RU2007144531A - Новые кристаллические формы тиотропийбромида - Google Patents

Новые кристаллические формы тиотропийбромида Download PDF

Info

Publication number
RU2007144531A
RU2007144531A RU2007144531/04A RU2007144531A RU2007144531A RU 2007144531 A RU2007144531 A RU 2007144531A RU 2007144531/04 A RU2007144531/04 A RU 2007144531/04A RU 2007144531 A RU2007144531 A RU 2007144531A RU 2007144531 A RU2007144531 A RU 2007144531A
Authority
RU
Russia
Prior art keywords
tiotropium bromide
crystalline
ray powder
diffraction pattern
powder diffraction
Prior art date
Application number
RU2007144531/04A
Other languages
English (en)
Russian (ru)
Inventor
Шерри Л. МОРИЗЕТТЕ (US)
Шерри Л. МОРИЗЕТТЕ
Марк Д. ТАУА (US)
Марк Д. ТАУА
Марк А. ОЛИВЕЙРА (US)
Марк А. ОЛИВЕЙРА
Original Assignee
БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)
Берингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE), Берингер Ингельхайм Интернациональ Гмбх filed Critical БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)
Publication of RU2007144531A publication Critical patent/RU2007144531A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2007144531/04A 2005-05-02 2006-04-21 Новые кристаллические формы тиотропийбромида RU2007144531A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67676005P 2005-05-02 2005-05-02
US60/676,760 2005-05-02

Publications (1)

Publication Number Publication Date
RU2007144531A true RU2007144531A (ru) 2009-06-10

Family

ID=36617384

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007144531/04A RU2007144531A (ru) 2005-05-02 2006-04-21 Новые кристаллические формы тиотропийбромида

Country Status (13)

Country Link
US (1) US20060246009A1 (enExample)
EP (1) EP1879888A2 (enExample)
JP (1) JP2008540367A (enExample)
KR (1) KR20080007656A (enExample)
CN (1) CN101203513A (enExample)
AU (1) AU2006243239A1 (enExample)
BR (1) BRPI0611091A2 (enExample)
CA (1) CA2606552A1 (enExample)
IL (1) IL187054A0 (enExample)
MX (1) MX2007013691A (enExample)
RU (1) RU2007144531A (enExample)
WO (1) WO2006117300A2 (enExample)
ZA (1) ZA200708175B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1869035E (pt) 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201101897A2 (tr) * 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
CN103130798B (zh) * 2011-11-30 2015-12-02 连云港润众制药有限公司 噻托溴铵的结晶
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
CN104341413A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵的新晶型
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
AU2002214996B2 (en) * 2000-10-12 2007-03-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
CA2450961C (en) * 2001-06-22 2010-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10214264A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen eines Anhydrats
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
AU2003303029A1 (en) * 2002-12-16 2004-07-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing hfc solution formulations
WO2005042527A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Neues kristallines anhydrat mit anticholinerger wirksamkeit

Also Published As

Publication number Publication date
JP2008540367A (ja) 2008-11-20
AU2006243239A1 (en) 2006-11-09
CN101203513A (zh) 2008-06-18
EP1879888A2 (en) 2008-01-23
CA2606552A1 (en) 2006-11-09
ZA200708175B (en) 2008-09-25
BRPI0611091A2 (pt) 2010-08-03
IL187054A0 (en) 2008-02-09
MX2007013691A (es) 2008-01-21
US20060246009A1 (en) 2006-11-02
WO2006117300A2 (en) 2006-11-09
KR20080007656A (ko) 2008-01-22
WO2006117300A3 (en) 2007-04-26

Similar Documents

Publication Publication Date Title
Suarez et al. Synthesis and study of novel fulleropyrrolidines bearing biologically active 1, 4-dihydropyridines
US9499483B2 (en) Crystal of pyrrole derivative and method for producing the same
RU2007144521A (ru) Новые кристаллические формы тиотропийбромида
JP2008540367A5 (enExample)
CN110770242B (zh) 作为vanin抑制剂的杂芳族化合物
CA2582233A1 (en) Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
ES2653522T3 (es) Un novedoso compuesto de triazolo-piridina
CN107531678B (zh) Egfr抑制剂及其药学上可接受的盐和多晶型物及其应用
AU2006304875A1 (en) Pyrazolo-pyrimidines as casein kinase II (CK2) modulators
ES2707726T3 (es) Amidas de benzoxazinona como moduladores del receptor de mineralocorticoides
Artamonov et al. Synthesis of isomeric 6-trifluoromethyl-3-azabicyclo [3.1. 0] hexanes: Conformationally restricted analogues of 4-trifluoromethylpiperidine
Ge et al. The synthesis, characterization and optical properties of novel pyrido [1, 2-a] benzimidazole derivatives
AU2021201177B2 (en) Processes for preparing an FGFR inhibitor
KR102723164B1 (ko) 피라졸로[1,5-a]피리미딘 화합물의 염 및 이의 결정
Pires et al. New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2
BR112013023480B1 (pt) Composto heterocíclico saturado contendo nitrogênio, seu uso e composição farmacêutica
Girgis et al. Synthesis of new 3-pyridinecarboxylates of potential vasodilation properties
Lu et al. Scaffold hopping approach to a new series of smoothened antagonists
Srinivasa et al. New coumarin carboxylates having trifluoromethyl, diethylamino and morpholino terminal groups: synthesis and mesomorphic characterisations
CN121511244A (zh) (s)-1-(1-(3-氯苯基)-2-(二甲氨基)乙基)-4-(5-吗啉代-1h-吡咯并[2,3-b]吡啶-3-基)吡啶-2(1h)-酮的盐，其制备及其作为erk激酶抑制剂的用途
ES2527032T3 (es) 5,6-dihidro-4H-pirrolo[1,2-a][1,4]-benzodiazepinas y 6H-pirrolo[1,2-a][1,4]benzodiazepinas sustituidas antifúngicas novedosas con derivados de benceno bicíclicos
ES2541668T3 (es) Proceso para preparación de solifenacina y/o de sus sales farmacéuticamente aceptables de alta pureza farmacéutica
ES2784826T3 (es) Forma cristalina de un compuesto de 4H-pirazol[1,5-]benzimidazol, procedimiento de preparación de la misma e intermediario de la misma
Kossakowski et al. Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XVII. Derivatives of 1-ethoxybicyclo [2.2. 2]-oct-5-one-2, 3-dicarboximide
Huang et al. The reaction of benzoyl substituted heterocyclic ketene aminals with 4-nitrobenzhydroximic acid chloride

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20100901