AR050260A1 - Derivados de diarilmetilpiperazinas, su preparacion y su utilizacion - Google Patents
Derivados de diarilmetilpiperazinas, su preparacion y su utilizacionInfo
- Publication number
- AR050260A1 AR050260A1 ARP050102998A ARP050102998A AR050260A1 AR 050260 A1 AR050260 A1 AR 050260A1 AR P050102998 A ARP050102998 A AR P050102998A AR P050102998 A ARP050102998 A AR P050102998A AR 050260 A1 AR050260 A1 AR 050260A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- diarilmetilpiperazinas
- derivatives
- diastereomers
- prodrugs
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401968A SE0401968D0 (sv) | 2004-08-02 | 2004-08-02 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US60236304P | 2004-08-18 | 2004-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050260A1 true AR050260A1 (es) | 2006-10-11 |
Family
ID=32906880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102998A AR050260A1 (es) | 2004-08-02 | 2005-07-20 | Derivados de diarilmetilpiperazinas, su preparacion y su utilizacion |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20070249619A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1781631B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5006785B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1993338B (cg-RX-API-DMAC7.html) |
| AR (1) | AR050260A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE542806T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005267929B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0514014A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2576067C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2379364T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ553539A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1781631T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1781631E (cg-RX-API-DMAC7.html) |
| RS (1) | RS52315B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2404172C2 (cg-RX-API-DMAC7.html) |
| SE (1) | SE0401968D0 (cg-RX-API-DMAC7.html) |
| SG (1) | SG155181A1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI1781631T1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI370124B (cg-RX-API-DMAC7.html) |
| UA (1) | UA87146C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006014133A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200700680B (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0401086A3 (en) | 2001-05-18 | 2011-07-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| KR101234421B1 (ko) * | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| JP5253514B2 (ja) | 2007-12-11 | 2013-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | ステアロイル−ＣｏＡデサチュラーゼの阻害剤 |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| US8314250B2 (en) | 2009-11-24 | 2012-11-20 | Hoffmann-La Roche Inc. | Sultam derivatives |
| US20110207745A1 (en) * | 2009-11-25 | 2011-08-25 | Astrazeneca Ab | Solid forms of 4--n,n-diethylbenzamide, compositions thereof, and uses therewith |
| US9073881B2 (en) | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583713A5 (cg-RX-API-DMAC7.html) * | 1973-06-29 | 1977-01-14 | Cermol Sa | |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5840896A (en) * | 1989-11-22 | 1998-11-24 | Janssen Pharmaceutica, N.V. | Method of preventing or limiting reperfusion damage |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| DE69425662T2 (de) * | 1993-07-30 | 2001-04-12 | Delta Pharmaceuticals, Inc. | Als heilmittel nutzbare piperazin verbindungen |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| HUP0401086A3 (en) * | 2001-05-18 | 2011-07-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds |
| SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| CN1596113B (zh) * | 2001-10-29 | 2010-05-26 | 蒙特库克生物科学公司 | δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
-
2004
- 2004-08-02 SE SE0401968A patent/SE0401968D0/xx unknown
-
2005
- 2005-07-20 AR ARP050102998A patent/AR050260A1/es not_active Application Discontinuation
- 2005-07-21 TW TW094124625A patent/TWI370124B/zh not_active IP Right Cessation
- 2005-07-27 EP EP05762524A patent/EP1781631B1/en not_active Expired - Lifetime
- 2005-07-27 US US11/572,948 patent/US20070249619A1/en not_active Abandoned
- 2005-07-27 ES ES05762524T patent/ES2379364T3/es not_active Expired - Lifetime
- 2005-07-27 CN CN2005800262747A patent/CN1993338B/zh not_active Expired - Fee Related
- 2005-07-27 SG SG200905179-8A patent/SG155181A1/en unknown
- 2005-07-27 JP JP2007524765A patent/JP5006785B2/ja not_active Expired - Fee Related
- 2005-07-27 AU AU2005267929A patent/AU2005267929B2/en not_active Ceased
- 2005-07-27 UA UAA200700154A patent/UA87146C2/ru unknown
- 2005-07-27 NZ NZ553539A patent/NZ553539A/en not_active IP Right Cessation
- 2005-07-27 CA CA2576067A patent/CA2576067C/en not_active Expired - Fee Related
- 2005-07-27 RU RU2007101522/04A patent/RU2404172C2/ru not_active IP Right Cessation
- 2005-07-27 SI SI200531515T patent/SI1781631T1/sl unknown
- 2005-07-27 RS RS20120167A patent/RS52315B/sr unknown
- 2005-07-27 PT PT05762524T patent/PT1781631E/pt unknown
- 2005-07-27 AT AT05762524T patent/ATE542806T1/de active
- 2005-07-27 WO PCT/SE2005/001186 patent/WO2006014133A1/en not_active Ceased
- 2005-07-27 PL PL05762524T patent/PL1781631T3/pl unknown
- 2005-07-27 BR BRPI0514014-5A patent/BRPI0514014A/pt not_active IP Right Cessation
- 2005-10-05 US US11/243,623 patent/US20060030569A1/en not_active Abandoned
-
2007
- 2007-01-24 ZA ZA200700680A patent/ZA200700680B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005267929B2 (en) | 2010-04-08 |
| US20070249619A1 (en) | 2007-10-25 |
| PT1781631E (pt) | 2012-05-07 |
| JP5006785B2 (ja) | 2012-08-22 |
| US20060030569A1 (en) | 2006-02-09 |
| WO2006014133A1 (en) | 2006-02-09 |
| RS52315B (sr) | 2012-12-31 |
| RU2404172C2 (ru) | 2010-11-20 |
| ATE542806T1 (de) | 2012-02-15 |
| PL1781631T3 (pl) | 2012-07-31 |
| ES2379364T3 (es) | 2012-04-25 |
| SI1781631T1 (sl) | 2012-05-31 |
| ZA200700680B (en) | 2008-09-25 |
| CN1993338B (zh) | 2011-07-06 |
| EP1781631A1 (en) | 2007-05-09 |
| NZ553539A (en) | 2010-09-30 |
| CA2576067A1 (en) | 2006-02-09 |
| UA87146C2 (ru) | 2009-06-25 |
| SG155181A1 (en) | 2009-09-30 |
| BRPI0514014A (pt) | 2008-05-27 |
| EP1781631B1 (en) | 2012-01-25 |
| CA2576067C (en) | 2011-05-03 |
| TWI370124B (en) | 2012-08-11 |
| CN1993338A (zh) | 2007-07-04 |
| SE0401968D0 (sv) | 2004-08-02 |
| AU2005267929A1 (en) | 2006-02-09 |
| RU2007101522A (ru) | 2008-09-10 |
| TW200612930A (en) | 2006-05-01 |
| JP2008508350A (ja) | 2008-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |