ATE363543T1 - Mikroarray-verfahren zur genotypisierung mehrerer proben für mehrere loci - Google Patents

Mikroarray-verfahren zur genotypisierung mehrerer proben für mehrere loci

Info

Publication number
ATE363543T1
ATE363543T1 AT01984136T AT01984136T ATE363543T1 AT E363543 T1 ATE363543 T1 AT E363543T1 AT 01984136 T AT01984136 T AT 01984136T AT 01984136 T AT01984136 T AT 01984136T AT E363543 T1 ATE363543 T1 AT E363543T1
Authority
AT
Austria
Prior art keywords
genotyping
loci
samples
microarray method
multiple samples
Prior art date
Application number
AT01984136T
Other languages
German (de)
English (en)
Inventor
Mark Schena
Original Assignee
Telechem International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24455485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE363543(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Telechem International Inc filed Critical Telechem International Inc
Application granted granted Critical
Publication of ATE363543T1 publication Critical patent/ATE363543T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
  • Image Generation (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT01984136T 2000-07-10 2001-07-03 Mikroarray-verfahren zur genotypisierung mehrerer proben für mehrere loci ATE363543T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/613,006 US6913879B1 (en) 2000-07-10 2000-07-10 Microarray method of genotyping multiple samples at multiple LOCI

Publications (1)

Publication Number Publication Date
ATE363543T1 true ATE363543T1 (de) 2007-06-15

Family

ID=24455485

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01984136T ATE363543T1 (de) 2000-07-10 2001-07-03 Mikroarray-verfahren zur genotypisierung mehrerer proben für mehrere loci

Country Status (16)

