JP2007515479A - ニコチン性アセチルコリンレセプターリガンド - Google Patents
ニコチン性アセチルコリンレセプターリガンド Download PDFInfo
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- JP2007515479A JP2007515479A JP2006546909A JP2006546909A JP2007515479A JP 2007515479 A JP2007515479 A JP 2007515479A JP 2006546909 A JP2006546909 A JP 2006546909A JP 2006546909 A JP2006546909 A JP 2006546909A JP 2007515479 A JP2007515479 A JP 2007515479A
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- Prior art keywords
- disease
- methanone
- oct
- diazabicyclo
- disorder
- Prior art date
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- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title claims description 22
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title claims description 22
- 239000003446 ligand Substances 0.000 title abstract description 6
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 15
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- 125000003118 aryl group Chemical group 0.000 claims description 23
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
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- DPTARYYFKCRQTE-CURYUGHLSA-N [(5r)-1,4-diazabicyclo[3.2.1]octan-4-yl]-(5-pyridin-3-yl-1,3-oxazol-2-yl)methanone;dihydrochloride Chemical compound Cl.Cl.C([C@@]1(C2)[H])CN2CCN1C(=O)C(O1)=NC=C1C1=CC=CN=C1 DPTARYYFKCRQTE-CURYUGHLSA-N 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- SRRYXXRXYHWRCC-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(1-methylindol-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C1=CC2=CC=CC=C2N1C SRRYXXRXYHWRCC-UHFFFAOYSA-N 0.000 claims description 2
- IBUKGKXJAFMRGQ-MRXNPFEDSA-N 3-[5-[(5r)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]thiophen-2-yl]-n,n-dimethylbenzamide Chemical compound C([C@@]1(C2)[H])CN2CCN1C(=O)C(S1)=CC=C1C1=CC=CC(C(=O)N(C)C)=C1 IBUKGKXJAFMRGQ-MRXNPFEDSA-N 0.000 claims description 2
- KDBYJAZTZNYSLV-MRXNPFEDSA-N 4-[5-[(5r)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]thiophen-2-yl]-n,n-dimethylbenzamide Chemical compound C([C@@]1(C2)[H])CN2CCN1C(=O)C(S1)=CC=C1C1=CC=C(C(=O)N(C)C)C=C1 KDBYJAZTZNYSLV-MRXNPFEDSA-N 0.000 claims description 2
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- ZLSKRDYRWRJPKZ-BTQNPOSSSA-N [(5r)-1,4-diazabicyclo[3.2.1]octan-4-yl]-(5-phenyl-1,3-oxazol-2-yl)methanone;hydrochloride Chemical compound Cl.C([C@@]1(C2)[H])CN2CCN1C(=O)C(O1)=NC=C1C1=CC=CC=C1 ZLSKRDYRWRJPKZ-BTQNPOSSSA-N 0.000 claims description 2
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- XCGBGBFIBJGCFK-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl(1h-indol-5-yl)methanone Chemical compound C1=C2NC=CC2=CC(C(N2C3CCN(C3)CC2)=O)=C1 XCGBGBFIBJGCFK-UHFFFAOYSA-N 0.000 claims 1
- JPYPFWJCVOBZFC-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl(naphthalen-2-yl)methanone Chemical compound C1=CC=CC2=CC(C(N3C4CCN(C4)CC3)=O)=CC=C21 JPYPFWJCVOBZFC-UHFFFAOYSA-N 0.000 claims 1
- DOQNLHXQIXLQHV-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(3-phenylphenyl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(C=1)=CC=CC=1C1=CC=CC=C1 DOQNLHXQIXLQHV-UHFFFAOYSA-N 0.000 claims 1
- BBBGZUNBNLXJDW-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(4-methoxyphenyl)methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1C(C2)CCN2CC1 BBBGZUNBNLXJDW-UHFFFAOYSA-N 0.000 claims 1
