RU2007130150A - Новая солевая форма агониста дофамина - Google Patents
Новая солевая форма агониста дофамина Download PDFInfo
- Publication number
- RU2007130150A RU2007130150A RU2007130150/04A RU2007130150A RU2007130150A RU 2007130150 A RU2007130150 A RU 2007130150A RU 2007130150/04 A RU2007130150/04 A RU 2007130150/04A RU 2007130150 A RU2007130150 A RU 2007130150A RU 2007130150 A RU2007130150 A RU 2007130150A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- propylmorpholin
- pyridin
- camsylate
- amine
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Claims (12)
1. 5-[(2R,5S)-5-метил-4-пропилморфолин-2-ил]пиридин-2-амина ди-S-камсилат
2. Соединение по п.1 в форме моногидрата.
3. Соединение по п.2, имеющее основные характеристические пики на картине дифракции рентгеновских лучей на порошке, генерированные с использованием медных К-альфат рентгеновских лучей (длина волны равна 1,54056 ангстрем), составляющие 6,3, 12,7, 15,1, 16,3 и 25,6 градусов 28.
4. Фармацевтическая композиция, содержащая 5-[(2R,5S)-5-метил-4-пропилморфолин-2-ил]пиридин-2-амина ди-S-камсилат и фармацевтически приемлемый разбавитель или носитель.
5. Фармацевтическая композиция по п.4, где 5-[(2R,5S)-5-метил-4-пропилморфолин-2-ил]пиридин-2-амина ди-S-камсилат находится в форме моногидрата.
6. Соединение по любому из пп.1-3 для применения в медицине.
7. Применение соединения по любому из пп.1-3 в приготовлении лекарственного средства для лечения сексуальной дисфункции.
8. Применение по п.7, где сексуальная дисфункция представляет собой мужскую эректильную дисфункцию или женскую сексуальную дисфункцию.
9. Применение соединения по любому из пп.1-3 в приготовлении лекарственного средства для лечения нейропсихиатрических расстройств или нейродегенеративных расстройств.
10. Способ получения 5-[(2R,5S)-5-метил-4-пропилморфолин-2-ил]пиридин-2-амина ди-S-камсилата моногидрата, включающий взаимодействие соединения формулы (X)
с (1S)-10-камфорсульфоновой кислотой в подходящем растворителе.
11. Способ по п.10, где растворителем является ацетон/вода.
12. Соединение формулы (VII)
и его фармацевтически приемлемые соли и сольваты.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0502509.3A GB0502509D0 (en) | 2005-02-07 | 2005-02-07 | Novel salt form of a dopamine agonist |
| GB0502509.3 | 2005-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007130150A true RU2007130150A (ru) | 2009-03-20 |
| RU2393153C2 RU2393153C2 (ru) | 2010-06-27 |
Family
ID=34355919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007130150/04A RU2393153C2 (ru) | 2005-02-07 | 2006-01-26 | Новая солевая форма агониста дофамина |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7498329B2 (ru) |
| EP (1) | EP1848709B1 (ru) |
| JP (1) | JP4157158B2 (ru) |
| KR (1) | KR100997033B1 (ru) |
| CN (1) | CN101115737B (ru) |
| AR (1) | AR053122A1 (ru) |
| AT (1) | ATE509924T1 (ru) |
| AU (1) | AU2006211033A1 (ru) |
| BR (1) | BRPI0608149A2 (ru) |
| CA (1) | CA2595815C (ru) |
| DO (1) | DOP2006000030A (ru) |
| ES (1) | ES2364345T3 (ru) |
| GB (1) | GB0502509D0 (ru) |
| GT (1) | GT200600040A (ru) |
| HN (1) | HN2006004827A (ru) |
| IL (1) | IL184395A0 (ru) |
| MX (1) | MX2007008462A (ru) |
| NL (1) | NL1031087C2 (ru) |
| NZ (1) | NZ556292A (ru) |
| PA (1) | PA8662001A1 (ru) |
| PE (1) | PE20061034A1 (ru) |
| RU (1) | RU2393153C2 (ru) |
| TW (1) | TWI314930B (ru) |
