JP2007532637A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007532637A5 JP2007532637A5 JP2007508300A JP2007508300A JP2007532637A5 JP 2007532637 A5 JP2007532637 A5 JP 2007532637A5 JP 2007508300 A JP2007508300 A JP 2007508300A JP 2007508300 A JP2007508300 A JP 2007508300A JP 2007532637 A5 JP2007532637 A5 JP 2007532637A5
- Authority
- JP
- Japan
- Prior art keywords
- aza
- bicyclo
- dihydro
- oct
- isoindol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(C=C1)C=NC(C*2C3C(CC4)CC*4C3)=C1C2=O Chemical compound CC(*)(C=C1)C=NC(C*2C3C(CC4)CC*4C3)=C1C2=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400970A SE0400970D0 (sv) | 2004-04-14 | 2004-04-14 | Nicotinic acetylcholine receptor ligands |
| PCT/SE2005/000500 WO2005100351A1 (en) | 2004-04-14 | 2005-04-06 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532637A JP2007532637A (ja) | 2007-11-15 |
| JP2007532637A5 true JP2007532637A5 (https=) | 2008-04-24 |
Family
ID=32294312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508300A Pending JP2007532637A (ja) | 2004-04-14 | 2005-04-06 | α７ニコチン性アセチルコリン受容体に対する新規な２−（１−アザ−ビシクロ［２．２．２］オクタ−３−イル）−２，３−ジヒドロイソインドール−１−オン／５，６−ジヒドロ−フロ［２，３−ｃ］ピロール−４−オン誘導体リガンド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7566727B2 (https=) |
| EP (1) | EP1737854A1 (https=) |
| JP (1) | JP2007532637A (https=) |
| CN (1) | CN1968951A (https=) |
| AU (1) | AU2005233492B2 (https=) |
| BR (1) | BRPI0509777A (https=) |
| CA (1) | CA2563010A1 (https=) |
| IL (1) | IL178241A0 (https=) |
| NO (1) | NO20065199L (https=) |
| RU (2) | RU2372350C2 (https=) |
| SE (1) | SE0400970D0 (https=) |
| UA (1) | UA86617C2 (https=) |
| WO (1) | WO2005100351A1 (https=) |
| ZA (1) | ZA200608412B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| TW200804281A (en) * | 2006-02-16 | 2008-01-16 | Astrazeneca Ab | New metabotropic glutamate receptor-potentiating isoindolones |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| EP2215074B1 (en) * | 2007-09-27 | 2014-02-19 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
| US8669259B2 (en) | 2009-08-26 | 2014-03-11 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
| KR101758046B1 (ko) * | 2009-12-22 | 2017-07-14 | 버텍스 파마슈티칼스 인코포레이티드 | 포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제 |
| NZ601526A (en) | 2009-12-31 | 2014-07-25 | Piramal Entpr Ltd | Inhibitors of diacylglycerol acyl transferase |
| JO3383B1 (ar) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| TW201726675A (zh) | 2015-12-23 | 2017-08-01 | 默沙東藥廠 | M4毒蕈鹼乙醯膽鹼受體之異位調節劑6,7-二氫-5h-吡咯并[3,4-b]吡啶-5-酮 |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| US10040804B2 (en) | 2016-12-21 | 2018-08-07 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018210229A1 (zh) * | 2017-05-18 | 2018-11-22 | 南京明德新药研发股份有限公司 | α-7尼古丁乙酰胆碱受体激动剂及应用 |
| CN107188900B (zh) * | 2017-05-27 | 2019-09-06 | 北京师范大学 | α7烟碱型乙酰胆碱受体的配体化合物及其应用 |
| WO2018226545A1 (en) * | 2017-06-09 | 2018-12-13 | Merck Sharp & Dohme Corp. | Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000237A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000236A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| WO2022115301A1 (en) * | 2020-11-24 | 2022-06-02 | Merck Sharp & Dohme Corp. | Modified isoindolinones as glucosylceramide synthase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| SE9201478D0 (sv) | 1992-05-11 | 1992-05-11 | Kabi Pharmacia Ab | Heteroaromatic quinuclidinenes, their use and preparation |
