RS69704A - Treating bening prostate hyperplasia with sarms - Google Patents

Treating bening prostate hyperplasia with sarms

Info

Publication number
RS69704A
RS69704A YU69704A YUP69704A RS69704A RS 69704 A RS69704 A RS 69704A YU 69704 A YU69704 A YU 69704A YU P69704 A YUP69704 A YU P69704A RS 69704 A RS69704 A RS 69704A
Authority
RS
Serbia
Prior art keywords
treating
type
subject
sarm
metabolite
Prior art date
Application number
YU69704A
Other languages
English (en)
Inventor
Mitchell Steiner
Karen Veverka
Duane Miller
James Dalton
Kiwon Chung
Wenqing Gao
Original Assignee
Gtx Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gtx Inc. filed Critical Gtx Inc.
Publication of RS69704A publication Critical patent/RS69704A/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Surgical Instruments (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

Pronalazak obezbeđuje metod tretiranja, sprečavanja, suzbijanja, inhibiranja ili smanjivanja pojavljivanja benigne hiperplazije prostate kod muškog subjekta, primenom na subjektu selektivnog modulatora raceptora androgena (SARM) i/ili njegovog analoga, derivata, izomera, metabolita, farmaceutski prihvatljive soli, farmaceutskog proizvoda, hidrata, N-oksida ili njihovih smeša kako je ovde opisano. Ovaj pronalazak takođe obezbeđuje metod tretiranja subjekta koji trpi gubitak kose, koji sadrži korak primene na subjektu terapeutski efektivnog iznosa inhibitora 5a-reduktaze izoenzima 1 ili 2, gde je označeni inhibotor selektivni modulator receptora androgena (SARM) i/ili njegov analog, derivate, isomer, metabolit, farmaceutski prihvatljiva so, farmaceutski proizvod, hidrat, W-oksid ili bilo koja njihova ovde opisana smeša. Ovaj pronalazak takođe obezbeđuje metod inhibiranja 5a- reduktaze izoenzima 1 ili 2, koji sadrži kontaktiranje enzima inhibirajući efektivnom količinom selektivnog modulatora receptora androgena (SARM) i/ili njegovog analoga, derivata, izomera, metabolita, farmaceutski prihvatljive soli, farmaceutskog proizvoda, hidrata, N-oksida ili njihovih smeša kako je ovde opisano.
YU69704A 2002-02-07 2003-02-06 Treating bening prostate hyperplasia with sarms RS69704A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35430002P 2002-02-07 2002-02-07
US36299702P 2002-03-11 2002-03-11
PCT/US2003/003447 WO2003065992A2 (en) 2002-02-07 2003-02-06 Treating benign prostate hyperplasia with sarms

Publications (1)

Publication Number Publication Date
RS69704A true RS69704A (en) 2006-12-15

Family

ID=27737453

Family Applications (1)

Application Number Title Priority Date Filing Date
YU69704A RS69704A (en) 2002-02-07 2003-02-06 Treating bening prostate hyperplasia with sarms

Country Status (21)

