RS20050946A - Pyrrolodihydroisoquinolines as pde10 inhibitors - Google Patents
Pyrrolodihydroisoquinolines as pde10 inhibitorsInfo
- Publication number
- RS20050946A RS20050946A YUP-2005/0946A YUP20050946A RS20050946A RS 20050946 A RS20050946 A RS 20050946A YU P20050946 A YUP20050946 A YU P20050946A RS 20050946 A RS20050946 A RS 20050946A
- Authority
- RS
- Serbia
- Prior art keywords
- pyrrolodihydroisoquinolines
- pde10 inhibitors
- pde10
- inhibitors
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Abstract
Pronalazak se odnosi na nove derivate pirolodihidroizohinolina, koji predstavljaju efikasne inhibitore PDE10.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03014424 | 2003-06-30 | ||
PCT/EP2004/051307 WO2005003129A1 (en) | 2003-06-30 | 2004-06-30 | Pyrrolodihydroisoquinolines as pde10 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20050946A true RS20050946A (en) | 2008-06-05 |
Family
ID=33560746
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0945A RS20050945A (en) | 2003-06-30 | 2004-06-30 | Novel pyrrolodihydroisoquinolines useful in the treatment of cancer |
YUP-2005/0946A RS20050946A (en) | 2003-06-30 | 2004-06-30 | Pyrrolodihydroisoquinolines as pde10 inhibitors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0945A RS20050945A (en) | 2003-06-30 | 2004-06-30 | Novel pyrrolodihydroisoquinolines useful in the treatment of cancer |
Country Status (22)
Country | Link |
---|---|
US (2) | US20060148840A1 (sr) |
EP (2) | EP1641794A1 (sr) |
JP (2) | JP2009513494A (sr) |
KR (1) | KR20060030483A (sr) |
CN (2) | CN1809565A (sr) |
AR (2) | AR045696A1 (sr) |
AT (1) | ATE478868T1 (sr) |
AU (2) | AU2004253690B2 (sr) |
BR (1) | BRPI0411897A (sr) |
CA (2) | CA2530316A1 (sr) |
DE (1) | DE602004028827D1 (sr) |
EA (1) | EA012110B1 (sr) |
IL (1) | IL171997A0 (sr) |
IS (1) | IS8238A (sr) |
MX (2) | MXPA05013553A (sr) |
NO (1) | NO20060202L (sr) |
NZ (1) | NZ544591A (sr) |
RS (2) | RS20050945A (sr) |
TW (2) | TW200510407A (sr) |
UA (1) | UA86591C2 (sr) |
WO (2) | WO2005003129A1 (sr) |
ZA (2) | ZA200509265B (sr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004253690B2 (en) * | 2003-06-30 | 2010-03-25 | Nycomed Gmbh | Pyrrolodihydroisoquinolines as PDE10 inhibitors |
DE602006006544D1 (de) * | 2005-01-12 | 2009-06-10 | Nycomed Gmbh | Neue pyrrolodihydroisochinoline als pde10-inhibitoren |
JP2008526817A (ja) * | 2005-01-12 | 2008-07-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のピロロジヒドロイソキノリン |
US20100179131A1 (en) | 2006-09-07 | 2010-07-15 | Nycomed Gmbh | Combination treatment for diabetes mellitus |
PT2152663E (pt) | 2007-06-04 | 2014-06-03 | Univ Ben Gurion | Compostos de triarilo e composições que compreendem os mesmos |
TW200918519A (en) * | 2007-09-19 | 2009-05-01 | Lundbeck & Co As H | Cyanoisoquinoline |
US7858620B2 (en) | 2007-09-19 | 2010-12-28 | H. Lundbeck A/S | Cyanoisoquinoline |
TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
EP2265334A2 (en) | 2008-02-29 | 2010-12-29 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | (二氫)咪唑並異〔5,1-a〕喹啉類 |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
TW201206935A (en) | 2010-07-16 | 2012-02-16 | Lundbeck & Co As H | Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor |
DE102010042833B4 (de) | 2010-10-22 | 2018-11-08 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung |
JO3089B1 (ar) | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
SG192839A1 (en) | 2011-02-18 | 2013-09-30 | Allergan Inc | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
WO2013045607A1 (en) | 2011-09-30 | 2013-04-04 | H. Lundbeck A/S | Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors |
WO2013050527A1 (en) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
TWI570124B (zh) | 2011-12-21 | 2017-02-11 | H 朗德貝克公司 | 作為pde10a酵素抑制劑的喹啉衍生物 |
WO2013127817A1 (en) | 2012-02-27 | 2013-09-06 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
CN103059029B (zh) * | 2012-12-28 | 2014-12-10 | 塔里木大学 | 一种六氢吡咯[2,3]并吲哚类化合物及其制备方法和在杀菌活性中的应用 |
CN105531272B (zh) * | 2013-07-25 | 2017-12-22 | 雅盖隆大学 | 作为5‑ht6拮抗剂的吡咯并喹啉衍生物、其制备方法和用途 |
JP6657101B2 (ja) | 2013-11-05 | 2020-03-04 | ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ | 糖尿病及びそれから生じる疾患合併症の治療のための化合物 |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