Country Link
US (2) US6913879B1 (https=)
EP (1) EP1343911B1 (https=)
JP (1) JP4175884B2 (https=)
KR (1) KR100756015B1 (https=)
CN (1) CN100520401C (https=)
AT (1) ATE363543T1 (https=)
AU (2) AU1874002A (https=)
CA (1) CA2414105C (https=)
DE (1) DE60128720T2 (https=)
IL (2) IL153848A0 (https=)
IS (1) IS2651B (https=)
NO (1) NO20030101L (https=)
NZ (1) NZ523560A (https=)
RU (1) RU2003103771A (https=)
TW (1) TWI280282B (https=)
WO (1) WO2002003849A2 (https=)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10000001A1 (de) * 2000-01-01 2001-07-19 Agrobiogen Gmbh DNA-Matrizes und deren Verwendung zur Untersuchung von Individuen einer Population
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
GB0208364D0 (en) * 2002-04-11 2002-05-22 Sec Dep For The Home Departmen Improvements in and relating to methods and apparatus for genotyping
AU2003283575A1 (en) * 2002-11-14 2004-06-03 John Nicholas Housby Polymorphism assay
US7097070B2 (en) 2003-08-15 2006-08-29 Protedyne Corporation Method and apparatus for handling small volume fluid samples
JP4458327B2 (ja) * 2003-08-28 2010-04-28 キヤノン株式会社 標的物質の定量方法および該方法に用いるプローブ担体
US7108979B2 (en) * 2003-09-03 2006-09-19 Agilent Technologies, Inc. Methods to detect cross-contamination between samples contacted with a multi-array substrate
US20080220420A1 (en) * 2004-11-19 2008-09-11 Shimadzu Corporation Method of Detecting Gene Polymorphism, Method of Diagnosing, Apparatus Therefor, and Test Reagent Kit
RU2348695C2 (ru) 2006-05-23 2009-03-10 Закрытое акционерное общество "Молекулярно-медицинские технологии" Дифференцирующий и специфический олигонуклеотиды для идентификации последовательностей днк инфекционных агентов в биологических материалах, способ видовой идентификации инфекционных агентов, биочип и набор для осуществления этого способа
GB0618514D0 (en) * 2006-09-20 2006-11-01 Univ Nottingham Trent Method of detecting interactions on a microarray using nuclear magnetic resonance
DK2099935T3 (da) * 2006-11-30 2014-04-07 Univ California Array for detektion af mikrober
EP2148885A4 (en) * 2007-05-31 2010-12-15 Monsanto Technology Llc SOYBEAN POLYMORPHISMS AND METHOD FOR THEIR GENOTYPIZATION
EP2476763A3 (en) 2007-08-29 2013-03-06 Monsanto Technology LLC Methods and compositions for breeding for preferred traits
EP2245199B1 (en) * 2008-02-01 2013-11-13 The General Hospital Corporation Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions
WO2009132089A2 (en) 2008-04-24 2009-10-29 Monsanto Technology Llc A method to identify asian soybean rust resistance quantitative trait loci in soybean and compositions thereof
US9393566B2 (en) 2008-06-23 2016-07-19 Canon U.S. Life Sciences, Inc. System and method for temperature referencing for melt curve data collection
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
BR112012001077A2 (pt) 2009-07-16 2020-08-11 The General Hospital Corporation extração de ácido nucleico, métodos para avaliar a qualidade de uma extração de ácido nucleico e de uma amostra biológica, para ober ácido nucleico a partir de uma amostra biológica, para analisar rna de microvesículas e para diagnosticar e monitorar um indivíduo, e, kit
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
EP2475989A4 (en) 2009-09-09 2013-02-27 Gen Hospital Corp USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
JP6219721B2 (ja) 2010-11-10 2017-10-25 エキソソーム ダイアグノスティックス インコーポレイテッド 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US10172305B2 (en) 2011-04-29 2019-01-08 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
CA2835641C (en) 2011-05-11 2019-05-28 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
EP3492606B1 (en) 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
PT3517615T (pt) 2011-08-31 2022-08-09 Seminis Vegetable Seeds Inc Métodos e composições para a firmeza da melancia
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
EP2776587A4 (en) 2011-11-10 2015-07-15 Exosome Diagnostics Inc LIQUOR ASSAY
US20130184165A1 (en) * 2012-01-13 2013-07-18 Data2Bio Genotyping by next-generation sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
CN104995311A (zh) 2012-08-30 2015-10-21 外来体诊断公司 用于核酸测定的对照
CA2887058C (en) 2012-10-03 2022-02-22 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
EP2917368A1 (en) 2012-11-07 2015-09-16 Good Start Genetics, Inc. Methods and systems for identifying contamination in samples
GB201220924D0 (en) 2012-11-21 2013-01-02 Cancer Res Inst Royal Materials and methods for determining susceptibility or predisposition to cancer
CA2892926C (en) * 2012-12-03 2023-02-21 Statens Serum Institut Method of diagnosing galactosemia in neonatal screening
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
AU2014305994B2 (en) 2013-08-06 2019-02-21 Exosome Diagnostics, Inc. Urine biomarker cohorts, gene expression signatures, and methods of use thereof
NZ630628A (en) 2013-10-08 2015-04-24 Seminis Vegetable Seeds Inc Methods and compositions for peronospora resistance in spinach
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
NZ735461A (en) 2013-11-27 2020-05-29 Seminis Vegetable Seeds Inc Disease resistance loci in onion
BR112016019007B1 (pt) 2014-02-21 2022-05-17 Syngenta Participations Ag Métodos para produzir uma planta de milho, que expressa vip3a ou germoplasma de milho com fertilidade masculina aumentada, programa de melhoramento, método para melhorar a produção de sementes de uma planta de milho que expressa vip3a, e programa de produção de sementes
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
EP3005862A1 (en) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melon plants with improved disease tolerance
EP4095261B1 (en) 2015-01-06 2025-05-28 Molecular Loop Biosciences, Inc. Screening for structural variants
PL3289087T3 (pl) 2015-04-28 2021-11-02 Monsanto Technology Llc Sposoby i kompozycje dla wytwarzania brachitycznych roślin kukurydzy
US10415101B2 (en) 2015-04-30 2019-09-17 Monsanto Technology Llc Methods for producing canola plants with clubroot resistance and compositions thereof
WO2017031059A1 (en) 2015-08-18 2017-02-23 Monsanto Technology Llc Methods for producing cotton plants with enhanced drought tolerance and compositions thereof
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
WO2017106731A1 (en) 2015-12-18 2017-06-22 Monsanto Technology Llc Methods for producing corn plants with northern leaf blight resistance and compositions thereof
SG11201809005TA (en) 2016-04-15 2018-11-29 Exosome Diagnostics Inc Plasma-based detection of anaplastic lymphoma kinase (alk) nucleic acids and alk fusion transcripts and uses thereof in diagnosis and treatment of cancer
AU2017263886B2 (en) 2016-05-13 2023-11-09 Exosome Diagnostics, Inc. Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids
EP3496528A4 (en) 2016-08-11 2020-03-18 Monsanto Technology LLC METHODS AND COMPOSITIONS FOR PRODUCING CORN PLANTS WITH RESISTANCE TO LATE FAILURE
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
US11396676B2 (en) 2016-10-21 2022-07-26 Exosome Diagnostics, Inc. Sequencing and analysis of exosome associated nucleic acids
JP7280823B2 (ja) 2016-11-30 2023-05-24 エクソサム ダイアグノスティクス,インコーポレイティド 非小細胞肺癌患者由来のエクソソームrna及び無細胞dnaを使用して血漿中の変異を検出するための方法と組成物
US20200149036A1 (en) 2017-01-02 2020-05-14 Exosome Diagnostics, Inc. Methods to distinguish rna and dna in a combined preparation
US11899024B2 (en) 2017-07-12 2024-02-13 Exosome Diagnostics, Inc. Treatment and diagnosis of parkinson's disease using isolated and enriched populations of biofluid-derived extracellular vesicles
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
CA3126761C (en) 2019-01-15 2023-01-10 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
SG10202008262UA (en) 2019-09-26 2021-04-29 Seminis Vegetable Seeds Inc Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
MX2024004405A (es) 2023-04-14 2024-11-08 Seminis Vegetable Seeds Inc Métodos y composiciones de resistencia a peronospora en la espinaca
WO2026059956A1 (en) 2024-09-11 2026-03-19 Seminis Vegetable Seeds, Inc. Qtls conferring resistance to cucurbit aphid-borne yellow virus

