RU2009101324A - Композиции и способы лечения воспаления слизистой оболочки - Google Patents
Композиции и способы лечения воспаления слизистой оболочки Download PDFInfo
- Publication number
- RU2009101324A RU2009101324A RU2009101324/15A RU2009101324A RU2009101324A RU 2009101324 A RU2009101324 A RU 2009101324A RU 2009101324/15 A RU2009101324/15 A RU 2009101324/15A RU 2009101324 A RU2009101324 A RU 2009101324A RU 2009101324 A RU2009101324 A RU 2009101324A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- patient
- formulas
- formula
- oxylypine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 23
- 206010061218 Inflammation Diseases 0.000 title claims abstract 7
- 230000004054 inflammatory process Effects 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title 1
- 210000004877 mucosa Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 48
- 229930184725 Lipoxin Natural products 0.000 claims abstract 14
- -1 lipoxin compound Chemical class 0.000 claims abstract 14
- 238000002512 chemotherapy Methods 0.000 claims abstract 9
- 210000004400 mucous membrane Anatomy 0.000 claims abstract 9
- 238000001959 radiotherapy Methods 0.000 claims abstract 9
- 229940079593 drug Drugs 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 6
- 206010028116 Mucosal inflammation Diseases 0.000 claims abstract 3
- 208000025865 Ulcer Diseases 0.000 claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 claims abstract 3
- 230000017074 necrotic cell death Effects 0.000 claims abstract 3
- 230000004936 stimulating effect Effects 0.000 claims abstract 3
- 230000004083 survival effect Effects 0.000 claims abstract 3
- 230000036269 ulceration Effects 0.000 claims abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 6
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 6
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 6
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 6
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83186606P | 2006-07-19 | 2006-07-19 | |
| US60/831,866 | 2006-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009101324A true RU2009101324A (ru) | 2010-07-27 |
Family
ID=38617335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009101324/15A RU2009101324A (ru) | 2006-07-19 | 2007-07-19 | Композиции и способы лечения воспаления слизистой оболочки |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100035989A1 (enExample) |
| EP (1) | EP2049099A1 (enExample) |
| JP (1) | JP2009545527A (enExample) |
| KR (1) | KR20090040323A (enExample) |
| CN (1) | CN101528218A (enExample) |
| AU (1) | AU2007275658B2 (enExample) |
| BR (1) | BRPI0714562A2 (enExample) |
| CA (1) | CA2658361C (enExample) |
| IL (1) | IL196465A0 (enExample) |
| MX (1) | MX2009000657A (enExample) |
| RU (1) | RU2009101324A (enExample) |
| SG (1) | SG173397A1 (enExample) |
| WO (1) | WO2008011085A1 (enExample) |
| ZA (1) | ZA200900388B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762557B1 (en) | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) * | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US20100190735A1 (en) * | 2006-03-28 | 2010-07-29 | Myrex Pharmaceuticals Inc. | Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis |
| DK2180787T3 (da) | 2007-08-01 | 2014-02-03 | Univ Pittsburgh | Nitrooliesyremodulering af type ii-diabetes |
| US20090118243A1 (en) * | 2007-10-12 | 2009-05-07 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of ophthalmic conditions |
| JP2011519373A (ja) | 2008-05-01 | 2011-07-07 | コンプレクザ インコーポレイテッド | ビニル置換脂肪酸 |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| EP2299997A4 (en) | 2008-06-19 | 2012-01-11 | Univ Utah Res Found | USE OF NITRATED LIPIDS FOR THE TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES |
| US20120122816A1 (en) * | 2009-02-05 | 2012-05-17 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for organ preservation |
| US8853437B2 (en) | 2009-02-20 | 2014-10-07 | The University Of Tokyo | Anti-inflammatory compounds |
| US9066902B2 (en) | 2009-07-31 | 2015-06-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Fatty acids as anti-inflammatory agents |
| WO2011041639A2 (en) | 2009-10-02 | 2011-04-07 | Miller Raymond A | Heteroatom containing substituted fatty acids |
| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| US20150018417A1 (en) * | 2012-02-03 | 2015-01-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fatty acids as anti-inflammatory agents |
