RU2006144821A - Пролонгирующие метки полипептидов, содержащие тетразольную группировку - Google Patents
Пролонгирующие метки полипептидов, содержащие тетразольную группировку Download PDFInfo
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- RU2006144821A RU2006144821A RU2006144821/04A RU2006144821A RU2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821/04 A RU2006144821/04 A RU 2006144821/04A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A
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- ethoxy
- lys
- tetrazol
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 20
- 229920001184 polypeptide Polymers 0.000 title claims 19
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical group C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- -1 heterocyclic carboxylic acid Chemical class 0.000 claims 58
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 43
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 28
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 27
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- 238000007911 parenteral administration Methods 0.000 claims 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401083 | 2004-07-08 | ||
| DKPA200401083 | 2004-07-08 | ||
| EP05102167 | 2005-03-18 | ||
| EP05102167.3 | 2005-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006144821A true RU2006144821A (ru) | 2008-08-20 |
Family
ID=35453538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006144821/04A RU2006144821A (ru) | 2004-07-08 | 2005-06-21 | Пролонгирующие метки полипептидов, содержащие тетразольную группировку |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20090111730A1 (https=) |
| EP (3) | EP2292272A3 (https=) |
| JP (1) | JP2008507477A (https=) |
| KR (1) | KR20070029247A (https=) |
| CN (1) | CN101005857A (https=) |
| AU (1) | AU2005261740A1 (https=) |
| BR (1) | BRPI0512988A (https=) |
| CA (1) | CA2572770A1 (https=) |
| ES (2) | ES2564167T3 (https=) |
| MX (1) | MXPA06015049A (https=) |
| RU (1) | RU2006144821A (https=) |
| WO (1) | WO2006005667A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8603972B2 (en) * | 2005-03-18 | 2013-12-10 | Novo Nordisk A/S | Extended GLP-1 compounds |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CN100374462C (zh) * | 2005-11-21 | 2008-03-12 | 大连帝恩生物工程有限公司 | 截短胰高血糖素样肽1(sGLP-1)、制法及其应用 |
| JP5252435B2 (ja) * | 2006-03-15 | 2013-07-31 | ノボ・ノルデイスク・エー／エス | アミリン誘導体 |
| WO2008023050A1 (en) | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| US20100056433A1 (en) * | 2007-01-18 | 2010-03-04 | Novo Nordisk A/S | Novel Peptides for Use in the Treatment of Obesity |
| WO2008087186A2 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| US20100022446A1 (en) * | 2007-01-18 | 2010-01-28 | Novo Nordisk A/S | Use of Peptides in Combination with Surgical Intervention for the Treatment of Obesity |
| US20100016238A1 (en) * | 2007-01-18 | 2010-01-21 | Novo Nordisk A/S | Peptides for Use in the Treatment of Obesity |
| EP2106407A2 (en) * | 2007-01-18 | 2009-10-07 | Novo Nordisk A/S | Novel peptides for use in the treatment of obesity |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| US20100292133A1 (en) * | 2007-09-05 | 2010-11-18 | Novo Nordisk A/S | Truncated glp-1 derivaties and their therapeutical use |
| EP2190872B1 (en) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| WO2009092758A1 (en) | 2008-01-23 | 2009-07-30 | Novo Nordisk Health Care Ag | New blood coagulation factor inhibitors |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| WO2009138511A1 (en) * | 2008-05-16 | 2009-11-19 | Novo Nordisk A/S | Long-acting y2 and/or y4 receptor agonists |
| EP2283037A1 (en) * | 2008-05-22 | 2011-02-16 | Novo Nordisk A/S | Process |
| MX2011000847A (es) | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Proteinas conjugadas con eficacia prolongada in vivo. |
| ES2662501T3 (es) | 2008-10-21 | 2018-04-06 | Novo Nordisk A/S | Derivados de amilina |
| BRPI0923853A2 (pt) * | 2008-12-29 | 2016-01-12 | Panacea Biotec Ltd | análogos de gpl-1 e usos dos mesmos. |
| MX2011007736A (es) | 2009-01-22 | 2011-09-06 | Novo Nordisk Healthcare Ag | Compuestos de hormona del crecimiento estables. |
