ATE49977T1 - Herstellung von dna in grossem umfang. - Google Patents

Herstellung von dna in grossem umfang.

Info

Publication number
ATE49977T1
ATE49977T1 AT85114561T AT85114561T ATE49977T1 AT E49977 T1 ATE49977 T1 AT E49977T1 AT 85114561 T AT85114561 T AT 85114561T AT 85114561 T AT85114561 T AT 85114561T AT E49977 T1 ATE49977 T1 AT E49977T1
Authority
AT
Austria
Prior art keywords
oligonucleotide
production
dna
polynucleotide
large scale
Prior art date
Application number
AT85114561T
Other languages
English (en)
Inventor
Nanibhushan Dr Dattagupta
Peter Dr Rae
Donald Dr Crothers
Thomas Dr Barnett
Original Assignee
Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Diagnostics Inc filed Critical Molecular Diagnostics Inc
Application granted granted Critical
Publication of ATE49977T1 publication Critical patent/ATE49977T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT85114561T 1984-11-27 1985-11-16 Herstellung von dna in grossem umfang. ATE49977T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/675,386 US4734363A (en) 1984-11-27 1984-11-27 Large scale production of DNA probes
EP85114561A EP0184056B1 (de) 1984-11-27 1985-11-16 Herstellung von DNA in grossem Umfang

Publications (1)

Publication Number Publication Date
ATE49977T1 true ATE49977T1 (de) 1990-02-15

Family

ID=24710259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85114561T ATE49977T1 (de) 1984-11-27 1985-11-16 Herstellung von dna in grossem umfang.

Country Status (6)

Country Link
US (1) US4734363A (de)
EP (1) EP0184056B1 (de)
JP (1) JPS61227785A (de)
AT (1) ATE49977T1 (de)
CA (1) CA1264452A (de)
DE (1) DE3575731D1 (de)

Families Citing this family (59)