| CN103417471A (zh) * | 2012-05-22 | 2013-12-04 | 吴升华 | 一种治疗湿疹等皮肤炎症的脂氧素乳膏 |
| ES2751495T3 (es) | 2013-08-19 | 2020-03-31 | Enzychem Lifesciences Corp | Composiciones que contienen un compuesto monoacetildiglicérido como un componente activo para prevenir o tratar la artritis reumatoide |
| DK3097910T3 (da) * | 2014-01-24 | 2020-07-27 | Univ Kyoto | Antiinflamatorisk middel indeholdende sjælden fedtsyre |
| TW201609086A (zh) | 2014-05-15 | 2016-03-16 | 安塞全生命科學公司 | 白血球減少症和血小板減少症之治療方法 |
| HRP20210543T1 (hr) | 2015-07-07 | 2021-05-14 | H. Lundbeck A/S | Inhibitori pde9 s imidazo triazinonskom okosnicom i imidazo pirazinonskom okosnicom za liječenje perifernih bolesti |
| MX2018004043A (es) | 2015-10-02 | 2018-11-09 | Complexa Inc | Prevencion, tratamiento y reversion de enfermedad usando cantidades terapeuticamente efectivas de acidos grasos activados. |
| US9808438B2 (en) * | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
| CN112469413B (zh) | 2018-05-25 | 2024-01-12 | 伊马拉公司 | 6-[(3s,4s)-4-甲基-1-(嘧啶-2-基甲基)吡咯烷-3-基]-3-四氢吡喃-4-基-7h-咪唑并[1,5-a]吡嗪-8-酮的一水合物和结晶形态 |
| EP3843737A4 (en) | 2018-08-31 | 2022-06-01 | Imara Inc. | PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US6887901B1 (en) * | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
| WO2000054761A2 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Regulation of phospholipase d activity |
| EP1762557B1 (en) * | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7700650B2 (en) * | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| DE60229640D1 (de) * | 2001-03-02 | 2008-12-11 | Brigham & Womens Hospital | Lipoxin analoge als neue inhibitoren der angiogenese |
| WO2003048148A2 (en) * | 2001-12-03 | 2003-06-12 | Novozymes A/S | Statin-like compounds |
| AU2002365167A1 (en) * | 2001-12-18 | 2003-07-09 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| EP1528909A4 (en) * | 2002-04-01 | 2006-05-24 | Univ Southern California | TRI-HYDROXY-POLYUNG-SATURATED EICOSANOIDS |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| ATE382597T1 (de) * | 2002-06-17 | 2008-01-15 | Resolvyx Pharmaceuticals | Analoga von omega-3-pufas abgeleiteten lipidmediatoren und anwendungsverfahren |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004014835A2 (en) * | 2002-08-12 | 2004-02-19 | Brigham And Women's Hospital | Resolvins: biotemplates for therapeutic interventions |
| US20050113443A1 (en) * | 2003-06-01 | 2005-05-26 | Karp Christopher L. | Modulation of airway inflammation in patients with cystic fibrosis and related diseases |
| US20050203184A1 (en) * | 2003-09-10 | 2005-09-15 | Petasis Nicos A. | Benzo lipoxin analogues |
| AU2005306320B2 (en) * | 2004-11-19 | 2011-09-08 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
-
2007
- 2007-07-19 EP EP07810597A patent/EP2049099A1/en not_active Withdrawn
- 2007-07-19 MX MX2009000657A patent/MX2009000657A/es not_active Application Discontinuation
- 2007-07-19 CN CNA2007800344854A patent/CN101528218A/zh active Pending
- 2007-07-19 CA CA2658361A patent/CA2658361C/en not_active Expired - Fee Related
- 2007-07-19 RU RU2009101324/15A patent/RU2009101324A/ru not_active Application Discontinuation
- 2007-07-19 BR BRPI0714562-4A patent/BRPI0714562A2/pt not_active IP Right Cessation
- 2007-07-19 KR KR1020097002754A patent/KR20090040323A/ko not_active Ceased
- 2007-07-19 WO PCT/US2007/016338 patent/WO2008011085A1/en not_active Ceased
- 2007-07-19 US US12/309,430 patent/US20100035989A1/en not_active Abandoned
- 2007-07-19 JP JP2009520828A patent/JP2009545527A/ja active Pending
- 2007-07-19 AU AU2007275658A patent/AU2007275658B2/en not_active Ceased
- 2007-07-19 SG SG2011052230A patent/SG173397A1/en unknown
-
2009
- 2009-01-12 IL IL196465A patent/IL196465A0/en unknown
- 2009-01-16 ZA ZA200900388A patent/ZA200900388B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090040323A (ko) | 2009-04-23 |
| WO2008011085A1 (en) | 2008-01-24 |
| CA2658361A1 (en) | 2008-01-24 |
| CA2658361C (en) | 2013-04-23 |
| JP2009545527A (ja) | 2009-12-24 |
| SG173397A1 (en) | 2011-08-29 |
| CN101528218A (zh) | 2009-09-09 |
| BRPI0714562A2 (pt) | 2013-04-02 |
| IL196465A0 (en) | 2009-11-18 |
| MX2009000657A (es) | 2009-05-28 |
| AU2007275658B2 (en) | 2011-09-01 |
| AU2007275658A1 (en) | 2008-01-24 |
| US20100035989A1 (en) | 2010-02-11 |
| ZA200900388B (en) | 2010-03-31 |
| EP2049099A1 (en) | 2009-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20121126 |