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
WO1993021345A1 (en) 1992-04-21 1993-10-28 The Regents Of The University Of California Multicolor in situ hybridization methods for genetic testing
US5403708A (en) 1992-07-06 1995-04-04 Brennan; Thomas M. Methods and compositions for determining the sequence of nucleic acids
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5834181A (en) 1994-07-28 1998-11-10 Genzyme Corporation High throughput screening method for sequences or genetic alterations in nucleic acids
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
AU3568897A (en) 1996-06-07 1998-01-05 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
US6013449A (en) 1997-11-26 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Probe-based analysis of heterozygous mutations using two-color labelling
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
AU6163399A (en) 1998-09-25 2000-04-17 Massachusetts Institute Of Technology Methods and products related to genotyping and dna analysis
US6268147B1 (en) * 1998-11-02 2001-07-31 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
WO2001061043A2 (en) * 2000-02-16 2001-08-23 Illumina, Inc. Parallel genotyping of multiple patient samples
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI

Also Published As

Publication number Publication date
US6913879B1 (en) 2005-07-05
NO20030101D0 (no) 2003-01-09
EP1343911B1 (en) 2007-05-30
NZ523560A (en) 2006-01-27
RU2003103771A (ru) 2004-08-20
IS6674A (is) 2003-01-09
IL153848A0 (en) 2003-07-31
KR100756015B1 (ko) 2007-09-07
US20050153318A1 (en) 2005-07-14
KR20030040352A (ko) 2003-05-22
JP2004502441A (ja) 2004-01-29
CN1636137A (zh) 2005-07-06
TWI280282B (en) 2007-05-01
JP4175884B2 (ja) 2008-11-05
DE60128720D1 (de) 2007-07-12
AU1874002A (en) 2002-01-21
EP1343911A2 (en) 2003-09-17
NO20030101L (no) 2003-03-07
IS2651B (is) 2010-08-15
CN100520401C (zh) 2009-07-29
AU2002218740B2 (en) 2007-03-22
IL153848A (en) 2009-09-22
DE60128720T2 (de) 2008-01-24
HK1057906A1 (en) 2004-04-23
CA2414105C (en) 2011-07-12
WO2002003849A3 (en) 2003-06-19
CA2414105A1 (en) 2002-01-17
WO2002003849A2 (en) 2002-01-17

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