KR930004269A - 헥사하이드로벤조[에프] 퀴놀리논 - Google Patents

헥사하이드로벤조[에프] 퀴놀리논 Download PDF

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Publication number
KR930004269A
KR930004269A KR1019920014993A KR920014993A KR930004269A KR 930004269 A KR930004269 A KR 930004269A KR 1019920014993 A KR1019920014993 A KR 1019920014993A KR 920014993 A KR920014993 A KR 920014993A KR 930004269 A KR930004269 A KR 930004269A
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South Korea
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alkyl
hydrogen
methyl
pharmaceutically acceptable
amino
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KR1019920014993A
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English (en)
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스티븐 허쉬 켄네쓰
데이비드 존스 챨스
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일라이 릴리 앤드 캄파니
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Publication of KR930004269A publication Critical patent/KR930004269A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

헥사하이드로벤조[에프] 퀴놀리논
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)을 갖는 화합물 및 그의 약학적으로 허용되는 염：
    상기식에서, R은 수소, C1-C4알킬, 비치환되거나 치환된 펜(C1-C4)알킬이고； Z 및 Z1은 독립적으로 수소 및 C1-C4알킬 중에서 선택되고；R1은 수소 또는 C1-C4알킬이고；n은 1 또는 2이고；X는；수소, 할로겐, NO2, 시아노, CF3, C1-C6알킬, C1-C6알콕시, 카복시, C1-C6알콕시카보닐, ；아미노, C1-C4알킬아미노, C1-C4디알킬아미노, 아미도, C1-C4알킬아미도, C1-C4디알킬아미도, 메르캅토, C1-C6알킬티오, C1-C6알킬설피닐, C1-C6알킬설포닐 또는 -A-R2그룹(이때, A는 C1-C6알킬렌, C2-C6알케닐렌 또는 C2-C6알키닐렌이고；R2는 할로겐, 하이드록시, CF3, C1-C6알콕시, 카복시, C1-C6알콕시카보닐, 아미노, C1-C4알킬아미노, C1-C4디알킬아미노, 아미도, C1-C4알킬아미도, C1-C4디알킬아미도, C1-C4알킬설포닐아미노, 아미노설포닐 또는 C1-C4알킬아미노설포닐이다)이나, 단 (a)R이 수소일때, X는 수소, 할로 또는 메톡시가 아니고；(b)R이 메틸, 에틸 또는 벤질일때, X는 메톡시가 아니고；(c)R이 메틸일때, R1은 메틸이 아니다.
  2. 제1항에 있어서, 8-브로모-4-메틸-1,2,3,4,5,6-헥사하이드로 밴조[f]퀴놀린-3-온 또는 그의 약학적으로 허용되는 염인 화합물.
  3. 제1항에 있어서, 4,8-디메틸-1,2,3,4,5,6-헥사하이드로밴조[f]퀴놀린-3-온 또는 그의 약학적으로 허용되는 염인 화합물.
  4. 제1항에 있어서, 8-메틸-1,2,3,4,5,6-헥사하이드로밴조[f]퀴놀린-3-온 또는 그의 약학적으로 허용되는 염인 화합물.
  5. 화성 성분으로 제1,2,3또는 4항에 청구된 화합물을 그에 대한 하나 이상의 약학적으로 허용되는 담체, 희석제 또는 부형제와 한께 포함하는 5α-환원효소 억제제제.
  6. 활성 성분으로 제1,2,3또는 4항에 청구된 화합물을 그에 대한 하나 이상의 약학적으로 허용되는 담체, 희석제 또는 부형제와 한께 포함하는 양성 전립선 과형성, 남성형 대머리, 남성형 다모증 또는 전립선 암 치료 제제.
  7. 활성 성분으로 제1,2,3또는 4항에 청구된 화합물을 그에 대한 하나 이상의 약학적으로 허용되는 담체, 희석제 또는 부형제와 한께 포함하는 안드로겐성 탈모증 또는 지루성 피부염치료 제제.
  8. 하기 일반식(Ⅰ)을 갖는 화합물 및 그의 약학적으로 허용되는 염을 안드로겐성 탈모증, 남성형 대머리 또는 남성형 다모증의 치료를 필요로 하는 성인에게 투여함을 포함하는, 성인에게서 상기 증상을 미용상 치료하는 방법；
    상기식에서, R은 수소, C1-C4알킬, 비치환되거나 치환된 펜(C1-C4)알킬이고； Z 및 Z1은 독립적으로 수소 및 C1-C4알킬 중에서 선택되고；R1은 수소 또는 C1-C4알킬이고；n은 1 또는 2이고；X는 수소, 할로겐, NO2, 시아노, CF3, C1-C6알킬, C1-C6알콕시, 카복시, C1-C6알콕시카보닐, 아미노, C1-C4알킬아미노, C1-C4디알킬아미노, 아미도, C1-C4알킬아미도, C1-C4디알킬아미도, 메르캅토, C1-C6알킬티오, C1-C6알킬설피닐, C1-C6알킬설포닐 또는 -A-R2그룹(이때, A는 C1-C6알킬렌, C2-C6알케닐렌 또는 C2-C6알키닐렌이고；R2는 할로겐, 하이드록시, CF3, C1-C6알콕시, 카복시, C1-C6알콕시카보닐, 아미노, C1-C4알킬아미노, C1-C4디알킬아미노, 아미도, C1-C4알킬아미도, C1-C4디알킬아미도, C1-C4알킬설포닐아미노, 아미노설포닐 또는 C1-C4알킬아미노설포닐이다)이나, 단 (a)R이 수소일때, X는 수소, 할로 또는 메톡시가 아니고；(b)R이 메틸, 에틸 또는 벤질일때, X는 메톡시가 아니고；(c)R이 메틸일때, R1은 메틸이 아니다.
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920014993A 1991-08-21 1992-08-20 헥사하이드로벤조[에프] 퀴놀리논 KR930004269A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74813491A 1991-08-21 1991-08-21
US748,134 1991-08-21
US07/780,166 US5250539A (en) 1991-08-21 1991-10-21 Hexahydrobenzo[f]quinolinones
US780,166 1991-10-21