| UY (1) | UY29365A1 (ru) |
| WO (1) | WO2006082511A1 (ru) |
| ZA (1) | ZA200605491B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8522799B2 (en) * | 2005-12-30 | 2013-09-03 | Lam Research Corporation | Apparatus and system for cleaning a substrate |
| KR100913791B1 (ko) * | 2006-07-21 | 2009-08-26 | 한미약품 주식회사 | (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물 |
| GB0700786D0 (en) * | 2007-01-15 | 2007-02-21 | Pfizer Ltd | Morpholine dopamine agonists for the treatment of pain |
| WO2011098971A1 (en) | 2010-02-12 | 2011-08-18 | Pfizer Inc. | Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
| WO2016067043A1 (en) | 2014-10-31 | 2016-05-06 | Indivior Uk Limited | Dopamine d3 receptor antagonists compounds |
| GB2543296A (en) * | 2015-10-13 | 2017-04-19 | Indivior Uk Ltd | Dopamine D3 receptor antagonists having a morpholine moiety |
| RU2622018C1 (ru) * | 2016-06-16 | 2017-06-08 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7323462B2 (en) * | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
| CA2508262C (en) * | 2002-12-10 | 2009-12-01 | Pfizer Inc. | Morpholine derivatives for use as dopamine agonists in the treatment of i.a. sexual dysfunction |
| BRPI0511571A (pt) * | 2004-05-27 | 2008-01-02 | Pfizer | derivados de aminopiridina como agonistas de dopamina d3 seletivos |
-
2005
- 2005-02-07 GB GBGB0502509.3A patent/GB0502509D0/en not_active Ceased
-
2006
- 2006-01-26 AT AT06701218T patent/ATE509924T1/de not_active IP Right Cessation
- 2006-01-26 EP EP06701218A patent/EP1848709B1/en not_active Not-in-force
- 2006-01-26 JP JP2007553731A patent/JP4157158B2/ja not_active Expired - Fee Related
- 2006-01-26 NZ NZ556292A patent/NZ556292A/en not_active IP Right Cessation
- 2006-01-26 CA CA2595815A patent/CA2595815C/en not_active Expired - Fee Related
- 2006-01-26 BR BRPI0608149-5A patent/BRPI0608149A2/pt not_active IP Right Cessation
- 2006-01-26 CN CN2006800042826A patent/CN101115737B/zh not_active Expired - Fee Related
- 2006-01-26 MX MX2007008462A patent/MX2007008462A/es active IP Right Grant
- 2006-01-26 RU RU2007130150/04A patent/RU2393153C2/ru not_active IP Right Cessation
- 2006-01-26 KR KR1020077018050A patent/KR100997033B1/ko not_active IP Right Cessation
- 2006-01-26 AU AU2006211033A patent/AU2006211033A1/en not_active Abandoned
- 2006-01-26 WO PCT/IB2006/000222 patent/WO2006082511A1/en active Application Filing
- 2006-01-26 ES ES06701218T patent/ES2364345T3/es active Active
- 2006-02-03 HN HN2006004827A patent/HN2006004827A/es unknown
- 2006-02-03 PE PE2006000138A patent/PE20061034A1/es not_active Application Discontinuation
- 2006-02-06 GT GT200600040A patent/GT200600040A/es unknown
- 2006-02-06 TW TW095103882A patent/TWI314930B/zh not_active IP Right Cessation
- 2006-02-06 AR ARP060100417A patent/AR053122A1/es unknown
- 2006-02-06 DO DO2006000030A patent/DOP2006000030A/es unknown
- 2006-02-06 NL NL1031087A patent/NL1031087C2/nl not_active IP Right Cessation
- 2006-02-06 US US11/349,324 patent/US7498329B2/en not_active Expired - Fee Related
- 2006-02-07 PA PA20068662001A patent/PA8662001A1/es unknown
- 2006-02-07 UY UY29365A patent/UY29365A1/es not_active Application Discontinuation
-
2007
- 2007-07-03 IL IL184395A patent/IL184395A0/en unknown
- 2007-07-05 ZA ZA200605491A patent/ZA200605491B/xx unknown
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120127 |