RU2006144821A - Пролонгирующие метки полипептидов, содержащие тетразольную группировку - Google Patents
Пролонгирующие метки полипептидов, содержащие тетразольную группировку Download PDFInfo
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- RU2006144821A RU2006144821A RU2006144821/04A RU2006144821A RU2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821/04 A RU2006144821/04 A RU 2006144821/04A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A
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- ethoxy
- lys
- tetrazol
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 20
- 229920001184 polypeptide Polymers 0.000 title claims 19
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical group C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- -1 heterocyclic carboxylic acid Chemical class 0.000 claims 58
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 43
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 28
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 27
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- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
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- SQZJBKPSJIVZHK-UHFFFAOYSA-N n-[2-[2-[2-[2-[2-(2-amino-2-oxoethoxy)ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethyl]-16-(2h-tetrazol-5-yl)hexadecanamide Chemical compound NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCC1=NN=NN1 SQZJBKPSJIVZHK-UHFFFAOYSA-N 0.000 claims 1
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- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
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- 0 *C(CCc1cnc[n]1)=O Chemical compound *C(CCc1cnc[n]1)=O 0.000 description 1
- WWJNGHRZEREFLO-UHFFFAOYSA-N CCCCCNC(COCCOCCNC(CCCS(NC(CCCCCCCCCCCCCCCc1nnn[nH]1)=O)(=O)=O)=O)=O Chemical compound CCCCCNC(COCCOCCNC(CCCS(NC(CCCCCCCCCCCCCCCc1nnn[nH]1)=O)(=O)=O)=O)=O WWJNGHRZEREFLO-UHFFFAOYSA-N 0.000 description 1
- WSBLYUZBKDJSJU-MHZLTWQESA-N CN[C@@H](CCCCNC(CCCOc(cc1)ccc1-c(cc1)ccc1-c(cc1)ccc1-c1nnn[nH]1)=O)C(O)=O Chemical compound CN[C@@H](CCCCNC(CCCOc(cc1)ccc1-c(cc1)ccc1-c(cc1)ccc1-c1nnn[nH]1)=O)C(O)=O WSBLYUZBKDJSJU-MHZLTWQESA-N 0.000 description 1
Classifications
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401083 | 2004-07-08 | ||
| DKPA200401083 | 2004-07-08 | ||
| EP05102167 | 2005-03-18 | ||
| EP05102167.3 | 2005-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006144821A true RU2006144821A (ru) | 2008-08-20 |
Family
ID=35453538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006144821/04A RU2006144821A (ru) | 2004-07-08 | 2005-06-21 | Пролонгирующие метки полипептидов, содержащие тетразольную группировку |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20090111730A1 (https=) |
| EP (3) | EP2289560B1 (https=) |
| JP (1) | JP2008507477A (https=) |
| KR (1) | KR20070029247A (https=) |
| CN (1) | CN101005857A (https=) |
| AU (1) | AU2005261740A1 (https=) |
| BR (1) | BRPI0512988A (https=) |
| CA (1) | CA2572770A1 (https=) |
| ES (2) | ES2542228T3 (https=) |
| MX (1) | MXPA06015049A (https=) |
| RU (1) | RU2006144821A (https=) |
| WO (1) | WO2006005667A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5755398B2 (ja) * | 2005-03-18 | 2015-07-29 | ノヴォ ノルディスク アー／エス | 伸長されたｇｌｐ−１化合物 |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CN100374462C (zh) * | 2005-11-21 | 2008-03-12 | 大连帝恩生物工程有限公司 | 截短胰高血糖素样肽1(sGLP-1)、制法及其应用 |
| JP5252435B2 (ja) * | 2006-03-15 | 2013-07-31 | ノボ・ノルデイスク・エー／エス | アミリン誘導体 |
| US20090318353A1 (en) * | 2006-08-25 | 2009-12-24 | Novo Nordisk A/S | Acylated Exendin-4 Compounds |
| JP2010516654A (ja) * | 2007-01-18 | 2010-05-20 | ノボ・ノルデイスク・エー／エス | 肥満の治療に使用される新規ペプチド |
| WO2008087188A2 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| WO2008087190A2 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Use of peptides in combination with surgical intervention for the treatment of obesity |
