RU2009101324A - Композиции и способы лечения воспаления слизистой оболочки - Google Patents
Композиции и способы лечения воспаления слизистой оболочки Download PDFInfo
- Publication number
- RU2009101324A RU2009101324A RU2009101324/15A RU2009101324A RU2009101324A RU 2009101324 A RU2009101324 A RU 2009101324A RU 2009101324/15 A RU2009101324/15 A RU 2009101324/15A RU 2009101324 A RU2009101324 A RU 2009101324A RU 2009101324 A RU2009101324 A RU 2009101324A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- patient
- formulas
- formula
- oxylypine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 23
- 206010061218 Inflammation Diseases 0.000 title claims abstract 7
- 230000004054 inflammatory process Effects 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title 1
- 210000004877 mucosa Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 48
- 229930184725 Lipoxin Natural products 0.000 claims abstract 14
- -1 lipoxin compound Chemical class 0.000 claims abstract 14
- 238000002512 chemotherapy Methods 0.000 claims abstract 9
- 210000004400 mucous membrane Anatomy 0.000 claims abstract 9
- 238000001959 radiotherapy Methods 0.000 claims abstract 9
- 229940079593 drug Drugs 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 6
- 206010028116 Mucosal inflammation Diseases 0.000 claims abstract 3
- 208000025865 Ulcer Diseases 0.000 claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 claims abstract 3
- 230000017074 necrotic cell death Effects 0.000 claims abstract 3
- 230000004936 stimulating effect Effects 0.000 claims abstract 3
- 230000004083 survival effect Effects 0.000 claims abstract 3
- 230000036269 ulceration Effects 0.000 claims abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 6
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 6
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 6
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 6
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83186606P | 2006-07-19 | 2006-07-19 | |
| US60/831,866 | 2006-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009101324A true RU2009101324A (ru) | 2010-07-27 |
Family
ID=38617335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009101324/15A RU2009101324A (ru) | 2006-07-19 | 2007-07-19 | Композиции и способы лечения воспаления слизистой оболочки |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100035989A1 (enExample) |
| EP (1) | EP2049099A1 (enExample) |
| JP (1) | JP2009545527A (enExample) |
| KR (1) | KR20090040323A (enExample) |
| CN (1) | CN101528218A (enExample) |
| AU (1) | AU2007275658B2 (enExample) |
| BR (1) | BRPI0714562A2 (enExample) |
| CA (1) | CA2658361C (enExample) |
| IL (1) | IL196465A0 (enExample) |
| MX (1) | MX2009000657A (enExample) |
| RU (1) | RU2009101324A (enExample) |
| SG (1) | SG173397A1 (enExample) |
| WO (1) | WO2008011085A1 (enExample) |
| ZA (1) | ZA200900388B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151299A0 (en) | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| US8481772B2 (en) * | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US20100190735A1 (en) * | 2006-03-28 | 2010-07-29 | Myrex Pharmaceuticals Inc. | Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis |
| EP2679224A1 (en) | 2007-08-01 | 2014-01-01 | University of Pittsburgh of the Commonwealth System of Higher Education | Nitro oleic acid modulation of type II diabetes |
| CN103191129A (zh) * | 2007-10-12 | 2013-07-10 | C.T.辨析有限公司 | 治疗眼睛病症的脂氧化物类化合物 |
| DK2280928T3 (en) | 2008-05-01 | 2018-11-05 | Complexa Inc | Vinyl-substituted fatty acids |
| CN102099024B (zh) | 2008-06-19 | 2015-11-25 | 犹他大学研究基金会 | 硝化脂质在毒性医疗疗法的副作用的治疗上的用途 |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| US20120122816A1 (en) * | 2009-02-05 | 2012-05-17 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for organ preservation |
| EP2415748A4 (en) | 2009-02-20 | 2013-08-07 | Univ Tokyo | NEW INFLAMMATORY COMPOUNDS |
| CA2769624C (en) * | 2009-07-31 | 2018-09-11 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Electrophilic fatty acid derivatives as anti-inflammatory agents |
| WO2011041639A2 (en) | 2009-10-02 | 2011-04-07 | Miller Raymond A | Heteroatom containing substituted fatty acids |
| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| WO2013116753A1 (en) * | 2012-02-03 | 2013-08-08 | University Of Pittsburgh-Of The Commonwelth System Of Higher Education | Fatty acids as anti-inflammatory agents |