- YAJCHOBSJSFSJL-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-phenylfuran-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(O1)=CC=C1C1=CC=CC=C1 YAJCHOBSJSFSJL-UHFFFAOYSA-N 0.000 claims 1
- YIDVOMHIXSRHJP-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-phenylthiophen-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(S1)=CC=C1C1=CC=CC=C1 YIDVOMHIXSRHJP-UHFFFAOYSA-N 0.000 claims 1
- PMDQATSTNUQJNH-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.1]octan-4-yl-(5-pyridin-3-ylthiophen-2-yl)methanone Chemical compound C1CN(C2)CCC2N1C(=O)C(S1)=CC=C1C1=CC=CN=C1 PMDQATSTNUQJNH-UHFFFAOYSA-N 0.000 claims 1
- PUHROTZEKWXENT-UHFFFAOYSA-N 1-benzofuran-2-yl(1,4-diazabicyclo[3.2.1]octan-4-yl)methanone Chemical compound C1=CC=C2OC(C(N3C4CCN(C4)CC3)=O)=CC2=C1 PUHROTZEKWXENT-UHFFFAOYSA-N 0.000 claims 1
- SYIQLHYXTUKKPA-UHFFFAOYSA-N [5-(4-chlorophenyl)furan-2-yl]-(1,4-diazabicyclo[3.2.1]octan-4-yl)methanone Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C(=O)N2C3CCN(C3)CC2)O1 SYIQLHYXTUKKPA-UHFFFAOYSA-N 0.000 claims 1
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- CVXGFPPAIUELDV-UHFFFAOYSA-N phenacylazanium;chloride Chemical compound [Cl-].[NH3+]CC(=O)C1=CC=CC=C1 CVXGFPPAIUELDV-UHFFFAOYSA-N 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YIUGRGNVKORTOL-UHFFFAOYSA-N tert-butyl n-(2-oxo-2-pyridin-4-ylethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCC(=O)C1=CC=NC=C1 YIUGRGNVKORTOL-UHFFFAOYSA-N 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53171003P | 2003-12-22 | 2003-12-22 | |
| PCT/SE2004/001941 WO2005061510A1 (en) | 2003-12-22 | 2004-12-20 | Nicotinic acetylcholine receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515479A true JP2007515479A (ja) | 2007-06-14 |
| JP2007515479A5 JP2007515479A5 (https=) | 2008-01-24 |
Family
ID=34710245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546909A Pending JP2007515479A (ja) | 2003-12-22 | 2004-12-20 | ニコチン性アセチルコリンレセプターリガンド |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070249588A1 (https=) |
| EP (1) | EP1699801A1 (https=) |
| JP (1) | JP2007515479A (https=) |
| KR (1) | KR20060123364A (https=) |
| CN (1) | CN1918166A (https=) |
| AR (1) | AR047337A1 (https=) |
| AU (1) | AU2004303738A1 (https=) |
| BR (1) | BRPI0417946A (https=) |
| CA (1) | CA2550655A1 (https=) |
| IL (1) | IL175993A0 (https=) |
| MX (1) | MXPA06007027A (https=) |
| NO (1) | NO20063354L (https=) |
| RU (1) | RU2006125636A (https=) |
| TW (1) | TW200529860A (https=) |
| UY (1) | UY28687A1 (https=) |
| WO (1) | WO2005061510A1 (https=) |
| ZA (1) | ZA200605027B (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4824578B2 (ja) * | 2003-12-22 | 2011-11-30 | メモリー・ファーマシューティカルズ・コーポレイション | インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用 |
| JP2013535434A (ja) * | 2010-07-15 | 2013-09-12 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 有害生物防除剤としての新規複素環式化合物 |
| JP2015521193A (ja) * | 2012-05-31 | 2015-07-27 | フェネックス ファーマシューティカルス アーゲー | オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体 |
| JP2015527406A (ja) * | 2012-09-11 | 2015-09-17 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| FR2865208B1 (fr) * | 2004-01-16 | 2009-01-16 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique |
| US20120071469A1 (en) * | 2009-05-14 | 2012-03-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
