RU2006132195A - Комбинация агонистов бета-2 адренорецептора, бензотиазол-2-онов и кортикостероидов, предназначенная для лечения респираторных заболеваний - Google Patents
Комбинация агонистов бета-2 адренорецептора, бензотиазол-2-онов и кортикостероидов, предназначенная для лечения респираторных заболеваний Download PDFInfo
- Publication number
- RU2006132195A RU2006132195A RU2006132195/15A RU2006132195A RU2006132195A RU 2006132195 A RU2006132195 A RU 2006132195A RU 2006132195/15 A RU2006132195/15 A RU 2006132195/15A RU 2006132195 A RU2006132195 A RU 2006132195A RU 2006132195 A RU2006132195 A RU 2006132195A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- group
- optionally
- substituents
- compound
- Prior art date
Links
- 208000023504 respiratory system disease Diseases 0.000 title claims 4
- 239000003246 corticosteroid Substances 0.000 title claims 2
- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical class C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 title 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
- 101710152983 Beta-2 adrenergic receptor Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 229960001334 corticosteroids Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 43
- 125000001424 substituent group Chemical group 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 20
- 150000002367 halogens Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- -1 C 1 -C 10 -alkyl Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
- 229940079593 drug Drugs 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 239000006185 dispersion Substances 0.000 claims 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 5
- 239000000443 aerosol Substances 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 125000006413 ring segment Chemical group 0.000 claims 5
- 239000011593 sulfur Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000003380 propellant Substances 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 230000000414 obstructive effect Effects 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- GTTZQULJQRNNER-HNNXBMFYSA-N 4-hydroxy-7-[(1r)-1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]-3h-1,3-benzothiazol-2-one Chemical compound C([C@H](O)C=1C=2SC(=O)NC=2C(O)=CC=1)NC(C)(C)CC1=CC=CC=C1 GTTZQULJQRNNER-HNNXBMFYSA-N 0.000 claims 1
- QTWVYUJFBIVOHT-RYQLBKOJSA-N 4-hydroxy-7-[(1r)-1-hydroxy-2-[[(1s,2r)-2-phenylmethoxycyclopentyl]amino]ethyl]-3h-1,3-benzothiazol-2-one Chemical compound O([C@@H]1CCC[C@@H]1NC[C@H](O)C=1C=2SC(=O)NC=2C(O)=CC=1)CC1=CC=CC=C1 QTWVYUJFBIVOHT-RYQLBKOJSA-N 0.000 claims 1
- QTWVYUJFBIVOHT-SZMVWBNQSA-N 4-hydroxy-7-[(1r)-1-hydroxy-2-[[(1s,2s)-2-phenylmethoxycyclopentyl]amino]ethyl]-3h-1,3-benzothiazol-2-one Chemical compound O([C@H]1CCC[C@@H]1NC[C@H](O)C=1C=2SC(=O)NC=2C(O)=CC=1)CC1=CC=CC=C1 QTWVYUJFBIVOHT-SZMVWBNQSA-N 0.000 claims 1
- ONNGKMAEIWXVBI-UHFFFAOYSA-N 4-hydroxy-7-[1-hydroxy-2-[2-[4-(4-phenylbutoxy)phenyl]ethylamino]ethyl]-3h-1,3-benzothiazol-2-one Chemical compound C=1C=C(O)C=2NC(=O)SC=2C=1C(O)CNCCC(C=C1)=CC=C1OCCCCC1=CC=CC=C1 ONNGKMAEIWXVBI-UHFFFAOYSA-N 0.000 claims 1
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229960000676 flunisolide Drugs 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000000962 organic group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 1
- 229950004432 rofleponide Drugs 0.000 claims 1
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 229960002117 triamcinolone acetonide Drugs 0.000 claims 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0402797.5A GB0402797D0 (en) | 2004-02-09 | 2004-02-09 | Organic compounds |
| GB0402797.5 | 2004-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006132195A true RU2006132195A (ru) | 2008-03-20 |
Family
ID=31985893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006132195/15A RU2006132195A (ru) | 2004-02-09 | 2005-02-08 | Комбинация агонистов бета-2 адренорецептора, бензотиазол-2-онов и кортикостероидов, предназначенная для лечения респираторных заболеваний |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1715860A1 (https=) |
| JP (1) | JP2007522141A (https=) |
| KR (1) | KR20060127974A (https=) |
| CN (1) | CN1917875A (https=) |
| AR (1) | AR047962A1 (https=) |
| AU (1) | AU2005210140A1 (https=) |
| BR (1) | BRPI0507544A (https=) |
| CA (1) | CA2552938A1 (https=) |
| GB (1) | GB0402797D0 (https=) |
| PE (1) | PE20050692A1 (https=) |
| RU (1) | RU2006132195A (https=) |
| TW (1) | TW200536533A (https=) |
