RO91262B - Procedeu pentru prepararea stearatului de acetileritromicina - Google Patents
Procedeu pentru prepararea stearatului de acetileritromicinaInfo
- Publication number
- RO91262B RO91262B RO117230A RO11723085A RO91262B RO 91262 B RO91262 B RO 91262B RO 117230 A RO117230 A RO 117230A RO 11723085 A RO11723085 A RO 11723085A RO 91262 B RO91262 B RO 91262B
- Authority
- RO
- Romania
- Prior art keywords
- erythromycin
- compound
- acetyl
- stearate
- ester
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 acetyl erythromycin stearate Chemical compound 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 229960004142 erythromycin stearate Drugs 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring (AREA)
Abstract
Inventia se refera la un compus antibiotic, stearatul de acetil-eritromicina cu formula : (vezi formula). Compusul, conform inventiei, se absoarbe repede în tractul alimentar. Acidul gastric nu-l converteste într-o forma ineficienta, cum se întâmpla cu alti antibiotici de eritromicina. Absorbtia este de asemenea buna cînd pacientul asocieaza luarea medicamentului cu mîncarea. Compusul, conform inventiei, se prepara prin reactia dintre eritromicina baza cu o halogenura de acetil într-un solvent organic în prezenta unui acceptator de acid. Sarea de stearat se separa din esterul obtinut fara a separa esterul într-o faza intermediara.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK5884A DK149776C (da) | 1984-01-06 | 1984-01-06 | Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO91262A RO91262A (ro) | 1987-06-30 |
| RO91262B true RO91262B (ro) | 1987-07-01 |
Family
ID=8089251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO117230A RO91262B (ro) | 1984-01-06 | 1985-01-07 | Procedeu pentru prepararea stearatului de acetileritromicina |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US4599326A (ro) |
| JP (1) | JPS60158197A (ro) |
| KR (1) | KR900006237B1 (ro) |
| AT (1) | AT386414B (ro) |
| AU (1) | AU565688B2 (ro) |
| BE (1) | BE901411A (ro) |
| BG (1) | BG43189A3 (ro) |
| CA (1) | CA1224461A (ro) |
| CH (1) | CH666275A5 (ro) |
| CS (1) | CS247191B2 (ro) |
| CY (1) | CY1462A (ro) |
| DE (1) | DE3500179A1 (ro) |
| DK (1) | DK149776C (ro) |
| ES (1) | ES8605818A1 (ro) |
| FI (1) | FI77249C (ro) |
| FR (1) | FR2557878B1 (ro) |
| GB (1) | GB2152502B (ro) |
| HK (1) | HK11590A (ro) |
| HU (1) | HU196221B (ro) |
| IE (1) | IE57967B1 (ro) |
| IL (1) | IL73885A (ro) |
| IS (1) | IS2968A7 (ro) |
| IT (1) | IT1184304B (ro) |
| KE (1) | KE3841A (ro) |
| LU (1) | LU85721A1 (ro) |
| MA (1) | MA20316A1 (ro) |
| MX (1) | MX156277A (ro) |
| NL (1) | NL8403979A (ro) |
| NO (1) | NO160263C (ro) |
| NZ (1) | NZ210606A (ro) |
| PH (1) | PH22471A (ro) |
| PL (1) | PL144349B1 (ro) |
| PT (1) | PT79777B (ro) |
| RO (1) | RO91262B (ro) |
| SE (1) | SE461854B (ro) |
| SU (1) | SU1410866A3 (ro) |
| YU (1) | YU44485B (ro) |
| ZA (1) | ZA8410143B (ro) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874614A (en) * | 1985-03-25 | 1989-10-17 | Abbott Laboratories | Pharmaceutical tableting method |
| US4863741A (en) * | 1985-03-25 | 1989-09-05 | Abbott Laboratories | Tablet composition for drug combinations |
| JP3382159B2 (ja) * | 1998-08-05 | 2003-03-04 | 株式会社東芝 | 情報記録媒体とその再生方法及び記録方法 |
| US8840928B2 (en) | 2002-07-05 | 2014-09-23 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| US10004729B2 (en) | 2002-07-05 | 2018-06-26 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| WO2004004693A1 (en) * | 2002-07-05 | 2004-01-15 | Collgegium Pharmaceutical | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
| US20050163841A1 (en) * | 2003-10-31 | 2005-07-28 | Wong Patrick S. | Compositions and dosage forms for enhanced absorption of 3-amino-n-butyl-phosphinic acid |
| EP3326617A1 (en) | 2004-06-12 | 2018-05-30 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
| WO2006025882A2 (en) | 2004-08-25 | 2006-03-09 | The Uab Research Foundation | Absorption enhancers for drug administration |
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| CA2743725A1 (en) | 2006-06-23 | 2007-12-27 | Aegis Therapeutics, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| KR102512178B1 (ko) | 2011-05-18 | 2023-03-20 | 메더리스 다이어비티즈, 엘엘씨 | 개선된 펩티드 제약 |
| US11065304B2 (en) | 2012-11-20 | 2021-07-20 | Mederis Diabetes, Llc | Peptide pharmaceuticals for insulin resistance |
