RU1771475C - Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты - Google Patents

Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты

Info

Publication number
RU1771475C
RU1771475C SU874028879A SU4028879A RU1771475C RU 1771475 C RU1771475 C RU 1771475C SU 874028879 A SU874028879 A SU 874028879A SU 4028879 A SU4028879 A SU 4028879A RU 1771475 C RU1771475 C RU 1771475C
Authority
RU
Russia
Prior art keywords
carboline
benziloxyl
production
carbonic acid
substituted
Prior art date
Application number
SU874028879A
Other languages
English (en)
Inventor
Бире Хельмут
Хут Андреас
Рац Дитер
Шмихен Ральф
Зайдельманн Дитер
Кер Вольфганг
Ханс Шнайдер Херберт
Энгельштофт Могенс
Джон Хансен Бондо
Ветьен Франк
Хоноре Таге
Original Assignee
Шеринг Аг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Аг (Фирма) filed Critical Шеринг Аг (Фирма)
Application granted granted Critical
Publication of RU1771475C publication Critical patent/RU1771475C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Fats And Perfumes (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

Использование: как психофармацевтические средства в медицине. Сущность изобретени : 6-замещенные сложные эфиры /5-карболин-З-карбоновой кислоты общей Формулы I RIСн2осн3 СН2°@лргсоосн(сн3 где RI - Н. СНз. СНзО, Hal или СМ. Реагент 1: 5-(Н1-замещенный оензилокси)-3-(1- изопропиламино-2-метоксиэтил)индол. Реагент 2: глицинанизальдегидизопропи- ловый эфир. Услови  реакции: в среде абс. ДМФА, в атмосфере азота при 95°С с последующим гидролизом 1 н. HCI в среде толуола. Реагент 3: формальдегид. Услови  реакции: в среде ксилола при 100°С. 1 п. ф-лы. 2 табл. со с

Description

Rl.
ОСН3 СН2
Таблица 1
° П2 С°гСН(СНз)2
Таблица 2
ОСН3 9Н2
C02R3
SU874028879A 1986-03-20 1987-01-30 Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты RU1771475C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863609699 DE3609699A1 (de) 1986-03-20 1986-03-20 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester

Publications (1)

Publication Number Publication Date
RU1771475C true RU1771475C (ru) 1992-10-23

Family

ID=6297016

Family Applications (2)

Application Number Title Priority Date Filing Date
SU874028879A RU1771475C (ru) 1986-03-20 1987-01-30 Способ получени 6-бензилоксизамещенных изопропиловых эфиров @ -карболин-3-карбоновой кислоты
SU915001115A RU2034845C1 (ru) 1986-03-20 1991-07-30 5- ИЛИ 6-ЗАМЕЩЕННЫЕ СЛОЖНЫЕ ЭФИРЫ β -КАРБОЛИН-3-КАРБОНОВОЙ КИСЛОТЫ, ОБЛАДАЮЩИЕ ПСИХОТРОПНОЙ АКТИВНОСТЬЮ, И ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ ДЛЯ ЛЕЧЕНИЯ ПСИХОТРОПНЫХ ЗАБОЛЕВАНИЙ

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU915001115A RU2034845C1 (ru) 1986-03-20 1991-07-30 5- ИЛИ 6-ЗАМЕЩЕННЫЕ СЛОЖНЫЕ ЭФИРЫ β -КАРБОЛИН-3-КАРБОНОВОЙ КИСЛОТЫ, ОБЛАДАЮЩИЕ ПСИХОТРОПНОЙ АКТИВНОСТЬЮ, И ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ ДЛЯ ЛЕЧЕНИЯ ПСИХОТРОПНЫХ ЗАБОЛЕВАНИЙ

Country Status (24)

