RS90504A - C-17 spirolactonization and 6,7 oxidation of steroids - Google Patents

C-17 spirolactonization and 6,7 oxidation of steroids

Info

Publication number
RS90504A
RS90504A YU90504A YUP90504A RS90504A RS 90504 A RS90504 A RS 90504A YU 90504 A YU90504 A YU 90504A YU P90504 A YUP90504 A YU P90504A RS 90504 A RS90504 A RS 90504A
Authority
RS
Serbia
Prior art keywords
spirolactonization
oxidation
steroids
preparation
steroid compounds
Prior art date
Application number
YU90504A
Other languages
English (en)
Inventor
Bruce Allen Pearlman
Amphlett Greg Padilla
Jeffrey Havens
Sonja Mackey
Haifeng Wu
Paula Miller
Mark Pozzo
Shine Chou
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of RS90504A publication Critical patent/RS90504A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)

Abstract

Opisani su novi postupci C-17 spirolaktonzijacije i 6,7-oksidacije steroidnih jedinjenja. U određenim preferentnim pristupima, predmetni pronalazak obezbeđuje dobijanje steroidnih jedinjenja koja su korisna za dobijanje metil vodonik 9,11 α-epoksi-17α-hidroksi-3-oksopregn-4-en-7α, 21-dikarboksilata, -laktona (označen još i kao eplerenon ili epoksimeksrenon).
YU90504A 2002-03-22 2003-03-21 C-17 spirolactonization and 6,7 oxidation of steroids RS90504A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36678402P 2002-03-22 2002-03-22
US41187402P 2002-09-19 2002-09-19
US42559602P 2002-11-12 2002-11-12
PCT/US2003/007792 WO2003082894A2 (en) 2002-03-22 2003-03-21 C-17 spirolactonization and 6,7 oxidation of steroids

Publications (1)

Publication Number Publication Date
RS90504A true RS90504A (en) 2006-10-27

Family

ID=28678917

Family Applications (2)

Application Number Title Priority Date Filing Date
YU83104A RS83104A (en) 2002-03-22 2003-03-21 Process to prepare eplerenone
YU90504A RS90504A (en) 2002-03-22 2003-03-21 C-17 spirolactonization and 6,7 oxidation of steroids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU83104A RS83104A (en) 2002-03-22 2003-03-21 Process to prepare eplerenone

Country Status (23)

Country Link
US (2) US20040024202A1 (sr)
EP (2) EP1487859B1 (sr)
JP (2) JP2005523306A (sr)
KR (3) KR20040097201A (sr)
CN (2) CN1653081A (sr)
AT (1) ATE404577T1 (sr)
AU (2) AU2003220251A1 (sr)
BR (2) BR0308660A (sr)
CA (2) CA2474072A1 (sr)
CY (1) CY1108453T1 (sr)
DE (1) DE60322852D1 (sr)
DK (1) DK1487859T3 (sr)
ES (1) ES2310666T3 (sr)
HK (1) HK1078588A1 (sr)
IL (2) IL164159A0 (sr)
MX (2) MXPA04009178A (sr)
MY (1) MY138479A (sr)
PL (2) PL372460A1 (sr)
PT (1) PT1487859E (sr)
RS (2) RS83104A (sr)
SI (1) SI1487859T1 (sr)
TW (2) TWI283245B (sr)
WO (2) WO2003082895A2 (sr)

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US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
CN1310941C (zh) * 2005-07-13 2007-04-18 南京大学 依普利酮的合成方法
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
JP2007297352A (ja) * 2006-05-02 2007-11-15 Toho Earthtech Inc ヨウ化アルキルの製造方法および２−アルキル置換シクロヘキサノンの製造方法
CN101802207A (zh) * 2007-07-11 2010-08-11 帝斯曼知识产权资产管理有限公司 对映异构选择性还原
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc g-LACTONES OF 3- (6,6-ETHYLENE-17β-HYDROXY-3-OXO-17α-PREGEN-4-EENE-17α-YL) PROGESTATIVE PROPIONIC ACID
CN102464551B (zh) * 2010-11-17 2014-03-26 中国石油化工股份有限公司 异丁烯歧化反应制四甲基乙烯的方法
US9562068B2 (en) 2014-10-17 2017-02-07 Industriale Chimica, S.R.L. Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
CN108003156B (zh) * 2018-01-29 2021-04-20 辽宁科技大学 一种咪唑并吡啶基1,2-乙二酮衍生物的合成方法