| AR077428A1 (es) | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| WO2012052412A1 (de) | 2010-10-22 | 2012-04-26 | Bayer Cropscience Ag | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| TW202142236A (zh) | 2020-02-03 | 2021-11-16 | 美商健臻公司 | 用於治療與溶體儲積症相關的神經症狀之方法 |
| KR20230043024A (ko) | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281423A (en) * | 1964-02-03 | 1966-10-25 | Merck & Co Inc | 1, 3-ethanopiperazines and process |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679673A (en) * | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
| FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| MXPA05006861A (es) * | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
-
2004
- 2004-12-08 TW TW093137975A patent/TW200529860A/zh unknown
- 2004-12-20 JP JP2006546909A patent/JP2007515479A/ja active Pending
- 2004-12-20 RU RU2006125636/04A patent/RU2006125636A/ru not_active Application Discontinuation
- 2004-12-20 AR ARP040104802A patent/AR047337A1/es not_active Application Discontinuation
- 2004-12-20 KR KR1020067012362A patent/KR20060123364A/ko not_active Withdrawn
- 2004-12-20 AU AU2004303738A patent/AU2004303738A1/en not_active Abandoned
- 2004-12-20 BR BRPI0417946-3A patent/BRPI0417946A/pt not_active IP Right Cessation
- 2004-12-20 WO PCT/SE2004/001941 patent/WO2005061510A1/en not_active Ceased
- 2004-12-20 UY UY28687A patent/UY28687A1/es not_active Application Discontinuation
- 2004-12-20 CN CNA2004800412947A patent/CN1918166A/zh active Pending
- 2004-12-20 US US10/583,576 patent/US20070249588A1/en not_active Abandoned
- 2004-12-20 MX MXPA06007027A patent/MXPA06007027A/es unknown
- 2004-12-20 EP EP04809114A patent/EP1699801A1/en not_active Withdrawn
- 2004-12-20 CA CA002550655A patent/CA2550655A1/en not_active Abandoned
-
2006
- 2006-05-29 IL IL175993A patent/IL175993A0/en unknown
- 2006-06-19 ZA ZA200605027A patent/ZA200605027B/en unknown
- 2006-07-19 NO NO20063354A patent/NO20063354L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281423A (en) * | 1964-02-03 | 1966-10-25 | Merck & Co Inc | 1, 3-ethanopiperazines and process |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4824578B2 (ja) * | 2003-12-22 | 2011-11-30 | メモリー・ファーマシューティカルズ・コーポレイション | インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用 |
| JP2013535434A (ja) * | 2010-07-15 | 2013-09-12 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 有害生物防除剤としての新規複素環式化合物 |
| JP2015521193A (ja) * | 2012-05-31 | 2015-07-27 | フェネックス ファーマシューティカルス アーゲー | オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体 |
| JP2015527406A (ja) * | 2012-09-11 | 2015-09-17 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06007027A (es) | 2006-08-31 |
| AR047337A1 (es) | 2006-01-18 |
| AU2004303738A1 (en) | 2005-07-07 |
| CA2550655A1 (en) | 2005-07-07 |
| NO20063354L (no) | 2006-09-21 |
| BRPI0417946A (pt) | 2007-04-17 |
| ZA200605027B (en) | 2007-12-27 |
| CN1918166A (zh) | 2007-02-21 |
| IL175993A0 (en) | 2006-10-05 |
| TW200529860A (en) | 2005-09-16 |
| WO2005061510A1 (en) | 2005-07-07 |
| KR20060123364A (ko) | 2006-12-01 |
| UY28687A1 (es) | 2005-07-29 |
| US20070249588A1 (en) | 2007-10-25 |
| RU2006125636A (ru) | 2008-01-27 |
| EP1699801A1 (en) | 2006-09-13 |
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