| CN103417471A (zh) * | 2012-05-22 | 2013-12-04 | 吴升华 | 一种治疗湿疹等皮肤炎症的脂氧素乳膏 |
| CA2921845C (en) | 2013-08-19 | 2018-07-10 | Korea Research Institute Of Bioscience And Biotechnology | Compositions containing monoacetyldiacylglycerol compound as an active indredient for preventing or treating rheumatoid arthritis |
| CN106163511A (zh) * | 2014-01-24 | 2016-11-23 | 国立大学法人京都大学 | 含有稀有脂肪酸的抗炎剂 |
| WO2015176012A1 (en) | 2014-05-15 | 2015-11-19 | Enzychem Lifesciences Corporation | Methods for treating leukopenia and thrombocytopenia |
| CA2990521C (en) | 2015-07-07 | 2023-10-10 | H. Lundbeck A/S | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| CN113440506A (zh) | 2015-10-02 | 2021-09-28 | 康普莱克夏公司 | 使用治疗有效量的活化脂肪酸预防、治疗和逆转疾病 |
| US9808438B2 (en) * | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
| BR112020024019A2 (pt) | 2018-05-25 | 2021-02-23 | Imara Inc. | monoidrato e formas cristalinas de 6-[(3s,4s)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetra-hidropiran-4-il-7h-imidazo[1,5-a]pirazin-8-ona |
| KR20250108770A (ko) | 2018-08-31 | 2025-07-15 | 카듀리온 파마슈티칼스, 인크. | 겸상 세포 질환의 치료를 위한 pde9 억제제 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US6887901B1 (en) * | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
| JP4392473B2 (ja) * | 1999-03-18 | 2010-01-06 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | ホスホリパーゼｄの活性の調節 |
| IL151299A0 (en) * | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| EP1268393A2 (en) * | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| EP1406698B1 (en) * | 2001-03-02 | 2008-10-29 | The Brigham and Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
| EP1453819A2 (en) * | 2001-12-03 | 2004-09-08 | Novozymes A/S | Statin-like compounds |
| AU2002365167A1 (en) * | 2001-12-18 | 2003-07-09 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| CA2467580C (en) * | 2001-12-18 | 2012-10-30 | Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US6949664B2 (en) * | 2002-04-01 | 2005-09-27 | University Of Southern California | Trihydroxy polyunsaturated eicosanoids |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7378444B2 (en) * | 2002-06-17 | 2008-05-27 | Brigham And Women's Hospital, Inc. | Analogues of lipid mediators derived from omega-3 PUFAs and methods of use |
| DK2216318T3 (en) * | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004110426A1 (en) * | 2003-06-01 | 2004-12-23 | Petasis Nicos A | Modulation of airway inflammation in patients with cystic fibrosis and related diseases |
| US20050203184A1 (en) * | 2003-09-10 | 2005-09-15 | Petasis Nicos A. | Benzo lipoxin analogues |
| CA2588166A1 (en) * | 2004-11-19 | 2006-05-26 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
-
2007
- 2007-07-19 BR BRPI0714562-4A patent/BRPI0714562A2/pt not_active IP Right Cessation
- 2007-07-19 CN CNA2007800344854A patent/CN101528218A/zh active Pending
- 2007-07-19 SG SG2011052230A patent/SG173397A1/en unknown
- 2007-07-19 AU AU2007275658A patent/AU2007275658B2/en not_active Ceased
- 2007-07-19 RU RU2009101324/15A patent/RU2009101324A/ru not_active Application Discontinuation
- 2007-07-19 MX MX2009000657A patent/MX2009000657A/es not_active Application Discontinuation
- 2007-07-19 EP EP07810597A patent/EP2049099A1/en not_active Withdrawn
- 2007-07-19 WO PCT/US2007/016338 patent/WO2008011085A1/en not_active Ceased
- 2007-07-19 KR KR1020097002754A patent/KR20090040323A/ko not_active Ceased
- 2007-07-19 US US12/309,430 patent/US20100035989A1/en not_active Abandoned
- 2007-07-19 JP JP2009520828A patent/JP2009545527A/ja active Pending
- 2007-07-19 CA CA2658361A patent/CA2658361C/en not_active Expired - Fee Related
-
2009
- 2009-01-12 IL IL196465A patent/IL196465A0/en unknown
- 2009-01-16 ZA ZA200900388A patent/ZA200900388B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL196465A0 (en) | 2009-11-18 |
| AU2007275658A1 (en) | 2008-01-24 |
| JP2009545527A (ja) | 2009-12-24 |
| CA2658361C (en) | 2013-04-23 |
| CA2658361A1 (en) | 2008-01-24 |
| CN101528218A (zh) | 2009-09-09 |
| KR20090040323A (ko) | 2009-04-23 |
| WO2008011085A1 (en) | 2008-01-24 |
| EP2049099A1 (en) | 2009-04-22 |
| BRPI0714562A2 (pt) | 2013-04-02 |
| ZA200900388B (en) | 2010-03-31 |
| US20100035989A1 (en) | 2010-02-11 |
| AU2007275658B2 (en) | 2011-09-01 |
| MX2009000657A (es) | 2009-05-28 |
| SG173397A1 (en) | 2011-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20121126 |