JP2007515478A5 - - Google Patents
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- Publication number
- JP2007515478A5 JP2007515478A5 JP2006546908A JP2006546908A JP2007515478A5 JP 2007515478 A5 JP2007515478 A5 JP 2007515478A5 JP 2006546908 A JP2006546908 A JP 2006546908A JP 2006546908 A JP2006546908 A JP 2006546908A JP 2007515478 A5 JP2007515478 A5 JP 2007515478A5
- Authority
- JP
- Japan
- Prior art keywords
- oxygen
- formula
- disease
- sulfur
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000003118 aryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000004430 oxygen atom Chemical group O* 0.000 claims 9
- 125000004434 sulfur atom Chemical group 0.000 claims 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011593 sulfur Substances 0.000 claims 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 230000006735 deficit Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 206010026749 Mania Diseases 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims 2
- 208000016620 Tourette disease Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 208000028683 bipolar I disease Diseases 0.000 claims 2
- 230000001713 cholinergic effect Effects 0.000 claims 2
- 230000007278 cognition impairment Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000006984 memory degeneration Effects 0.000 claims 2
- 208000023060 memory loss Diseases 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 210000000225 synapse Anatomy 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- -1 3-fluoro-thiophenyl Chemical group 0.000 claims 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000020358 Learning disease Diseases 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000003935 attention Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 235000019788 craving Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53171203P | 2003-12-22 | 2003-12-22 | |
| PCT/SE2004/001940 WO2005061494A1 (en) | 2003-12-22 | 2004-12-20 | Nicotinic acetylcholine receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515478A JP2007515478A (ja) | 2007-06-14 |
| JP2007515478A5 true JP2007515478A5 (https=) | 2008-01-31 |
Family
ID=34710246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546908A Abandoned JP2007515478A (ja) | 2003-12-22 | 2004-12-20 | ニコチン性アセチルコリンレセプターリガンド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20070270458A1 (https=) |
| EP (1) | EP1699786A1 (https=) |
| JP (1) | JP2007515478A (https=) |
| KR (1) | KR20060125812A (https=) |
| CN (1) | CN1914201A (https=) |
| AU (1) | AU2004303737A1 (https=) |
| BR (1) | BRPI0417927A (https=) |
| CA (1) | CA2550844A1 (https=) |
| IL (1) | IL176071A0 (https=) |
| MX (1) | MXPA06007026A (https=) |
| NO (1) | NO20063356L (https=) |
| SG (1) | SG149052A1 (https=) |
| WO (1) | WO2005061494A1 (https=) |
| ZA (1) | ZA200605074B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX337106B (es) | 2010-05-27 | 2016-02-12 | Targacept Inc | Antagonistas no competitivos de receptores nicotinicos. |
| JP5996532B2 (ja) * | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
| CA3169697A1 (en) * | 2020-02-28 | 2021-09-02 | Dominic Reynolds | Thiophenyl derivatives useful for modulating nucleic acid splicing |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2529548A1 (fr) * | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| EP0287196B1 (en) * | 1987-02-18 | 1994-11-23 | Beecham Group Plc | Indole derivatives, process for their preparation and pharmaceutical compositions containing them |
| SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| US6599916B2 (en) * | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002016355A2 (en) * | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands |
| AU2001282875A1 (en) * | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| DE10156719A1 (de) * | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
-
2004
- 2004-12-20 BR BRPI0417927-7A patent/BRPI0417927A/pt not_active IP Right Cessation
- 2004-12-20 CN CNA2004800412932A patent/CN1914201A/zh active Pending
- 2004-12-20 WO PCT/SE2004/001940 patent/WO2005061494A1/en not_active Ceased
- 2004-12-20 AU AU2004303737A patent/AU2004303737A1/en not_active Abandoned
- 2004-12-20 JP JP2006546908A patent/JP2007515478A/ja not_active Abandoned
- 2004-12-20 US US10/583,582 patent/US20070270458A1/en not_active Abandoned
- 2004-12-20 MX MXPA06007026A patent/MXPA06007026A/es unknown
- 2004-12-20 EP EP04809113A patent/EP1699786A1/en not_active Withdrawn
- 2004-12-20 SG SG200809495-5A patent/SG149052A1/en unknown
- 2004-12-20 CA CA002550844A patent/CA2550844A1/en not_active Abandoned
- 2004-12-20 KR KR1020067012361A patent/KR20060125812A/ko not_active Withdrawn
-
2006
- 2006-05-31 IL IL176071A patent/IL176071A0/en unknown
- 2006-06-20 ZA ZA200605074A patent/ZA200605074B/en unknown
- 2006-07-19 NO NO20063356A patent/NO20063356L/no not_active Application Discontinuation
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