламидина | |
| KR930021628A (ko) | 심장 혈관계 활성을 갖는 벤족사지논 및 벤조티아지논 유도체 | |
| RU2003133143A (ru) | Содержание имидазотриазиноны составы для назального введения | |
| DE3786896D1 (de) | Verwendung eines spermin-derivats mit anti-neoplastischer wirkung zur herstellung pharmazeutischer zusammensetzungen. | |
| RU2008100587A (ru) | Применение санглиферина для лечения вируса гепатита с | |
| RU2004102398A (ru) | Производные бензо[g]хинолина для лечения глаукомы и близорукости | |
| JP2007525527A5 (enExample) | ||
| JP2003508513A5 (enExample) | ||
| SE8804688L (sv) | Substituerade styrenderivat | |
| EA200300272A1 (ru) | Новые производные хиназолина, способ их получения и фармацевтические композиции, содержащие их |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20121024 |