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US3053856A (en) * 1958-10-29 1962-09-11 Shell Oil Co Epoxidation of ethylenic compounds with peroxycarboximidic acids
US3200113A (en) * 1963-01-09 1965-08-10 Sterling Drug Inc 7-cyano steroids and derivatives thereof
US3300489A (en) * 1964-07-24 1967-01-24 Smith Kline French Lab Steroidal c-17 spirolactones and processes and intermediates used in the preparation thereof
US3413288A (en) * 1965-07-07 1968-11-26 Parke Davis & Co Process for the production of steroidal c-17 spirolactones
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
DE2404947C2 (de) * 1973-02-06 1983-04-21 Roussel-Uclaf, 75007 Paris Steroidspirolactone, Verfahren zu ihrer Herstellung und deren Verwendung
FR2216276B1 (sr) * 1973-02-06 1976-11-05 Roussel Uclaf
FR2216273B1 (sr) * 1973-02-06 1977-07-22 Roussel Uclaf
FR2260569B1 (sr) * 1974-02-08 1978-06-16 Ugine Kuhlmann
US3957826A (en) * 1974-03-04 1976-05-18 Hoffmann-La Roche Inc. Spirolactone production
FR2281357A1 (fr) * 1974-08-08 1976-03-05 Roussel Uclaf Nouveau procede de preparation de spirolactones steroides
FR2285137A1 (fr) * 1974-09-18 1976-04-16 Roussel Uclaf Nouveaux derives steroides 17-spirosultines, les g-hydroxyacides correspondants, leur procede de preparation et leur application comme medicament
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DE3344057A1 (de) * 1982-12-09 1984-06-14 Ciba-Geigy Ag, Basel Eine neue lactonverbindung und pharmazeutische zusammensetzungen davon, sowie verfahren zu ihrer herstellung
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US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
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US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
BR9714510A (pt) * 1996-12-11 2000-11-28 Searle & Co Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone

Also Published As

Publication number Publication date
WO2003082894A3 (en) 2004-04-15
US20070129332A1 (en) 2007-06-07
MXPA04009216A (es) 2005-01-25
IL164166A0 (en) 2005-12-18
ATE404577T1 (de) 2008-08-15
EP1487859A2 (en) 2004-12-22
ES2310666T3 (es) 2009-01-16
BR0308466A (pt) 2005-04-26
AU2003220251A1 (en) 2003-10-13
PT1487859E (pt) 2008-10-23
JP2005528371A (ja) 2005-09-22
KR20050028907A (ko) 2005-03-23
TW200401781A (en) 2004-02-01
AU2003259022A1 (en) 2003-10-13
DK1487859T3 (da) 2008-10-06
KR20100131018A (ko) 2010-12-14
WO2003082894A2 (en) 2003-10-09
CA2474072A1 (en) 2003-10-09
EP1490390A2 (en) 2004-12-29
KR20040097201A (ko) 2004-11-17
MXPA04009178A (es) 2004-11-26
PL372460A1 (en) 2005-07-25
CN100473660C (zh) 2009-04-01
EP1487859B1 (en) 2008-08-13
WO2003082895A3 (en) 2004-04-22
JP2005523306A (ja) 2005-08-04
MY138479A (en) 2009-06-30
PL373189A1 (en) 2005-08-22
CN1633445A (zh) 2005-06-29
TWI283245B (en) 2007-07-01
US20040024202A1 (en) 2004-02-05
IL164159A0 (en) 2005-12-18
TW200404079A (en) 2004-03-16
CY1108453T1 (el) 2014-04-09
HK1078588A1 (en) 2006-03-17
BR0308660A (pt) 2005-01-25
RS83104A (en) 2006-10-27
WO2003082895A2 (en) 2003-10-09
DE60322852D1 (de) 2008-09-25
CA2480151A1 (en) 2003-10-09
CN1653081A (zh) 2005-08-10
SI1487859T1 (sl) 2008-10-31

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