| WO (1) | WO2005074924A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200740781A (en) * | 2005-08-29 | 2007-11-01 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702456D0 (en) * | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| EP2011534A1 (en) * | 2007-07-03 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Metered dose inhaler actuator |
| JP4686650B2 (ja) | 2007-11-30 | 2011-05-25 | ファイザー・リミテッド | 新規なグルココルチコイド受容体アゴニスト |
| JP5570996B2 (ja) | 2007-12-14 | 2014-08-13 | エアロデザインズ インコーポレイテッド | エアロゾル化可能な食料品の送達 |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
| AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009018A1 (en) * | 1997-08-14 | 1999-02-25 | Kirin Beer Kabushiki Kaisha | BENZOTHIAZOLONE DERIVATIVES HAVING SELECTIVE β2 RECEPTOR AGONIST ACTIVITY |
| PE20050130A1 (es) * | 2002-08-09 | 2005-03-29 | Novartis Ag | Compuestos organicos |
-
2004
- 2004-02-09 GB GBGB0402797.5A patent/GB0402797D0/en not_active Ceased
-
2005
- 2005-02-05 TW TW094103838A patent/TW200536533A/zh unknown
- 2005-02-08 WO PCT/EP2005/001241 patent/WO2005074924A1/en not_active Ceased
- 2005-02-08 JP JP2006551821A patent/JP2007522141A/ja active Pending
- 2005-02-08 CN CNA2005800044314A patent/CN1917875A/zh active Pending
- 2005-02-08 KR KR1020067016003A patent/KR20060127974A/ko not_active Withdrawn
- 2005-02-08 EP EP05707254A patent/EP1715860A1/en not_active Withdrawn
- 2005-02-08 RU RU2006132195/15A patent/RU2006132195A/ru not_active Application Discontinuation
- 2005-02-08 BR BRPI0507544-0A patent/BRPI0507544A/pt not_active IP Right Cessation
- 2005-02-08 CA CA002552938A patent/CA2552938A1/en not_active Abandoned
- 2005-02-08 AU AU2005210140A patent/AU2005210140A1/en not_active Abandoned
- 2005-02-09 AR ARP050100452A patent/AR047962A1/es not_active Application Discontinuation
- 2005-02-09 PE PE2005000154A patent/PE20050692A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0507544A (pt) | 2007-06-12 |
| EP1715860A1 (en) | 2006-11-02 |
| AR047962A1 (es) | 2006-03-15 |
| KR20060127974A (ko) | 2006-12-13 |
| WO2005074924A1 (en) | 2005-08-18 |
| TW200536533A (en) | 2005-11-16 |
| JP2007522141A (ja) | 2007-08-09 |
| CN1917875A (zh) | 2007-02-21 |
| PE20050692A1 (es) | 2005-11-15 |
| CA2552938A1 (en) | 2005-08-18 |
| GB0402797D0 (en) | 2004-03-10 |
| AU2005210140A1 (en) | 2005-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2006132195A (ru) | Комбинация агонистов бета-2 адренорецептора, бензотиазол-2-онов и кортикостероидов, предназначенная для лечения респираторных заболеваний | |
| JP2007522141A5 (https=) | ||
| RU2003119549A (ru) | Органические соединения | |
| RU2006144810A (ru) | Комбинации гликопирролата и агонистов в-2 адреноцептора | |
| JP2004514739A5 (https=) | ||
| BRPI0709510A2 (pt) | formulações de soluções farmacêuticas para inaladores dosimetrados pressurizados | |
| JP2002528399A (ja) | Δ９テトラヒドロカナビノール（δ９ｔｈｃ）溶液計量ずみ投与量吸入器および使用方法 | |
| BRPI0511662B1 (pt) | Combinação e usos de um antagonista de receptores muscarínicos m3 e de um agonista beta2 no tratamento de distúrbios respiratórios | |
| CN106999462B (zh) | 包含选择性s1p1受体激动剂的药物组合物 | |
| JP2008500990A5 (https=) | ||
| RU2008124833A (ru) | Лечение астмы и хронического обструктивного заболевания легких с использованием тройных комбинаций | |
| JP2015519356A5 (https=) | ||
| WO2011136754A1 (en) | A medicament developed for the treatment of respiratory diseases | |
| RU2008124838A (ru) | Органические соединения | |
| RU2008124825A (ru) | Органические соединения, включающие соль гликопиррония | |
| RU2011140239A (ru) | Фармацевтическая композиция, содержащая стероидное производное (3,2-с)пиразола и второе фармацевтически активное соединение | |
| RU2008124836A (ru) | Органические соединения, включающие соль гликопиррония | |
| US20030064031A1 (en) | Use of a combination of compounds in a dry powder inhaler | |
| WO2011136753A1 (en) | Combination of carmoterol and fluticasone for use in the treatment respiratory diseases | |
| ES2371601T3 (es) | Composición para inhalación. | |
| BR112020013282A2 (pt) | composição de cetamina em pó seco para uso no tratamento de depressão por administração pulmonar | |
| MXPA05001903A (es) | Composicion para inhalacion. | |
| RU2012112454A (ru) | Фармацевтические аэрозольные препараты формотерола и беклометазона дипропионата | |
| RU2012155690A (ru) | Алкалоидные производные сложных аминоэфиров и включающие их лекарственные композиции | |
| RU2010120806A (ru) | Композиции для ингаляции, содержащие кислоту монтелукаст и ингибитор pde-4 или ингаляционный кортикостероид |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20090619 |
|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20090619 |