| WO2008087187A1 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| EP2106405A2 (en) * | 2007-01-18 | 2009-10-07 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| WO2009030774A1 (en) * | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| EP2190872B1 (en) * | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| US20100261637A1 (en) | 2007-09-05 | 2010-10-14 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| EP2235042A1 (en) * | 2008-01-23 | 2010-10-06 | Novo Nordisk Health Care AG | New blood coagulation factor inhibitors |
| CN102037008B (zh) | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
| CN102027007A (zh) * | 2008-05-16 | 2011-04-20 | 诺沃-诺迪斯克有限公司 | 长效的y2和/或y4受体激动剂 |
| WO2009141392A1 (en) * | 2008-05-22 | 2009-11-26 | Novo Nordisk A/S | Process |
| KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
| CN102197049B (zh) | 2008-10-21 | 2015-03-25 | 诺沃-诺迪斯克有限公司 | 胰岛淀粉样多肽衍生物 |
| AU2009334289A1 (en) * | 2008-12-29 | 2011-07-28 | Panacea Biotec Ltd | GLP-1 analogs and uses thereof |
| JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| BRPI1007313A2 (pt) | 2009-01-23 | 2016-02-10 | Novo Nordisk As | derivados de fgf21 com ligante de albumina a-b-c-d-e e seu uso. |
| JP6086528B2 (ja) | 2009-08-06 | 2017-03-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 長期のインビボ有効性を有する成長ホルモン |
| EP2477643A1 (en) * | 2009-09-18 | 2012-07-25 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| WO2011058165A1 (en) * | 2009-11-13 | 2011-05-19 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| EP2512518A1 (en) | 2009-12-16 | 2012-10-24 | Novo Nordisk A/S | Glp-1 receptor agonist compounds with a modified n-terminus |
| JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| CN118767117A (zh) | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| US9040660B2 (en) | 2010-04-20 | 2015-05-26 | Novo Nordisk A/S | Long-acting gastrin derivatives |
| EP2595647A1 (en) * | 2010-07-20 | 2013-05-29 | Novo Nordisk A/S | N-terminal modified fgf21 compounds |
| MX377589B (es) | 2010-12-16 | 2025-03-10 | Novo Nordisk As | Composiciones sólidas que comprenden agonista de glp-1 y sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico. |
| RU2602601C2 (ru) | 2011-04-12 | 2016-11-20 | Ново Нордиск А/С | Дважды ацилированные производные glp-1 |
| JP6046161B2 (ja) | 2011-12-29 | 2016-12-14 | ノヴォ ノルディスク アー／エス | 非タンパク質新生アミノ酸を含むジペプチド |
| EP3542790B1 (en) | 2012-03-22 | 2023-09-13 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
| CN104203266B (zh) | 2012-03-22 | 2017-12-26 | 诺和诺德股份有限公司 | Glp‑1肽组合物及其制备 |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| US20150273069A1 (en) | 2012-10-17 | 2015-10-01 | Novo Nordisk A/S | Fatty acid acylated amino acids for oral peptide delivery |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| JP6672140B2 (ja) | 2013-05-02 | 2020-03-25 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１化合物の経口投薬 |
| CN103304499B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304502B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| CN103304503B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304501B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| WO2014209034A1 (en) * | 2013-06-27 | 2014-12-31 | Lg Life Sciences Ltd. | Biaryl derivatives as gpr120 agonists |
| US10583172B2 (en) | 2013-11-15 | 2020-03-10 | Novo Nordisk A/S | HPYY(1-36) having a beta-homoarginine substitution at position 35 |
| MX369818B (es) | 2013-11-15 | 2019-11-22 | Novo Nordisk As | Compuestos selectivos de peptido yy (pyy) y usos de los mismos. |
| DK3006045T3 (en) | 2014-10-07 | 2017-07-17 | Cyprumed Gmbh | Pharmaceutical formulations for oral administration of peptide or protein drugs |
| AR103246A1 (es) | 2014-12-23 | 2017-04-26 | Novo Nordiks As | Derivados de fgf21 y sus usos |
| MA43205A (fr) | 2015-06-12 | 2018-09-19 | Novo Nordisk As | Composés pyy sélectifs et leurs utilisations |
| EP3359181A1 (en) | 2015-10-07 | 2018-08-15 | Cyprumed GmbH | Pharmaceutical formulations for the oral delivery of peptide drugs |
| WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