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EP0215942B1 (de) * 1985-03-15 1995-07-12 Antivirals Inc. Immunotestmittel für polynukleotid und verfahren
CA1278755C (en) * 1985-03-15 1991-01-08 William J. Knowles Labelling of oligonucleotides
US4808520A (en) * 1985-03-15 1989-02-28 Molecular Diagnostics, Inc. Labelling of oligonucleotides
ZA862335B (en) * 1985-03-28 1987-11-25 Cetus Corp Process for amplifying nucleic acid sequences
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
AU619170B2 (en) * 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
CA1317535C (en) * 1987-06-30 1993-05-11 Nanibhushan Dattagupta Assay of sequences using amplified genes
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US5273879A (en) * 1987-07-23 1993-12-28 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
GB2209754A (en) * 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
WO1989003395A1 (en) * 1987-10-16 1989-04-20 University Of Georgia Research Foundation, Inc. Receptor for natural killer and non-specific cytotoxic cells
WO1989003394A1 (en) * 1987-10-16 1989-04-20 University Of Georgia Research Foundation, Inc. Antigen recognized by natural killer and non-specific cytotoxic cells
US5028424A (en) * 1987-10-16 1991-07-02 University Of Georgia Research Foundation Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells
US5229494A (en) * 1987-10-16 1993-07-20 University Of Georgia Research Foundation Receptor for natural killer and non-specific cytotoxic cells
US5185430A (en) * 1987-10-16 1993-02-09 University Of Georgia Research Foundation, Inc. Antigen recognized by natural killer and non-specific cytotoxic cells
WO1989004874A1 (en) * 1987-11-03 1989-06-01 Molecular Biosystems, Inc. Method and apparatus for fixation of biopolymers to a solid support by centrifugation
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
JPH084519B2 (ja) * 1987-12-25 1996-01-24 エフ・ホフマン―ラ ロシュ アーゲー ハイブリッド形成用担体およびその調整方法
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
JPH04501353A (ja) * 1988-07-26 1992-03-12 ジエネラブス・テクノロジーズ・インコーポレイテツド Ｒｎａ及びｄｎａ増幅法
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
CA2003500C (en) * 1988-11-21 2000-01-18 Erik Hornes Process for producing cdna
US5759820A (en) * 1988-11-21 1998-06-02 Dynal As Process for producing cDNA
CA2004326A1 (en) * 1988-12-23 1990-06-23 Nanibushan Dattagupta Assay of sequences using amplified genes
ATE143696T1 (de) * 1989-02-28 1996-10-15 Canon Kk Partiell doppelsträngiges oligonukleotid und verfahren zu seiner bildung
CA2011818A1 (en) * 1989-03-17 1990-09-17 Fred T. Oakes Methods for purification, amplification and detection of a nucleic acid
GB8926269D0 (en) * 1989-11-21 1990-01-10 Dynal As Plasmid
US6013431A (en) * 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5888819A (en) * 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
EP0533952A4 (en) * 1991-04-15 1993-07-07 Sumitomo Electric Industries, Ltd. Process for separating or extracting nucleic acid from specimen containing the same
WO1993013220A1 (en) * 1991-12-24 1993-07-08 Tepnel Medical Limited Manipulating nucleic acid sequences
GB9127415D0 (en) * 1991-12-24 1992-02-19 Swordfish Int Ltd Solid support bound detection and diagnostic system
US6300058B1 (en) 1992-01-29 2001-10-09 Hitachi Chemical Research Center, Inc. Method for measuring messenger RNA
EP0675965A4 (de) * 1992-01-29 1999-01-20 Hitachi Chemical Co Ltd Träger zur immobilisierung von polynukleotiden.
DE69333650T2 (de) * 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5440025A (en) * 1992-03-12 1995-08-08 University Of Massachusetts At Lowell Process for separating nucleic acid polymers
EP0652971A4 (de) * 1992-07-28 1998-12-02 Hitachi Chemical Co Ltd Detektionssystem für gene.
US5580971A (en) * 1992-07-28 1996-12-03 Hitachi Chemical Company, Ltd. Fungal detection system based on rRNA probes
SE9203320D0 (sv) * 1992-11-06 1992-11-06 Pharmacia Lkb Biotech A method of processing nucleic acid samples
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
JPH07203998A (ja) * 1994-01-26 1995-08-08 Hamamatsu Photonics Kk 核酸塩基配列決定方法
AU707391B2 (en) * 1994-05-28 1999-07-08 Tepnel Medical Limited Producing copies of nucleic acids
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
JP4532608B2 (ja) 1997-02-07 2010-08-25 オリンパス株式会社 走査型プローブ顕微鏡を用いた核酸検出方法
AU6339598A (en) * 1997-02-24 1998-09-09 Tm Technologies, Inc. Telomerase extension assay
US6136568A (en) * 1997-09-15 2000-10-24 Hiatt; Andrew C. De novo polynucleotide synthesis using rolling templates
EP1021558A1 (de) * 1997-10-10 2000-07-26 President And Fellows Of Harvard College Oberflächengebundene, doppelsträngige dna-protein-arrays
CN1762990A (zh) * 1999-06-08 2006-04-26 拉卓拉药物公司 包含氨基氧基的化合价平台分子
DE60114525T2 (de) * 2000-07-31 2006-07-20 Agilent Technologies Inc., A Delaware Corp., Palo Alto Array-basierende Methoden zur Synthese von Nukleinsäuregemischen
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US20080261220A1 (en) * 2000-11-30 2008-10-23 Third Wave Technologies, Inc. Nucleic Acid Detection Assays
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US20060078889A1 (en) * 2004-10-08 2006-04-13 Arindam Bhattacharjee Array-based methods for producing ribonucleic acids
US7977119B2 (en) * 2004-12-08 2011-07-12 Agilent Technologies, Inc. Chemical arrays and methods of using the same
EP2759602A1 (de) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Nichtinvasive Verfahren zur pränatalen Gendiagnose

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US4139346A (en) * 1977-11-28 1979-02-13 Enzo Bio Chem Incorporated Nucleic acid and protein binding paper
US4302204A (en) * 1979-07-02 1981-11-24 The Board Of Trustees Of Leland Stanford Junior University Transfer and detection of nucleic acids
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
IL67576A0 (en) * 1982-12-28 1983-05-15 Wreschner Daniel Hyam Carrier sheets of paper and nitrocellulose bearing polyuridylic acid and polythymidylic acid residues and their use in the preparative recovery of mrna
EP0135587B2 (de) * 1983-02-22 2002-12-18 Syngene, Inc. Einzelstrang-oligonukleotide bestimmter sequenz, markergruppen enthaltend, verfahren zu deren chemischer synthese und nukleotide zur verwendung darin
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
EP0155950B1 (de) * 1983-09-02 1990-01-17 Molecular Biosystems, Inc. Oligonukleotid-polymer-tragsystem
FR2567523B1 (fr) * 1984-07-12 1987-11-13 Pasteur Institut Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention
FR2568254B1 (fr) * 1984-07-25 1988-04-29 Centre Nat Rech Scient Application d'oligonucleotides lies a un agent intercalant, notamment a titre de medicament
FR2569407B1 (fr) * 1984-08-22 1989-02-17 Pasteur Institut Sondes comportant des groupements adenine modifiee, leur preparation et leurs utilisations

Also Published As

Publication number Publication date
DE3575731D1 (de) 1990-03-08
EP0184056A3 (en) 1987-04-15
EP0184056A2 (de) 1986-06-11
EP0184056B1 (de) 1990-01-31
CA1264452A (en) 1990-01-16
US4734363A (en) 1988-03-29
JPS61227785A (ja) 1986-10-09

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