RU2006145020A - Полипептиды и конъюгаты интерферона-альфа - Google Patents
Полипептиды и конъюгаты интерферона-альфа Download PDFInfo
- Publication number
- RU2006145020A RU2006145020A RU2006145020/04A RU2006145020A RU2006145020A RU 2006145020 A RU2006145020 A RU 2006145020A RU 2006145020/04 A RU2006145020/04 A RU 2006145020/04A RU 2006145020 A RU2006145020 A RU 2006145020A RU 2006145020 A RU2006145020 A RU 2006145020A
- Authority
- RU
- Russia
- Prior art keywords
- polypeptide
- seq
- conjugate
- sequence
- group
- Prior art date
Links
- 102000006992 Interferon-alpha Human genes 0.000 title 1
- 108010047761 Interferon-alpha Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 95
- 102000004196 processed proteins & peptides Human genes 0.000 claims 95
- 108090000765 processed proteins & peptides Proteins 0.000 claims 95
- 210000004027 cell Anatomy 0.000 claims 20
- 230000000840 anti-viral effect Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 229930182817 methionine Natural products 0.000 claims 9
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 241000711549 Hepacivirus C Species 0.000 claims 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 241000700721 Hepatitis B virus Species 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 102220598625 5-hydroxytryptamine receptor 1E_F48A_mutation Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 238000000605 extraction Methods 0.000 claims 4
- 210000003000 inclusion body Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 102220598658 5-hydroxytryptamine receptor 1E_F65A_mutation Human genes 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 230000001279 glycosylating effect Effects 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 102200104804 rs34056189 Human genes 0.000 claims 2
- 230000003381 solubilizing effect Effects 0.000 claims 2
- 102220510810 APC membrane recruitment protein 1_F90A_mutation Human genes 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 102220631575 Natriuretic peptides B_M93L_mutation Human genes 0.000 claims 1
- 102220507208 Rab11 family-interacting protein 1_M21A_mutation Human genes 0.000 claims 1
- 102220533724 Ribonuclease pancreatic_N95D_mutation Human genes 0.000 claims 1
- 102220602180 Synaptotagmin-3_F55A_mutation Human genes 0.000 claims 1
- 102220536494 THAP domain-containing protein 1_S55A_mutation Human genes 0.000 claims 1
- 102220575111 UDP-glucuronosyltransferase 1A10_F90Y_mutation Human genes 0.000 claims 1
- 102220380138 c.151A>C Human genes 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 102200036626 rs104893877 Human genes 0.000 claims 1
- 102220223162 rs1060502962 Human genes 0.000 claims 1
- 102220294979 rs140094683 Human genes 0.000 claims 1
- 102220256581 rs1553585708 Human genes 0.000 claims 1
- 102200057159 rs2307397 Human genes 0.000 claims 1
- 102220035353 rs281865438 Human genes 0.000 claims 1
- 102220045375 rs587782052 Human genes 0.000 claims 1
- 102220049406 rs587784324 Human genes 0.000 claims 1
- 102220001969 rs696217 Human genes 0.000 claims 1
- 102220214173 rs74936036 Human genes 0.000 claims 1
- 102200065571 rs762020512 Human genes 0.000 claims 1
- 102220115707 rs886039770 Human genes 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57250404P | 2004-05-19 | 2004-05-19 | |
| US60/572,504 | 2004-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006145020A true RU2006145020A (ru) | 2008-06-27 |
Family
ID=35428915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006145020/04A RU2006145020A (ru) | 2004-05-19 | 2005-05-18 | Полипептиды и конъюгаты интерферона-альфа |
Country Status (14)
| Country | Link |
|---|---|
| US (9) | US7318918B2 (https=) |
| EP (1) | EP1753779A2 (https=) |
| JP (1) | JP2008507298A (https=) |
| CN (1) | CN101115769A (https=) |
| AR (1) | AR049177A1 (https=) |
| AU (1) | AU2005245918A1 (https=) |
| BR (1) | BRPI0511196A (https=) |
| CA (1) | CA2566247A1 (https=) |
| IL (1) | IL178470A0 (https=) |
| MX (1) | MXPA06013412A (https=) |
| NO (1) | NO20065084L (https=) |
| RU (1) | RU2006145020A (https=) |
| TW (1) | TW200611910A (https=) |