Publications (1)

Publication Number Publication Date
KR930004269A true KR930004269A (ko) 1993-03-22

Family

ID=27114886

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920014993A KR930004269A (ko) 1991-08-21 1992-08-20 헥사하이드로벤조[에프] 퀴놀리논

Country Status (17)

Country Link
US (1) US5250539A (ko)
EP (1) EP0531026B1 (ko)
JP (1) JPH05213889A (ko)
KR (1) KR930004269A (ko)
CN (1) CN1069488A (ko)
AT (1) ATE173467T1 (ko)
AU (1) AU2118292A (ko)
BR (1) BR9203266A (ko)
CA (1) CA2076509A1 (ko)
CZ (1) CZ256792A3 (ko)
DE (1) DE69227612T2 (ko)
FI (1) FI923751A (ko)
HU (1) HUT68064A (ko)
IL (1) IL102880A0 (ko)
MX (1) MX9204815A (ko)
NO (1) NO923266L (ko)
TW (1) TW218011B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654573B2 (en) * 1991-08-21 1994-11-10 Eli Lilly And Company Benzo(f)quinolinones
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
GB9317314D0 (en) * 1993-08-20 1993-10-06 Smithkline Beecham Corp Compounds
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
FR2737721B1 (fr) 1995-08-08 1997-09-05 Roussel Uclaf Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant
EP0926148A1 (en) 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
GB0222516D0 (en) * 2002-09-27 2002-11-06 Karobio Ab Novel compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102046A1 (en) * 1982-08-26 1984-03-07 Schering Corporation Tricyclic lactams, method for making them, pharmaceutical compositions containing them
US4511569A (en) * 1982-08-26 1985-04-16 Schering Corporation Tricyclic lactams and derivatives useful in increasing cardiac contractility
US5120742A (en) * 1984-02-27 1992-06-09 Merck & Co., Inc. 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors
US4859681A (en) * 1984-02-27 1989-08-22 Merck & Co., Inc. 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
YU7087A (en) * 1986-01-23 1988-06-30 Hoffmann La Roche Process for obtaining benzazecine derivatives
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3872937T2 (de) * 1987-05-11 1993-01-21 Ono Pharmaceutical Co Benzoylaminophenoxybuttersaeure-derivate.
IN167395B (ko) * 1987-07-21 1990-10-20 Hoffmann La Roche
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Also Published As

Publication number Publication date
CA2076509A1 (en) 1993-02-22
CN1069488A (zh) 1993-03-03
HUT68064A (en) 1995-05-29
MX9204815A (es) 1993-12-01
DE69227612D1 (de) 1998-12-24
NO923266L (no) 1993-02-22
BR9203266A (pt) 1993-04-06
EP0531026B1 (en) 1998-11-18
IL102880A0 (en) 1993-01-31
FI923751A0 (fi) 1992-08-20
AU2118292A (en) 1993-02-25
DE69227612T2 (de) 1999-05-06
CZ256792A3 (en) 1993-04-14
JPH05213889A (ja) 1993-08-24
FI923751A (fi) 1993-02-22
NO923266D0 (no) 1992-08-20
US5250539A (en) 1993-10-05
ATE173467T1 (de) 1998-12-15
TW218011B (ko) 1993-12-21
EP0531026A1 (en) 1993-03-10

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