| CN107589246B (zh) * | 2017-03-07 | 2019-10-01 | 上海原科实业发展有限公司 | 一种纤维蛋白激活剂、其制备方法，包括该激活剂的试剂盒及采用该试剂盒的检测方法 |
| WO2019016300A1 (en) | 2017-07-19 | 2019-01-24 | Novo Nordisk A/S | EGF ANALOGUES (A), PREPARATION, FORMULATIONS AND USES THEREOF |
| WO2019098254A1 (ja) * | 2017-11-14 | 2019-05-23 | 千寿製薬株式会社 | Ｐａｃａｐの安定化ペプチド |
| PL3746111T3 (pl) | 2018-02-02 | 2024-01-15 | Novo Nordisk A/S | Stałe kompozycje zawierające agonistę glp-1 i sól kwasu n-(8-(2- hydroksybenzoilo)amino kaprylowego i substancję poślizgową |
| EP3773475A1 (en) | 2018-04-06 | 2021-02-17 | Cyprumed GmbH | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| WO2019229242A1 (en) | 2018-05-31 | 2019-12-05 | Novo Nordisk A/S | Derivatives comprising an apelin analogue and uses thereof |
| SG11202106167XA (en) | 2018-12-11 | 2021-07-29 | Sanofi Sa | Insulin conjugates |
| CN119529057A (zh) * | 2019-12-30 | 2025-02-28 | 甘李药业股份有限公司 | 长效glp-1化合物 |
| CN111333714A (zh) * | 2020-03-05 | 2020-06-26 | 成都奥达生物科技有限公司 | 一种长效glp-1化合物 |
| EP4142695B1 (en) | 2020-04-29 | 2025-11-05 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| WO2022049310A1 (en) | 2020-09-07 | 2022-03-10 | Cyprumed Gmbh | Improved pharmaceutical formulations of glp-1 receptor agonists |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| JP2026502943A (ja) | 2022-12-30 | 2026-01-27 | アルギファルマ エーエス | 経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| CN120731085A (zh) * | 2023-03-02 | 2025-09-30 | 甘李药业股份有限公司 | 一种glp-1化合物的医药用途 |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3869437A (en) * | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
| US4423224A (en) * | 1980-09-08 | 1983-12-27 | Sds Biotech Corporation | 4-Me-1-(2-(1H-tetrazol-5-yl)ethyl)benzene sulfonate and N-2-(1H-tetrazol-5-yl)ethyl methanesulfonamide |
| JPS604165A (ja) * | 1983-06-21 | 1985-01-10 | Taiho Yakuhin Kogyo Kk | スルホニウム誘導体 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3626130A1 (de) * | 1986-08-01 | 1988-02-11 | Merck Patent Gmbh | Aminosaeurederivate |
| WO1992001476A1 (en) | 1990-07-26 | 1992-02-06 | University Of Iowa Research Foundation | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
| US6492531B1 (en) * | 1992-02-18 | 2002-12-10 | Warner-Lambert Company | Method of treating cognitive disorders |
| TW289757B (https=) * | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| US5776927A (en) * | 1994-04-18 | 1998-07-07 | Corvas International, Inc. | Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors |
| US5883107A (en) * | 1994-06-17 | 1999-03-16 | Corvas International, Inc. | Arginine mimic derivatives as enzyme inhibitors |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| DE19521653A1 (de) * | 1995-06-14 | 1996-12-19 | Hoechst Schering Agrevo Gmbh | Substituierte Tetrazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| EP0761680A3 (en) * | 1995-09-12 | 1999-05-06 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
| JPH09136878A (ja) | 1995-09-12 | 1997-05-27 | Ono Pharmaceut Co Ltd | テトラゾール誘導体 |
| US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| JP2002514635A (ja) | 1998-05-12 | 2002-05-21 | アメリカン・ホーム・プロダクツ・コーポレイション | インスリン耐性および高血糖の処置に有用なビフェニルオキソ−酢酸 |
| US6358705B1 (en) | 1998-07-16 | 2002-03-19 | Novo Nordisk A/S | Method of making proteins in transformed yeast cells |
| US6337340B1 (en) * | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
| DK1143989T3 (da) * | 1999-01-14 | 2007-04-16 | Amylin Pharmaceuticals Inc | Exendiner til glucagonundertrykkelse |
| AU2002236830A1 (en) * | 2001-01-26 | 2002-08-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors |
| CA2437409C (en) * | 2001-02-20 | 2010-10-19 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| EP1406872B1 (en) * | 2001-06-20 | 2007-12-19 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| JP2004537580A (ja) * | 2001-08-10 | 2004-12-16 | エピックス メディカル， インコーポレイテッド | 延長された循環半減期を有するポリペプチド結合体 |
| DE60220424T2 (de) * | 2001-09-14 | 2008-03-06 | Novo Nordisk A/S | NEUE LIGANDEN FÜR DIE HisB10 Zn2+ STELLEN DES INSULIN-HEXAMERS IN DER R-KONFORMATION |