| WO (1) | WO2005113592A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2360011A1 (en) | 1999-01-05 | 2000-07-13 | Trustees Of Boston University | Ordered gene assembly |
| US20040005673A1 (en) | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
| AU2001277014A1 (en) * | 2000-07-21 | 2002-02-05 | Trustees Of Boston University | Modular vector systems |
| US7435562B2 (en) | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
| JP2008500750A (ja) * | 2004-05-12 | 2008-01-10 | フュージョンワン インコーポレイテッド | 高度な連絡先識別システム |
| WO2006053131A1 (en) | 2004-11-11 | 2006-05-18 | Modular Genetics, Inc. | Ladder assembly and system for generating diversity |
| AU2006257286B2 (en) * | 2005-03-09 | 2012-08-16 | Superlab Far East Limited | Uses of recombinant super-compound interferons |
| EP1888633A4 (en) | 2005-05-18 | 2010-01-27 | Maxygen Inc | UNFOLDED INTERFERON ALPHA POLYPEPTIDE |
| AR078117A1 (es) * | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
| US20080014616A1 (en) * | 2006-07-11 | 2008-01-17 | Kevin Jarrell | Methods of introducing targeted diversity into nucleic acid molecules |
| WO2008013082A1 (en) * | 2006-07-25 | 2008-01-31 | Galpharma Co., Ltd. | Galectin 9-polymer conjugate |
| US7808342B2 (en) * | 2006-10-02 | 2010-10-05 | Skyworks Solutions, Inc. | Harmonic phase tuning filter for RF switches |
| WO2008124086A2 (en) | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| WO2009006579A1 (en) * | 2007-07-05 | 2009-01-08 | Pharmaessentia Corp. | Peptide-polymer conjugates |
| WO2009046080A1 (en) | 2007-10-01 | 2009-04-09 | Pharmaessentia Corp. | N-terminal modified interferon-alpha |
| KR20100103595A (ko) * | 2008-01-18 | 2010-09-27 | 에프. 호프만-라 로슈 아게 | 비-글라이코실화된 단백질의 정제 |
| US7954022B2 (en) * | 2008-01-30 | 2011-05-31 | Alcatel-Lucent Usa Inc. | Apparatus and method for controlling dynamic modification of a scan path |
| MX2011005051A (es) * | 2008-11-17 | 2011-06-01 | Genentech Inc | Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas. |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| US9944688B2 (en) | 2011-06-02 | 2018-04-17 | Hanmi Science Co., Ltd. | Non-peptidyl polymer-insulin multimer and method for producing the same |
| AU2012275390A1 (en) | 2011-06-28 | 2014-01-16 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| CN102358897B (zh) * | 2011-10-31 | 2013-02-13 | 北京三元基因工程有限公司 | 重组人寡腺苷酸合成酶-1的制备方法 |
| WO2015168474A1 (en) * | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
| ES2630106T3 (es) * | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| CN115400220A (zh) | 2015-12-30 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 减少聚山梨酯降解的制剂 |
| CN116769054A (zh) * | 2016-02-05 | 2023-09-19 | 奥里尼斯生物科学私人有限公司 | 双特异性信号传导剂及其用途 |
| RU2650755C1 (ru) * | 2017-05-24 | 2018-04-17 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ очистки лекарственного средства пролонгированного действия на основе рекомбинантного аналога интерферона альфа-17 для лечения вирусного гепатита С |
| EP4093755A4 (en) * | 2020-01-24 | 2024-07-31 | Alkermes Pharma Ireland Limited | PURIFICATION PROCESSES |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610830B1 (en) * | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| ES506955A0 (es) | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| WO1983002461A1 (en) | 1982-01-19 | 1983-07-21 | Cetus Corp | Multiclass hybrid interferons |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| JPS60152058A (ja) * | 1984-01-20 | 1985-08-10 | Toshiba Corp | 半導体記憶装置 |
| EP0205404B1 (en) * | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US4695626A (en) * | 1986-07-29 | 1987-09-22 | Pfizer Inc. | 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters |
| AU660633B2 (en) | 1990-10-17 | 1995-07-06 | Amgen, Inc. | Methods and compositions for the treatment of cell proliferation disorders |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| PT741577E (pt) | 1994-03-07 | 2003-03-31 | Imperial College | Utilizacao do subtipo de interferao alfa 8 na preparacao de medicamentos para tratar infeccoes virais do figado |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| ES2297889T3 (es) | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