| NO2005012I1 (no) * | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| IT1303123B1 (it) | 1998-10-13 | 2000-10-30 | Rotta Research Lab | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
| DE10045112A1 (de) | 2000-09-11 | 2002-03-21 | Merck Patent Gmbh | Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems |
| ATE385497T1 (de) * | 2000-12-01 | 2008-02-15 | Neurosearch As | 3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten |
| DE10118551A1 (de) | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Nikotinische Acetylcholinrezeptor Liganden |
| AU2002320958B2 (en) | 2001-07-06 | 2008-02-28 | Neurosearch A/S | Novel compounds, their preparation and use |
| WO2004016608A1 (en) | 2002-08-14 | 2004-02-26 | Neurosearch A/S | Novel quinuclidine derivatives and their use |
-
2004
- 2004-04-14 SE SE0400970A patent/SE0400970D0/xx unknown
-
2005
- 2005-04-06 AU AU2005233492A patent/AU2005233492B2/en not_active Expired - Fee Related
- 2005-04-06 WO PCT/SE2005/000500 patent/WO2005100351A1/en not_active Ceased
- 2005-04-06 CN CNA2005800194932A patent/CN1968951A/zh active Pending
- 2005-04-06 EP EP05722314A patent/EP1737854A1/en not_active Withdrawn
- 2005-04-06 BR BRPI0509777-0A patent/BRPI0509777A/pt not_active IP Right Cessation
- 2005-04-06 JP JP2007508300A patent/JP2007532637A/ja active Pending
- 2005-04-06 RU RU2006135481/04A patent/RU2372350C2/ru not_active IP Right Cessation
- 2005-04-06 CA CA002563010A patent/CA2563010A1/en not_active Abandoned
- 2005-04-06 US US10/599,839 patent/US7566727B2/en not_active Expired - Fee Related
- 2005-06-04 UA UAA200610315A patent/UA86617C2/ru unknown
-
2006
- 2006-09-21 IL IL178241A patent/IL178241A0/en unknown
- 2006-10-09 ZA ZA200608412A patent/ZA200608412B/xx unknown
- 2006-11-13 NO NO20065199A patent/NO20065199L/no not_active Application Discontinuation
-
2009
- 2009-07-10 RU RU2009126341/04A patent/RU2009126341A/ru not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007532637A5 (https=) | ||
| RU2006135481A (ru) | Новые производные 2-(1-аза-бицикло[2.2.2]окт-3-ил)-2,3-дигидроизоиндол-1-она/5,6-дигидро-фуро[2, 3-с]пиррол-4-она в качестве лигандов к альфа 7 никотиновому ацетилхолиновому рецептору | |
| JP2006507241A5 (https=) | ||
| JP2003514818A5 (https=) | ||
| JP2003523342A5 (https=) | ||
| JP2003513073A5 (https=) | ||
| JP2003512374A5 (https=) | ||
| JP2001510194A5 (https=) | ||
| JP2003513071A5 (https=) | ||
| TWI657078B (zh) | 作爲單胺氧化酶（ｍａｏ）抑制劑之經取代之萘啶及喹啉化合物 | |
| RU2002118302A (ru) | Новые биарилкарбоксамиды | |
| JP2018534326A5 (https=) | ||
| JP2008539195A (ja) | 新規のオキサジアゾール誘導体及びそれらの医学的使用 | |
| JP2005534624A5 (https=) | ||
| JP2011529049A5 (https=) | ||
| JP2010505794A5 (https=) | ||
| JP2002534519A5 (https=) | ||
| JP2014521653A5 (https=) | ||
| JP2015516429A5 (https=) | ||
| HRP20151077T1 (hr) | Derivati pirazola | |
| JP2005527588A5 (https=) | ||
| CA2702482A1 (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| JP2007515479A5 (https=) | ||
| JP2017528515A5 (https=) | ||
| JP2019537592A5 (https=) |