RU2007144531A - Новые кристаллические формы тиотропийбромида - Google Patents

Новые кристаллические формы тиотропийбромида Download PDF

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Publication number
RU2007144531A
RU2007144531A RU2007144531/04A RU2007144531A RU2007144531A RU 2007144531 A RU2007144531 A RU 2007144531A RU 2007144531/04 A RU2007144531/04 A RU 2007144531/04A RU 2007144531 A RU2007144531 A RU 2007144531A RU 2007144531 A RU2007144531 A RU 2007144531A
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RU
Russia
Prior art keywords
tiotropium bromide
crystalline
ray powder
diffraction pattern
powder diffraction
Prior art date
Application number
RU2007144531/04A
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English (en)
Russian (ru)
Inventor
Шерри Л. МОРИЗЕТТЕ (US)
Шерри Л. МОРИЗЕТТЕ
Марк Д. ТАУА (US)
Марк Д. ТАУА
Марк А. ОЛИВЕЙРА (US)
Марк А. ОЛИВЕЙРА
Original Assignee
БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)
Берингер Ингельхайм Интернациональ Гмбх
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Application filed by БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE), Берингер Ингельхайм Интернациональ Гмбх filed Critical БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)
Publication of RU2007144531A publication Critical patent/RU2007144531A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2007144531/04A 2005-05-02 2006-04-21 Новые кристаллические формы тиотропийбромида RU2007144531A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67676005P 2005-05-02 2005-05-02
US60/676,760 2005-05-02

Publications (1)

Publication Number Publication Date
RU2007144531A true RU2007144531A (ru) 2009-06-10

Family

ID=36617384

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007144531/04A RU2007144531A (ru) 2005-05-02 2006-04-21 Новые кристаллические формы тиотропийбромида

Country Status (13)

Country Link
US (1) US20060246009A1 (https=)
EP (1) EP1879888A2 (https=)
JP (1) JP2008540367A (https=)
KR (1) KR20080007656A (https=)
CN (1) CN101203513A (https=)
AU (1) AU2006243239A1 (https=)
BR (1) BRPI0611091A2 (https=)
CA (1) CA2606552A1 (https=)
IL (1) IL187054A0 (https=)
MX (1) MX2007013691A (https=)
RU (1) RU2007144531A (https=)
WO (1) WO2006117300A2 (https=)
ZA (1) ZA200708175B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1966196A2 (en) * 2005-12-19 2008-09-10 Sicor, Inc. Pure and stable tiotropium bromide
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
RS52663B2 (sr) * 2005-12-19 2018-05-31 Sicor Inc Nova kristalna forma tiotropijum bromida i proces njene pripreme
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201101897A2 (tr) * 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
CN103130798B (zh) * 2011-11-30 2015-12-02 连云港润众制药有限公司 噻托溴铵的结晶
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
UA115888C2 (uk) * 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
CN104341413A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵的新晶型
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) * 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CN100519558C (zh) * 2000-10-12 2009-07-29 贝林格尔英格海姆法玛两合公司 结晶单水合物、其制备方法及其在制备药物组合中的用途
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
CZ302786B6 (cs) * 2001-06-22 2011-11-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Krystalický bezvodý tiotropiumbromid, zpusob jeho výroby a jeho použití pro výrobu léciva pro lécbu asthmatu
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214264A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen eines Anhydrats
MXPA05006383A (es) * 2002-12-16 2005-08-29 Boehringer Ingelheim Pharma Formulaciones de soluciones de hidrofluorocarburo que contienen tiotropio.
ES2338563T3 (es) * 2003-11-03 2010-05-10 Boehringer Ingelheim International Gmbh Nuevo anhidrato cristalino con efecto anticolinergico.

Also Published As

Publication number Publication date
EP1879888A2 (en) 2008-01-23
WO2006117300A3 (en) 2007-04-26
CA2606552A1 (en) 2006-11-09
KR20080007656A (ko) 2008-01-22
WO2006117300A2 (en) 2006-11-09
JP2008540367A (ja) 2008-11-20
IL187054A0 (en) 2008-02-09
ZA200708175B (en) 2008-09-25
BRPI0611091A2 (pt) 2010-08-03
US20060246009A1 (en) 2006-11-02
CN101203513A (zh) 2008-06-18
AU2006243239A1 (en) 2006-11-09
MX2007013691A (es) 2008-01-21

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Effective date: 20100901