Country Link
US (2) US7776921B2 (sr)
EP (1) EP1480634B1 (sr)
JP (3) JP4677516B2 (sr)
KR (2) KR101032661B1 (sr)
CN (2) CN101732298B (sr)
AT (1) ATE518537T1 (sr)
AU (2) AU2003216174C1 (sr)
BR (1) BRPI0307699A2 (sr)
CA (2) CA2475108A1 (sr)
CY (1) CY1111917T1 (sr)
DK (1) DK1480634T3 (sr)
EA (2) EA200901492A1 (sr)
GE (1) GEP20074122B (sr)
HK (1) HK1068103A1 (sr)
HR (2) HRP20040793A2 (sr)
IL (2) IL163380A (sr)
MX (1) MXPA04007639A (sr)
PT (1) PT1480634E (sr)
RS (1) RS69704A (sr)
TW (2) TW200918043A (sr)
WO (1) WO2003065992A2 (sr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759520B2 (en) 1996-11-27 2010-07-20 University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US7518013B2 (en) 2000-08-24 2009-04-14 University Of Tennessee Research Foundation Selective androgen receptor modulators
US7026500B2 (en) * 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7645898B2 (en) 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US20040260108A1 (en) * 2001-06-25 2004-12-23 Dalton James T. Metabolites of selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
US20060276539A1 (en) * 2002-10-16 2006-12-07 Dalton James T Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS
CA2501874A1 (en) * 2002-10-16 2004-04-29 Gtx, Inc. Treating androgen decline in aging male (adam)-associated conditions with sarms
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
FI20030958A0 (fi) * 2003-06-27 2003-06-27 Orion Corp Uusia yhdisteitä
KR20060035629A (ko) * 2003-06-27 2006-04-26 오리온 코포레이션 안드로젠 수용체 모듈레이터로 유용한 프로피온아마이드유도체들
AU2004281708B2 (en) * 2003-10-14 2011-02-17 University Of Tennessee Research Foundation Treating bone-related disorders with selective androgen receptor modulators
BRPI0507670A (pt) 2004-02-13 2007-07-17 Warner Lambert Co moduladores do receptor de androgênio
EP1737813A1 (en) * 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
CA2562672C (en) 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
CN102976973B (zh) * 2004-06-07 2015-10-21 田纳西大学研究基金会 选择性雄激素受体调节剂及其使用方法
US20110237664A1 (en) * 2004-06-07 2011-09-29 Dalton James T Selective androgen receptor modulators for treating diabetes
JP4201818B2 (ja) * 2004-06-07 2008-12-24 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション 選択的アンドロゲン受容体調節剤及びその使用方法
UA87854C2 (en) * 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP4874965B2 (ja) 2004-07-08 2012-02-15 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲン調節剤
WO2006036266A1 (en) 2004-07-16 2006-04-06 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
US20090104122A1 (en) * 2006-04-03 2009-04-23 Medexis S.A. DETECTION OF MEMBRANE ANDROGEN RECEPTOR (mAR) AGENTS
BRPI0714526A2 (pt) 2006-08-24 2013-04-30 Univ Tennessee Res Foundation acilanilidas substituÍdas e seus mÉtodos de uso
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
EP2822556A1 (en) * 2012-03-07 2015-01-14 Ligand Pharmaceuticals Inc. Steroid hormone and cholesterol pathways as one unified homestatic system
CA2868500C (en) * 2012-04-06 2020-04-21 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
KR102122941B1 (ko) 2012-07-13 2020-06-15 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
WO2015122858A1 (en) 2014-02-15 2015-08-20 Erdal Can Alkoçlar A composition containing synthetic components formed for suppressing ribonucleotide reductase
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
EP3206675A4 (en) * 2014-10-16 2018-07-11 GTx, Inc. METHODS OF TREATING UROLOGICAL DISORDERS USING SARMs

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US644970A (en) * 1899-02-06 1900-03-06 Thomas Graham Donaldson Dental flask.
US935044A (en) * 1909-01-12 1909-09-28 Lenn G Mccorry Valve.
US935045A (en) * 1909-06-19 1909-09-28 Robert J Mckelvey Turn-table.
GB1360001A (en) 1971-06-16 1974-07-17 Scherico Ltd Pharmaceutical compositions comprising substituted anilides
US3875229A (en) 1972-11-24 1975-04-01 Schering Corp Substituted carboxanilides
JPS6044294B2 (ja) 1976-04-15 1985-10-02 帝国臓器製薬株式会社 アニリド誘導体
US4139638A (en) 1976-09-23 1979-02-13 Schering Corporation Methods for the treatment of hirsutism
EP0002309B1 (en) 1977-10-12 1982-12-01 Imperial Chemical Industries Plc Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
NZ197008A (en) 1980-05-22 1984-10-19 Ici Ltd Acylanilide derivatives and pharmaceutical compositions
JPS57171904A (en) 1981-04-15 1982-10-22 Mitsubishi Petrochem Co Ltd Tri- or tetra-substituted phenoxycarboxylic acid anilide type herbicide
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB8617653D0 (en) * 1986-07-18 1986-08-28 Ici Plc Amide derivatives
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
JPH09508125A (ja) 1994-01-21 1997-08-19 セプラコー，インコーポレイテッド 光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成
US5609849A (en) 1994-03-11 1997-03-11 The Trustees Of The University Of Pennsylvania Serotonin (5-HT1A) receptor ligands and imaging agents
US5656651A (en) 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
WO1998005962A1 (en) 1996-08-02 1998-02-12 Panvera Corporation A method for quantitating competitive binding of molecules to proteins utilizing fluorescence polarization
US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6492554B2 (en) 2000-08-24 2002-12-10 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
US20090264534A1 (en) * 1996-11-27 2009-10-22 Dalton James T Selective androgen receptor modulators
US7205437B2 (en) * 1996-11-27 2007-04-17 University Of Tennessee Research Foundation Selective androgen receptor modulators
US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
JPH10182457A (ja) 1996-12-25 1998-07-07 Yuichi Hashimoto 抗アンドロゲン剤
US6160011A (en) 1997-05-30 2000-12-12 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
WO1998055153A1 (en) * 1997-06-04 1998-12-10 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
JPH1135558A (ja) * 1997-07-18 1999-02-09 Zeria Pharmaceut Co Ltd ３−ベンゾイルインドール誘導体及びそれらを含有する医薬
GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
AU775928B2 (en) 1999-10-14 2004-08-19 Bristol-Myers Squibb Company Crystallographic structure of the androgen receptor ligand binding domain
CA2387570A1 (en) 1999-10-19 2001-04-26 Nobex Corporation Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof
US6593492B1 (en) 1999-10-27 2003-07-15 Nobex Corporation Resolution of intermediates in the synthesis of substantially pure bicalutamide
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
MXPA02012605A (es) 2000-06-28 2003-05-14 Squibb Bristol Myers Co Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso.
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
SI1401801T1 (sl) * 2000-08-24 2007-04-30 Univ Tennessee Res Foundation Selektivni modulatorji androgenskega receptorja in postopki za njihovo uporabo
US20030232792A1 (en) 2000-08-24 2003-12-18 Dalton James T. Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting

