CY1111917T1 - Επιλεκτικος ρυθμιστης του υποδοχεα των ανδρογονων (sarm) για την αντιμετωπιση της καλοηθους υπερπλασιας του προστατη - Google Patents
Επιλεκτικος ρυθμιστης του υποδοχεα των ανδρογονων (sarm) για την αντιμετωπιση της καλοηθους υπερπλασιας του προστατηInfo
- Publication number
- CY1111917T1 CY1111917T1 CY20111101039T CY111101039T CY1111917T1 CY 1111917 T1 CY1111917 T1 CY 1111917T1 CY 20111101039 T CY20111101039 T CY 20111101039T CY 111101039 T CY111101039 T CY 111101039T CY 1111917 T1 CY1111917 T1 CY 1111917T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sarm
- optional
- androgen receptor
- type
- metabolite
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Plant Substances (AREA)
- Percussion Or Vibration Massage (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Η εφεύρεση αυτή παρέχει μέθοδο αντιμετώπισης, πρόληψης, καταστολής, αναστολής ή μείωσης των επιπτώσεων της καλοήθους υπερπλασίας του προστάτη σε άρρεν άτομο, χορηγώντας στο άτομο επιλεκτικό ρυθμιστή του υποδοχέα των ανδρογόνων (selective androgen receptor modulator, SARM) και/ή ανάλογο, παράγωγο, ισομερές, μεταβολίτης, φαρμακευτικά αποδεκτό άλας, φαρμακευτικό προϊόν, ένυδρη μορφή, Ν-οξείδίο αυτού ή οποιοδήποτε μίγμα από τα ανωτέρω, όπως περιγράφεται στο παρόν. Η εφεύρεση αυτή παρέχει επίσης μέθοδο θεραπείας ατόμου που πάσχει από τριχόπτωση, που περιλαμβάνει το βήμα της χορήγησης στο άτομο μιας θεραπευτικά αποτελεσματικής ποσότητας αναστολέα του ενζύμου 5-α αναγωγάσης τύπου 1 και /ή τύπου 2, όπου ο εν λόγω αναστολέας είναι επιλεκτικός ρυθμιστής του υποδοχέα των ανδρογόνων (SARM) και/ή ανάλογο, παράγωγο, ισομερές, μεταβολίτης, φαρμακευτικά αποδεκτό άλας, φαρμακευτικό προϊόν, ένυδρη μορφή, Ν-οξείδιο αυτού ή οποιοδήποτε μίγμα από τα ανωτέρω, όπως περιγράφεται στο παρόν. Η εφεύρεση αυτή παρέχει επίσης μέθοδο αναστολής του ενζύμου 5-α αναγωγάσης τύπου 1 και/ή τύπου 2, που περιλαμβάνει την συνεύρεση του ενζύμου με αποτελεσματική ποσότητα επιλεκτικού ρυθμιστή του υποδοχέα των ανδρογόνων (SARM) για την αναστολή της 5-α αναγωγάσης, και/ή αναλόγου, παραγώγου, ισομερούς, μεταβολίτη, φαρμακευτικά αποδεκτού άλατος, φαρμακευτικού προϊόντος, ένυδρης μορφής, Ν-οξειδίου ή οποιουδήποτε μίγματος από τα ανωτέρω, όπως περιγράφεται στο παρόν.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35430002P | 2002-02-07 | 2002-02-07 | |
| US36299702P | 2002-03-11 | 2002-03-11 | |
| EP03737647A EP1480634B1 (en) | 2002-02-07 | 2003-02-06 | Selective androgen receptor modulators (SARMs) for treating benign prostate hyperplasia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111917T1 true CY1111917T1 (el) | 2015-11-04 |
Family
ID=27737453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101039T CY1111917T1 (el) | 2002-02-07 | 2011-10-31 | Επιλεκτικος ρυθμιστης του υποδοχεα των ανδρογονων (sarm) για την αντιμετωπιση της καλοηθους υπερπλασιας του προστατη |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7776921B2 (el) |
| EP (1) | EP1480634B1 (el) |
| JP (3) | JP4677516B2 (el) |
| KR (2) | KR20100112659A (el) |
| CN (2) | CN1646115B (el) |
| AT (1) | ATE518537T1 (el) |
| AU (2) | AU2003216174C1 (el) |
| BR (1) | BRPI0307699A2 (el) |
| CA (2) | CA2689080C (el) |
| CY (1) | CY1111917T1 (el) |
| DK (1) | DK1480634T3 (el) |
| EA (2) | EA200901492A1 (el) |
| GE (1) | GEP20074122B (el) |
| HK (1) | HK1068103A1 (el) |
| HR (2) | HRP20040793A2 (el) |
| IL (2) | IL163380A (el) |
| MX (1) | MXPA04007639A (el) |
| PT (1) | PT1480634E (el) |
| RS (1) | RS69704A (el) |
| TW (2) | TWI374737B (el) |
| WO (1) | WO2003065992A2 (el) |
Families Citing this family (47)
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| US7759520B2 (en) | 1996-11-27 | 2010-07-20 | University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
| US7518013B2 (en) | 2000-08-24 | 2009-04-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators |
| US20060019931A1 (en) * | 2003-10-14 | 2006-01-26 | Dalton James T | Treating bone-related disorders with selective androgen receptor modulators |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| CN1726020A (zh) * | 2002-10-16 | 2006-01-25 | Gtx公司 | 用sarm治疗老年男性雄激素缺乏(adam)相关的疾病 |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| DE602004026583D1 (de) * | 2003-06-27 | 2010-05-27 | Orion Corp | Als androgenrezeptormodulatoren geeignete propionamidderivate |