| CN102361647B (zh) | 2009-01-23 | 2018-02-16 | 诺沃-诺迪斯克有限公司 | 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用 |
| WO2011015649A1 (en) | 2009-08-06 | 2011-02-10 | Novo Nordisk Health Care Ag | Growth hormones with prolonged in-vivo efficacy |
| WO2011033068A1 (en) * | 2009-09-18 | 2011-03-24 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| EP2498800A1 (en) * | 2009-11-13 | 2012-09-19 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| JP6006118B2 (ja) | 2009-12-16 | 2016-10-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アナログ及び誘導体 |
| MX338357B (es) | 2010-01-22 | 2016-04-13 | Novo Nordisk Healthcare Ag | Compuestos estables de la hormona de crecimiento. |
| RS59459B1 (sr) | 2010-01-22 | 2019-11-29 | Novo Nordisk Healthcare Ag | Hormoni rasta sa produženom in-vivo efikasnošću |
| EP2560675A1 (en) | 2010-04-20 | 2013-02-27 | Novo Nordisk A/S | Long-acting gastrin derivatives |
| CN103415300B (zh) * | 2010-07-20 | 2018-02-23 | 诺沃—诺迪斯克有限公司 | N‑末端修饰的fgf21化合物 |
| SI2651398T1 (en) | 2010-12-16 | 2018-04-30 | Novo Nordisk A/S | SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS |
| PL2696687T3 (pl) | 2011-04-12 | 2017-06-30 | Novo Nordisk A/S | Pochodne podwójnie acylowanej GLP-1 |
| CN110041399B (zh) | 2011-12-29 | 2023-12-12 | 诺沃—诺迪斯克有限公司 | 包含非成蛋白质性的氨基酸的二肽 |
| HRP20181447T1 (hr) | 2012-03-22 | 2018-11-02 | Novo Nordisk A/S | Pripravci glp-1 peptida i njihova priprava |
| ES2965469T3 (es) | 2012-03-22 | 2024-04-15 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y preparación de estas |
| PT2827845T (pt) | 2012-03-22 | 2019-03-29 | Novo Nordisk As | Composições compreendendo um agente de entrega e sua preparação |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| WO2014060472A1 (en) | 2012-10-17 | 2014-04-24 | Novo Nordisk A/S | Fatty acid acylated amino acids for oral peptide delivery |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| KR102272671B1 (ko) | 2013-05-02 | 2021-07-06 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| CN103304502B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| CN103304499B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304501B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| CN103304503B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| EP3013796B9 (en) * | 2013-06-27 | 2020-07-01 | LG Chem, Ltd. | Biaryl derivatives as gpr120 agonists |
| EP3068795B1 (en) | 2013-11-15 | 2019-03-06 | Novo Nordisk A/S | Hpyy(1-36) having a beta-homoarginine substitution at position 35 |
| CN105722526B (zh) | 2013-11-15 | 2020-12-08 | 诺和诺德股份有限公司 | 选择性pyy化合物及其用途 |
| ES2630106T3 (es) | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| AR103246A1 (es) | 2014-12-23 | 2017-04-26 | Novo Nordiks As | Derivados de fgf21 y sus usos |
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- 2005-06-21 ES ES05754105.4T patent/ES2564167T3/es not_active Expired - Lifetime
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- 2005-06-21 CN CNA2005800274689A patent/CN101005857A/zh active Pending
- 2005-06-21 ES ES10176012.2T patent/ES2542228T3/es not_active Expired - Lifetime
- 2005-06-21 EP EP05754105.4A patent/EP1765408B1/en not_active Expired - Lifetime
- 2005-06-21 JP JP2007519766A patent/JP2008507477A/ja active Pending
- 2005-06-21 KR KR20077000466A patent/KR20070029247A/ko not_active Withdrawn
- 2005-06-21 WO PCT/EP2005/052874 patent/WO2006005667A2/en not_active Ceased
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2011
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| EP2292272A2 (en) | 2011-03-09 |
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| WO2006005667A2 (en) | 2006-01-19 |
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| US20090111730A1 (en) | 2009-04-30 |
| WO2006005667A3 (en) | 2006-10-12 |
| EP2289560A3 (en) | 2011-10-19 |
| CA2572770A1 (en) | 2006-01-19 |
| ES2564167T3 (es) | 2016-03-18 |
| EP1765408A2 (en) | 2007-03-28 |
| EP2289560B1 (en) | 2015-04-22 |
| AU2005261740A1 (en) | 2006-01-19 |
| MXPA06015049A (es) | 2007-02-08 |
| JP2008507477A (ja) | 2008-03-13 |
| CN101005857A (zh) | 2007-07-25 |
| EP2289560A2 (en) | 2011-03-02 |
| US20120088716A1 (en) | 2012-04-12 |
| KR20070029247A (ko) | 2007-03-13 |
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