RU2007138584A - Соединения, обладающие активностью для коррекции процессинга мутантного cftr, и их применение - Google Patents

Соединения, обладающие активностью для коррекции процессинга мутантного cftr, и их применение Download PDF

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Publication number
RU2007138584A
RU2007138584A RU2007138584/04A RU2007138584A RU2007138584A RU 2007138584 A RU2007138584 A RU 2007138584A RU 2007138584/04 A RU2007138584/04 A RU 2007138584/04A RU 2007138584 A RU2007138584 A RU 2007138584A RU 2007138584 A RU2007138584 A RU 2007138584A
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group
pharmaceutical composition
pharmaceutically acceptable
composition according
hydrogen
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RU2007138584/04A
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English (en)
Russian (ru)
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Алан ВЕРКМЭН (US)
Алан Веркмэн
Николетта ПЕДЕМОНТЕ (US)
Николетта ПЕДЕМОНТЕ
Луис Дж. В. ГАЛЬЕТТА (US)
Луис Дж. В. ГАЛЬЕТТА
Original Assignee
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния (Us)
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния
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Publication of RU2007138584A publication Critical patent/RU2007138584A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2007138584/04A 2005-03-18 2006-03-08 Соединения, обладающие активностью для коррекции процессинга мутантного cftr, и их применение RU2007138584A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66350105P 2005-03-18 2005-03-18
US60/663,501 2005-03-18

Publications (1)

Publication Number Publication Date
RU2007138584A true RU2007138584A (ru) 2009-04-27

Family

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RU2007138584/04A RU2007138584A (ru) 2005-03-18 2006-03-08 Соединения, обладающие активностью для коррекции процессинга мутантного cftr, и их применение

Country Status (12)

Country Link
US (1) US8143295B2 (US20080318984A1-20081225-C00010.png)
EP (1) EP1863522A4 (US20080318984A1-20081225-C00010.png)
JP (1) JP2008538107A (US20080318984A1-20081225-C00010.png)
KR (1) KR20070114820A (US20080318984A1-20081225-C00010.png)
CN (1) CN101605543A (US20080318984A1-20081225-C00010.png)
AU (1) AU2006227833A1 (US20080318984A1-20081225-C00010.png)
BR (1) BRPI0608453A2 (US20080318984A1-20081225-C00010.png)
CA (1) CA2600869A1 (US20080318984A1-20081225-C00010.png)
IL (1) IL185999A0 (US20080318984A1-20081225-C00010.png)
MX (1) MX2007011512A (US20080318984A1-20081225-C00010.png)
RU (1) RU2007138584A (US20080318984A1-20081225-C00010.png)
WO (1) WO2006101740A2 (US20080318984A1-20081225-C00010.png)

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Publication number Publication date
WO2006101740A2 (en) 2006-09-28
MX2007011512A (es) 2007-12-07
CA2600869A1 (en) 2006-09-28
US20080318984A1 (en) 2008-12-25
WO2006101740A3 (en) 2009-06-04
JP2008538107A (ja) 2008-10-09
KR20070114820A (ko) 2007-12-04
CN101605543A (zh) 2009-12-16
AU2006227833A1 (en) 2006-09-28
BRPI0608453A2 (pt) 2009-12-29
US8143295B2 (en) 2012-03-27
EP1863522A4 (en) 2010-11-10
IL185999A0 (en) 2008-08-07
EP1863522A2 (en) 2007-12-12

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