RU2005110960A - Конъюгаты комплексов тс и группировок, обеспечивающих направленную доставку, и их применение в диагностике методом магнито-резонансной визуализации - Google Patents
Конъюгаты комплексов тс и группировок, обеспечивающих направленную доставку, и их применение в диагностике методом магнито-резонансной визуализации Download PDFInfo
- Publication number
- RU2005110960A RU2005110960A RU2005110960/15A RU2005110960A RU2005110960A RU 2005110960 A RU2005110960 A RU 2005110960A RU 2005110960/15 A RU2005110960/15 A RU 2005110960/15A RU 2005110960 A RU2005110960 A RU 2005110960A RU 2005110960 A RU2005110960 A RU 2005110960A
- Authority
- RU
- Russia
- Prior art keywords
- technetium complex
- technetium
- acid
- composition
- ligand
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 238000012384 transportation and delivery Methods 0.000 title claims 2
- 238000012800 visualization Methods 0.000 title claims 2
- 230000005291 magnetic effect Effects 0.000 title 1
- 229910052713 technetium Inorganic materials 0.000 claims abstract 26
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims abstract 25
- 239000000203 mixture Substances 0.000 claims abstract 23
- 239000003446 ligand Substances 0.000 claims abstract 12
- 239000012217 radiopharmaceutical Substances 0.000 claims abstract 6
- 229940121896 radiopharmaceutical Drugs 0.000 claims abstract 6
- 230000002799 radiopharmaceutical effect Effects 0.000 claims abstract 6
- 238000002360 preparation method Methods 0.000 claims abstract 3
- 230000003537 radioprotector Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 150000007524 organic acids Chemical class 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical group NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229960004050 aminobenzoic acid Drugs 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001515 polyalkylene glycol Chemical group 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 238000010668 complexation reaction Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- -1 technetium metal complex Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0224799.7 | 2002-10-25 | ||
| GBGB0224799.7A GB0224799D0 (en) | 2002-10-25 | 2002-10-25 | Improved complex compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005110960A true RU2005110960A (ru) | 2005-11-20 |
Family
ID=9946533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005110960/15A RU2005110960A (ru) | 2002-10-25 | 2003-10-24 | Конъюгаты комплексов тс и группировок, обеспечивающих направленную доставку, и их применение в диагностике методом магнито-резонансной визуализации |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1553986B1 (https=) |
| JP (1) | JP2006508084A (https=) |
| KR (1) | KR20050070080A (https=) |
| CN (1) | CN1708322A (https=) |
| AT (1) | ATE402720T1 (https=) |
| AU (1) | AU2003279444A1 (https=) |
| BR (1) | BR0315578A (https=) |
| CA (1) | CA2501684A1 (https=) |
| DE (1) | DE60322562D1 (https=) |
| ES (1) | ES2309361T3 (https=) |
| GB (1) | GB0224799D0 (https=) |
| MX (1) | MXPA05004418A (https=) |
| NO (1) | NO20051811L (https=) |
| RU (1) | RU2005110960A (https=) |
| WO (1) | WO2004037297A1 (https=) |
| ZA (1) | ZA200502835B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0515974D0 (en) * | 2005-08-03 | 2005-09-07 | Ge Healthcare Ltd | Compounds and imaging methods |
| GB0520527D0 (en) * | 2005-10-10 | 2005-11-16 | Ge Healthcare Ltd | Automated method |
| GB0614337D0 (en) * | 2006-07-19 | 2006-08-30 | Acal Energy Ltd | Fuel Cells |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| DK2598175T3 (da) | 2010-07-27 | 2020-08-03 | Serac Healthcare Ltd | Radiofarmaceutiske sammensætninger |
| CN103370084B (zh) | 2010-12-21 | 2016-11-09 | 通用电气健康护理有限公司 | 苯胺在肟连接的放射稳定化中的应用 |
| EP2655353B9 (en) * | 2010-12-22 | 2015-08-05 | Tfchem | Derivatives of glyco-cf2-serine and glyco-cf2-threonine |
| GB201103696D0 (en) * | 2011-03-04 | 2011-04-20 | Ge Healthcare Ltd | Technetium labelled peptides |
| US20130195756A1 (en) * | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
| GB201610176D0 (en) * | 2016-06-10 | 2016-07-27 | Edinburgh Molecular Imaging Ltd | Imaging agents and methods of use |
| CN112830940B (zh) * | 2020-09-07 | 2022-03-01 | 中国科学院宁波材料技术与工程研究所 | 2,5-呋喃二甲醛肟金属络合物及其制备方法、及在抗菌除霉消毒剂中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2332277A1 (en) * | 1998-05-15 | 1999-11-25 | Nycomed Amersham Plc | Labelled glutamine and lysine analogues |
| CA2405469C (en) * | 2000-04-12 | 2012-03-20 | Amersham Health As | Integrin binding peptide derivatives |
| WO2001089584A2 (en) * | 2000-05-23 | 2001-11-29 | Amersham Health As | Contrast agents |
| NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| GB0105224D0 (en) * | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
-
2002
- 2002-10-25 GB GBGB0224799.7A patent/GB0224799D0/en not_active Ceased
-
2003
- 2003-10-24 MX MXPA05004418A patent/MXPA05004418A/es not_active Application Discontinuation
- 2003-10-24 KR KR1020057006999A patent/KR20050070080A/ko not_active Withdrawn
- 2003-10-24 ES ES03772392T patent/ES2309361T3/es not_active Expired - Lifetime
- 2003-10-24 CA CA002501684A patent/CA2501684A1/en not_active Abandoned
- 2003-10-24 WO PCT/GB2003/004573 patent/WO2004037297A1/en not_active Ceased
- 2003-10-24 JP JP2004546174A patent/JP2006508084A/ja not_active Withdrawn
- 2003-10-24 EP EP03772392A patent/EP1553986B1/en not_active Expired - Lifetime
- 2003-10-24 CN CNA2003801020619A patent/CN1708322A/zh active Pending
- 2003-10-24 AU AU2003279444A patent/AU2003279444A1/en not_active Abandoned
- 2003-10-24 AT AT03772392T patent/ATE402720T1/de not_active IP Right Cessation
- 2003-10-24 DE DE60322562T patent/DE60322562D1/de not_active Expired - Lifetime
- 2003-10-24 RU RU2005110960/15A patent/RU2005110960A/ru not_active Application Discontinuation
- 2003-10-24 BR BR0315578-1A patent/BR0315578A/pt not_active IP Right Cessation
-
2005
- 2005-04-14 NO NO20051811A patent/NO20051811L/no not_active Application Discontinuation
-
2006
- 2006-01-19 ZA ZA200502835A patent/ZA200502835B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050070080A (ko) | 2005-07-05 |
| MXPA05004418A (es) | 2005-11-23 |
| ES2309361T3 (es) | 2008-12-16 |
| ATE402720T1 (de) | 2008-08-15 |
| JP2006508084A (ja) | 2006-03-09 |
| EP1553986B1 (en) | 2008-07-30 |
| BR0315578A (pt) | 2005-10-25 |
| GB0224799D0 (en) | 2002-12-04 |
| WO2004037297A1 (en) | 2004-05-06 |
| AU2003279444A1 (en) | 2004-05-13 |
| CN1708322A (zh) | 2005-12-14 |
| NO20051811L (no) | 2005-06-27 |
| DE60322562D1 (de) | 2008-09-11 |
| NO20051811D0 (no) | 2005-04-14 |
| ZA200502835B (en) | 2006-03-29 |
| CA2501684A1 (en) | 2004-05-06 |
| EP1553986A1 (en) | 2005-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080320 |