MX2007011512A - Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos. - Google Patents

Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos.

Info

Publication number
MX2007011512A
MX2007011512A MX2007011512A MX2007011512A MX2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A MX 2007011512 A MX2007011512 A MX 2007011512A
Authority
MX
Mexico
Prior art keywords
containing compounds
compounds
activity
mutant
cftr
Prior art date
Application number
MX2007011512A
Other languages
English (en)
Inventor
Alan Verkman
Nicoletta Pedemonte
Luis J V Galietta
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2007011512A publication Critical patent/MX2007011512A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La invencion proporciona composiciones, preparaciones farmaceuticas y metodos para corregir procesamiento celular (por ejemplo, doblado, trafico o modificacion post-traslacional) de una proteina reguladora de conductancia de transmembrana de fibrosis quistica mutante (por ejemplo, ?F508 CFTR) que son utiles para el tratamiento de fibrosis quistica (CF). Las composiciones y preparaciones farmaceuticas de la invencion pueden comprender uno o mas compuestos conteniendo aminobenzotiazol, compuestos conteniendo aminoariltiazol, compuestos conteniendo quinazolinilaminopirimidona, compuestos conteniendo bisaminometilbitiazol o compuestos conteniendo fenilaminoquinolina de la invencion, o un analogo o derivado de los mismos.
MX2007011512A 2005-03-18 2006-03-08 Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos. MX2007011512A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66350105P 2005-03-18 2005-03-18
PCT/US2006/008267 WO2006101740A2 (en) 2005-03-18 2006-03-08 Compounds having activity in correcting mutant-cftr processing and uses thereof

Publications (1)

Publication Number Publication Date
MX2007011512A true MX2007011512A (es) 2007-12-07

Family

ID=37024308

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007011512A MX2007011512A (es) 2005-03-18 2006-03-08 Compuestos que tienen actividad para corregir procesamiento de cftr-mutante y usos de los mismos.

Country Status (12)

Country Link
US (1) US8143295B2 (es)
EP (1) EP1863522A4 (es)
JP (1) JP2008538107A (es)
KR (1) KR20070114820A (es)
CN (1) CN101605543A (es)
AU (1) AU2006227833A1 (es)
BR (1) BRPI0608453A2 (es)
CA (1) CA2600869A1 (es)
IL (1) IL185999A0 (es)
MX (1) MX2007011512A (es)
RU (1) RU2007138584A (es)
WO (1) WO2006101740A2 (es)

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RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
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WO2012027247A2 (en) 2010-08-23 2012-03-01 Vertex Pharmaceuticals Incorporated Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof
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CA2754237A1 (en) 2011-05-27 2012-11-27 The Regents Of The University Of California Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof
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Also Published As

Publication number Publication date
WO2006101740A3 (en) 2009-06-04
US8143295B2 (en) 2012-03-27
EP1863522A4 (en) 2010-11-10
IL185999A0 (en) 2008-08-07
BRPI0608453A2 (pt) 2009-12-29
US20080318984A1 (en) 2008-12-25
KR20070114820A (ko) 2007-12-04
EP1863522A2 (en) 2007-12-12
JP2008538107A (ja) 2008-10-09
WO2006101740A2 (en) 2006-09-28
AU2006227833A1 (en) 2006-09-28
RU2007138584A (ru) 2009-04-27
CA2600869A1 (en) 2006-09-28
CN101605543A (zh) 2009-12-16

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