Country Link
US (2) US5414002A (ru)
EP (1) EP0239667B1 (ru)
JP (1) JPH0670053B2 (ru)
AT (1) ATE63119T1 (ru)
AU (1) AU596385B2 (ru)
CA (1) CA1332837C (ru)
CS (2) CS277411B6 (ru)
DD (1) DD260068A5 (ru)
DE (2) DE3609699A1 (ru)
DK (1) DK168953B1 (ru)
ES (1) ES2039346T3 (ru)
FI (2) FI864498A0 (ru)
GR (1) GR3002085T3 (ru)
HU (1) HU195218B (ru)
IE (1) IE59344B1 (ru)
IL (1) IL80667A (ru)
MX (1) MX9203701A (ru)
NO (2) NO864362D0 (ru)
NZ (1) NZ218482A (ru)
PH (1) PH25100A (ru)
PT (1) PT83763B (ru)
RU (2) RU1771475C (ru)
UA (2) UA13475A (ru)
ZA (1) ZA872072B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122722A1 (de) * 1991-07-06 1993-01-07 Schering Ag Verfahren zur herstellung von indol-derivaten
DE19502753A1 (de) * 1995-01-23 1996-07-25 Schering Ag Neue 9H-Pyrido[3,4-b]indol-Derivate
DE10136842A1 (de) * 2001-07-23 2003-02-13 Schering Ag GABA¶A¶-Rezeptor-Modulatoren mit NMDA-antagonistischer Aktivität
US20030045541A1 (en) * 2001-07-23 2003-03-06 Christopher Bruckner GABA-Receptor modulators with NMDA-Antagonistic activity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung
DE3540653A1 (de) * 1985-11-13 1987-05-14 Schering Ag Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3545776A1 (de) * 1985-12-20 1987-06-25 Schering Ag 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент US № 4435403. кл. С 07 D 487/14, 1984. Патент DE № 3322895, кл. С 07 D 487/04, 1984. *

Also Published As

Publication number Publication date
DD260068A5 (de) 1988-09-14
DE3609699A1 (de) 1987-09-24
HUT41787A (en) 1987-05-28
DK536386A (da) 1987-09-21
NO865121D0 (no) 1986-12-17
ATE63119T1 (de) 1991-05-15
NO864362D0 (no) 1986-10-31
FI83321B (fi) 1991-03-15
AU596385B2 (en) 1990-05-03
US5414002A (en) 1995-05-09
MX9203701A (es) 1992-09-01
IL80667A (en) 1991-04-15
PT83763A (de) 1986-12-01
IE59344B1 (en) 1994-02-09
EP0239667A1 (de) 1987-10-07
DE3679059D1 (de) 1991-06-06
CA1332837C (en) 1994-11-01
EP0239667B1 (de) 1991-05-02
ZA872072B (en) 1987-09-14
NO163737C (no) 1990-07-11
IE863094L (en) 1987-09-20
GR3002085T3 (en) 1992-12-30
JPS62221684A (ja) 1987-09-29
PT83763B (pt) 1989-07-31
FI83321C (fi) 1991-06-25
DK168953B1 (da) 1994-07-18
CS363490A3 (en) 1992-11-18
CS277411B6 (en) 1993-03-17
JPH0670053B2 (ja) 1994-09-07
FI865058A (fi) 1987-09-21
RU2034845C1 (ru) 1995-05-10
DK536386D0 (da) 1986-11-10
PH25100A (en) 1991-02-19
AU6516886A (en) 1987-09-24
NO163737B (no) 1990-04-02
FI864498A0 (fi) 1986-11-05
FI865058A0 (fi) 1986-12-11
HU195218B (en) 1988-04-28
CS277498B6 (en) 1993-02-17
NZ218482A (en) 1990-01-29
UA26390A (uk) 1999-08-30
US5700808A (en) 1997-12-23
UA13475A (uk) 1997-04-25
CS938686A3 (en) 1992-11-18
IL80667A0 (en) 1987-02-27
ES2039346T3 (es) 1993-10-01
NO865121L (no) 1987-09-21

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