| DK2922877T3 (da) | 2012-11-20 | 2019-01-02 | Eumederis Pharmaceuticals Inc | Forbedrede peptidlægemidler |
| WO2014140699A1 (en) * | 2013-03-13 | 2014-09-18 | Calyx Chemicals And Pharmaceuticals Ltd | A novel process of liberation of erythromycin and preparation of its salts |
| CN117582516A (zh) | 2014-05-28 | 2024-02-23 | 梅德瑞斯糖尿病有限责任公司 | 针对胰岛素抵抗的改良肽药物 |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| BR112019024264A2 (pt) | 2017-05-19 | 2020-06-02 | Lunella Biotech, Inc. | Antimitoscinas: inibidores direcionados da biogênese mitoconcrial para erradicação de células-tronco de câncer |
| WO2019108729A1 (en) | 2017-12-01 | 2019-06-06 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| JP6941224B2 (ja) | 2018-02-06 | 2021-09-29 | イージス セラピューティクス，エルエルシー | 疾患の処置のための鼻腔内エピネフリン製剤及び方法 |
| DE112019000683T5 (de) | 2018-02-06 | 2020-10-15 | Aegis Therapeutics, Llc | Intranasale epinephrin-formulierungen und verfahren zur behandlung von erkrankungen |
| JP7641897B2 (ja) * | 2018-12-17 | 2025-03-07 | ルネラ・バイオテック・インコーポレーテッド | 抗加齢のための三剤組合せ療法 |
| AU2019403048B2 (en) * | 2018-12-17 | 2025-01-23 | Lunella Biotech, Inc. | Triple combination therapies for targeting mitochondria and killing cancer stem cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1179208A (fr) * | 1953-11-16 | 1959-05-21 | Abbott Lab | Procédé de préparation de sels d'érythromycine |
| DE1011117B (de) * | 1953-11-16 | 1957-06-27 | Abbott Lab | Verfahren zur Herstellung von reinen stabilen Erythromycin-Saeure-Additionssalzen |
| GB834397A (en) * | 1958-07-29 | 1960-05-04 | Lilly Co Eli | Therapeutic compositions comprising erythromycin esters |
| US4150220A (en) * | 1977-02-04 | 1979-04-17 | Pfizer Inc. | Semi-synthetic 4"-erythromycin A derivatives |
| FR2473525A1 (fr) * | 1980-01-11 | 1981-07-17 | Roussel Uclaf | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
-
1984
- 1984-01-06 DK DK5884A patent/DK149776C/da not_active IP Right Cessation
- 1984-12-18 NZ NZ210606A patent/NZ210606A/en unknown
- 1984-12-20 IL IL73885A patent/IL73885A/xx not_active IP Right Cessation
- 1984-12-21 AU AU37059/84A patent/AU565688B2/en not_active Ceased
- 1984-12-21 GB GB08432368A patent/GB2152502B/en not_active Expired
- 1984-12-27 US US06/686,753 patent/US4599326A/en not_active Expired - Fee Related
- 1984-12-28 ZA ZA8410143A patent/ZA8410143B/xx unknown
- 1984-12-28 BE BE0/214265A patent/BE901411A/fr not_active IP Right Cessation
- 1984-12-28 SE SE8406671A patent/SE461854B/sv not_active IP Right Cessation
- 1984-12-28 PT PT79777A patent/PT79777B/pt not_active IP Right Cessation
- 1984-12-28 IS IS2968A patent/IS2968A7/is unknown
- 1984-12-31 NL NL8403979A patent/NL8403979A/nl not_active Application Discontinuation
-
1985
- 1985-01-02 FR FR8500005A patent/FR2557878B1/fr not_active Expired
- 1985-01-02 MA MA20540A patent/MA20316A1/fr unknown
- 1985-01-02 NO NO850007A patent/NO160263C/no unknown
- 1985-01-03 FI FI850023A patent/FI77249C/fi not_active IP Right Cessation
- 1985-01-03 AT AT0000985A patent/AT386414B/de not_active IP Right Cessation
- 1985-01-04 PL PL1985251457A patent/PL144349B1/pl unknown
- 1985-01-04 IE IE22/85A patent/IE57967B1/en not_active IP Right Cessation
- 1985-01-04 KR KR1019850000008A patent/KR900006237B1/ko not_active Expired
- 1985-01-04 CH CH31/85A patent/CH666275A5/de not_active IP Right Cessation
- 1985-01-04 LU LU85721A patent/LU85721A1/fr unknown
- 1985-01-04 DE DE19853500179 patent/DE3500179A1/de active Granted
- 1985-01-04 CS CS8596A patent/CS247191B2/cs unknown
- 1985-01-04 ES ES539349A patent/ES8605818A1/es not_active Expired
- 1985-01-04 SU SU853836820A patent/SU1410866A3/ru active
- 1985-01-04 IT IT19012/85A patent/IT1184304B/it active
- 1985-01-04 CA CA000471563A patent/CA1224461A/en not_active Expired
- 1985-01-04 YU YU20/85A patent/YU44485B/xx unknown
- 1985-01-04 HU HU8537A patent/HU196221B/hu not_active IP Right Cessation
- 1985-01-05 BG BG068285A patent/BG43189A3/xx unknown
- 1985-01-07 JP JP60000744A patent/JPS60158197A/ja active Granted
- 1985-01-07 PH PH31689A patent/PH22471A/en unknown
- 1985-01-07 RO RO117230A patent/RO91262B/ro unknown
- 1985-01-07 MX MX203973A patent/MX156277A/es unknown
-
1988
- 1988-10-28 KE KE3841A patent/KE3841A/xx unknown
-
1989
- 1989-07-21 CY CY1462A patent/CY1462A/en unknown
-
1990
- 1990-02-15 HK HK115/90A patent/HK11590A/xx unknown
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