RU2006125636A - Лиганды никотиновых рецепторов ацетилхолина - Google Patents
Лиганды никотиновых рецепторов ацетилхолина Download PDFInfo
- Publication number
- RU2006125636A RU2006125636A RU2006125636/04A RU2006125636A RU2006125636A RU 2006125636 A RU2006125636 A RU 2006125636A RU 2006125636/04 A RU2006125636/04 A RU 2006125636/04A RU 2006125636 A RU2006125636 A RU 2006125636A RU 2006125636 A RU2006125636 A RU 2006125636A
- Authority
- RU
- Russia
- Prior art keywords
- methanone
- oct
- disease
- compound according
- diazabicyclo
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 230000001771 impaired effect Effects 0.000 claims 5
- 125000004434 sulfur atom Chemical group 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000000044 Amnesia Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 206010012335 Dependence Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 206010026749 Mania Diseases 0.000 claims 3
- 208000026139 Memory disease Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 208000025966 Neurological disease Diseases 0.000 claims 3
- 206010057852 Nicotine dependence Diseases 0.000 claims 3
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 3
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 208000025569 Tobacco Use disease Diseases 0.000 claims 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims 3
- 208000016620 Tourette disease Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 3
- 208000028683 bipolar I disease Diseases 0.000 claims 3
- 230000001713 cholinergic effect Effects 0.000 claims 3
- 230000027288 circadian rhythm Effects 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000006984 memory degeneration Effects 0.000 claims 3
- 208000023060 memory loss Diseases 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 230000005586 smoking cessation Effects 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 210000000225 synapse Anatomy 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- -1 1-methyl-1H-pyrrolyl Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002349 favourable effect Effects 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- XCGBGBFIBJGCFK-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl(1h-indol-5-yl)methanone Chemical compound C1=C2NC=CC2=CC(C(N2C3CCN(C3)CC2)=O)=C1 XCGBGBFIBJGCFK-UHFFFAOYSA-N 0.000 claims 1
- JPYPFWJCVOBZFC-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl(naphthalen-2-yl)methanone Chemical compound C1=CC=CC2=CC(C(N3C4CCN(C4)CC3)=O)=CC=C21 JPYPFWJCVOBZFC-UHFFFAOYSA-N 0.000 claims 1
- SRRYXXRXYHWRCC-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(1-methylindol-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C1=CC2=CC=CC=C2N1C SRRYXXRXYHWRCC-UHFFFAOYSA-N 0.000 claims 1
- BBBGZUNBNLXJDW-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(4-methoxyphenyl)methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1C(C2)CCN2CC1 BBBGZUNBNLXJDW-UHFFFAOYSA-N 0.000 claims 1
- YAJCHOBSJSFSJL-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-phenylfuran-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(O1)=CC=C1C1=CC=CC=C1 YAJCHOBSJSFSJL-UHFFFAOYSA-N 0.000 claims 1
- YIDVOMHIXSRHJP-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-phenylthiophen-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(S1)=CC=C1C1=CC=CC=C1 YIDVOMHIXSRHJP-UHFFFAOYSA-N 0.000 claims 1
- PMDQATSTNUQJNH-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-pyridin-3-ylthiophen-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(S1)=CC=C1C1=CC=CN=C1 PMDQATSTNUQJNH-UHFFFAOYSA-N 0.000 claims 1
- PUHROTZEKWXENT-UHFFFAOYSA-N 1-benzofuran-2-yl(1,4-diazabicyclo[3.2.1]octan-4-yl)methanone Chemical compound C1=CC=C2OC(C(N3C4CCN(C4)CC3)=O)=CC2=C1 PUHROTZEKWXENT-UHFFFAOYSA-N 0.000 claims 1
- IBUKGKXJAFMRGQ-MRXNPFEDSA-N 3-[5-[(5r)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]thiophen-2-yl]-n,n-dimethylbenzamide Chemical compound C([C@@]1(C2)[H])CN2CCN1C(=O)C(S1)=CC=C1C1=CC=CC(C(=O)N(C)C)=C1 IBUKGKXJAFMRGQ-MRXNPFEDSA-N 0.000 claims 1
- KDBYJAZTZNYSLV-MRXNPFEDSA-N 4-[5-[(5r)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]thiophen-2-yl]-n,n-dimethylbenzamide Chemical compound C([C@@]1(C2)[H])CN2CCN1C(=O)C(S1)=CC=C1C1=CC=C(C(=O)N(C)C)C=C1 KDBYJAZTZNYSLV-MRXNPFEDSA-N 0.000 claims 1
- ZLSKRDYRWRJPKZ-BTQNPOSSSA-N [(5r)-1,4-diazabicyclo[3.2.1]octan-4-yl]-(5-phenyl-1,3-oxazol-2-yl)methanone;hydrochloride Chemical compound Cl.C([C@@]1(C2)[H])CN2CCN1C(=O)C(O1)=NC=C1C1=CC=CC=C1 ZLSKRDYRWRJPKZ-BTQNPOSSSA-N 0.000 claims 1
- MRGPTNAFIJKARD-GFCCVEGCSA-N [(5r)-1,4-diazabicyclo[3.2.1]octan-4-yl]-(5-pyridin-3-yl-1,3-oxazol-2-yl)methanone Chemical compound N1([C@@H]2CCN(C2)CC1)C(=O)C(O1)=NC=C1C1=CC=CN=C1 MRGPTNAFIJKARD-GFCCVEGCSA-N 0.000 claims 1