| AU2002348948A1 (en) * | 2001-11-30 | 2003-06-10 | Pfizer Products Inc. | Pharmaceutical compositions and methods for administering EP2 receptors selective agonists |
| ATE448193T1 (de) * | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| US20050070506A1 (en) * | 2002-01-18 | 2005-03-31 | Doherty George A. | Selective s1p1/edg1 receptor agonists |
| TW200400035A (en) * | 2002-03-28 | 2004-01-01 | Glaxo Group Ltd | Novel compounds |
| HRP20041220A2 (hr) * | 2002-05-28 | 2006-04-30 | 3-Dimensional Pharmaceuticals | Novi tiofen amidini, njihovi pripravci i postupci liječenja komplementom posredovanih bolesti i stanja |
| AU2003240164A1 (en) | 2002-06-07 | 2003-12-22 | Ranbaxy Laboratories Limited | Extended release formulation of divalproex sodium |
| US20060154926A1 (en) * | 2002-06-11 | 2006-07-13 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
| WO2004050657A2 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE |
| KR101032582B1 (ko) * | 2002-12-03 | 2011-05-06 | 시바 홀딩 인크 | 헤테로방향족 그룹을 갖는 옥심 에스테르 광개시제 |
| EP1585541B1 (en) | 2002-12-20 | 2007-11-14 | Novo Nordisk A/S | Pharmaceutical compositions comprising insulin and legends of insulin hexamer |
| EP1610812A1 (en) | 2003-03-11 | 2006-01-04 | Novo Nordisk A/S | Pharmaceutical preparations comprising acid-stabilised insulin |
| US20050096466A1 (en) * | 2003-09-19 | 2005-05-05 | Schwinden Mark D. | Process for the preparation of tetrazol-derived compounds as growth hormone secretagogues |
| KR101241862B1 (ko) * | 2003-09-19 | 2013-03-13 | 노보 노르디스크 에이/에스 | 신규 ｇｌｐ-1 유도체 |
| JP2007537981A (ja) * | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| JP2007537142A (ja) * | 2003-12-18 | 2007-12-20 | ノボ ノルディスク アクティーゼルスカブ | アルブミン様物質に結合した新規のｇｌｐ−１類似物 |
| WO2006082204A1 (en) * | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| RU2610175C2 (ru) * | 2011-09-23 | 2017-02-08 | Ново Нордиск А/С | Новые аналоги глюкагона |
-
2005
- 2005-06-21 MX MXPA06015049A patent/MXPA06015049A/es unknown
- 2005-06-21 US US11/631,889 patent/US20090111730A1/en not_active Abandoned
- 2005-06-21 JP JP2007519766A patent/JP2008507477A/ja active Pending
- 2005-06-21 ES ES10176012.2T patent/ES2542228T3/es not_active Expired - Lifetime
- 2005-06-21 EP EP20100176012 patent/EP2289560B1/en not_active Expired - Lifetime
- 2005-06-21 CN CNA2005800274689A patent/CN101005857A/zh active Pending
- 2005-06-21 WO PCT/EP2005/052874 patent/WO2006005667A2/en not_active Ceased
- 2005-06-21 RU RU2006144821/04A patent/RU2006144821A/ru unknown
- 2005-06-21 KR KR20077000466A patent/KR20070029247A/ko not_active Withdrawn
- 2005-06-21 EP EP20100179209 patent/EP2292272A3/en not_active Withdrawn
- 2005-06-21 AU AU2005261740A patent/AU2005261740A1/en not_active Abandoned
- 2005-06-21 CA CA 2572770 patent/CA2572770A1/en not_active Abandoned
- 2005-06-21 BR BRPI0512988-5A patent/BRPI0512988A/pt not_active IP Right Cessation
- 2005-06-21 EP EP05754105.4A patent/EP1765408B1/en not_active Expired - Lifetime
- 2005-06-21 ES ES05754105.4T patent/ES2564167T3/es not_active Expired - Lifetime
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2011
- 2011-12-15 US US13/327,378 patent/US9061067B2/en not_active Expired - Fee Related
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| US20090111730A1 (en) | 2009-04-30 |
| ES2542228T3 (es) | 2015-08-03 |
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| BRPI0512988A (pt) | 2008-04-22 |
| CA2572770A1 (en) | 2006-01-19 |
| EP2292272A3 (en) | 2011-10-26 |
| JP2008507477A (ja) | 2008-03-13 |
| ES2564167T3 (es) | 2016-03-18 |
| EP1765408B1 (en) | 2015-12-09 |
| MXPA06015049A (es) | 2007-02-08 |
| KR20070029247A (ko) | 2007-03-13 |
| WO2006005667A2 (en) | 2006-01-19 |
| EP2289560A2 (en) | 2011-03-02 |
| US20120088716A1 (en) | 2012-04-12 |
| AU2005261740A1 (en) | 2006-01-19 |
| EP1765408A2 (en) | 2007-03-28 |
| CN101005857A (zh) | 2007-07-25 |
| EP2289560B1 (en) | 2015-04-22 |
| WO2006005667A3 (en) | 2006-10-12 |
| US9061067B2 (en) | 2015-06-23 |
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