| CA2359345A1 (en) | 1999-01-14 | 2000-07-20 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| AU3725600A (en) * | 1999-03-02 | 2000-09-21 | Maxygen, Inc. | Surrogate orphan ligands for orphan receptors |
| RU2262510C9 (ru) | 1999-05-19 | 2006-04-20 | Лексиген Фармасьютикэлс Корп. | Слитый белок, обладающий биологической активностью интерферона-альфа, димерный слитый белок, фармацевтическая композиция, их содержащая, молекула днк (варианты) и способ адресования интерферона-альфа в ткани печени |
| WO2001025438A2 (en) | 1999-10-07 | 2001-04-12 | Maxygen, Inc. | Ifn-alpha homologues |
| US20040002474A1 (en) * | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
| CA2390292A1 (en) * | 1999-11-12 | 2001-05-25 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
| IL152804A0 (en) | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| WO2002044197A2 (en) | 2000-12-01 | 2002-06-06 | Fish Eleanor N | Cytokine receptor binding peptides |
| KR100459105B1 (ko) | 2001-02-15 | 2004-12-03 | 선바이오(주) | 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체 |
| ATE337017T1 (de) * | 2002-11-15 | 2006-09-15 | Hoffmann La Roche | Positionelle isomeren von pegyliertem interferon alpha 2a |
| EP1565205A4 (en) * | 2002-11-18 | 2006-07-05 | Maxygen Inc | Interferon-alpha polypeptides and conjugates |
-
2005
- 2005-05-18 CN CNA2005800241473A patent/CN101115769A/zh active Pending
- 2005-05-18 EP EP05751765A patent/EP1753779A2/en not_active Withdrawn
- 2005-05-18 TW TW094116107A patent/TW200611910A/zh unknown
- 2005-05-18 RU RU2006145020/04A patent/RU2006145020A/ru unknown
- 2005-05-18 CA CA002566247A patent/CA2566247A1/en not_active Abandoned
- 2005-05-18 JP JP2007527427A patent/JP2008507298A/ja active Pending
- 2005-05-18 BR BRPI0511196-0A patent/BRPI0511196A/pt not_active Application Discontinuation
- 2005-05-18 WO PCT/US2005/017471 patent/WO2005113592A2/en not_active Ceased
- 2005-05-18 US US11/132,722 patent/US7318918B2/en not_active Expired - Fee Related
- 2005-05-18 MX MXPA06013412A patent/MXPA06013412A/es unknown
- 2005-05-18 AU AU2005245918A patent/AU2005245918A1/en not_active Abandoned
- 2005-05-19 AR ARP050102059A patent/AR049177A1/es unknown
-
2006
- 2006-09-13 US US11/531,557 patent/US7531324B2/en not_active Expired - Fee Related
- 2006-09-13 US US11/531,570 patent/US20070020734A1/en not_active Abandoned
- 2006-09-13 US US11/531,531 patent/US7531630B2/en not_active Expired - Fee Related
- 2006-09-14 US US11/532,045 patent/US20070225205A1/en not_active Abandoned
- 2006-09-14 US US11/532,024 patent/US20070225204A1/en not_active Abandoned
- 2006-10-05 IL IL178470A patent/IL178470A0/en unknown
- 2006-11-03 NO NO20065084A patent/NO20065084L/no unknown
-
2007
- 2007-05-04 US US11/744,424 patent/US7541436B2/en not_active Expired - Fee Related
- 2007-08-14 US US11/838,730 patent/US7541163B2/en not_active Expired - Fee Related
- 2007-08-15 US US11/839,493 patent/US7537755B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080171363A1 (en) | 2008-07-17 |
| TW200611910A (en) | 2006-04-16 |
| AR049177A1 (es) | 2006-07-05 |
| US7541163B2 (en) | 2009-06-02 |
| WO2005113592A3 (en) | 2006-04-06 |
| US20070225205A1 (en) | 2007-09-27 |
| US7541436B2 (en) | 2009-06-02 |
| BRPI0511196A (pt) | 2007-12-04 |
| US20070025966A1 (en) | 2007-02-01 |
| IL178470A0 (en) | 2007-02-11 |
| US20080031853A1 (en) | 2008-02-07 |
| US20080076710A1 (en) | 2008-03-27 |
| US20050266465A1 (en) | 2005-12-01 |
| US7537755B2 (en) | 2009-05-26 |
| EP1753779A2 (en) | 2007-02-21 |
| JP2008507298A (ja) | 2008-03-13 |
| CA2566247A1 (en) | 2005-12-01 |
| CN101115769A (zh) | 2008-01-30 |
| US20070225204A1 (en) | 2007-09-27 |
| US20070020235A1 (en) | 2007-01-25 |
| US20070020734A1 (en) | 2007-01-25 |
| NO20065084L (no) | 2006-12-01 |
| MXPA06013412A (es) | 2007-01-23 |
| WO2005113592A2 (en) | 2005-12-01 |
| US7531324B2 (en) | 2009-05-12 |
| AU2005245918A1 (en) | 2005-12-01 |
| US7531630B2 (en) | 2009-05-12 |
| US7318918B2 (en) | 2008-01-15 |
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