- GPSANNSGFOQYQJ-GFCCVEGCSA-N [(5r)-1,4-diazabicyclo[3.2.1]octan-4-yl]-(5-pyridin-4-yl-1,3-oxazol-2-yl)methanone Chemical compound C([C@@]1(C2)[H])CN2CCN1C(=O)C(O1)=NC=C1C1=CC=NC=C1 GPSANNSGFOQYQJ-GFCCVEGCSA-N 0.000 claims 1
- SYIQLHYXTUKKPA-UHFFFAOYSA-N [5-(4-chlorophenyl)furan-2-yl]-(1,4-diazabicyclo[3.2.1]octan-4-yl)methanone Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C(=O)N2C3CCN(C3)CC2)O1 SYIQLHYXTUKKPA-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53171003P | 2003-12-22 | 2003-12-22 | |
| US60/531,710 | 2003-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006125636A true RU2006125636A (ru) | 2008-01-27 |
Family
ID=34710245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006125636/04A RU2006125636A (ru) | 2003-12-22 | 2004-12-20 | Лиганды никотиновых рецепторов ацетилхолина |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070249588A1 (https=) |
| EP (1) | EP1699801A1 (https=) |
| JP (1) | JP2007515479A (https=) |
| KR (1) | KR20060123364A (https=) |
| CN (1) | CN1918166A (https=) |
| AR (1) | AR047337A1 (https=) |
| AU (1) | AU2004303738A1 (https=) |
| BR (1) | BRPI0417946A (https=) |
| CA (1) | CA2550655A1 (https=) |
| IL (1) | IL175993A0 (https=) |
| MX (1) | MXPA06007027A (https=) |
| NO (1) | NO20063354L (https=) |
| RU (1) | RU2006125636A (https=) |
| TW (1) | TW200529860A (https=) |
| UY (1) | UY28687A1 (https=) |
| WO (1) | WO2005061510A1 (https=) |
| ZA (1) | ZA200605027B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| DE602004010299T2 (de) * | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
| FR2865208B1 (fr) * | 2004-01-16 | 2009-01-16 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique |
| US20120071469A1 (en) * | 2009-05-14 | 2012-03-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
| AR077428A1 (es) | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| WO2012007500A2 (de) * | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| WO2012052412A1 (de) | 2010-10-22 | 2012-04-26 | Bayer Cropscience Ag | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
| CN107007597A (zh) | 2012-05-31 | 2017-08-04 | 菲尼克斯药品股份公司 | 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途 |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| TW202142236A (zh) | 2020-02-03 | 2021-11-16 | 美商健臻公司 | 用於治療與溶體儲積症相關的神經症狀之方法 |
| KR20230043024A (ko) | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281423A (en) * | 1964-02-03 | 1966-10-25 | Merck & Co Inc | 1, 3-ethanopiperazines and process |
| US5679673A (en) * | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
| FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| MXPA05006861A (es) * | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
-
2004
- 2004-12-08 TW TW093137975A patent/TW200529860A/zh unknown
- 2004-12-20 JP JP2006546909A patent/JP2007515479A/ja active Pending
- 2004-12-20 RU RU2006125636/04A patent/RU2006125636A/ru not_active Application Discontinuation
- 2004-12-20 AR ARP040104802A patent/AR047337A1/es not_active Application Discontinuation
- 2004-12-20 KR KR1020067012362A patent/KR20060123364A/ko not_active Withdrawn
- 2004-12-20 AU AU2004303738A patent/AU2004303738A1/en not_active Abandoned
- 2004-12-20 BR BRPI0417946-3A patent/BRPI0417946A/pt not_active IP Right Cessation
- 2004-12-20 WO PCT/SE2004/001941 patent/WO2005061510A1/en not_active Ceased
- 2004-12-20 UY UY28687A patent/UY28687A1/es not_active Application Discontinuation
- 2004-12-20 CN CNA2004800412947A patent/CN1918166A/zh active Pending
- 2004-12-20 US US10/583,576 patent/US20070249588A1/en not_active Abandoned
- 2004-12-20 MX MXPA06007027A patent/MXPA06007027A/es unknown
- 2004-12-20 EP EP04809114A patent/EP1699801A1/en not_active Withdrawn
- 2004-12-20 CA CA002550655A patent/CA2550655A1/en not_active Abandoned
-
2006
- 2006-05-29 IL IL175993A patent/IL175993A0/en unknown
- 2006-06-19 ZA ZA200605027A patent/ZA200605027B/en unknown
- 2006-07-19 NO NO20063354A patent/NO20063354L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06007027A (es) | 2006-08-31 |
| JP2007515479A (ja) | 2007-06-14 |
| AR047337A1 (es) | 2006-01-18 |
| AU2004303738A1 (en) | 2005-07-07 |
| CA2550655A1 (en) | 2005-07-07 |
| NO20063354L (no) | 2006-09-21 |
| BRPI0417946A (pt) | 2007-04-17 |
| ZA200605027B (en) | 2007-12-27 |
| CN1918166A (zh) | 2007-02-21 |
| IL175993A0 (en) | 2006-10-05 |
| TW200529860A (en) | 2005-09-16 |
| WO2005061510A1 (en) | 2005-07-07 |
| KR20060123364A (ko) | 2006-12-01 |
| UY28687A1 (es) | 2005-07-29 |
| US20070249588A1 (en) | 2007-10-25 |
| EP1699801A1 (en) | 2006-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080828 |