| FI20030958A0 (fi) * | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
| AP2006003700A0 (en) | 2004-02-13 | 2006-08-31 | Warner Lambert Co | Androgen receptor modulators |
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| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| DK1753417T3 (da) * | 2004-06-07 | 2012-07-23 | Univ Tennessee Res Foundation | Selektiv androgenreceptormodulator og medicinske anvendelser deraf |
| PL1753417T3 (pl) * | 2004-06-07 | 2012-09-28 | Univ Tennessee Res Found | Selektywny modulator receptora androgenowego i jego zastosowania medyczne |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| BRPI0513020A (pt) | 2004-07-08 | 2008-04-22 | Warner Lambert Co | moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação |
| ATE485300T1 (de) | 2004-07-16 | 2010-11-15 | Sunesis Pharmaceuticals Inc | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
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| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| ES2581765T3 (es) | 2006-08-24 | 2016-09-07 | University Of Tennessee Research Foundation | Acilanilidas sustituidas y métodos de uso de las mismas |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
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| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
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| KR20020091047A (ko) | 1999-10-19 | 2002-12-05 | 노벡스 코포레이션 | 카소덱스, 그의 유도체 및 중간산물의 에난티오머를비대칭 합성하는 방법 |
| KR20020067509A (ko) | 1999-10-27 | 2002-08-22 | 노벡스 코포레이션 | 실질적으로 순수한 비칼루타마이드의 합성시 중간산물을분리하는 방법 |
| UA74826C2 (en) * | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| AU8821301A (en) | 2000-06-28 | 2002-01-08 | Bristol Myers Squibb Co | Selective androgen receptor modulators and methods for their identification, design and use |
| GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
| US20030232792A1 (en) | 2000-08-24 | 2003-12-18 | Dalton James T. | Selective androgen receptor modulators and methods of use thereof |
| IL154425A0 (en) | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| AU8523001A (en) * | 2000-08-24 | 2002-03-04 | Gtx Inc | Selective androgen receptor modulators and methods of use thereof |
| BR0215115A (pt) | 2001-12-06 | 2005-04-19 | Gtx Inc | Tratamento de perda muscular com moduladores de receptores de androgênio seletivos |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
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2003
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- 2003-02-06 AU AU2003216174A patent/AU2003216174C1/en not_active Ceased
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- 2003-02-06 AT AT03737647T patent/ATE518537T1/de active
- 2003-02-06 GE GEAP8396A patent/GEP20074122B/en unknown
- 2003-02-06 MX MXPA04007639A patent/MXPA04007639A/es active IP Right Grant
- 2003-02-06 RS YU69704A patent/RS69704A/sr unknown
- 2003-02-06 DK DK03737647.2T patent/DK1480634T3/da active
- 2003-02-06 CA CA2689080A patent/CA2689080C/en not_active Expired - Fee Related
- 2003-02-06 KR KR1020107021280A patent/KR20100112659A/ko not_active Application Discontinuation
- 2003-02-06 EA EA200901492A patent/EA200901492A1/ru unknown
- 2003-02-06 JP JP2003565418A patent/JP4677516B2/ja not_active Expired - Fee Related
- 2003-02-06 CA CA002475108A patent/CA2475108A1/en not_active Abandoned
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- 2003-02-06 KR KR1020047012236A patent/KR101032661B1/ko not_active IP Right Cessation
- 2003-02-06 CN CN2009101619003A patent/CN101732298B/zh not_active Expired - Fee Related
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2004
- 2004-08-05 IL IL163380A patent/IL163380A/en not_active IP Right Cessation
- 2004-09-01 HR HR20040793A patent/HRP20040793A2/xx not_active Application Discontinuation
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2005
- 2005-02-22 HK HK05101488.2A patent/HK1068103A1/xx not_active IP Right Cessation
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2009
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2010
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