RU2003103771A - Способ генотипирования на микрочипах множества образцов по множественным локусам - Google Patents
Способ генотипирования на микрочипах множества образцов по множественным локусам Download PDFInfo
- Publication number
- RU2003103771A RU2003103771A RU2003103771/13A RU2003103771A RU2003103771A RU 2003103771 A RU2003103771 A RU 2003103771A RU 2003103771/13 A RU2003103771/13 A RU 2003103771/13A RU 2003103771 A RU2003103771 A RU 2003103771A RU 2003103771 A RU2003103771 A RU 2003103771A
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- Prior art keywords
- samples
- synthetic oligonucleotides
- microchip
- genomic fragments
- labeled synthetic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 28
- 238000003205 genotyping method Methods 0.000 title claims abstract 5
- 108091034117 Oligonucleotide Proteins 0.000 claims abstract 12
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims abstract 12
- 230000002068 genetic effect Effects 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 6
- 238000002493 microarray Methods 0.000 claims abstract 4
- 230000000295 complement effect Effects 0.000 claims abstract 3
- 239000012634 fragment Substances 0.000 claims 11
- 238000009396 hybridization Methods 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 1
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
- Image Generation (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/613,006 US6913879B1 (en) | 2000-07-10 | 2000-07-10 | Microarray method of genotyping multiple samples at multiple LOCI |
| US09/613,006 | 2000-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003103771A true RU2003103771A (ru) | 2004-08-20 |
Family
ID=24455485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003103771/13A RU2003103771A (ru) | 2000-07-10 | 2001-07-03 | Способ генотипирования на микрочипах множества образцов по множественным локусам |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6913879B1 (https=) |
| EP (1) | EP1343911B1 (https=) |
| JP (1) | JP4175884B2 (https=) |
| KR (1) | KR100756015B1 (https=) |
| CN (1) | CN100520401C (https=) |
| AT (1) | ATE363543T1 (https=) |
| AU (2) | AU1874002A (https=) |
| CA (1) | CA2414105C (https=) |
| DE (1) | DE60128720T2 (https=) |
| IL (2) | IL153848A0 (https=) |
| IS (1) | IS2651B (https=) |
| NO (1) | NO20030101L (https=) |
| NZ (1) | NZ523560A (https=) |
| RU (1) | RU2003103771A (https=) |
| TW (1) | TWI280282B (https=) |
| WO (1) | WO2002003849A2 (https=) |
Families Citing this family (82)
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| DE10000001A1 (de) * | 2000-01-01 | 2001-07-19 | Agrobiogen Gmbh | DNA-Matrizes und deren Verwendung zur Untersuchung von Individuen einer Population |
| US6913879B1 (en) * | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
| GB0208364D0 (en) * | 2002-04-11 | 2002-05-22 | Sec Dep For The Home Departmen | Improvements in and relating to methods and apparatus for genotyping |
| AU2003283575A1 (en) * | 2002-11-14 | 2004-06-03 | John Nicholas Housby | Polymorphism assay |
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| JP4458327B2 (ja) * | 2003-08-28 | 2010-04-28 | キヤノン株式会社 | 標的物質の定量方法および該方法に用いるプローブ担体 |
| US7108979B2 (en) * | 2003-09-03 | 2006-09-19 | Agilent Technologies, Inc. | Methods to detect cross-contamination between samples contacted with a multi-array substrate |
| US20080220420A1 (en) * | 2004-11-19 | 2008-09-11 | Shimadzu Corporation | Method of Detecting Gene Polymorphism, Method of Diagnosing, Apparatus Therefor, and Test Reagent Kit |
| RU2348695C2 (ru) | 2006-05-23 | 2009-03-10 | Закрытое акционерное общество "Молекулярно-медицинские технологии" | Дифференцирующий и специфический олигонуклеотиды для идентификации последовательностей днк инфекционных агентов в биологических материалах, способ видовой идентификации инфекционных агентов, биочип и набор для осуществления этого способа |
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| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
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-
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- 2000-07-10 US US09/613,006 patent/US6913879B1/en not_active Expired - Fee Related
-
2001
- 2001-07-03 WO PCT/US2001/021163 patent/WO2002003849A2/en not_active Ceased
- 2001-07-03 CA CA2414105A patent/CA2414105C/en not_active Expired - Fee Related
- 2001-07-03 KR KR1020037000360A patent/KR100756015B1/ko not_active Expired - Fee Related
- 2001-07-03 AT AT01984136T patent/ATE363543T1/de not_active IP Right Cessation
- 2001-07-03 AU AU1874002A patent/AU1874002A/xx active Pending
- 2001-07-03 DE DE60128720T patent/DE60128720T2/de not_active Expired - Lifetime
- 2001-07-03 EP EP01984136A patent/EP1343911B1/en not_active Expired - Lifetime
- 2001-07-03 IL IL15384801A patent/IL153848A0/xx unknown
- 2001-07-03 RU RU2003103771/13A patent/RU2003103771A/ru not_active Application Discontinuation
- 2001-07-03 CN CNB018139728A patent/CN100520401C/zh not_active Expired - Fee Related
- 2001-07-03 NZ NZ523560A patent/NZ523560A/en unknown
- 2001-07-03 JP JP2002508311A patent/JP4175884B2/ja not_active Expired - Fee Related
- 2001-07-03 AU AU2002218740A patent/AU2002218740B2/en not_active Ceased
- 2001-07-09 TW TW090116726A patent/TWI280282B/zh not_active IP Right Cessation
-
2003
- 2003-01-08 IL IL153848A patent/IL153848A/en not_active IP Right Cessation
- 2003-01-09 NO NO20030101A patent/NO20030101L/no not_active Application Discontinuation
- 2003-01-09 IS IS6674A patent/IS2651B/is unknown
-
2004
- 2004-11-05 US US10/981,829 patent/US20050153318A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6913879B1 (en) | 2005-07-05 |
| NO20030101D0 (no) | 2003-01-09 |
| EP1343911B1 (en) | 2007-05-30 |
| NZ523560A (en) | 2006-01-27 |
| IS6674A (is) | 2003-01-09 |
| IL153848A0 (en) | 2003-07-31 |
| KR100756015B1 (ko) | 2007-09-07 |
| US20050153318A1 (en) | 2005-07-14 |
| KR20030040352A (ko) | 2003-05-22 |
| JP2004502441A (ja) | 2004-01-29 |
| CN1636137A (zh) | 2005-07-06 |
| TWI280282B (en) | 2007-05-01 |
| JP4175884B2 (ja) | 2008-11-05 |
| DE60128720D1 (de) | 2007-07-12 |
| AU1874002A (en) | 2002-01-21 |
| EP1343911A2 (en) | 2003-09-17 |
| NO20030101L (no) | 2003-03-07 |
| IS2651B (is) | 2010-08-15 |
| CN100520401C (zh) | 2009-07-29 |
| AU2002218740B2 (en) | 2007-03-22 |
| IL153848A (en) | 2009-09-22 |
| DE60128720T2 (de) | 2008-01-24 |
| HK1057906A1 (en) | 2004-04-23 |
| CA2414105C (en) | 2011-07-12 |
| WO2002003849A3 (en) | 2003-06-19 |
| ATE363543T1 (de) | 2007-06-15 |
| CA2414105A1 (en) | 2002-01-17 |
| WO2002003849A2 (en) | 2002-01-17 |
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