RU1771475C - Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты - Google Patents
Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислотыInfo
- Publication number
- RU1771475C RU1771475C SU874028879A SU4028879A RU1771475C RU 1771475 C RU1771475 C RU 1771475C SU 874028879 A SU874028879 A SU 874028879A SU 4028879 A SU4028879 A SU 4028879A RU 1771475 C RU1771475 C RU 1771475C
- Authority
- RU
- Russia
- Prior art keywords
- carboline
- benziloxyl
- production
- carbonic acid
- isopropyl ethers
- Prior art date
Links
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical class CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 title abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Carbon And Carbon Compounds (AREA)
- Fats And Perfumes (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863609699 DE3609699A1 (de) | 1986-03-20 | 1986-03-20 | 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU1771475C true RU1771475C (ru) | 1992-10-23 |
Family
ID=6297016
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU874028879A RU1771475C (ru) | 1986-03-20 | 1987-01-30 | Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты |
| SU915001115A RU2034845C1 (ru) | 1986-03-20 | 1991-07-30 | 5- ИЛИ 6-ЗАМЕЩЕННЫЕ СЛОЖНЫЕ ЭФИРЫ β -КАРБОЛИН-3-КАРБОНОВОЙ КИСЛОТЫ, ОБЛАДАЮЩИЕ ПСИХОТРОПНОЙ АКТИВНОСТЬЮ, И ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ ДЛЯ ЛЕЧЕНИЯ ПСИХОТРОПНЫХ ЗАБОЛЕВАНИЙ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU915001115A RU2034845C1 (ru) | 1986-03-20 | 1991-07-30 | 5- ИЛИ 6-ЗАМЕЩЕННЫЕ СЛОЖНЫЕ ЭФИРЫ β -КАРБОЛИН-3-КАРБОНОВОЙ КИСЛОТЫ, ОБЛАДАЮЩИЕ ПСИХОТРОПНОЙ АКТИВНОСТЬЮ, И ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ ДЛЯ ЛЕЧЕНИЯ ПСИХОТРОПНЫХ ЗАБОЛЕВАНИЙ |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5414002A (cs) |
| EP (1) | EP0239667B1 (cs) |
| JP (1) | JPH0670053B2 (cs) |
| AT (1) | ATE63119T1 (cs) |
| AU (1) | AU596385B2 (cs) |
| CA (1) | CA1332837C (cs) |
| CS (2) | CS277411B6 (cs) |
| DD (1) | DD260068A5 (cs) |
| DE (2) | DE3609699A1 (cs) |
| DK (1) | DK168953B1 (cs) |
| ES (1) | ES2039346T3 (cs) |
| FI (2) | FI864498A0 (cs) |
| GR (1) | GR3002085T3 (cs) |
| HU (1) | HU195218B (cs) |
| IE (1) | IE59344B1 (cs) |
| IL (1) | IL80667A (cs) |
| MX (1) | MX9203701A (cs) |
| NO (2) | NO864362D0 (cs) |
| NZ (1) | NZ218482A (cs) |
| PH (1) | PH25100A (cs) |
| PT (1) | PT83763B (cs) |
| RU (2) | RU1771475C (cs) |
| UA (2) | UA13475A (cs) |
| ZA (1) | ZA872072B (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4122722A1 (de) * | 1991-07-06 | 1993-01-07 | Schering Ag | Verfahren zur herstellung von indol-derivaten |
| DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
| US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
| DE10136842A1 (de) * | 2001-07-23 | 2003-02-13 | Schering Ag | GABA¶A¶-Rezeptor-Modulatoren mit NMDA-antagonistischer Aktivität |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| DE3240511A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinderivaten |
| DE3322895A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s) |
| DE3335323A1 (de) * | 1983-09-27 | 1985-04-04 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DK240184D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
| DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
| DE3504045A1 (de) * | 1985-02-04 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinen durch dehydrierung |
| DE3540653A1 (de) * | 1985-11-13 | 1987-05-14 | Schering Ag | Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE3545776A1 (de) * | 1985-12-20 | 1987-06-25 | Schering Ag | 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
-
1986
- 1986-03-20 DE DE19863609699 patent/DE3609699A1/de not_active Withdrawn
- 1986-10-29 EP EP86115006A patent/EP0239667B1/de not_active Expired - Lifetime
- 1986-10-29 DE DE8686115006T patent/DE3679059D1/de not_active Expired - Lifetime
- 1986-10-29 ES ES198686115006T patent/ES2039346T3/es not_active Expired - Lifetime
- 1986-10-29 AT AT86115006T patent/ATE63119T1/de not_active IP Right Cessation
- 1986-10-31 NO NO864362A patent/NO864362D0/no unknown
- 1986-11-05 FI FI864498A patent/FI864498A0/fi not_active Application Discontinuation
- 1986-11-10 DK DK536386A patent/DK168953B1/da not_active IP Right Cessation
- 1986-11-13 AU AU65168/86A patent/AU596385B2/en not_active Expired
- 1986-11-17 IL IL80667A patent/IL80667A/xx not_active IP Right Cessation
- 1986-11-17 HU HU864740A patent/HU195218B/hu unknown
- 1986-11-18 PT PT83763A patent/PT83763B/pt unknown
- 1986-11-25 IE IE309486A patent/IE59344B1/en not_active IP Right Cessation
- 1986-12-03 NZ NZ218482A patent/NZ218482A/en unknown
- 1986-12-11 FI FI865058A patent/FI83321C/fi not_active IP Right Cessation
- 1986-12-16 CS CS869386A patent/CS277411B6/cs not_active IP Right Cessation
- 1986-12-16 CS CS903634A patent/CS277498B6/cs not_active IP Right Cessation
- 1986-12-17 NO NO865121A patent/NO163737C/no not_active IP Right Cessation
- 1986-12-18 PH PH34618A patent/PH25100A/en unknown
- 1986-12-26 JP JP61308969A patent/JPH0670053B2/ja not_active Expired - Fee Related
- 1986-12-30 DD DD86298773A patent/DD260068A5/de not_active IP Right Cessation
-
1987
- 1987-01-06 CA CA000526775A patent/CA1332837C/en not_active Expired - Fee Related
- 1987-01-30 UA UA4028879A patent/UA13475A/uk unknown
- 1987-01-30 RU SU874028879A patent/RU1771475C/ru active
- 1987-03-20 ZA ZA872072A patent/ZA872072B/xx unknown
-
1989
- 1989-10-03 US US07/416,629 patent/US5414002A/en not_active Expired - Lifetime
-
1991
- 1991-06-07 GR GR91400757T patent/GR3002085T3/el unknown
- 1991-07-30 RU SU915001115A patent/RU2034845C1/ru not_active IP Right Cessation
- 1991-07-30 UA UA5001115A patent/UA26390A/uk unknown
-
1992
- 1992-06-29 MX MX9203701A patent/MX9203701A/es unknown
-
1994
- 1994-05-18 US US08/245,278 patent/US5700808A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Патент US № 4435403. кл. С 07 D 487/14, 1984. Патент DE № 3322895, кл. С 07 D 487/04, 1984. * |
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