RS55515B1 - Postupak pripremanja pemetrekseda i njegovih lizinskih soli - Google Patents

Postupak pripremanja pemetrekseda i njegovih lizinskih soli

Info

Publication number
RS55515B1
RS55515B1 RS20161202A RSP20161202A RS55515B1 RS 55515 B1 RS55515 B1 RS 55515B1 RS 20161202 A RS20161202 A RS 20161202A RS P20161202 A RSP20161202 A RS P20161202A RS 55515 B1 RS55515 B1 RS 55515B1
Authority
RS
Serbia
Prior art keywords
pemetrexed
mixture
salt
lysine
water
Prior art date
Application number
RS20161202A
Other languages
English (en)
Serbian (sr)
Inventor
Fabrizio Bonaccorsi
Federico Calvani
Franco Pasqui
Original Assignee
Berlin-Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin-Chemie Ag filed Critical Berlin-Chemie Ag
Publication of RS55515B1 publication Critical patent/RS55515B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20161202A 2012-08-08 2013-08-08 Postupak pripremanja pemetrekseda i njegovih lizinskih soli RS55515B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.
EP13777144.0A EP2882753B1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
PCT/IB2013/056497 WO2014024164A1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof

Publications (1)

Publication Number Publication Date
RS55515B1 true RS55515B1 (sr) 2017-05-31

Family

ID=47018368

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20161202A RS55515B1 (sr) 2012-08-08 2013-08-08 Postupak pripremanja pemetrekseda i njegovih lizinskih soli

Country Status (23)

Country Link
EP (1) EP2882753B1 (OSRAM)
KR (1) KR102288417B1 (OSRAM)
CN (1) CN104736540B (OSRAM)
AU (1) AU2013301156B2 (OSRAM)
BR (1) BR112015002429A8 (OSRAM)
CY (1) CY1118514T1 (OSRAM)
DK (1) DK2882753T3 (OSRAM)
ES (1) ES2607890T3 (OSRAM)
HR (1) HRP20170011T1 (OSRAM)
HU (1) HUE032304T2 (OSRAM)
IN (1) IN2015DN00833A (OSRAM)
IT (1) ITRM20120398A1 (OSRAM)
LT (1) LT2882753T (OSRAM)
MX (1) MX362858B (OSRAM)
PL (1) PL2882753T3 (OSRAM)
PT (1) PT2882753T (OSRAM)
RS (1) RS55515B1 (OSRAM)
RU (1) RU2609006C2 (OSRAM)
SI (1) SI2882753T1 (OSRAM)
SM (2) SMT201600474T1 (OSRAM)
TW (1) TWI609017B (OSRAM)
WO (1) WO2014024164A1 (OSRAM)
ZA (1) ZA201501549B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641124A (zh) * 2016-07-22 2018-01-30 上海创诺制药有限公司 一种培美曲塞二酸新晶型及其制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
CA3090483A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
CN110128428A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞丙氨酸盐
CN110128426B (zh) * 2018-02-09 2021-12-14 鲁南制药集团股份有限公司 培美曲塞谷氨酸盐
CN110128427A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞缬氨酸盐
CN111333658A (zh) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 一种培美曲塞二钠水合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005128A1 (fr) 1988-10-31 1990-05-17 Mitsui Toatsu Chemicals, Inc. Procede de preparation d'un hydrure de sodium-aluminium substitue par un groupe organique
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
RU2127274C1 (ru) * 1992-09-25 1999-03-10 Эли Лилли Энд Компани СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
DE19725647A1 (de) 1997-06-18 1998-12-24 Basf Ag Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme
ZA987550B (en) 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
IL150480A0 (en) 2000-02-25 2002-12-01 Lilly Co Eli A NOVEL-CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4, 7-DIHYDRO-4-OXO-3H-PYRROLO[2, 3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
EP1934226A2 (en) * 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
JP2008543973A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
JP2013540104A (ja) 2010-07-28 2013-10-31 イーグル・ファーマシューティカルズ・インコーポレーテッド 延長された保存安定性を有するペメトレキセドを含有する医薬組成物
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

Also Published As

Publication number Publication date
SMT201600474T1 (it) 2017-03-08
ITRM20120398A1 (it) 2014-02-09
CN104736540A (zh) 2015-06-24
SI2882753T1 (sl) 2017-02-28
BR112015002429A2 (pt) 2017-07-04
PT2882753T (pt) 2016-12-27
KR102288417B1 (ko) 2021-08-11
AU2013301156B2 (en) 2017-08-31
HRP20170011T1 (hr) 2017-03-10
RU2015108042A (ru) 2016-09-27
EP2882753A1 (en) 2015-06-17
CY1118514T1 (el) 2017-07-12
ZA201501549B (en) 2016-01-27
TW201412741A (zh) 2014-04-01
SMT201600474B (it) 2017-03-08
IN2015DN00833A (OSRAM) 2015-06-12
CN104736540B (zh) 2017-08-25
BR112015002429A8 (pt) 2019-07-30
HUE032304T2 (en) 2017-09-28
LT2882753T (lt) 2016-12-12
TWI609017B (zh) 2017-12-21
DK2882753T3 (en) 2017-01-16
WO2014024164A1 (en) 2014-02-13
MX362858B (es) 2019-02-20
PL2882753T3 (pl) 2017-04-28
HK1209426A1 (en) 2016-04-01
KR20150045458A (ko) 2015-04-28
AU2013301156A1 (en) 2015-02-05
EP2882753B1 (en) 2016-10-05
ES2607890T3 (es) 2017-04-04
MX2015001712A (es) 2015-08-14
RU2609006C2 (ru) 2017-01-30

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