Also Published As

Publication number Publication date
TW200307537A (en) 2003-12-16
EP1480634B1 (en) 2011-08-03
IL202675A (en) 2011-06-30
US8088828B2 (en) 2012-01-03
CN101732298B (zh) 2012-09-19
TWI374737B (en) 2012-10-21
US20100280107A1 (en) 2010-11-04
MXPA04007639A (es) 2005-07-13
JP2013144713A (ja) 2013-07-25
KR20100112659A (ko) 2010-10-19
CN101732298A (zh) 2010-06-16
EP1480634A2 (en) 2004-12-01
KR101032661B1 (ko) 2011-05-06
AU2003216174C1 (en) 2010-01-28
JP4677516B2 (ja) 2011-04-27
CA2689080C (en) 2011-07-05
PT1480634E (pt) 2011-10-12
KR20040089606A (ko) 2004-10-21
US7776921B2 (en) 2010-08-17
CY1111917T1 (el) 2015-11-04
AU2003216174A1 (en) 2003-09-02
WO2003065992A2 (en) 2003-08-14
JP2010209102A (ja) 2010-09-24
TW200918043A (en) 2009-05-01
CN1646115A (zh) 2005-07-27
AU2003216174B8 (en) 2009-01-15
JP2005522431A (ja) 2005-07-28
CA2475108A1 (en) 2003-08-14
GEP20074122B (en) 2007-06-11
AU2003216174B2 (en) 2008-12-18
CN1646115B (zh) 2010-06-09
IL163380A (en) 2010-06-30
AU2009201084A1 (en) 2009-04-09
WO2003065992A3 (en) 2004-02-26
CA2689080A1 (en) 2003-08-14
EA200401043A1 (ru) 2005-06-30
BRPI0307699A2 (pt) 2015-06-16
HK1068103A1 (en) 2005-04-22
US20040053897A1 (en) 2004-03-18
EA013399B1 (ru) 2010-04-30
EA200901492A1 (ru) 2010-08-30
ATE518537T1 (de) 2011-08-15
EP1480634A4 (en) 2008-01-16
HRP20100067A2 (hr) 2010-04-30
HRP20040793A2 (en) 2006-10-31
DK1480634T3 (da) 2011-11-14

Similar Documents

Publication Publication Date Title
RS69704A (en) Treating bening prostate hyperplasia with sarms
AU2003297260A1 (en) Fast-disintegrating solid dosage forms being not friable and comprising pullulan
IN2005KO00312A (sr)
WO2001070675A3 (en) Inhibitors of histone deacetylase
WO2005000213A3 (en) Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
HRP20020170A2 (en) Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001044247A3 (en) Agents and methods for the treatment of proliferative diseases
WO2004108157A8 (en) Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
WO2003065988A3 (en) A combination for treating cold and cough
WO2004093826A3 (en) Compositions of cyclooxygenase-2 selective inhibitors and 5-ht1b/1d agonists for the treatment and prevention of migraine
WO2003088958A3 (en) Combinations of cox-2 inhibitors and other agents for the treatment of parkinson’s disease
WO2004064735A3 (en) Treatment of benign prostatic hyperplasia
WO2003092606A3 (en) Cholinesterase inhibitors to prevent injuries caused by chemicals
WO2004052236A3 (en) Methods and compositions for treatment of otitis media
WO2005016327A3 (en) Treatment of sleep disorders with cholinesterase inhibitors
ZA200502909B (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2.
HRP20030892A2 (en) Prevention of addiction in pain management
WO2005041886A3 (en) Methods for generating or increasing revenues related to pain inhibitor commerce
WO2001044235A3 (en) Agents and methods for the treatment of proliferative diseases
MX2007007051A (es) Nuevos derivados de tiofenpirimidiona sustituida como inhibidores de la 17??-hidroxiesteroide deshidrogenasa.
WO2004056353A3 (en) Device and method for delivering mmp inhibitors
WO2007034207A3 (en) Troventol formulation
MXPA04005310A (es) Inhibidores de fosfolipasa a2 citosolica.
WO2004066922A3 (en) A method of treating breast cancer with androgen receptor antagonists
WO2003074002A3 (en) Methods of treating pin1 associated disorders