CN106456647A (zh) | 2014-04-18 | 2017-02-22 | 康塞特医药品有限公司 | 治疗高血糖症的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE690792A (sr) * | 1966-12-07 | 1967-05-16 | ||
DE3401018A1 (de) * | 1984-01-13 | 1985-07-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen |
FR2761358B1 (fr) * | 1997-03-27 | 1999-05-07 | Adir | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU2002227985A1 (en) * | 2000-12-13 | 2002-06-24 | Bayer Aktiengesellschaft | Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors |
IL149106A0 (en) * | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
US20030032579A1 (en) * | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
US20030018047A1 (en) * | 2001-04-20 | 2003-01-23 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
DE10130151A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Neue Verwendung für PDE 10A-Inhibitoren |
US20030236276A1 (en) * | 2001-08-06 | 2003-12-25 | Ulrich Niewohner | Pyrrolo[2.1-a]isoquinoline derivatives |
WO2003014115A1 (en) * | 2001-08-06 | 2003-02-20 | Bayer Aktiengesellschaft | 3-substituted pyrrolo (2.1-a) isoquinoline derivatives |
WO2003051877A1 (en) * | 2001-12-18 | 2003-06-26 | Bayer Corporation | 2-substituted pyrrolo[2.1-a]isoquinolines against cancer |
AU2004253690B2 (en) * | 2003-06-30 | 2010-03-25 | Nycomed Gmbh | Pyrrolodihydroisoquinolines as PDE10 inhibitors |
DE602006006544D1 (de) * | 2005-01-12 | 2009-06-10 | Nycomed Gmbh | Neue pyrrolodihydroisochinoline als pde10-inhibitoren |
JP2008526817A (ja) * | 2005-01-12 | 2008-07-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のピロロジヒドロイソキノリン |
-
2004
- 2004-06-30 AU AU2004253690A patent/AU2004253690B2/en not_active Ceased
- 2004-06-30 WO PCT/EP2004/051307 patent/WO2005003129A1/en active Application Filing
- 2004-06-30 CA CA002530316A patent/CA2530316A1/en not_active Abandoned
- 2004-06-30 BR BRPI0411897-9A patent/BRPI0411897A/pt not_active IP Right Cessation
- 2004-06-30 US US10/562,137 patent/US20060148840A1/en not_active Abandoned
- 2004-06-30 AR ARP040102291A patent/AR045696A1/es not_active Application Discontinuation
- 2004-06-30 JP JP2006516197A patent/JP2009513494A/ja active Pending
- 2004-06-30 NZ NZ544591A patent/NZ544591A/xx unknown
- 2004-06-30 UA UAA200600505A patent/UA86591C2/ru unknown
- 2004-06-30 EA EA200501928A patent/EA012110B1/ru not_active IP Right Cessation
- 2004-06-30 EP EP04766106A patent/EP1641794A1/en not_active Withdrawn
- 2004-06-30 DE DE602004028827T patent/DE602004028827D1/de active Active
- 2004-06-30 CA CA002530317A patent/CA2530317A1/en not_active Abandoned
- 2004-06-30 KR KR1020057024872A patent/KR20060030483A/ko not_active Application Discontinuation
- 2004-06-30 US US10/562,149 patent/US20060148838A1/en not_active Abandoned
- 2004-06-30 CN CNA2004800175231A patent/CN1809565A/zh active Pending
- 2004-06-30 AU AU2004253694A patent/AU2004253694A1/en not_active Abandoned
- 2004-06-30 AR ARP040102290A patent/AR044956A1/es not_active Application Discontinuation
- 2004-06-30 EP EP04741932A patent/EP1641792B1/en active Active
- 2004-06-30 MX MXPA05013553A patent/MXPA05013553A/es active IP Right Grant
- 2004-06-30 RS YUP-2005/0945A patent/RS20050945A/sr unknown
- 2004-06-30 TW TW093119589A patent/TW200510407A/zh unknown
- 2004-06-30 TW TW093119579A patent/TW200510413A/zh unknown
- 2004-06-30 WO PCT/EP2004/051315 patent/WO2005003130A1/en active Application Filing
- 2004-06-30 JP JP2006516198A patent/JP2009513495A/ja active Pending
- 2004-06-30 RS YUP-2005/0946A patent/RS20050946A/sr unknown
- 2004-06-30 CN CNA2004800175104A patent/CN1809564A/zh active Pending
- 2004-06-30 AT AT04741932T patent/ATE478868T1/de not_active IP Right Cessation
- 2004-06-30 MX MXPA05013822A patent/MXPA05013822A/es unknown
-
2005
- 2005-11-16 IL IL171997A patent/IL171997A0/en unknown
- 2005-11-16 ZA ZA200509265A patent/ZA200509265B/en unknown
- 2005-11-16 ZA ZA200509267A patent/ZA200509267B/en unknown
-
2006
- 2006-01-13 NO NO20060202A patent/NO20060202L/no not_active Application Discontinuation
- 2006-01-18 IS IS8238A patent/IS8238A/is unknown
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