RU2003126913A - 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс - Google Patents
3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс Download PDFInfo
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- RU2003126913A RU2003126913A RU2003126913/04A RU2003126913A RU2003126913A RU 2003126913 A RU2003126913 A RU 2003126913A RU 2003126913/04 A RU2003126913/04 A RU 2003126913/04A RU 2003126913 A RU2003126913 A RU 2003126913A RU 2003126913 A RU2003126913 A RU 2003126913A
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- compound
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- prodrug
- pharmaceutically acceptable
- solvate
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- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 54
- 229940002612 prodrug Drugs 0.000 claims 49
- 239000000651 prodrug Substances 0.000 claims 49
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 27
- 239000012453 solvate Substances 0.000 claims 27
- 150000002431 hydrogen Chemical class 0.000 claims 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 229910004013 NO 2 Inorganic materials 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
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- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
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- GTXSRFUZSLTDFX-HRCADAONSA-N (2s)-n-[(2s)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-4-methyl-2-[[(2s)-2-sulfanyl-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butanoyl]amino]pentanamide Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](S)CCN1C(=O)N(C)C(C)(C)C1=O GTXSRFUZSLTDFX-HRCADAONSA-N 0.000 claims 2
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Classifications
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- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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| Country | Link |
|---|---|
| US (1) | US20030097004A1 (enExample) |
| EP (1) | EP1355875A1 (enExample) |
| JP (1) | JP2004529911A (enExample) |
| KR (1) | KR20030090629A (enExample) |
| CN (1) | CN1575273A (enExample) |
| AU (1) | AU2002303084B2 (enExample) |
| BR (1) | BR0206968A (enExample) |
| CA (1) | CA2436351A1 (enExample) |
| CZ (1) | CZ20032098A3 (enExample) |
| EC (1) | ECSP034712A (enExample) |
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| IL (1) | IL156793A0 (enExample) |
| MX (1) | MXPA03006950A (enExample) |
| NO (1) | NO20033424L (enExample) |
| NZ (1) | NZ527947A (enExample) |
| PL (1) | PL367534A1 (enExample) |
| RU (1) | RU2003126913A (enExample) |
| SK (1) | SK9782003A3 (enExample) |
| WO (1) | WO2002076926A1 (enExample) |
| ZA (1) | ZA200305881B (enExample) |
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-
2002
- 2002-02-01 PL PL02367534A patent/PL367534A1/xx not_active Application Discontinuation
- 2002-02-01 MX MXPA03006950A patent/MXPA03006950A/es not_active Application Discontinuation
- 2002-02-01 IL IL15679302A patent/IL156793A0/xx unknown
- 2002-02-01 JP JP2002576189A patent/JP2004529911A/ja active Pending
- 2002-02-01 CA CA002436351A patent/CA2436351A1/en not_active Abandoned
- 2002-02-01 CZ CZ20032098A patent/CZ20032098A3/cs unknown
- 2002-02-01 SK SK978-2003A patent/SK9782003A3/sk not_active Application Discontinuation
- 2002-02-01 EP EP02731085A patent/EP1355875A1/en not_active Withdrawn
- 2002-02-01 HU HU0304047A patent/HUP0304047A2/hu unknown
- 2002-02-01 KR KR10-2003-7009958A patent/KR20030090629A/ko not_active Ceased
- 2002-02-01 CN CNA028045173A patent/CN1575273A/zh active Pending
- 2002-02-01 NZ NZ527947A patent/NZ527947A/en unknown
- 2002-02-01 AU AU2002303084A patent/AU2002303084B2/en not_active Ceased
- 2002-02-01 US US10/062,006 patent/US20030097004A1/en not_active Abandoned
- 2002-02-01 BR BR0206968-7A patent/BR0206968A/pt not_active IP Right Cessation
- 2002-02-01 RU RU2003126913/04A patent/RU2003126913A/ru not_active Application Discontinuation
- 2002-02-01 WO PCT/US2002/002888 patent/WO2002076926A1/en not_active Ceased
-
2003
- 2003-07-30 ZA ZA2003/05881A patent/ZA200305881B/en unknown
- 2003-07-31 NO NO20033424A patent/NO20033424L/no not_active Application Discontinuation
- 2003-08-01 EC EC2003004712A patent/ECSP034712A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03006950A (es) | 2003-11-18 |
| NO20033424D0 (no) | 2003-07-31 |
| EP1355875A1 (en) | 2003-10-29 |
| WO2002076926A1 (en) | 2002-10-03 |
| NO20033424L (no) | 2003-09-30 |
| CN1575273A (zh) | 2005-02-02 |
| SK9782003A3 (en) | 2004-01-08 |
| AU2002303084B2 (en) | 2006-05-25 |
| JP2004529911A (ja) | 2004-09-30 |
| CZ20032098A3 (cs) | 2004-01-14 |
| KR20030090629A (ko) | 2003-11-28 |
| CA2436351A1 (en) | 2002-10-03 |
| HUP0304047A2 (hu) | 2004-04-28 |
| ECSP034712A (es) | 2003-09-24 |
| BR0206968A (pt) | 2004-03-09 |
| IL156793A0 (en) | 2004-02-08 |
| NZ527947A (en) | 2005-10-28 |
| US20030097004A1 (en) | 2003-05-22 |
| PL367534A1 (en) | 2005-02-21 |
| ZA200305881B (en) | 2005-01-26 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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