RS52315B - Derivati diarilmetil piperazina, njihova priprema i njihova upotreba - Google Patents

Derivati diarilmetil piperazina, njihova priprema i njihova upotreba

Info

Publication number
RS52315B
RS52315B RS20120167A RSP20120167A RS52315B RS 52315 B RS52315 B RS 52315B RS 20120167 A RS20120167 A RS 20120167A RS P20120167 A RSP20120167 A RS P20120167A RS 52315 B RS52315 B RS 52315B
Authority
RS
Serbia
Prior art keywords
compound
compounds
rats
drug
added
Prior art date
Application number
RS20120167A
Other languages
English (en)
Serbian (sr)
Inventor
Thomas Hudzik
William Brown
Andrew Griffin
Carla Maciag
Gennady Smagin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32906880&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS52315(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of RS52315B publication Critical patent/RS52315B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RS20120167A 2004-08-02 2005-07-27 Derivati diarilmetil piperazina, njihova priprema i njihova upotreba RS52315B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0401968A SE0401968D0 (sv) 2004-08-02 2004-08-02 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US60236304P 2004-08-18 2004-08-18
PCT/SE2005/001186 WO2006014133A1 (en) 2004-08-02 2005-07-27 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
RS52315B true RS52315B (sr) 2012-12-31

Family

ID=32906880

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20120167A RS52315B (sr) 2004-08-02 2005-07-27 Derivati diarilmetil piperazina, njihova priprema i njihova upotreba

Country Status (22)

Country Link
US (2) US20070249619A1 (cg-RX-API-DMAC7.html)
EP (1) EP1781631B1 (cg-RX-API-DMAC7.html)
JP (1) JP5006785B2 (cg-RX-API-DMAC7.html)
CN (1) CN1993338B (cg-RX-API-DMAC7.html)
AR (1) AR050260A1 (cg-RX-API-DMAC7.html)
AT (1) ATE542806T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005267929B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0514014A (cg-RX-API-DMAC7.html)
CA (1) CA2576067C (cg-RX-API-DMAC7.html)
ES (1) ES2379364T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ553539A (cg-RX-API-DMAC7.html)
PL (1) PL1781631T3 (cg-RX-API-DMAC7.html)
PT (1) PT1781631E (cg-RX-API-DMAC7.html)
RS (1) RS52315B (cg-RX-API-DMAC7.html)
RU (1) RU2404172C2 (cg-RX-API-DMAC7.html)
SE (1) SE0401968D0 (cg-RX-API-DMAC7.html)
SG (1) SG155181A1 (cg-RX-API-DMAC7.html)
SI (1) SI1781631T1 (cg-RX-API-DMAC7.html)
TW (1) TWI370124B (cg-RX-API-DMAC7.html)
UA (1) UA87146C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006014133A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200700680B (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0401086A3 (en) 2001-05-18 2011-07-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
KR101234421B1 (ko) * 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
JP5253514B2 (ja) 2007-12-11 2013-07-31 エフ．ホフマン−ラ ロシュ アーゲー ステアロイル−ＣｏＡデサチュラーゼの阻害剤
JP2011520956A (ja) * 2008-05-20 2011-07-21 アストラゼネカ・アクチエボラーグ 不安大うつ病性障害を処置する方法
US8314250B2 (en) 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
US20110207745A1 (en) * 2009-11-25 2011-08-25 Astrazeneca Ab Solid forms of 4--n,n-diethylbenzamide, compositions thereof, and uses therewith
US9073881B2 (en) 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583713A5 (cg-RX-API-DMAC7.html) * 1973-06-29 1977-01-14 Cermol Sa
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
DE69425662T2 (de) * 1993-07-30 2001-04-12 Delta Pharmaceuticals, Inc. Als heilmittel nutzbare piperazin verbindungen
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
HUP0401086A3 (en) * 2001-05-18 2011-07-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds
SE0101766D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
CN1596113B (zh) * 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203300D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof

Also Published As

Publication number Publication date
AU2005267929B2 (en) 2010-04-08
US20070249619A1 (en) 2007-10-25
PT1781631E (pt) 2012-05-07
JP5006785B2 (ja) 2012-08-22
US20060030569A1 (en) 2006-02-09
WO2006014133A1 (en) 2006-02-09
RU2404172C2 (ru) 2010-11-20
ATE542806T1 (de) 2012-02-15
PL1781631T3 (pl) 2012-07-31
ES2379364T3 (es) 2012-04-25
SI1781631T1 (sl) 2012-05-31
ZA200700680B (en) 2008-09-25
CN1993338B (zh) 2011-07-06
EP1781631A1 (en) 2007-05-09
NZ553539A (en) 2010-09-30
CA2576067A1 (en) 2006-02-09
UA87146C2 (ru) 2009-06-25
SG155181A1 (en) 2009-09-30
AR050260A1 (es) 2006-10-11
BRPI0514014A (pt) 2008-05-27
EP1781631B1 (en) 2012-01-25
CA2576067C (en) 2011-05-03
TWI370124B (en) 2012-08-11
CN1993338A (zh) 2007-07-04
SE0401968D0 (sv) 2004-08-02
AU2005267929A1 (en) 2006-02-09
RU2007101522A (ru) 2008-09-10
TW200612930A (en) 2006-05-01
JP2008508350A (ja) 2008-03-21

Similar Documents

Publication Publication Date Title
HUP0401086A2 (hu) 4-[(Fenil-piperazinil)-metil]-benzamid-származékok és alkalmazásuk fájdalom, szorongás vagy gasztrointesztinális zavarok kezelésére szolgáló gyógyszerkészítmények előállítására és eljárás a vegyületek előállítására
RS52315B (sr) Derivati diarilmetil piperazina, njihova priprema i njihova upotreba
MX2007009574A (es) Sal de monoclorhidrato de 1-[3-[3-(4-clorofenil)propoxi]-propil]- piperidina.
RU2454414C2 (ru) N-(2-гидроксиэтил)-n-метил-4-(хинолин-8-ил(1-(тиазол-4-илметил)пиперидин-4-илиден)метил)бензамид, способ его получения и его применение для лечения боли, тревоги и депрессии
KR20050072482A (ko) 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증 또는위장 장애의 치료에 있어서의 그의 용도
CN100422151C (zh) 二芳基亚甲基哌啶衍生物、其制备及其用途
KR20050072794A (ko) 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증 또는위장 장애 치료에 있어서의 그의 용도
CN1989126A (zh) 新的杂环羧酸酰胺衍生物
HUP0300295A2 (hu) Helyettesített benzamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US20100168130A1 (en) Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof
CN100430379C (zh) 二芳基亚甲基哌啶衍生物、其制备及其用途
US20080262229A1 (en) Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof
Smagin et al. Brown et a1.
JP2006515352A (ja) 疼痛、不安及び機能的胃腸管障害の治療のためのデルタオピオイド受容体リガンドとしての４−｛［３−（スルホニルアミノ）フェニル］［１−（シクロメチル）ピペリジン−４−イリデン］メチル｝ベンズアミド誘導体
HUP0401610A2 (hu) 4-[Fenil-(4-piperidinil)-amino]-benzamid-származékok, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HK1102815B (en) Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US20070066653A1 (en) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof